What Happens After Discharge? A 2+ Year Follow-Up After Laparoscopic Subtotal Fenestrating and Reconstituting Cholecystectomy
Am Surg. 2024 Apr 2:31348241241617. doi: 10.1177/00031348241241617. Online ahead of print.ABSTRACTLaparoscopic subtotal cholecystectomy (LSC) is utilized to prevent complications in the difficult cholecystectomy. Medium-term outcomes are poorly studied for fenestrating and reconstituting operative techniques. A single-institution retrospective review was undertaken of all LSCs. A telephone survey was used to identify complications addressed at other institutions. We performed subgroup analyses by operative approach and of patients requiring postoperative endoscopic intervention (ERC). 28 patients met inclusion criteria. Th...
Source: The American Surgeon - April 2, 2024 Category: Surgery Authors: Sunjay S Kumar Erin Briggs Sami Tannouri Talar Tatarian Michael J Pucci Renee M Tholey Karen A Chojnacki Courtney Foley Francesco Palazzo Source Type: research
Aldicarb disturbed bile acid, steroid hormone and oxylipin homeostasis in C57BL/6 J mice
Ecotoxicol Environ Saf. 2024 Apr 1;275:116285. doi: 10.1016/j.ecoenv.2024.116285. Online ahead of print.ABSTRACTMounting evidence has shown that the gut microbiota plays a key role in human health. The homeostasis of the gut microbiota could be affected by many factors, including environmental chemicals. Aldicarb is a carbamate insecticide used to control a variety of insects and nematode pests in agriculture. Aldicarb is highly toxic and its wide existence has become a global public health concern. In our previous study, we have demonstrated that aldicarb disturbed the gut microbial community structure and composition. Ho...
Source: Ecotoxicology and Environmental Safety - April 2, 2024 Category: Environmental Health Authors: Xin Liu Pengcheng Tu Ying Zhang Weichen Xu Jinjun Shan Bei Gao Source Type: research
Bile salt hydrolase activity-based probes for monitoring gut microbial bile acid metabolism
Chembiochem. 2024 Apr 2:e202300821. doi: 10.1002/cbic.202300821. Online ahead of print.ABSTRACTBile acids are bioactive metabolites that are biotransformed into secondary bile acids by the gut microbiota, a vast consortium of microbes that inhabit the intestines. The first step in intestinal secondary bile acid metabolism is carried out by a critical enzyme, bile salt hydrolase (BSH), that catalyzes the gateway reaction that precedes all subsequent microbial metabolism of these important metabolites. As gut microbial metabolic activity is difficult to probe due to the complex nature of the gut microbiome, approaches are ne...
Source: Chembiochem - April 2, 2024 Category: Biochemistry Authors: Lin Han Raymond Xu Amanda Conwell Sola Takahashi Bibudha Parasar Pamela Chang Source Type: research
Arsenic's shadowy influence: A systematic review of its carcinogenic role in gallbladder cancer
ConclusionThere is a strong link between arsenic exposure and gallbladder cancer or cholangiocarcinoma. Even chronic exposure to low-moderate amounts could lead to gallbladder carcinoma. These findings stress the need for more comprehensive and dedicated studies, to control arsenic water/soil levels and seek other preventive measures for this high mortality disease. (Source: Journal of Hepato-Biliary-Pancreatic Surgery)
Source: Journal of Hepato-Biliary-Pancreatic Surgery - April 2, 2024 Category: Surgery Authors: Anas Elgenidy,
Ramez M. Odat,
Horiah Amer Al ‐Ghorbany,
Hatim Nasruldin Shahin,
Ibrahim S. Abdel‐bary,
Roaa AbdulTawab AbdulHamid,
Amal Dhahab,
Moustafa Salem,
Youmna A. Negm,
Nada Mostafa El Attar,
Ahmed Assem Abdelfattah,
Mai M. Khaliel, Tags: SYSTEMATIC REVIEW Source Type: research
Long-term surgical outcomes of bile duct tumor thrombus versus portal vein tumor thrombus for hepatocellular carcinoma: a propensity score matching analysis
ConclusionAggressive hemihepatectomy provides an acceptable prognosis for HCC patients with macro-BDTT. Furthermore, the long-term surgical outcomes of HCC patients with macro-BDTT were significantly better than those of HCC patients with macro-PVTT. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research
Surgical interpretation of the WHO subclassification of intrahepatic cholangiocarcinoma: a narrative review
AbstractIntrahepatic cholangiocarcinoma (iCCA) has been subclassified by its gross morphology into the mass-forming (MF), periductal-infiltrating (PI), and intraductal growth (IG) types and their combinations. This classification correlates well with clinical features; for example, MF-iCCA has less lymph-node metastasis and a better prognosis than PI-iCCA. According to the recently accumulated evidence from histological investigations, the WHO classification endorsed a subclassification scheme in which iCCA cases are classified into small- and large-duct types. Small-duct iCCA is considered to originate from septal or smal...
