A Rare Case of Benign Recurrent Intrahepatic Cholestasis Initially Diagnosed in Middle-age
CONCLUSION: The comprehensive diagnosis of a middle-aged male patient with BRIC-2, which involved extensive radiological, hematological, and genetic investigations, informed a tailored tapering prednisone regimen, highlighting the importance of personalized medicine in managing atypical presentations of this rare cholestatic disorder.PMID:38607191 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Fang Liu Wei Li Ming-Gang Zhang Zhen-Mei Song Xiao-di Wang Xiu-Hong Wang Shi-Yu Du Source Type: research
NADPH OXIDASE-GENERATED REACTIVE OXYGEN SPECIES ARE INVOLVED IN ESTRADIOL 17 ß-d-GLUCURONIDE-INDUCED CHOLESTASIS
Biochimie. 2024 Apr 10:S0300-9084(24)00077-4. doi: 10.1016/j.biochi.2024.04.002. Online ahead of print.ABSTRACTThe endogenous metabolite of estradiol, estradiol 17β-D-glucuronide (E17G), is considered the main responsible of the intrahepatic cholestasis of pregnancy. E17G alters the activity of canalicular transporters through a signaling pathway-dependent cellular internalization, phenomenon that was attributed to oxidative stress in different cholestatic conditions. However, there are no reports involving oxidative stress in E17G-induced cholestasis, representing this the aim of our work. Using polarized hepatocyte cult...
Source: Biochimie - April 12, 2024 Category: Biochemistry Authors: Gimena Salas Alen A Litta Anabela C Medeot Virginia Schuck Romina B Andermatten Gisel S Miszczuk Nadia Ciriaci Ma Valeria Razori Ismael R Barosso Enrique J S ánchez Pozzi Marcelo G Roma Cecilia L Basiglio Fernando A Crocenzi Source Type: research
A Rare Case of Benign Recurrent Intrahepatic Cholestasis Initially Diagnosed in Middle-age
CONCLUSION: The comprehensive diagnosis of a middle-aged male patient with BRIC-2, which involved extensive radiological, hematological, and genetic investigations, informed a tailored tapering prednisone regimen, highlighting the importance of personalized medicine in managing atypical presentations of this rare cholestatic disorder.PMID:38607191 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Fang Liu Wei Li Ming-Gang Zhang Zhen-Mei Song Xiao-di Wang Xiu-Hong Wang Shi-Yu Du Source Type: research
NADPH oxidase-generated reactive oxygen species are involved in estradiol 17 ß-d-glucuronide-induced cholestasis
Biochimie. 2024 Apr 10;223:41-53. doi: 10.1016/j.biochi.2024.04.002. Online ahead of print.ABSTRACTThe endogenous metabolite of estradiol, estradiol 17β-D-glucuronide (E17G), is considered the main responsible of the intrahepatic cholestasis of pregnancy. E17G alters the activity of canalicular transporters through a signaling pathway-dependent cellular internalization, phenomenon that was attributed to oxidative stress in different cholestatic conditions. However, there are no reports involving oxidative stress in E17G-induced cholestasis, representing this the aim of our work. Using polarized hepatocyte cultures, we sho...
Source: Biochimie - April 12, 2024 Category: Biochemistry Authors: Gimena Salas Alen A Litta Anabela C Medeot Virginia S Schuck Romina B Andermatten Gisel S Miszczuk Nadia Ciriaci Ma Valeria Razori Ismael R Barosso Enrique J S ánchez Pozzi Marcelo G Roma Cecilia L Basiglio Fernando A Crocenzi Source Type: research
GSE261749 High-throughput Fitness Experiments Reveal Specific Vulnerabilities of Human-Adapted Salmonella During Stress and Infection- Barseq2 (Bile, iron restriction, osmotic pressure, heat)
Contributors : Benjamin X Wang ; Denise M MonackSeries Type : OtherOrganism : Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 ; Salmonella enterica subsp. enterica serovar Typhi str. Ty2 ; Salmonella enterica subsp. enterica serovar Typhimurium str. D23580 ; Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74Salmonella enterica is comprised of genetically distinct “serovars”, that together provide an intriguing model for exploring the genetic basis of pathogen evolution. While the genomes of numerous Salmonella isolates with broad variations in host range and human disease manifes...
