From blood coagulation to innate and adaptive immunity: the role of platelets in the physiology and pathology of autoimmune disorders
AbstractThrombosis and cardiovascular complications are common manifestations of a variety of pathological conditions, including infections and chronic inflammatory diseases. Hence, there is great interest in determining the hitherto unforeseen immune role of the main blood coagulation executor —the platelet. Platelets store and release a plethora of immunoactive molecules, generate microparticles, and interact with cells classically belonging to the immune system. The observed effects of platelet involvement in immune processes, especially in autoimmune diseases, are conflicting—from inciting inflammation to m...
Source: Rheumatology International - May 15, 2018 Category: Rheumatology Source Type: research

Factors associated with severe dry eye in primary Sj ögren’s syndrome diagnosed patients
ConclusionSevere or very severe dry eye is associated with the presence of inflammatory joint involvement in patients with pSS. These results suggest that a directed anamnesis including systemic comorbidities, such as the presence of inflammatory joint involvement or dry mouth in patients with dry eye, would be useful to suspect a pSS. (Source: Rheumatology International)
Source: Rheumatology International - May 15, 2018 Category: Rheumatology Source Type: research

Comparison of the diagnostic potential of three anti-citrullinated protein antibodies as adjuncts to rheumatoid factor and CCP in a cohort of South African rheumatoid arthritis patients
ConclusionThese observations in this unique cohort of RA patients indicated novel associations of all three autoantibodies in regard to HLA-SE risk alleles, disease severity and tobacco use that were not reported before. Elevated anti-Sa titers designated a propensity of higher disease and high-risk alleles in our cohort. Anti-CEP-1 association with HLA-SE homozygosity and high-risk alleles is also novel in this group. Of note, measurement of anti-MCV antibodies on presentation, either as an adjunctive or even as a stand-alone test, surpassed all other biomarkers investigated here and, therefore, may add value to clinical ...
Source: Rheumatology International - May 15, 2018 Category: Rheumatology Source Type: research

Denosumab mid-term densitometric gain in postmenopausal osteoporosis women in clinical practice: comment on “Variability of denosumab densitometric response in postmenopausal osteoporosis”
AbstractWe aim to confirm previous observations among postmenopausal osteoporotic women who received denosumab in terms of densitometric changes. We performed an observational clinical practice scenario study assessing baseline bone mineral density and its change after 2 years of treatment in postmenopausal osteoporotic women. Most of our patients were severe and had previous fracture and had received several treatments before denosumab initiation. We observed a 10.06% ( ± 3.46) improvement in spine, and a 4.87% (± 4.78) improvement in femoral neck. Our findings are in accordance with other auth...
Source: Rheumatology International - May 15, 2018 Category: Rheumatology Source Type: research

Takayasu arteritis in childhood: misdiagnoses at disease onset and associated diseases
AbstractJuvenile-Takayasu arteritis (j-TA) is a difficult diagnosis and some patients develop uncommon manifestations and associated diseases that may contribute to the delayed diagnosis. Our aim was to identify the misdiagnoses, the associated diseases and the atypical manifestations observed in a j-TA Brazilian multicentre study. 71 children and adolescents who met the classification criteria for j-TA were included. The misdiagnoses, the associated diseases and the atypical manifestations were evaluated. 19 (26.8%) patients had misdiagnoses. The most common of them was aortic coarctation in six (8.4%) patients, followed ...
Source: Rheumatology International - May 15, 2018 Category: Rheumatology Source Type: research

Mean platelet volume can estimate the current vasculitis activity of microscopic polyangiitis
In conclusion, MPV is significantly associated with BVAS and it can estimate the current BVAS in patients with MPA. (Source: Rheumatology International)
Source: Rheumatology International - May 15, 2018 Category: Rheumatology Source Type: research

