Clinical spectrum of active tuberculosis in patients with systemic lupus erythematosus
ConclusionIncidence of tuberculosis in SLE is higher than general population and is associated with different phenotype and higher mortality. Male gender was associated with increased risk of tuberculosis in SLE. (Source: Rheumatology International)
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

Association of polymorphisms in promoter region of TNF- α -238 and -308 with clinical outcomes in patients with immune-mediated inflammatory diseases on anti-TNF therapy
AbstractThe hypothesis of the study was that polymorphisms in promoter regions -238 and -308 ofTNF- α could be associated with different clinical outcomes in inflammatory bowel diseases (IBD) and immune-mediated rheumatic diseases (IMRD). The aim was to examine the possible association of both polymorphisms with concentration of C-reactive protein (CRP) and fecal calprotectin (fCAL), onset of the remission and development of the ADA in patients on therapy with anti-TNF inhibitors. The prospective study was done in patients with IBD and IMRD on infliximab (IFX) or adalimumab (ADM). Patients were genotyped forTNF- &alp...
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

Epidemiology and genetics of granulomatosis with polyangiitis
AbstractGranulomatosis with polyangiitis (GPA) previously known as Wegener ’s granulomatosis (WG) is a rare rheumatic disease affecting subjects of all ages. Prevalence and incidence of this systemic disease greatly varies across different ethnic groups. GPA is the commonest form of ANCA-associated vasculitis (AAV) with PR3 positivity among 85–95% of the cases. Scient ific investigations of GPA is warranted because its severity, clinical heterogeneity, fast disease manifestation and end-organ damage. The etiology of GPA is still unknown. Major role of HLA and non-HLA genes with immune functions were i...
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

Are YouTube videos enough to learn anakinra self-injection?
AbstractAnakinra is a drug that can be administered subcutaneously as a self-injection in both children and adults. We aimed to evaluate the content, reliability, and quality of the videos most viewed on “anakinra self-injection” on YouTube, which is an easily accessible source of information. We performed a YouTube search using the keywords “anakinra”, “anakinra injection”, and “anakinra self-injection” in addition to the generic and commercial names of the biologic agent in Septemb er 2021. The quality and reliability of the videos were assessed according to the Global Qual...
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

Changing trends in rheumatoid arthritis mortality in Mexico, from 1998 to 2017
AbstractThe aim was to analyze the distribution and trends of deaths reported for rheumatoid arthritis (RA) in Mexico in 1998 –2017. We carried out a cross-sectional study. Data were obtained from Dynamic Cubes, General Direction of Health Information, on deaths related to RA in Mexico. Seropositive RA was diagnosed using the International Classification of Diseases version 10. Variables were categorized by diagnosis, ag e, and gender. Time trends of age-standardized mortality rates (ASMRs) were analyzed for RA, and the annual percent change (APC) was estimated using Joinpoint trend analysis. We found 714 deaths ment...
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

Emerging epigenetic targets in rheumatoid arthritis
This article focuses on various epigenetic factors involved in the pathogenesis of rheumatoid arthritis. Further, various epigenetic therapies that might be successful in inhibiting these epigenetic modifications are summarized. Several therapeutic agents alter the epigenetic modifications occurring in various diseases and many of the epigenetic therapies are under pre-clinical and clinical trial. However, exploring these epigenetic prognostic biomarkers would give a broader perspective and provide more ideas and knowledge regarding the process and pathways through which the diseases occur, and also combining various thera...
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

COVID-19 from a rheumatology perspective: bibliometric and altmetric analysis
This study included 1430 retrieved articles with open access mostly. The top five journals in this field were Annals of the Rheumatic Diseases (n = 65), Rheumatology International (n = 51), Clinical Rheumatology (n = 50), Lancet Rheumatology (n = 50), and Frontiers In Immunology (n = 33). Most studies originate from countries with a high incidence of COVID-19 among the general population (the USA—387; Italy—268; UK—184; France—114; Germany—110; India—98 and Spain—96, China—94, Canada—73 Turkey—6...
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