Source: Surgery Today - April 2, 2024 Category: Surgery Source Type: research
Functional mechanism of baicalein in alleviating severe acute pancreatitis-acute lung injury by blocking the TLR4/MyD88/TRIF signaling pathway
In conclusion, baicalein can inhibit the TLR4/MyD88/TRIF pathway and alleviate inflammatory response and oxidative stress in SAP-ALI rats by upregulating miR-182 and suppressing TLR4, thus ameliorating SAP-ALI.PMID:38557861 | DOI:10.14670/HH-18-733 (Source: Histology and Histopathology)
Source: Histology and Histopathology - April 1, 2024 Category: Cytology Authors: Qingjing Yang Chao Yue Xing Huang Zihe Wang Zhenlu Li Weiming Hu Huimin Lu Source Type: research
Arsenic's shadowy influence: A systematic review of its carcinogenic role in gallbladder cancer
CONCLUSION: There is a strong link between arsenic exposure and gallbladder cancer or cholangiocarcinoma. Even chronic exposure to low-moderate amounts could lead to gallbladder carcinoma. These findings stress the need for more comprehensive and dedicated studies, to control arsenic water/soil levels and seek other preventive measures for this high mortality disease.PMID:38561626 | DOI:10.1002/jhbp.1428 (Source: Cancer Control)
Source: Cancer Control - April 1, 2024 Category: Cancer & Oncology Authors: Anas Elgenidy Ramez M Odat Horiah Amer Al-Ghorbany Hatim Nasruldin Shahin Ibrahim S Abdel-Bary Roaa AbdulTawab AbdulHamid Amal Dhahab Moustafa Salem Youmna A Negm Nada Mostafa El Attar Ahmed Assem Abdelfattah Mai M Khaliel Shehab M Moawad Ahmed M Afifi Source Type: research
Management of Choledocholithiasis in a Community Hospital: Laparoscopic Common Bile Duct Exploration Versus Endoscopic Retrograde Cholangiopancreatography
DISCUSSION: Since implementation of LC + CBDE, there has been reduced LOS without increasing complication rates. Operative times are increased with LC + CBDE but offset by reduced LOS, additional anesthesia events, and procedures. Our institution will continue to pursue LC + CBDE when indicated with efforts to improve resource allocation.PMID:38557206 | DOI:10.1177/00031348241241626 (Source: The American Surgeon)
Source: The American Surgeon - April 1, 2024 Category: Surgery Authors: Molly M McNamee Michael P Stolz Robert Tyler Harvell Christopher A Staley Emilie E Green Hedaya D Othman Brian H Gibson Source Type: research
Functional mechanism of baicalein in alleviating severe acute pancreatitis-acute lung injury by blocking the TLR4/MyD88/TRIF signaling pathway
In conclusion, baicalein can inhibit the TLR4/MyD88/TRIF pathway and alleviate inflammatory response and oxidative stress in SAP-ALI rats by upregulating miR-182 and suppressing TLR4, thus ameliorating SAP-ALI.PMID:38557861 | DOI:10.14670/HH-18-733 (Source: Histology and Histopathology)
Source: Histology and Histopathology - April 1, 2024 Category: Cytology Authors: Qingjing Yang Chao Yue Xing Huang Zihe Wang Zhenlu Li Weiming Hu Huimin Lu Source Type: research
Multicenter Validation of Large Airway Bronchial Wash (LABW) Bile Acid Signature for the Diagnosis of Aspiration and Prediction of Chronic Lung Allograft Dysfunction