Monocyte chemoattractant protein-1 as a marker of systemic lupus erythematosus: an observational study
AbstractThere is a pivotal need for new markers to be tested in every day clinical practice for systemic lupus erythematosus (SLE) and lupus nephritis (LN). The levels of monocyte chemoattractant protein-1 (MCP-1) in the serum and urine of 72 SLE patients (27 with LN and 45 without LN involvement) and 30 healthy individuals were studied to establish their clinical significance. The SLE Disease Activity Index (SLEDAI) was used to establish the disease activity. Urine and serum MCP-1 was determined using the sandwich enzyme immunosorbent assay. Urinary, but not serum MCP-1, positively correlated with proteinuria (r =&...
Source: Rheumatology International - May 15, 2018 Category: Rheumatology Source Type: research

Monogenic systemic lupus erythematosus: insights in pathophysiology
AbstractSystemic lupus erythematosus (SLE) is a complex disease with different genetic, immunologic, and environmental factors contributing to the pathogenesis. Monogenic SLE could help us understand the main phases of immune dysregulation in SLE. The aim of this review is to summarize the current knowledge on monogenic SLE with the implications of the respective genes on disease pathogenesis. A comprehensive literature search on monogenic SLE was conducted utilizing the Cochrane Library and MEDLINE/PubMed databases. The main affected pathways in disease pathogenesis are identified as follows: complement system, apoptosis,...
Source: Rheumatology International - May 15, 2018 Category: Rheumatology Source Type: research

The impact of exercise on sleep (time, quality, and disturbance) in patients with rheumatoid arthritis: a study protocol for a pilot randomised controlled trial
AbstractPoor sleep is an issue for people with rheumatoid arthritis (RA), which may curtail their ability to function appropriately and reduce their activity levels. This paper describes a protocol for a pilot randomised controlled trial of an aerobic exercise intervention compared with exercise advice designed to improve sleep in people with RA. Objectives are to obtain reliable estimates regarding recruitment rates, participant retention and protocol adherence and to generate potential effect size estimates for a main trial. Participants will be identified from an existing database held at a University Hospital and in pe...
Source: Rheumatology International - May 15, 2018 Category: Rheumatology Source Type: research

English-language videos on YouTube as a source of information on self-administer subcutaneous anti-tumour necrosis factor agent injections
AbstractThe aim of this study was to evaluate the reliability, content, and quality of videos for patients available on YouTube for learning how to self-administer subcutaneous anti-tumour necrosis factor (TNF) injections. We searched for the termsHumira injection, Enbrel injection, Simponi injection, andCimzia injection. Videos were categorised as useful information, misleading information, useful patient opinion, and misleading patient opinion by two physicians. Videos were rated for quality on a 5-point global quality scale (GQS; 1  = poor quality, 5 = excellent quality) and reliability and c...
Source: Rheumatology International - May 14, 2018 Category: Rheumatology Source Type: research

Cardiopulmonary factors affecting 6-min walk distance in patients with idiopathic inflammatory myopathies
In conclusion, impaired DLCO due to interstitial lung disease was suggested to be a fundamental parameter affecting exercise capacity, in addition to heart involvement, in patients with idiopathic inflammatory myopathies. (Source: Rheumatology International)
Source: Rheumatology International - May 14, 2018 Category: Rheumatology Source Type: research

Serum profile of transferrin isoforms in juvenile idiopathic arthritis: a preliminary study
AbstractIt is reported that alterations in protein glycosylation are present in adult rheumatic diseases; however, the data related to pediatric rheumatic conditions are very scarce. The aim of this study was to assess the effect of juvenile idiopathic arthritis (JIA) on the serum glycosylation profile of transferrin isoforms. Twenty-five patients with different clinical forms of an active JIA and 22 healthy controls were studied. Serum samples were analyzed by capillary electrophoresis on MINICAP electrophoretic system (Sebia, France) to determine the levels of transferrin isoforms. In patients with JIA, tetrasialotransfe...
Source: Rheumatology International - May 14, 2018 Category: Rheumatology Source Type: research

