Bile Acids Aspiration Induces Fibrosis and Disrupts Surfactant Homeostasis in Human Lungs
Purpose: Lung transplantation remains the only treatment for end stage lung disease. However, survival remains limited by chronic lung allograft dysfunction (CLAD) characterized by progressive distal airway fibrosis. Multiple risk factors have been associated with CLAD, including gastroesophageal reflux aspiration. Previous studies have established Bile Acids (BA), detected in the airways, as marker of reflux aspiration and predictors of CLAD. The action of BA on human broncho-alveolar cell and tissue components is poorly explored, although its understanding could contribute to define mechanisms for CLAD. (Source: The Jour...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Russum, E. Floris, M. Della Zoppa, B. Kim, S. Ryeom, L. Benvenuto, F. D'Ovidio Source Type: research
Signs of Aspiration on Lung Allograft Transbronchial Biopsy are Associated with Reflux, Airway Bile Acids, and Chronic Lung Allograft Dysfunction (CLAD)
Purpose: Microaspiration is an established risk factor for CLAD. However, there are limited clinically available tools to assess for microaspiration. While pH-impedance testing is the current gold-standard to measure reflux, it does not identify aspiration into the lungs. Although biomarkers of aspiration, such as airway bile acids, have been identified, they are not yet available for clinical use. Transbronchial biopsies (TBBx) are routinely used to monitor and detect acute rejection in lung transplant recipients (LTRs). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K. Zhang, P. Bell, L. Levy, P. Pal, D. Hwang, E. Huszti, M. Aversa, A. Sage, S. Keshavjee, T. Martinu Source Type: research
Impacts of pancreatic exocrine insufficiency on gut microbiota
AbstractPancreatic exocrine insufficiency (PEI) can be induced by various kinds of diseases, including chronic pancreatitis, acute pancreatitis, and post-pancreatectomy. The main pathogenetic mechanism of PEI involves the decline of trypsin synthesis, disorder of pancreatic fluid flow, and imbalance of secretion feedback. Animal studies have shown that PEI could induce gut bacterial overgrowth and dysbiosis, with the abundance ofLactobacillus andBifidobacterium increasing the most, which could be partially reversed by pancreatic enzyme replacement therapy. Clinical studies have also confirmed the association between PEI an...
Source: Journal of Zhejiang University. Science. B. - April 1, 2024 Category: Universities & Medical Training Source Type: research
Clinical Analysis and in Vitro Correlation of BCRP-Mediated Drug-Drug Interaction in the Gastrointestinal Tract
In this study, we performed a ROS uptake study using human colon cancer-derived Caco-2 cells and confirmed that BCRP inhibitors significantly increased the intracellular accumulation of ROS. The correlation between the cell to medium (C/M) ratio of ROS obtained by the in vitro study and the absorption rate constant (ka) ratio obtained by clinical analysis was examined, and a significant positive correlation was observed. Therefore, it is suggested that the in vitro study using Caco-2 cells could be used to quantitatively estimate BCRP-mediated DDI with ROS in the gastrointestinal tract.PMID:38556260 | DOI:10.1248/bpb.b23-0...
Source: Biological and Pharmaceutical Bulletin - March 31, 2024 Category: Drugs & Pharmacology Authors: Liyanage Manosika Buddhini Perera Kenzo Okazaki Yunje Woo Saori Takahashi Xieyi Zhang Kenta Mizoi Toshinari Takahashi Takuo Ogihara Source Type: research
Clinical Analysis and in Vitro Correlation of BCRP-Mediated Drug-Drug Interaction in the Gastrointestinal Tract
In this study, we performed a ROS uptake study using human colon cancer-derived Caco-2 cells and confirmed that BCRP inhibitors significantly increased the intracellular accumulation of ROS. The correlation between the cell to medium (C/M) ratio of ROS obtained by the in vitro study and the absorption rate constant (ka) ratio obtained by clinical analysis was examined, and a significant positive correlation was observed. Therefore, it is suggested that the in vitro study using Caco-2 cells could be used to quantitatively estimate BCRP-mediated DDI with ROS in the gastrointestinal tract.PMID:38556260 | DOI:10.1248/bpb.b23-0...
Source: Biological and Pharmaceutical Bulletin - March 31, 2024 Category: Drugs & Pharmacology Authors: Liyanage Manosika Buddhini Perera Kenzo Okazaki Yunje Woo Saori Takahashi Xieyi Zhang Kenta Mizoi Toshinari Takahashi Takuo Ogihara Source Type: research
Clinical Analysis and in Vitro Correlation of BCRP-Mediated Drug-Drug Interaction in the Gastrointestinal Tract
In this study, we performed a ROS uptake study using human colon cancer-derived Caco-2 cells and confirmed that BCRP inhibitors significantly increased the intracellular accumulation of ROS. The correlation between the cell to medium (C/M) ratio of ROS obtained by the in vitro study and the absorption rate constant (ka) ratio obtained by clinical analysis was examined, and a significant positive correlation was observed. Therefore, it is suggested that the in vitro study using Caco-2 cells could be used to quantitatively estimate BCRP-mediated DDI with ROS in the gastrointestinal tract.PMID:38556260 | DOI:10.1248/bpb.b23-0...