Purpose: Microaspiration of gastrointestinal contents into the tracheobronchial tree has been previously identified to be a risk factor for chronic lung allograft dysfunction (CLAD) in lung transplant recipients (LTRs). Bile acids (BA) measured in airways of LTRs has been independently validated as a marker of aspiration and linked to an increased risk of CLAD. Indeed, BA in bronchoalveolar lavage and in LABW at 3 months are predictive of CLAD and correlate with increased levels of cytokines and lipids in the airway. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , R. Ramendra, A. Sage, J. Havlin, M. Leiva-Juarez, E. Floris, R. Nandakumar, S. Cremers, E. Huszti, L. Benvenuto, S. Arcasoy, S. Keshavjee, T. Martinu, F. D'Ovidio Source Type: research
Bile Acids Aspiration Induces Fibrosis and Disrupts Surfactant Homeostasis in Human Lungs
Purpose: Lung transplantation remains the only treatment for end stage lung disease. However, survival remains limited by chronic lung allograft dysfunction (CLAD) characterized by progressive distal airway fibrosis. Multiple risk factors have been associated with CLAD, including gastroesophageal reflux aspiration. Previous studies have established Bile Acids (BA), detected in the airways, as marker of reflux aspiration and predictors of CLAD. The action of BA on human broncho-alveolar cell and tissue components is poorly explored, although its understanding could contribute to define mechanisms for CLAD. (Source: The Jour...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Russum, E. Floris, M. Della Zoppa, B. Kim, S. Ryeom, L. Benvenuto, F. D'Ovidio Source Type: research
Signs of Aspiration on Lung Allograft Transbronchial Biopsy are Associated with Reflux, Airway Bile Acids, and Chronic Lung Allograft Dysfunction (CLAD)
Purpose: Microaspiration is an established risk factor for CLAD. However, there are limited clinically available tools to assess for microaspiration. While pH-impedance testing is the current gold-standard to measure reflux, it does not identify aspiration into the lungs. Although biomarkers of aspiration, such as airway bile acids, have been identified, they are not yet available for clinical use. Transbronchial biopsies (TBBx) are routinely used to monitor and detect acute rejection in lung transplant recipients (LTRs). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , K. Zhang, P. Bell, L. Levy, P. Pal, D. Hwang, E. Huszti, M. Aversa, A. Sage, S. Keshavjee, T. Martinu Source Type: research
Impacts of pancreatic exocrine insufficiency on gut microbiota
AbstractPancreatic exocrine insufficiency (PEI) can be induced by various kinds of diseases, including chronic pancreatitis, acute pancreatitis, and post-pancreatectomy. The main pathogenetic mechanism of PEI involves the decline of trypsin synthesis, disorder of pancreatic fluid flow, and imbalance of secretion feedback. Animal studies have shown that PEI could induce gut bacterial overgrowth and dysbiosis, with the abundance ofLactobacillus andBifidobacterium increasing the most, which could be partially reversed by pancreatic enzyme replacement therapy. Clinical studies have also confirmed the association between PEI an...
Source: Journal of Zhejiang University. Science. B. - April 1, 2024 Category: Universities & Medical Training Source Type: research