HBsAg-negative and anti-HBc-positive in eosinophilic granulomatosis with polyangiitis: a retrospective pilot study
In conclusion, resolved HBV infection may importantly influence vasculitis activity at diagnosis and subsequently relapse after remission in EGPA patients. (Source: Rheumatology International)
Source: Rheumatology International - May 12, 2018 Category: Rheumatology Source Type: research

The many faces of IgG4-related disease: report of a case with inaugural recurrent aortic aneurism ruptures and literature review
AbstractVascular involvement in IgG4-related disease (IgG4-RD), is a well-recognized feature and large vessel commitment, especially the aorta, can be the only manifestation of the disease. Being a newly recognized disease, its diagnosis and workup still represents a challenge in clinical practice. A 47-year-old-man with two aortic aneurysms ruptures, one at abdominal and the other at thoracic level, was referred to our rheumatology department. The initial analysis of the surgical specimen obtained 3  years earlier revealed a nonspecific aortitis. Re-evaluation of the biopsy with immunohistology now demonstrated the p...
Source: Rheumatology International - May 12, 2018 Category: Rheumatology Source Type: research

Dynamic of changes in coronary artery calcification in early rheumatoid arthritis patients over 18  months
AbstractThe coronary artery calcification (CAC) progression may be useful noninvasive predictor of future cardiovascular events (CVE). The progression rate of CAC in patients with early rheumatoid arthritis (RA) is poorly understood. To assess the dynamic of CAC scores in early RA patients for 18  months, 74 RA adult patients (ACR/EULAR criteria, 2010, duration ≤ 12 months, with moderate/high RA activity, without prior administration of disease-modifying anti-rheumatic drugs or glucocorticoids) were enrolled within the framework of the observational study: women 73%, median age 56 year s, median RA dura...
Source: Rheumatology International - May 11, 2018 Category: Rheumatology Source Type: research

Efficacy and safety of interleukin-1 antagonists in rheumatoid arthritis: a systematic review and meta-analysis
AbstractRheumatoid arthritis patients have a high level of pro-inflammatory interleukin-1. Augmenting the blockade of interleukin-1 receptors by external interleukin-1 receptor antagonist modifies the progression of the disease. Therefore, the aim of this study was to evaluate the clinical efficacy and safety of interleukin-1 receptor antagonist (anakinra) in the treatment of rheumatoid arthritis. Clinical trials and extension studies that compared anakinra with placebo or other medications were included. Electronic bibliographic databases: PubMed, Scopus, and Web of Sciences were searched from inception to November 2017. ...
Source: Rheumatology International - May 8, 2018 Category: Rheumatology Source Type: research

Coronary flow reserve in systemic rheumatic diseases: a systematic review and meta-analysis
The objective of this study is to conduct a systematic review and meta-analysis of studies with small sample size investigating the associations between the presence of RDs and CFR to increase statistical power and accuracy. PubMed, Web of Science, Scopus, and Google Scholar, from inception to March 2018, were searched for studies reporting on CFR in RDs in comparison to healthy subjects. Standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated. Meta-regressions and sensitivity analyses assessed study heterogeneity by type of RDs, age, traditional cardiovascular risk factors, systemic inflamma...
Source: Rheumatology International - May 7, 2018 Category: Rheumatology Source Type: research

Renal involvement in antiphospholipid syndrome
AbstractThis is a review of scientific publications on renal involvement in antiphospholipid syndrome (APS), with focus on clinical and histopathological findings and treatment. A search for English-language articles on renal involvement in APS covering the period 1980 –2017 was conducted in Medline/PubMed and Scopus databases using the MeSH terms “antiphospholipid syndrome”, “antiphospholipid antibodies”, “glomerulonephritis” and “thrombotic microangiopathy” (TMA). APS nephropathy is primarily the result of thromboses in renal arteries or veins, intraparenchymatous art...
Source: Rheumatology International - May 5, 2018 Category: Rheumatology Source Type: research