The role of IL-17 rs2275913, IL-17RC rs708567 and TGFB1 rs1800469 SNPs and IL-17A serum levels in patients with lupus nephritis
AbstractSystemic lupus erythematosus (SLE) is a multifactorial autoimmune disease and polymorphisms in the cytokine genes and their receptors are thought to influence its development. The aim of this case –control study was to investigate the association of theIL-17A rs2275913,IL-17RC rs708567 andTGFB1 rs1800469 polymorphisms with SLE, its clinical manifestations and the polymorphisms influence on the IL-17A serum levels. Altogether 59 SLE patients with lupus nephritis and 95 healthy controls were genotyped by TaqMan assay. Serum levels were determined by Human IL-17A Platinum ELISA kit. From the studied polymorphism...
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

The synergistic role of TNFA  − 308G/A and IL10 − 1082A/G polymorphisms in ankylosing spondylitis
ConclusionTNFA − 308 A-allele is essential for reducing susceptibility to AS, with a considerable synergistic protective effect of the combined TNF-α − 308 (GA/AA)/IL-10 − 1082AA genotypes. In addition, the presence of this variant allele is associated with more benign clinical phenotype of the disease. No conclusive statements on the functional relevance of both gene variants on cytokines production should be made. (Source: Rheumatology International)
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

YouTube as a source of information on COVID-19 vaccination in rheumatic diseases
AbstractAs the most well-known and popular video-sharing platform around the world, YouTube is an influential tool for the dissemination of health-related information. In addition, considering the increase in obtaining information from internet-based sources in pandemic conditions, YouTube has become more important in the presentation of information related to COVID-19. Therefore, the aim of this study was to evaluate videos related to COVID-19 vaccination in rheumatic diseases (RD) on YouTube. In this descriptive study, 334 video URLs listed with six search terms were recorded (26 July 2021). Three quality groups (high, i...
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

Rehabilitative management of post-acute COVID-19: clinical pictures and outcomes
This study aimed to detect patients ’ characteristics who suffered severe and critical COVID-19 pneumonia admitted to the post-acute COVID-19 rehabilitation clinic in Ankara City Hospital, Physical Medicine and Rehabilitation Hospital and to share our experiences and outcomes of rehabilitation programmes applied. This study was desi gned as a single-centre, retrospective, observational study. Severe and critical COVID-19 patients, admitted to the post-acute COVID-19 rehabilitation clinic, were included in patient-based rehabilitation programmes, targeting neuromuscular and respiratory recovery. Functional status, oxy...
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

Prevalence of large vessel vasculitis in ANCA-associated vasculitis: a retrospective cohort study
AbstractANCA-associated vasculitis (AAV) in general involves small blood vessels and includes granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA), and microscopic polyangiitis (MPA). Although reported in a few studies, the prevalence of large vessel vasculitis (LVV) in patients with AAV remains to be further explored. The goal of the present study was  to assess the prevalence of LVV in a cohort of patients with AAV and to characterize this population. We conducted a ten-year retrospective study of a single-center cohort of AAV, including 101 patients with GPA (n&thin...
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

Cardiorespiratory fitness and physical activity in people who have rheumatoid arthritis at an increased risk of cardiovascular disease: a cross-sectional study
The objectives of this study were to determine the levels of CRF and PA in people who have CVD-RA and to investigate the association of CRF with PA in people who have CVD-RA. A total of 24 consecutive patients (19 women) with CVD-RA (>  4% for 10-year risk of fatal CVD development as calculated using the Systematic Coronary Risk Evaluation)—were included in the study. CRF was assessed with a graded maximal exercise test determining maximal oxygen uptake (VO2max). PA was assessed with an accelerometer to determine the amount of step count, sedentary, light and moderate-to-vigorous physical activity (MVPA) mi...
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

Association of extended myositis panel results, clinical features, and diagnoses: a single-center retrospective observational study
AbstractMyositis-specific antibodies (MSA) and myositis-associated antibodies (MAA) are a feature of the idiopathic inflammatory myopathies (IIM), but are also seen in other rheumatic diseases, and in individuals with no clinical symptoms. The aim of this study was to assess the clinical utility of MSA and MAA and in particular the clinical relevance of weakly positive results. We included all patients at our institution who had at least one positive result on the Immunoblot EUROLINE myositis panel over a 6-year period (2015 –2020). Associations with clinical features and final diagnosis were evaluated. Eighty-seven ...
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