Source: Biological and Pharmaceutical Bulletin - March 31, 2024 Category: Drugs & Pharmacology Authors: Liyanage Manosika Buddhini Perera Kenzo Okazaki Yunje Woo Saori Takahashi Xieyi Zhang Kenta Mizoi Toshinari Takahashi Takuo Ogihara Source Type: research
Ex vivo resection, vessel reconstruction and liver autotransplantation for cholangiocarcinoma: A report of two cases
CONCLUSIONS: ERAT should be considered as a therapeutic option for selected patients with cholangiocarcinoma invading caudate lobe, the retrohepatic vena cava and hepatic veins. It is crucial to reconstruct the outflow of hepatic venous according to different situations.PMID:38555210 | DOI:10.1016/j.asjsur.2024.03.001 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - March 30, 2024 Category: Surgery Authors: Dong Chen Wanguang Zhang Lai Wei Source Type: research
Ex vivo resection, vessel reconstruction and liver autotransplantation for cholangiocarcinoma: A report of two cases
CONCLUSIONS: ERAT should be considered as a therapeutic option for selected patients with cholangiocarcinoma invading caudate lobe, the retrohepatic vena cava and hepatic veins. It is crucial to reconstruct the outflow of hepatic venous according to different situations.PMID:38555210 | DOI:10.1016/j.asjsur.2024.03.001 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - March 30, 2024 Category: Surgery Authors: Dong Chen Wanguang Zhang Lai Wei Source Type: research
Ex vivo resection, vessel reconstruction and liver autotransplantation for cholangiocarcinoma: A report of two cases
CONCLUSIONS: ERAT should be considered as a therapeutic option for selected patients with cholangiocarcinoma invading caudate lobe, the retrohepatic vena cava and hepatic veins. It is crucial to reconstruct the outflow of hepatic venous according to different situations.PMID:38555210 | DOI:10.1016/j.asjsur.2024.03.001 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - March 30, 2024 Category: Surgery Authors: Dong Chen Wanguang Zhang Lai Wei Source Type: research
Ex vivo resection, vessel reconstruction and liver autotransplantation for cholangiocarcinoma: A report of two cases
CONCLUSIONS: ERAT should be considered as a therapeutic option for selected patients with cholangiocarcinoma invading caudate lobe, the retrohepatic vena cava and hepatic veins. It is crucial to reconstruct the outflow of hepatic venous according to different situations.PMID:38555210 | DOI:10.1016/j.asjsur.2024.03.001 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - March 30, 2024 Category: Surgery Authors: Dong Chen Wanguang Zhang Lai Wei Source Type: research
Cancers, Vol. 16, Pages 1368: FXR Agonism with Bile Acid Mimetic Reduces Pre-Clinical Triple-Negative Breast Cancer Burden
In conclusion, agonism of FXR by primary bile acid memetic OCA yields potent anti-tumor effects potentially through inhibition of proliferation and migration and reduced cell viability. These findings suggest that FXR is a tumor suppressor gene with a high potential for use in personalized therapeutic strategies for individuals with BC. (Source: Cancers)
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Sydney C. Joseph Samson Eugin Simon Margaret S. Bohm Minjeong Kim Madeline E. Pye Boston W. Simmons Dillon G. Graves Stacey M. Thomas-Gooch Ubaid A. Tanveer Jeremiah R. Holt Suriyan Ponnusamy Laura M. Sipe D. Neil Hayes Katherine L. Cook Ramesh Narayanan Tags: Article Source Type: research
Comparative Risks of Post-ERCP Adverse Events in Patients with Asymptomatic and Symptomatic Choledocholithiasis: A Systematic Review and Meta-Analysis
ConclusionsAsymptomatic patients with choledocholithiasis appear to have a higher risk of PEP than symptomatic patients, while the risk of other post-ERCP adverse events is similar between the two groups. Interventional endoscopists should thoroughly discuss potential adverse events (particularly PEP) with asymptomatic patients before performing ERCP and utilize PEP-prevention measures more liberally in this subgroup of patients. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 30, 2024 Category: Gastroenterology Source Type: research
How to do it: rescue duct-to-duct biliary reconstruction techniques to avoid severe biliary complications of hepatic resection for hepatocellular carcinoma
AbstractThere are few reports on duct-to-duct biliary reconstruction for complex liver resection with limited bile duct resection. We performed duct-to-duct biliary reconstruction in two patients undergoing limited bile duct resection where Roux-en-Y hepaticojejunostomy (HJ) was difficult. An external biliary drainage tube was placed routinely at the anastomotic site to prevent stenosis. In case 1, the tumor-infiltrated part of the left hepatic duct (LHD) was resected and the LHD was repaired using duct-to-duct reconstruction with interrupted sutures. In case 2, after the tumor-infiltrated part of the LHD and posterior hep...
Source: Surgery Today - March 29, 2024 Category: Surgery Source Type: research
Effects of nicotine on microRNA-124 expression in bile duct ligation-induced liver fibrosis in rats
CONCLUSION: Considering that miRNA-124 is an anti-inflammatory miRNA, it can be concluded that the decrease in its expression due to nicotine exposure leads to an increase in inflammatory processes and subsequently to an increase in liver fibrosis.PMID:38549169 | DOI:10.1186/s40360-024-00749-3 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 29, 2024 Category: Drugs & Pharmacology Authors: Khalil Hajiasgharzadeh Parviz Shahabi Elham Karimi-Sales Mohammad Reza Alipour Source Type: research