Spectrum of systemic lupus erythematosus in Oman: from childhood to adulthood
AbstractSLE is a disease that mainly affects women of childbearing age, however, a total of 15 –20% of cases present in children. Although adult onset SLE (aSLE) and childhood onset SLE (cSLE) share the same diagnostic criteria, differences have been identified. The aim of this study is to compare the similarities and differences in between cSLE and aSLE in an Arab population from Oman. We evaluated 225 SLE patients, 139 adults and 86 children, who fulfilled the criteria for diagnosis. At disease onset, 99% of SLE cohort fulfilled the SLICC criteria; however the ACR 1997 criteria were fulfilled in 66% aSLE and 80% cS...
Source: Rheumatology International - May 2, 2018 Category: Rheumatology Source Type: research

Nutritional intervention in patients with juvenile systemic lupus erythematosus: protective effect against the increase in fat mass
AbstractPatients with juvenile systemic lupus erythematosus (JSLE) usually have an increase in fat mass and decrease in lean body mass. The purpose of this study was to assess the effect of a nutritional intervention on changes in body composition and food consumption of adolescents with JSLE compared with a control group and its variation over time and to assess the association of total fat mass with clinical parameters. This randomized controlled study evaluated 31 girls. Body composition and food intake were evaluated at baseline. The patients were randomly allocated into a nutritional intervention group and a control g...
Source: Rheumatology International - May 2, 2018 Category: Rheumatology Source Type: research

Current status of ultrasound and dual-energy computed tomography in the evaluation of gout
This article reports the current status of these two modalities in regard to diagnosis and therapy follow-up. (Source: Rheumatology International)
Source: Rheumatology International - May 2, 2018 Category: Rheumatology Source Type: research

Pyoderma gangrenosum-like ulcerations in granulomatosis with polyangiitis: two cases and literature review
AbstractGranulomatosis with polyangiitis (GPA) is a systemic necrotizing small vessel vasculitis associated with circulating anti-neutrophil cytoplasmic antibodies (ANCAs). Skin manifestations, mostly represented by palpable purpura, papulonodular lesions and livedo reticularis, are present in up to 50% of the cases. Ulcerations with undermined, raised erythematous –violaceous border resembling pyoderma gangrenosum (PG) have rarely been reported as skin involvement in GPA. The presence of circulating ANCAs with a cytoplasmic labelling pattern, the involvement of internal organs, particularly of the lung, and the abse...
Source: Rheumatology International - May 2, 2018 Category: Rheumatology Source Type: research

Inverse Gottron papules in juvenile dermatomyositis: an under recognized clinical entity
The objective of this study was to report four children having juvenile dermatomyositis (JDM) with inverse Gottron sign along with a brief review of literature of similarly published cases. This is a retrospective review of case records of all children diagnosed with JDM at a single tertiary care centre in North India. Children who were found to have Gottron papules over palmar surface were identified. A total of 127 children were diagnosed with JDM in the last 24  years (1994–2017). Out of these 127 patients, 4 were found to have Gottron papules over palmar surface. The median age at presentation of these four ...
Source: Rheumatology International - May 2, 2018 Category: Rheumatology Source Type: research

Physician –patient communication in rheumatology: a systematic review
AbstractThe nature of physician –patient interaction can have a significant impact on patient outcomes through information-sharing and disease-specific education that can enhance patients’ active involvement in their care. The aim of this systematic review was to examine all the empirical evidence pertaining to aspects of phys ician–patient communication and its impact on patient outcomes. A systematic search of five electronic databases (MEDLINE, PsycINFO, EMBASE, CINAHL, and Web of Science) was undertaken from earliest record to December 2016. Studies were eligible if they: (1) included adult participan...
Source: Rheumatology International - April 20, 2018 Category: Rheumatology Source Type: research

