Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
LyGenesis Commences Phase II Trial for Growth of Liver Organoids in Patient Lymph Nodes
LyGenesis has been working towards liver organoid transplantation as a treatment for liver failure for some years now. Organs such as the liver, thymus, and a few others do not need to be in any specific place in the body to carry out many of their varied functions. Some of the vital work of the liver, for example, can be conducted in small organoids grown from liver cells transplanted into lymph nodes or other parts of the body that can act as stable bioreactors.
Even setting aside the possibility of growing functional liver organoids from patient cells or universal cell lines, it is worth noting that the old appro...
Source: Fight Aging! - April 9, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
What Do Fats Do in the Body?
It’s common knowledge that too much cholesterol and other fats can lead to disease and that a healthy diet involves watching how much fatty food we eat. However, our bodies need a certain amount of fat to function—and we can’t make it from scratch.
Hepatocytes, like the one shown here, are the most abundant type of cell in the human liver. One important role they play is producing bile, a liquid that aids in digesting fats. Credit: Donna Beer Stolz, University of Pittsburgh.
Triglycerides, cholesterol, and other essential fatty acids—the fats our bodies can’t make on their own—store energy, ins...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 24, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Common questions Source Type: blogs
HDL dysfunction & It ’ s clinical Implication
High-density lipoproteins (HDLs) represent a class of lipids, very heterogeneous in structure, composition, and biological functions .The density is between 1.063 to 1.210. It has at least 5 sub-types. Normal HDL level in blood should be above 35mg (50-60mg Ideal). When it goes beyond 60 there is not much benefit to accrue and also some surprise findings are there.(Article will be linked)
We know ,HDL carries free cholesterol from peripheral cells, including macrophages and endothelial cells. After reaching the liver, HDL receptors in the hepatocellular surface, metabolize it into bile acid or neutral lipids, which are ...
Source: Dr.S.Venkatesan MD - January 21, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
poem
ConsentThere is a risk of bleedingA risk of infectionOf dyingAnything you say Can and will be usedAgainst you In the courtOf arbitrary opinionPlace your hand over your heartFace the sunTo which it standsOne nation under the influenceOf cynical fraudstersAnd half hearted huggers O ’er the ramparts we bumpedOur fists and agreedThat there are no guarantees hereThat everything could go horribly wrongWake up with whisksInstead of handsLeak bile when cutAnd shit bloodIn the morning Forget your nameAnd never miss itAmerica! America!God shat his graceOn theeFor this is your last chanceTo do something&nb...
Source: Buckeye Surgeon - January 9, 2024 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Fight Aging! Newsletter, January 1st 2024
Discussion of What is Need to Speed the Pace at which Drugs to Treat Aging Arrive in the Clinic
Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Blunt Thoughts on Calculating the Revealed Value of Human Life
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
Towards Adjustment of the Gut Microbiome to Slow Aging
Gene Therapy Enhances Object Recognition Memory in Young and Old Mice
Benefits of Sem...
Source: Fight Aging! - December 31, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Taurine is a semi-essential amino acid. Dietary taurine supplementation has been shown to modestly slow aging in mice, though as for all such interventions there is always the question of whether it will prove to be less useful in humans, and also whether these results in mice will be disproved by the much more rigorous Interventions Testing Program (ITP), once that group gets around to assessing taurine supplementation. Few of the numerous interventions thought to modestly slow aging in mice on the basis of earlier research actually held up once subjected to the ITP degree of experimental rigor.
Speculatively, taur...
Source: Fight Aging! - December 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 25th 2023
This study generates a comprehensive single-cell transcriptomic atlas of human atherosclerosis including 118,578 high-quality cells from atherosclerotic coronary and carotid arteries. By performing systematic benchmarking of integration methods, we mitigated data overcorrection while separating major cell lineages. Notably, we define cell subtypes that have not been previously identified from individual human atherosclerosis scRNA-seq studies.
Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome...
Source: Fight Aging! - December 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Contributions of Circadian Rhythm Dysfunction and Dysbiosis to Blood-Brain Barrier Leakage
The blood-brain barrier is a layer of specialized cells wrapping blood vessels that pass through the brain. Only certain molecules and cells are admitted. The metabolism of the brain is thus isolated from that of the rest of the body. In particular, the immune system of the brain is quite different from that of the rest of the body. Unfortunately, this isolation is a vulnerability when, like all biological systems, the blood-brain barrier begins to break down and leak. The leakage of inappropriate molecules and cells into the brain provokes inflammation and dysfunction, and this is likely a contributing factor in the devel...
Source: Fight Aging! - December 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 18th 2023
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
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Aged Transplant Organs Cause Harm to Younger Recipients
https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/
Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent me...
Source: Fight Aging! - December 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Changes in the Gut Microbiome Correlate with Aging and Renal Function
The gut microbiome changes with age. Pro-inflammatory microbial populations grow in size at the expense of populations that produce beneficial metabolites. As researchers produce increasingly large databases of the composition of the gut microbiome across ages and populations, they are also mapping a growing number of specific connections between microbial species and aspects of aging. Some of this work shows causation, but most human data can only show correlations between aspects of the gut microbiome and aspects of aging. In today's open access paper, the authors focused on finding links between the gut microbiome and t...
Source: Fight Aging! - December 15, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Novel Mitophagy Inducing Compound
A sizable fraction of research aimed at treating aging involves screening natural compounds in search of those that can modestly slow aging in short-lived animal models. This is because the economics of developing such a compound into a drug or supplement are well understood by investors, and because it dovetails well with the scientific goal of increased understanding of how aging progresses at the level of cellular biochemistry, rather than because it is going to make a big difference for patients. If sizable gains in healthy life span were the driving incentive, the field would look very different, and the emphasis woul...
Source: Fight Aging! - November 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution.
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Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Pigs as a Model to Explore Links Between the Gut Microbiome and Chronic Inflammation in Aging
This study employed a comprehensive metagenomic analysis encompassing saliva and stool samples obtained from 45 pigs representing three distinct age groups, alongside serum metabolomics and lipidomics profiling. Our findings unveiled discernible modifications in the gut and oral microbiomes, serum metabolome, and lipidome at each age stage. Specifically, we identified 87 microbial species in stool samples and 68 in saliva samples that demonstrated significant age-related changes. Notably, 13 species in stool, including Clostridiales bacterium, Lactobacillus johnsonii, and Oscillibacter spp., exhibited age-dependent alterat...
Source: Fight Aging! - October 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
My First MDMA Journey (Solo)
Yesterday I had my first MDMA journey, alone. I had planned to do it about two weeks in advance, knowing it was going to be a big deal for me. It was not what I expected. But I think it was the most remarkably life-shifting experience I’ve ever had. I can tell it changed me profoundly.
The short version is that it was like having my higher self embody me fully for 8-9 hours, letting me feel HIS feelings, hear HIS thoughts, speak with HIS voice, understand HIS perspective, and experience HIS energy. No, it wasn’t LIKE that. It was EXACTLY that.
Here’s the more detailed version:
I got up early that...
Source: Steve Pavlina's Personal Development Blog - September 17, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Lifestyle Source Type: blogs
