Risk Factor Analysis of Hepatic Encephalopathy and the Establishment of Diagnostic Model
In this study, the HE diagnostic model was established using logistic regression analysis, which could benefit patients in early HE differential diagnosis. Particularly, combined detection of serum homocysteine and bile acid levels was considered to be more significant.PMID:35909486 | PMC:PMC9325620 | DOI:10.1155/2022/3475325 (Source: Biomed Res)
Source: Biomed Res - August 1, 2022 Category: Research Authors: Fangfang Chen Jing Li Wenjie Zhang Caixia Mao Yanxia Wang Yan Qu Shuju Tian Fanhong Li Source Type: research

IL-25 ameliorates acute cholestatic liver injury via promoting hepatic bile acid secretion
In conclusion, IL-25 exhibited a protective effect against ANIT-induced cholestatic liver injury in mice, which may be related to the regulation on bile acids secretion. These results provide a theoretical basis for the use of IL-25 in the treatment of cholestatic hepatopathy.PMID:35914403 | DOI:10.1016/j.cyto.2022.155979 (Source: Cytokine)
Source: Cytokine - August 1, 2022 Category: Molecular Biology Authors: Zewei Zhao Siqi Liu Shiya Luo Lin Zhou Junxi Liu Bingxiu Qian Jianglin Shi Yayun Zhou Jin Li Tao Jiang Zhiyue Lv Zhonghan Yang Source Type: research

5-Aminosalicylic acid ameliorates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota and bile acid metabolism
In conclusion, 5-ASA can ameliorate DSS-induced colitis in mice by modulating gut microbiota and bile acid metabolism. These findings documented the new therapeutic mechanisms of 5-ASA in clinical colitis treatment.PMID:35913641 | DOI:10.1007/s00018-022-04471-3 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - August 1, 2022 Category: Cytology Authors: Ling Huang Junping Zheng Guangjun Sun Huabing Yang Xiongjie Sun Xiaowei Yao Aizhen Lin Hongtao Liu Source Type: research

Pretransplant Evaluation and Liver Transplantation Outcome in PBC Patients
Can J Gastroenterol Hepatol. 2022 Jul 22;2022:7831165. doi: 10.1155/2022/7831165. eCollection 2022.ABSTRACTPrimary biliary cholangitis (PBC) is an autoimmune chronic cholestatic liver disease characterized by progressive cholangiocyte and bile duct destruction leading to fibrosis and finally to liver cirrhosis. The presence of disease-specific serological antimitochondrial antibody (AMA) together with elevated alkaline phosphatase (ALP) as a biomarker of cholestasis is sufficient for diagnosis. Ursodeoxycholic acid (UDCA) is the first treatment option for PBC. Up to 40% of patients have an incomplete response to therapy, a...
Source: Canadian Journal of Gastroenterology - August 1, 2022 Category: Gastroenterology Authors: Maja Mijic Ivona Saric Bozena Delija Milos Lalovac Nikola Sobocan Eva Radetic Dora Martincevic Tajana Filipec Kanizaj Source Type: research

Emerging Trends and Hot Spots in Hepatic Glycolipid Metabolism Research From 2002 to 2021: A Bibliometric Analysis
We described the overall structure of scientific research on hepatic glycolipid metabolism and presented systematic information to other researchers. The current focus on NAFLD and gut microbiota is critical to further study and will help explore effective therapeutic strategy for aberrant glycolipid metabolism in liver.PMID:35911114 | PMC:PMC9326119 | DOI:10.3389/fnut.2022.933211 (Source: Atherosclerosis)
Source: Atherosclerosis - August 1, 2022 Category: Cardiology Authors: Yanyu Zhou Xiaoqi Lin Suqing Yin Ling Zhu Yuting Yang Yixuan Li Baoshan Wang Yingfu Jiao Weifeng Yu Po Gao Liqun Yang Source Type: research

IL-25 ameliorates acute cholestatic liver injury via promoting hepatic bile acid secretion
In conclusion, IL-25 exhibited a protective effect against ANIT-induced cholestatic liver injury in mice, which may be related to the regulation on bile acids secretion. These results provide a theoretical basis for the use of IL-25 in the treatment of cholestatic hepatopathy.PMID:35914403 | DOI:10.1016/j.cyto.2022.155979 (Source: Cancer Control)
Source: Cancer Control - August 1, 2022 Category: Cancer & Oncology Authors: Zewei Zhao Siqi Liu Shiya Luo Lin Zhou Junxi Liu Bingxiu Qian Jianglin Shi Yayun Zhou Jin Li Tao Jiang Zhiyue Lv Zhonghan Yang Source Type: research

Risk Factor Analysis of Hepatic Encephalopathy and the Establishment of Diagnostic Model
In this study, the HE diagnostic model was established using logistic regression analysis, which could benefit patients in early HE differential diagnosis. Particularly, combined detection of serum homocysteine and bile acid levels was considered to be more significant.PMID:35909486 | PMC:PMC9325620 | DOI:10.1155/2022/3475325 (Source: Biomed Res)
Source: Biomed Res - August 1, 2022 Category: Research Authors: Fangfang Chen Jing Li Wenjie Zhang Caixia Mao Yanxia Wang Yan Qu Shuju Tian Fanhong Li Source Type: research

IL-25 ameliorates acute cholestatic liver injury via promoting hepatic bile acid secretion
In conclusion, IL-25 exhibited a protective effect against ANIT-induced cholestatic liver injury in mice, which may be related to the regulation on bile acids secretion. These results provide a theoretical basis for the use of IL-25 in the treatment of cholestatic hepatopathy.PMID:35914403 | DOI:10.1016/j.cyto.2022.155979 (Source: Cytokine)
Source: Cytokine - August 1, 2022 Category: Molecular Biology Authors: Zewei Zhao Siqi Liu Shiya Luo Lin Zhou Junxi Liu Bingxiu Qian Jianglin Shi Yayun Zhou Jin Li Tao Jiang Zhiyue Lv Zhonghan Yang Source Type: research

5-Aminosalicylic acid ameliorates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota and bile acid metabolism
In conclusion, 5-ASA can ameliorate DSS-induced colitis in mice by modulating gut microbiota and bile acid metabolism. These findings documented the new therapeutic mechanisms of 5-ASA in clinical colitis treatment.PMID:35913641 | DOI:10.1007/s00018-022-04471-3 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - August 1, 2022 Category: Cytology Authors: Ling Huang Junping Zheng Guangjun Sun Huabing Yang Xiongjie Sun Xiaowei Yao Aizhen Lin Hongtao Liu Source Type: research

Pretransplant Evaluation and Liver Transplantation Outcome in PBC Patients
Can J Gastroenterol Hepatol. 2022 Jul 22;2022:7831165. doi: 10.1155/2022/7831165. eCollection 2022.ABSTRACTPrimary biliary cholangitis (PBC) is an autoimmune chronic cholestatic liver disease characterized by progressive cholangiocyte and bile duct destruction leading to fibrosis and finally to liver cirrhosis. The presence of disease-specific serological antimitochondrial antibody (AMA) together with elevated alkaline phosphatase (ALP) as a biomarker of cholestasis is sufficient for diagnosis. Ursodeoxycholic acid (UDCA) is the first treatment option for PBC. Up to 40% of patients have an incomplete response to therapy, a...
Source: Canadian Journal of Gastroenterology - August 1, 2022 Category: Gastroenterology Authors: Maja Mijic Ivona Saric Bozena Delija Milos Lalovac Nikola Sobocan Eva Radetic Dora Martincevic Tajana Filipec Kanizaj Source Type: research