Anemia and Low Body Mass Index in Axial Spondyloarthritis: Results from ChinaSpA, the Chinese Spondyloarthritis Registry
ConclusionAll-cause anemia and low BMI are prevalent complications in patients with axSpA, exhibiting a significant correlation with elevated inflammation status and functional impairment. The simultaneous occurrence of anemia and low BMI particularly exacerbates clinical outcomes, emphasizing the critical role of comprehensive nutritional assessment and management in the therapeutic strategy for axSpA. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - February 13, 2024 Category: Rheumatology Source Type: research
Progression of subclinical atherosclerosis in ankylosing spondylitis: a 10-year prospective study
AbstractChronic systemic inflammation contributes to increased CVD burden in Ankylosing Spondylitis (AS). Since long-term follow-up data on subclinical atherosclerosis acceleration are lacking, we examined its progression in contemporary AS patients during 10 years. Fifty-three (89% male, aged 50.4 (36.3–55.9) years,) non-diabetic, CVD-free AS patients and 53 age-sex-matched non-diabetic, control individuals were re-evaluated after 9.2–10.2 years by ultrasonography for carotid/femoral atheromatosis, pulse wave velocity (PWV) and intima-media thick ness (IMT), performed by the same operator/protocol. New atheromatic ...
Source: Rheumatology International - February 13, 2024 Category: Rheumatology Source Type: research
Population pharmacokinetics and exposure-response analyses for efficacy and safety of apadacitinib in patients with axial Spondyloarthritis
Clin Transl Sci. 2024 Feb;17(2):e13733. doi: 10.1111/cts.13733.ABSTRACTUpadacitinib is an orally administered, selective, Janus kinase inhibitor that is approved for several auto-immune conditions, such as axial spondyloarthritis, an inflammatory rheumatic disease that includes ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). The approvals of upadacitinib for the treatment of AS and nr-axSpA were based on the safety and efficacy data for upadacitinib 15 mg once-daily compared to placebo from the SELECT-AXIS 1 and SELECT-AXIS 2 studies. Population pharmacokinetic analyses based on data fr...
Source: Herpes - February 12, 2024 Category: Infectious Diseases Authors: Sumit Bhatnagar Doerthe Eckert Sven Stodtmann In-Ho Song Peter Wung Wei Liu Mohamed-Eslam F Mohamed Source Type: research
Aberrant DNA Methylation Profile of Dickkopf-1 in Ankylosing Spondylitis
Biochem Genet. 2024 Feb 12. doi: 10.1007/s10528-024-10675-y. Online ahead of print.ABSTRACTIn recent years, the impact of methylation modifications on Dickkopf-1 (DKK1) in relation to ankylosing spondylitis (AS) has remained elusive. Our objective was to investigate the potential link between DKK1 methylation patterns and transcript levels and AS susceptibility. DNA methylation level of DKK1 was measured in 82 AS and 82 healthy controls (HCs) using targeted bisulfite sequencing. In addition, the transcript level of DKK1 in peripheral blood mononuclear cells from 35 AS patients and 35 HCs was detected using real-time quanti...
Source: Biochemical Genetics - February 12, 2024 Category: Genetics & Stem Cells Authors: Xiaoya Sun Yujie Deng Man Ni Tao Zhang Xinqi Wang Ye Wu Zongwen Shuai Faming Pan Source Type: research
Associations of < em > IL6R < /em > and < em > IL10 < /em > Gene Polymorphisms with Susceptibility to Ankylosing Spondylitis with or without Acute Anterior Uveitis
CONCLUSION: Our study suggests that the IL10 gene contributes to the susceptibility of the Chinese population to AS with AAU.PMID:38346238 | DOI:10.1080/09273948.2024.2309279 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - February 12, 2024 Category: Allergy & Immunology Authors: Li Lin Fuzhen Li Haixin Fang Pengyi Zhou Jiankang Shan Kunpeng Xie Bo Jin Haiyan Zhu Xuemin Jin Liping Du Peizeng Yang Source Type: research
The universal effects of low-dose interleukin-2 across 13 autoimmune diseases in a basket clinical trial
CONCLUSION: IL-2LD was well-tolerated, exhibiting specific Treg activation and clinical improvements across the 13 autoimmune diseases.CLINICAL IMPLICATION: Tregs stimulation by IL-2LD is a promising therapeutic strategy and IL-2LD holds considerable promise for integration into combinatorial therapeutic approaches.PMID:38330545 | DOI:10.1016/j.jaut.2024.103172 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - February 8, 2024 Category: Allergy & Immunology Authors: Roberta Lorenzon Claire Ribet Fabien Pitoiset Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Patrice Cacoub Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Ars ène Mekinian Elodie Regnier David Saadoun Joe Source Type: research
Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis
ConclusionOur MR analysis suggested a genetic-level causal relationship between specific gut microbiota and SpA, providing insights into the underlying mechanisms behind SpA development mediated by gut microbiota. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - February 8, 2024 Category: Allergy & Immunology Source Type: research
Causality between Ankylosing Spondylitis and osteoarthritis in European ancestry: a bidirectional Mendelian randomization study
ConclusionIn European population, individuals with AS have a relatively lower risk of knee OA, whereas AS serves as a risk factor for hand OA. However, no significant causal relationship was found between AS and hip OA. Additionally, it offers novel insights into genetic research on AS and OA. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - February 6, 2024 Category: Allergy & Immunology Source Type: research
Ankylosing spondylitis complicated with multiple Andersson lesions
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - February 5, 2024 Category: Rheumatology Authors: Ming ‐Xue Zhao,
Qiang Xu Tags: CLINICAL IMAGE Source Type: research
Cardiovascular events risk in patients with systemic autoimmune diseases: a prognostic systematic review and meta-analysis
ConclusionPatients with SAD present an increased risk of CV morbidity and mortality, which should be considered when establishing therapeutic strategies. These findings support the role of systemic inflammation in the development of atherosclerosis-driven disease.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 1, 2024 Category: Cardiology Source Type: research
Depression as a possible determinant of fatigue in patients with axial spondyloarthritis
CONCLUSIONS: The study found correlation between fatigue and disease activity and depression in patients with axSpA. These findings suggest that depression could represent the major determinant of fatigue in patients with axSpA, independently of clinical activity.PMID:38294018 | DOI:10.55563/clinexprheumatol/d4cq48 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 31, 2024 Category: Rheumatology Authors: Riccardo Bixio Chiara Bonetto Elena Fracassi Branko Ristic Francesca Mastropaolo Giulio Pacenza Maurizio Rossini Doriana Cristofalo Antonio Carletto Sarah Tosato Source Type: research
A new mathematical model for evaluating surface changes in the mid-abdominal sagittal plane after two-level pedicle reduction osteotomy in patients with ankylosing spondylitis
The purpose of this study was to create a mathematical model to precalculate the acreage change in the abdominal median sagittal plane (ac-AMSP) of patients with ankylosing spondylitis (AS) for whom two-level ... (Source: BMC Surgery)
Source: BMC Surgery - January 28, 2024 Category: Surgery Authors: Wen Yin, Guohui Zheng, Wei Zhang, Yunlei Zhai, Haijiang Li, Lele Sun, Kangkang Wang, Jishi Jiang, Zikai Hua, Xilong Cui and Haiyang Yu Tags: Research Source Type: research
Isofraxidin inhibits the proliferation and differentiation of the osteoblast MC3T3-E1 subclone 14 cell line
Cell Mol Biol (Noisy-le-grand). 2023 Dec 31;69(15):44-50. doi: 10.14715/cmb/2023.69.15.7.ABSTRACTAnkylosing spondylitis (AS) is an autoimmune inflammatory disease associated with joint inflammation and destruction. Current treatment modalities alleviate symptoms; however, they cannot cure the disease and are associated with significant side effects. Thus, we aimed to confirm the inhibitory effect of isofraxidin, a herbal extract, on pathological osteogenesis in ankylosing spondylitis to better treat patients affected by the disease. Mouse preosteoblast MC3T3-E1 subclone 14 cells were used in vitro to establish control and ...
Source: Cellular and Molecular Biology - January 27, 2024 Category: Molecular Biology Authors: Junliang Xu Wei Ji Source Type: research
Molecules in the hippo pathway that regulate Th17 differentiation reveal the severity of ankylosing spondylitis
ConclusionOur findings suggest that the Hippo pathway plays a significant role in the regulation of Th17 differentiation and disease activity in patients with AS. The upregulation of TAZ and downregulation of key Hippo pathway proteins, such as MST1/2 and NDR1/2, may contribute to AS pathogenesis. These proteins may serve as biomarkers and may lead to the development of novel therapeutic strategies for AS. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - January 25, 2024 Category: Rheumatology Authors: Xiaohan Xu,
Wanlin Liu,
Yue Liu,
Dongmei Wu,
Bo Pang,
Zhe Zhao,
Yanan Zhao,
Hongxiao Liu Tags: ORIGINAL ARTICLE Source Type: research
Validation of diagnosis algorithms for ankylosing spondylitis in claim ‐based database
ConclusionsWhile performing database studies, researchers should be aware of the low PPV of specific algorithms when defining AS. Algorithms with higher PPV were recommended to be adopted to avoid misclassification biases. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - January 25, 2024 Category: Rheumatology Authors: Shuo ‐Yan Gau,
Hsiang‐En Tsai,
Yu‐Hsun Wang,
James Cheng‐Chung Wei Tags: ORIGINAL ARTICLE Source Type: research