Demyelinating disease (multiple sclerosis) in a patient with psoriatic arthritis treated with adalimumab: a case-based review
We describe a patient with psoriasis, psoriatic arthritis and uveitis who was treated with adalimum ab and after 4 months of the treatment developed clinical and neuroradiological signs of demyelinating disease of the central nervous system. She experienced no signs and symptoms of neurological disease prior to adalimumab administration. After a detailed neurological work-up she was diagnosed wit h relapsing–remitting type of multiple sclerosis and treated with oral and pulse glucocorticoids and later with dimethyl fumarate. Adalimumab was discontinued. The question remains was the demyelination induced by the T...
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

Clinical and technical determinants of positive temporal artery biopsy: a retrospective cohort study
In conclusion, old age, male gender, elevated ESR, and PMR symptoms increase the odds of positive TAB. Technical factors, such as biopsy length and the number of cross-sections, did not influence eventual biopsy results, highlighting the pivotal role of the clinical presentation of the patients in selecting patients for TAB. (Source: Rheumatology International)
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

Alternatives for erroneous finger probe pulse oximetry in systemic sclerosis patients during COVID-19 pandemic
(Source: Rheumatology International)
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

Adverse events of six COVID-19 vaccines in patients with autoimmune rheumatic diseases: a cross-sectional study
AbstractData regarding COVID-19 vaccine efficacy and adverse events  (AE) in patients with autoimmune and inflammatory rheumatic diseases (AIIRD) have been published recently although these mostly include the mRNA vaccines (Pfizer-BioNTech and Moderna) and the ChAdOx1 nCoV-19/AZD1222 (Oxford-AstraZeneca). This research aimed to study the prevalence of AE presented with six different SARS-CoV-2 vaccines {ChadOX1 nCoV-19 (AZD1222), Ad5-nCoV2, Ad26.COV2.S, mRNA-1273, BNT162b2, and CoronaVac} in Mexican patients with AIIRD. We performed a cross-sectional study about vaccine history. Two hundred and twenty five consecutive...
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

Correction to: COVID-19 and eosinophilic granulomatosis with polyangiitis or COVID-19 mimicking eosinophilic granulomatosis with polyangiitis?
(Source: Rheumatology International)
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

The stratification of primary Sjogren ’s syndrome: is it really solving the problem?
(Source: Rheumatology International)
Source: Rheumatology International - October 31, 2021 Category: Rheumatology Source Type: research

Clinical spectrum of active tuberculosis in patients with systemic lupus erythematosus
ConclusionIncidence of tuberculosis in SLE is higher than general population and is associated with different phenotype and higher mortality. Male gender was associated with increased risk of tuberculosis in SLE. (Source: Rheumatology International)
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

Association of polymorphisms in promoter region of TNF- α -238 and -308 with clinical outcomes in patients with immune-mediated inflammatory diseases on anti-TNF therapy
AbstractThe hypothesis of the study was that polymorphisms in promoter regions -238 and -308 ofTNF- α could be associated with different clinical outcomes in inflammatory bowel diseases (IBD) and immune-mediated rheumatic diseases (IMRD). The aim was to examine the possible association of both polymorphisms with concentration of C-reactive protein (CRP) and fecal calprotectin (fCAL), onset of the remission and development of the ADA in patients on therapy with anti-TNF inhibitors. The prospective study was done in patients with IBD and IMRD on infliximab (IFX) or adalimumab (ADM). Patients were genotyped forTNF- &alp...
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

Epidemiology and genetics of granulomatosis with polyangiitis
AbstractGranulomatosis with polyangiitis (GPA) previously known as Wegener ’s granulomatosis (WG) is a rare rheumatic disease affecting subjects of all ages. Prevalence and incidence of this systemic disease greatly varies across different ethnic groups. GPA is the commonest form of ANCA-associated vasculitis (AAV) with PR3 positivity among 85–95% of the cases. Scient ific investigations of GPA is warranted because its severity, clinical heterogeneity, fast disease manifestation and end-organ damage. The etiology of GPA is still unknown. Major role of HLA and non-HLA genes with immune functions were i...
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