Source: GEO: Gene Expression Omnibus - April 12, 2024 Category: Genetics & Stem Cells Tags: Other Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhimurium str. D23580 Salmonella enterica subsp. enterica serovar Source Type: research
Author's reply: “Bile reflux is associated with Barrett's esophagus”
We extend our gratitude to Dr. Li [1] and colleagues for their keen interest in our research, as expressed through their research letter which comments on our article, entitled “Association between endoscopic evidence of bile reflux and Barrett's esophagus: A large-scale case-control study” [2]. They conducted a meta-analysis including 6 cohort studies and concluded that bile reflux was associated with an increased risk of Barrett's esophagus, consistent with our study results. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 12, 2024 Category: Gastroenterology Authors: Yugo Iwaya Tags: Correspondence Source Type: research
Bile Acid –Targeted Hyaluronic Acid Nanoparticles for Enhanced Oral Absorption of Deferoxamine
AbstractPatients with β-thalassemia and sickle cell disease often rely on blood transfusions which can lead to hemochromatosis and chronic oxidative stress in cells and tissues. Deferoxamine (DFO) is clinically approved to treat hemochromatosis but is suboptimal to patients due to its poor pharmacokinetics which require s long-term infusion regimens. Although the oral route is preferable, DFO has limited oral bioavailability. Studies have shown that hyaluronic acid (HA) and bile acid (BA) can enhance the oral absorption of poorly absorbed drugs. To improve upon the oral delivery of DFO, we report on the synthesis a nd cha...
Source: The AAPS Journal - April 12, 2024 Category: Drugs & Pharmacology Source Type: research
Medium-Term Outcomes from a Series of 1000 One Anastomosis Gastric Bypass in Australia: A Case Series
ConclusionOAGB results has echoed previously published work as being efficacious and safe in a short-medium term. The prevalence of complications, especially bile reflux is overall low in our population and no current evidence exists to support an increased risk of metaplasia or malignancy related to bile within the stomach.Graphical Abstract (Source: Obesity Surgery)
Source: Obesity Surgery - April 12, 2024 Category: Surgery Source Type: research
Identification and biological characteristics of < em > Enterococcus casseliflavus < /em > TN-47 isolated from < em > Monochamus alternatus < /em >
This study aimed to investigate the in vitro antimicrobial and biological characteristics of Enterococcus casseliflavus TN-47 (PP411196), isolated from the gastrointestinal tract of M. alternatus in Jilin Province, PR China. Among 13 isolates obtained from the insects, five were preliminarily screened for antimicrobial activity. E. casseliflavus TN-47, which exhibited the strongest antimicrobial activity, was identified. E. casseliflavus TN-47 possessed antimicrobial activity against Staphylococcus aureus USA300 and Salmonella enterica serovar Pullorum ATCC 19945. Furthermore, E. casseliflavus TN-47 was sensitive to tetrac...
Source: International Journal of Systematic and Evolutionary Microbiology - April 11, 2024 Category: Microbiology Authors: Zi-Ran Peng Jian-Gang Zhang Jia-Bao Zhang Xiao-Qi Lin Wei Chen Yong-Jun Yang Zhen-Zhen Liu Source Type: research
Long-term safety of lanthanum carbonate in the real word: a 19-year disproportionality analysis from the FDA Adverse Event Reporting System
CONCLUSIONS: This study affirms lanthanum carbonate's long-term safety for reducing elevated blood phosphorus levels. While gastrointestinal disorders were common, attention must focus on emerging AEs, particularly stress, especially in elderly patients.PMID:38602862 | DOI:10.1080/14740338.2024.2343014 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 11, 2024 Category: Drugs & Pharmacology Authors: Mengjia Ying Jian Shi Yahao Ling Tao Shi Lele Liao Linhui Cao Source Type: research
Identification and biological characteristics of < em > Enterococcus casseliflavus < /em > TN-47 isolated from < em > Monochamus alternatus < /em >
This study aimed to investigate the in vitro antimicrobial and biological characteristics of Enterococcus casseliflavus TN-47 (PP411196), isolated from the gastrointestinal tract of M. alternatus in Jilin Province, PR China. Among 13 isolates obtained from the insects, five were preliminarily screened for antimicrobial activity. E. casseliflavus TN-47, which exhibited the strongest antimicrobial activity, was identified. E. casseliflavus TN-47 possessed antimicrobial activity against Staphylococcus aureus USA300 and Salmonella enterica serovar Pullorum ATCC 19945. Furthermore, E. casseliflavus TN-47 was sensitive to tetrac...
