Bile Acids Aspiration Induces Fibrosis and Disrupts Surfactant Homeostasis in Human Lungs

Purpose: Lung transplantation remains the only treatment for end stage lung disease. However, survival remains limited by chronic lung allograft dysfunction (CLAD) characterized by progressive distal airway fibrosis. Multiple risk factors have been associated with CLAD, including gastroesophageal reflux aspiration. Previous studies have established Bile Acids (BA), detected in the airways, as marker of reflux aspiration and predictors of CLAD. The action of BA on human broncho-alveolar cell and tissue components is poorly explored, although its understanding could contribute to define mechanisms for CLAD.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research