Are YouTube videos enough to learn anakinra self-injection?
AbstractAnakinra is a drug that can be administered subcutaneously as a self-injection in both children and adults. We aimed to evaluate the content, reliability, and quality of the videos most viewed on “anakinra self-injection” on YouTube, which is an easily accessible source of information. We performed a YouTube search using the keywords “anakinra”, “anakinra injection”, and “anakinra self-injection” in addition to the generic and commercial names of the biologic agent in Septemb er 2021. The quality and reliability of the videos were assessed according to the Global Qual...
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

Changing trends in rheumatoid arthritis mortality in Mexico, from 1998 to 2017
AbstractThe aim was to analyze the distribution and trends of deaths reported for rheumatoid arthritis (RA) in Mexico in 1998 –2017. We carried out a cross-sectional study. Data were obtained from Dynamic Cubes, General Direction of Health Information, on deaths related to RA in Mexico. Seropositive RA was diagnosed using the International Classification of Diseases version 10. Variables were categorized by diagnosis, ag e, and gender. Time trends of age-standardized mortality rates (ASMRs) were analyzed for RA, and the annual percent change (APC) was estimated using Joinpoint trend analysis. We found 714 deaths ment...
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

Emerging epigenetic targets in rheumatoid arthritis
This article focuses on various epigenetic factors involved in the pathogenesis of rheumatoid arthritis. Further, various epigenetic therapies that might be successful in inhibiting these epigenetic modifications are summarized. Several therapeutic agents alter the epigenetic modifications occurring in various diseases and many of the epigenetic therapies are under pre-clinical and clinical trial. However, exploring these epigenetic prognostic biomarkers would give a broader perspective and provide more ideas and knowledge regarding the process and pathways through which the diseases occur, and also combining various thera...
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

COVID-19 from a rheumatology perspective: bibliometric and altmetric analysis
This study included 1430 retrieved articles with open access mostly. The top five journals in this field were Annals of the Rheumatic Diseases (n = 65), Rheumatology International (n = 51), Clinical Rheumatology (n = 50), Lancet Rheumatology (n = 50), and Frontiers In Immunology (n = 33). Most studies originate from countries with a high incidence of COVID-19 among the general population (the USA—387; Italy—268; UK—184; France—114; Germany—110; India—98 and Spain—96, China—94, Canada—73 Turkey—6...
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

The role of IL-17 rs2275913, IL-17RC rs708567 and TGFB1 rs1800469 SNPs and IL-17A serum levels in patients with lupus nephritis
AbstractSystemic lupus erythematosus (SLE) is a multifactorial autoimmune disease and polymorphisms in the cytokine genes and their receptors are thought to influence its development. The aim of this case –control study was to investigate the association of theIL-17A rs2275913,IL-17RC rs708567 andTGFB1 rs1800469 polymorphisms with SLE, its clinical manifestations and the polymorphisms influence on the IL-17A serum levels. Altogether 59 SLE patients with lupus nephritis and 95 healthy controls were genotyped by TaqMan assay. Serum levels were determined by Human IL-17A Platinum ELISA kit. From the studied polymorphism...
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

The synergistic role of TNFA  − 308G/A and IL10 − 1082A/G polymorphisms in ankylosing spondylitis
ConclusionTNFA − 308 A-allele is essential for reducing susceptibility to AS, with a considerable synergistic protective effect of the combined TNF-α − 308 (GA/AA)/IL-10 − 1082AA genotypes. In addition, the presence of this variant allele is associated with more benign clinical phenotype of the disease. No conclusive statements on the functional relevance of both gene variants on cytokines production should be made. (Source: Rheumatology International)
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