The effectiveness of the low-power laser and kinesiotaping in the treatment of carpal tunnel syndrome, a pilot study
In conclusion, low-power laser and kinesiotaping method in the treatment of CTS may be an effective and reliable treatment option in clinical parameter s. (Source: Rheumatology International)
Source: Rheumatology International - April 20, 2018 Category: Rheumatology Source Type: research

Frailty in end-stage hip or knee osteoarthritis: validation of the Groningen Frailty Indicator (GFI) questionnaire
This study assesses the validity of the GFI in this patient group. End-stage hip or knee OA patients completed the GFI (range 0 –15, ≥ 4 = frail) before arthroplasty surgery. Convergent validity was determined by Spearman-rank correlation between the SF-12 physical (PCS) and mental (MCS) component scores and the physical and mental GFI-domains, respectively. Discriminant validity was assessed by means of overall GFI- score and the pain-domain of the Hip/Knee Osteoarthritis Outcome Score (HOOS/KOOS). Altogether 3275 patients were included of whom 2957 (90.3%) completed the GFI. Mean GFI-scores w...
Source: Rheumatology International - April 20, 2018 Category: Rheumatology Source Type: research

2D:4D finger length ratio and radiographic hand osteoarthritis
AbstractTo evaluate the association between the index and ring finger ’s (2D:4D) length ratio with the prevalence and severity of radiographic hand osteoarthritis (OA). A population-based sample included 802 males (mean age 46.98 ± 17.10 years) and 738 females (mean age 48.65 ± 16.62 years) who had participated in a Chuvashian skeletal aging study. Age, sex, basic demographics, anthropometric data and X-rays of both hands were acquired. Each hand was visually classified on X-ray as either type 1—index finger longer than the ring finger; type 2—index and ring fin...
Source: Rheumatology International - April 20, 2018 Category: Rheumatology Source Type: research

Periodontal condition is associated with disease duration and motoric disabilities in patients with ankylosing spondylitis: results of a cross-sectional study
AbstractObjectiveRecent literature reveals worse periodontal health condition in ankylosing spondylitis (AS). However, roles of AS-related parameters, periodontal condition, and their association appear unclear. This cross-sectional study aimed at investigating dental and periodontal health as well as potentially periodontal pathogenic bacteria in patients with AS compared to healthy control subjects (HC).MethodsDental examination comprised dental findings (DMF-T), periodontal probing depth (PPD), bleeding on probing, clinical attachment loss (CAL), papillary bleeding index, and microbiological analysis based on polymerase...
Source: Rheumatology International - April 20, 2018 Category: Rheumatology Source Type: research

Can neck pain be an initial symptom of rheumatoid arthritis? A case report and literature review
In this report, we presented a case of RA presenting with cervical spine involvement without peripheral arthritis to underline the importance of this kind of involvement in clinical practice. We also briefly reviewed other cases similar to ours in light of literature. (Source: Rheumatology International)
Source: Rheumatology International - April 20, 2018 Category: Rheumatology Source Type: research

Greater rheumatoid arthritis joint improvement with more subjects achieving response across improvement categories using novel versus existing ultrasound methods
AbstractWe compared the change in joint inflammation and the proportion of subjects achieving threshold levels of improvement using the existing methods employing ultrasonography on pre-determined joint sites versus novel methods. These novel methods select the most affected joints based on (i) ultrasonography —the Individualized-Ultrasound (IUS) method, or (ii) ultrasonography and clinical joint assessment—the individualized-Composite-Ultrasound (ICUS) method. Mean 3-month change in total inflammation score (ΔTIS) and 95% CI was computed for each method on 24 RA subjects initiated or escalated on tr eatm...
Source: Rheumatology International - April 20, 2018 Category: Rheumatology Source Type: research