Source: International Journal of Systematic and Evolutionary Microbiology - April 11, 2024 Category: Microbiology Authors: Zi-Ran Peng Jian-Gang Zhang Jia-Bao Zhang Xiao-Qi Lin Wei Chen Yong-Jun Yang Zhen-Zhen Liu Source Type: research
Ursodeoxycholic acid loaded dual-modified graphene oxide nanocomposite alleviates cholestatic liver injury through inhibiting hepatocyte apoptosis
Colloids Surf B Biointerfaces. 2024 Apr 7;238:113904. doi: 10.1016/j.colsurfb.2024.113904. Online ahead of print.ABSTRACTUrsodeoxycholic acid (UDCA) is the preferred treatment for various types of cholestasis, however, its effectiveness is limited because of its insolubility in water. We used polyethylene glycol (PEG) and cationic polymer polyethylenimine (PEI) to double-modify graphite oxide (PPG) as a drug delivery system. UDCA was successfully loaded onto PPG through intermolecular interactions to form UDCA-PPG nanoparticles. UDCA-PPG nanoparticles not only improve the solubility and dispersibility of UDCA, but also hav...
Source: Colloids and Surfaces - April 11, 2024 Category: Biotechnology Authors: Wanyi Zhou Xinrui Yang Yaru Yin Si Chen Luxun Yang Tao Li Jing Liu Binghui Lu Zhangyou Yang Rong Li Mingman Zhang Source Type: research
Long-term safety of lanthanum carbonate in the real word: a 19-year disproportionality analysis from the FDA Adverse Event Reporting System
CONCLUSIONS: This study affirms lanthanum carbonate's long-term safety for reducing elevated blood phosphorus levels. While gastrointestinal disorders were common, attention must focus on emerging AEs, particularly stress, especially in elderly patients.PMID:38602862 | DOI:10.1080/14740338.2024.2343014 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 11, 2024 Category: Drugs & Pharmacology Authors: Mengjia Ying Jian Shi Yahao Ling Tao Shi Lele Liao Linhui Cao Source Type: research
Ursodeoxycholic acid loaded dual-modified graphene oxide nanocomposite alleviates cholestatic liver injury through inhibiting hepatocyte apoptosis
Colloids Surf B Biointerfaces. 2024 Apr 7;238:113904. doi: 10.1016/j.colsurfb.2024.113904. Online ahead of print.ABSTRACTUrsodeoxycholic acid (UDCA) is the preferred treatment for various types of cholestasis, however, its effectiveness is limited because of its insolubility in water. We used polyethylene glycol (PEG) and cationic polymer polyethylenimine (PEI) to double-modify graphite oxide (PPG) as a drug delivery system. UDCA was successfully loaded onto PPG through intermolecular interactions to form UDCA-PPG nanoparticles. UDCA-PPG nanoparticles not only improve the solubility and dispersibility of UDCA, but also hav...
Source: Colloids and Surfaces - April 11, 2024 Category: Biotechnology Authors: Wanyi Zhou Xinrui Yang Yaru Yin Si Chen Luxun Yang Tao Li Jing Liu Binghui Lu Zhangyou Yang Rong Li Mingman Zhang Source Type: research
Long-term safety of lanthanum carbonate in the real word: a 19-year disproportionality analysis from the FDA Adverse Event Reporting System
CONCLUSIONS: This study affirms lanthanum carbonate's long-term safety for reducing elevated blood phosphorus levels. While gastrointestinal disorders were common, attention must focus on emerging AEs, particularly stress, especially in elderly patients.PMID:38602862 | DOI:10.1080/14740338.2024.2343014 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 11, 2024 Category: Drugs & Pharmacology Authors: Mengjia Ying Jian Shi Yahao Ling Tao Shi Lele Liao Linhui Cao Source Type: research