YouTube as a source of information on COVID-19 vaccination in rheumatic diseases
AbstractAs the most well-known and popular video-sharing platform around the world, YouTube is an influential tool for the dissemination of health-related information. In addition, considering the increase in obtaining information from internet-based sources in pandemic conditions, YouTube has become more important in the presentation of information related to COVID-19. Therefore, the aim of this study was to evaluate videos related to COVID-19 vaccination in rheumatic diseases (RD) on YouTube. In this descriptive study, 334 video URLs listed with six search terms were recorded (26 July 2021). Three quality groups (high, i...
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

Rehabilitative management of post-acute COVID-19: clinical pictures and outcomes
This study aimed to detect patients ’ characteristics who suffered severe and critical COVID-19 pneumonia admitted to the post-acute COVID-19 rehabilitation clinic in Ankara City Hospital, Physical Medicine and Rehabilitation Hospital and to share our experiences and outcomes of rehabilitation programmes applied. This study was desi gned as a single-centre, retrospective, observational study. Severe and critical COVID-19 patients, admitted to the post-acute COVID-19 rehabilitation clinic, were included in patient-based rehabilitation programmes, targeting neuromuscular and respiratory recovery. Functional status, oxy...
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

Prevalence of large vessel vasculitis in ANCA-associated vasculitis: a retrospective cohort study
AbstractANCA-associated vasculitis (AAV) in general involves small blood vessels and includes granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA), and microscopic polyangiitis (MPA). Although reported in a few studies, the prevalence of large vessel vasculitis (LVV) in patients with AAV remains to be further explored. The goal of the present study was  to assess the prevalence of LVV in a cohort of patients with AAV and to characterize this population. We conducted a ten-year retrospective study of a single-center cohort of AAV, including 101 patients with GPA (n&thin...
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

Cardiorespiratory fitness and physical activity in people who have rheumatoid arthritis at an increased risk of cardiovascular disease: a cross-sectional study
The objectives of this study were to determine the levels of CRF and PA in people who have CVD-RA and to investigate the association of CRF with PA in people who have CVD-RA. A total of 24 consecutive patients (19 women) with CVD-RA (>  4% for 10-year risk of fatal CVD development as calculated using the Systematic Coronary Risk Evaluation)—were included in the study. CRF was assessed with a graded maximal exercise test determining maximal oxygen uptake (VO2max). PA was assessed with an accelerometer to determine the amount of step count, sedentary, light and moderate-to-vigorous physical activity (MVPA) mi...
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

Association of extended myositis panel results, clinical features, and diagnoses: a single-center retrospective observational study
AbstractMyositis-specific antibodies (MSA) and myositis-associated antibodies (MAA) are a feature of the idiopathic inflammatory myopathies (IIM), but are also seen in other rheumatic diseases, and in individuals with no clinical symptoms. The aim of this study was to assess the clinical utility of MSA and MAA and in particular the clinical relevance of weakly positive results. We included all patients at our institution who had at least one positive result on the Immunoblot EUROLINE myositis panel over a 6-year period (2015 –2020). Associations with clinical features and final diagnosis were evaluated. Eighty-seven ...
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

Demyelinating disease (multiple sclerosis) in a patient with psoriatic arthritis treated with adalimumab: a case-based review
We describe a patient with psoriasis, psoriatic arthritis and uveitis who was treated with adalimum ab and after 4 months of the treatment developed clinical and neuroradiological signs of demyelinating disease of the central nervous system. She experienced no signs and symptoms of neurological disease prior to adalimumab administration. After a detailed neurological work-up she was diagnosed wit h relapsing–remitting type of multiple sclerosis and treated with oral and pulse glucocorticoids and later with dimethyl fumarate. Adalimumab was discontinued. The question remains was the demyelination induced by the T...
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

Clinical and technical determinants of positive temporal artery biopsy: a retrospective cohort study
In conclusion, old age, male gender, elevated ESR, and PMR symptoms increase the odds of positive TAB. Technical factors, such as biopsy length and the number of cross-sections, did not influence eventual biopsy results, highlighting the pivotal role of the clinical presentation of the patients in selecting patients for TAB. (Source: Rheumatology International)
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

Alternatives for erroneous finger probe pulse oximetry in systemic sclerosis patients during COVID-19 pandemic
(Source: Rheumatology International)
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

Adverse events of six COVID-19 vaccines in patients with autoimmune rheumatic diseases: a cross-sectional study
AbstractData regarding COVID-19 vaccine efficacy and adverse events  (AE) in patients with autoimmune and inflammatory rheumatic diseases (AIIRD) have been published recently although these mostly include the mRNA vaccines (Pfizer-BioNTech and Moderna) and the ChAdOx1 nCoV-19/AZD1222 (Oxford-AstraZeneca). This research aimed to study the prevalence of AE presented with six different SARS-CoV-2 vaccines {ChadOX1 nCoV-19 (AZD1222), Ad5-nCoV2, Ad26.COV2.S, mRNA-1273, BNT162b2, and CoronaVac} in Mexican patients with AIIRD. We performed a cross-sectional study about vaccine history. Two hundred and twenty five consecutive...
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

Correction to: COVID-19 and eosinophilic granulomatosis with polyangiitis or COVID-19 mimicking eosinophilic granulomatosis with polyangiitis?
(Source: Rheumatology International)
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

The stratification of primary Sjogren ’s syndrome: is it really solving the problem?
(Source: Rheumatology International)
Source: Rheumatology International - October 27, 2021 Category: Rheumatology Source Type: research

Ankylosing spondylitis rehabilitation publications and the global productivity: a Web of Science-based bibliometric analysis (2000 –2019)
AbstractRehabilitation programs have an important place in the treatment of ankylosing spondylitis (AS), but there is no comprehensive bibliometric research that assesses publications on AS rehabilitation in a holistic way. The aim of this study was to investigate the quantity and quality of articles related to AS rehabilitation and to reveal the features of global productivity in this topic. This bibliometric study was conducted utilizing the Web of Science (WoS) database with the keywords ‘ankylosing spondylitis rehabilitation’, ‘ankylosing spondylitis exercise’, ‘ankylosing spondylitis phys...
Source: Rheumatology International - October 1, 2021 Category: Rheumatology Source Type: research

Local and systemic reactogenicity of COVID-19 vaccine BNT162b2 in patients with systemic lupus erythematosus and rheumatoid arthritis
This study explores the safety and reactogenicity of BNT162b2 among patients with rheumatic diseases. Patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), median age 58.8  years, 285 subjects in total, were vaccinated twice with the BNT162b2 (Pfizer/BioNTech). Questionnaires on reactogenicity matching the original phase 3 study were answered seven days after completed vaccination. The majority of SLE and RA patients experienced either local (78.0%) or systemic react ions (80.1%). Only 1.8% experienced a grade-4 reaction. Compared to the original study, we found more frequent fatigue [Odds ra...
Source: Rheumatology International - October 1, 2021 Category: Rheumatology Source Type: research

Factors associated with drug survival on first biologic therapy in patients with rheumatoid arthritis: a population-based cohort study
AbstractLack of sufficient head-to-head trials comparing biologic disease-modifying antirheumatic drugs (bDMARDs) in rheumatoid arthritis (RA), makes the choice of the first bDMARD a matter of rheumatologist ’s preference. Longer drug survival on the first bDMARD usually correlates with early remission. We aimed to identify factors associated with longer drug survival. We conducted a population-based retrospective longitudinal cohort study. We identified RA patients using the relevant International Cl assification of Disease 9th codes. “True” RA patients were defined as patients fulfilling, additionally, ...
Source: Rheumatology International - October 1, 2021 Category: Rheumatology Source Type: research

Esophageal dysmotility and lung disease in patients with systemic sclerosis: is there a possible association or correlation? A retrospective chart review
ConclusionThe presence of esophageal dysmotility was associated with increased pulmonary involvement in the form of abnormal DLCO with worsening progression rates per year. There was no statistically significant difference in PASP and FVC between the two groups; however, the progression rate for FVC was worse in adjusted models. (Source: Rheumatology International)
Source: Rheumatology International - October 1, 2021 Category: Rheumatology Source Type: research

Short-term outcomes in children recovered from multisystem inflammatory syndrome associated with SARS-CoV-2 infection
AbstractMulti-system inflammatory syndrome in children (MIS-C) associated with COVID-19 is a recently recognised potentially life-threatening entity. There is limited data on post-MIS-C sequelae. 21 children fulfilling the WHO criteria for MIS-C were included in our study. Data were collected at baseline and at 12 –16 weeks post-discharge to look for any persistent sequelae mainly relating to the lungs or heart including coronary arteries. Fever was the most common presentation, found in 18 (85.7%) patients. All had a marked hyper-inflammatory state. Low ejection fraction (EF) was found in 10 (47.6%), but none h...
Source: Rheumatology International - October 1, 2021 Category: Rheumatology Source Type: research

COVID-19 and fertility —at the crossroads of autoimmunity and thrombosis
AbstractThe SARS-CoV-2 virus is known to mediate attack via ACE-2 Receptor, thus having adverse effects on cardiovascular, respiratory, digestive and reproductive systems, the latter being an area of emerging concern, due to the associated impact on fertility, with potential for an outsized effect on population distribution and socioeconomic road map in subsequent years. This narrative review aims to put forth the current evidence of effect of SARS-CoV-2 on human fertility from a multipronged immunologic, haematologic, and gynaecologic perspective; highlighting the areas of contradiction and potential future measures. A li...
Source: Rheumatology International - October 1, 2021 Category: Rheumatology Source Type: research

In the era of disease-modifying antirheumatic drugs, how close are we to treating rheumatoid arthritis without the use of glucocorticoids?
AbstractWe wanted to see how close we could get to our goal of treating rheumatoid arthritis (RA) without the use of glucocorticoids (GCs) in the disease-modifying antirheumatic drugs (DMARDs) era using real-life data. Established in 2017, the TReasure database is a web-based, prospective, observational cohort for Turkey. As of May 2019, there were 2,690 RA patients recorded as receiving biologic and targeted synthetic DMARDs (bDMARDs and tsDMARDs) therapy. At the start of the bDMARDs or tsDMARDs, patients with follow-up visits of at least 3  months were registered. At the time of registration and the last visit, dose...
Source: Rheumatology International - October 1, 2021 Category: Rheumatology Source Type: research

Resilience in women with primary Sj ögren’s syndrome
AbstractTo assess the relationship between resilience and several diseases and individual features in primary Sj ӧgren's Syndrome (SS) patients. Resilience was assessed using the Resilience Scale (RS-14). Disease activity, damage, and reported symptoms were assessed by means of ESSDAI (EULAR Sjögren's syndrome disease activity index), SSDDI (Sjӧgren's Syndrome Disease Damage Index) and ESSPRI (EULAR Sjӧgre n's Syndrome Patient Reported Index). EuroQol, HADS (Hospital Anxiety and Depression Scale), SF-12 (Short-form 12 health survey), FAS (Fatigue Assessment Scale), FACIT-F (Functional Assessment of Chronic Illness ...
Source: Rheumatology International - October 1, 2021 Category: Rheumatology Source Type: research

Reactive arthritis after COVID-19: a case-based review
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 19 (COVID-19) pandemic, which is deeply affecting the whole world. In this new case for the scientific world, scientists are investigating the etiopathogenesis of viral infection-induced damage and have started to focus on the short and long-term immune system effects and alterations after SARS-CoV-2 infection. The case is here reported of a 53-year-old female patient with acute monoarthritis after SARS-CoV-2 infection, who responded adequately to 150  mg/day diclofenac treatment, and the available ca...
Source: Rheumatology International - October 1, 2021 Category: Rheumatology Source Type: research

A survey to evaluate knowledge, perceptions and attitudes toward COVID-19 vaccinations among rheumatologists in Germany
This study shows that almost all rheumatologists in Germany support the COVID-19 vaccination for their IRD patients without reducing or terminating the actual immunomodulatory medication to potentially improve the respo nse to the vaccine. This attitude is in accordance with the current recommendations of the German Society of Rheumatology regarding COVID-19 vaccination in IRD patients, and indicates that these have been well accepted and work in everyday clinical practice. (Source: Rheumatology International)
Source: Rheumatology International - October 1, 2021 Category: Rheumatology Source Type: research