Ultrasound plus low-level laser therapy for knee osteoarthritis rehabilitation: a randomized, placebo-controlled trial
This study evaluated the synergistic effects of ultrasound (US) and low-level laser therapy (LLLT) with or without therapeutic exercises (TE) in women with knee osteoarthritis. Forty-two Caucasian women with knee osteoarthritis were allocated into three groups: (1) the placebo group who did not perform TE, but the prototype without emitting light or ultrasonic waves was applied, (2) the US  + LLLT group in which only the prototype was applied and (3) the TE + US + LLLT group that performed TE before the prototype was applied. However, 35 women completed the full clinical trial. Pre...
Source: Rheumatology International - April 20, 2018 Category: Rheumatology Source Type: research

Correction to: Spanish transcultural adaptation and validation of the English version of the compliance questionnaire in rheumatology
AbstractIn the original published article, the family name was incorrectly tagged for two co-authors. The correct family names of authors Jos é Ramón Maneiro Fernández is Maneiro Fernández and Alejandro Souto Vilas is Souto Vilas. (Source: Rheumatology International)
Source: Rheumatology International - April 20, 2018 Category: Rheumatology Source Type: research

Pseudogout among Patients Fulfilling a Billing Code Algorithm for Calcium Pyrophosphate Deposition Disease
AbstractTo test the performance of a billing claims-based calcium pyrophosphate deposition disease (CPPD) algorithm for identifying pseudogout. We applied a published CPPD algorithm at an academic institution and randomly selected 100 patients for electronic medical record review for 3 phenotypes: (1) definite/probable CPPD, (2) definite/probable pseudogout; (3) definite pseudogout. Clinical data were recorded and positive predictive value (PPV) (95% CI) for each phenotype was calculated. We then modified the published algorithm to require  ≥ 1 of 4 relevant terms (“pseudogout”, “calcium ...
Source: Rheumatology International - April 17, 2018 Category: Rheumatology Source Type: research

Skeletal muscle stem cell characteristics and myonuclei content in patients with rheumatoid arthritis: a cross-sectional study
AbstractTo investigate satellite cells (SCs) and myonuclei characteristics in patients with rheumatoid arthritis (RA). Resting biopsies from m. vastus lateralis were obtained from thirteen RA patients and thirteen matched healthy controls (CON). Muscle biopsies were immunohistochemically stained and analyzed for fiber type specific content of SCs (Pax7+), proliferating SCs (Pax7+/MyoD+) and differentiating SCs (myogenin+). Furthermore, we quantified fiber type specific content of myonuclei and myofiber cross-sectional area (CSA). Finally, newly formed/regenerating fibers expressing neonatal MHC (nMHC+) were determined. The...
Source: Rheumatology International - April 12, 2018 Category: Rheumatology Source Type: research

Sexual health in patients with rheumatoid arthritis and the association between physical fitness and sexual function: a cross-sectional study
AbstractThe aim of this study was to examine sexual health in patients with rheumatoid arthritis (RA), and  to analyse factors associated with sexual health with a focus on physical fitness. One hundred RA patients aged between 18 and 65 years were included in a cross-sectional study. Handgrip strength and knee extensor strength were measured with a dynamometer, and physical performance with the Short Physical Performance Battery (SPPB). Fifty-four patients, mean age 47.8 (SD 10.6) years, 61% female, answered a questionnaire about sexual health. Fifty-seven percent reported, at least, sometimes having difficulty ...
Source: Rheumatology International - April 11, 2018 Category: Rheumatology Source Type: research

Successful treatment of antisynthetase syndrome presenting as rhabdomyolysis with rituximab
In this report, we present a patient who presented with features of rhabdomyolysis and was diagnosed with antisynthetase syndrome. This patient was treated with systemic steroids with partial improvement, foll owed by rituximab, which led to significant improvement in his condition. In addition, we summarize all cases reported in the literature of inflammatory myopathy-associated rhabdomyolysis. (Source: Rheumatology International)
Source: Rheumatology International - April 11, 2018 Category: Rheumatology Source Type: research

Do pulmonary findings of granulomatosis with polyangiitis respond to anti-tuberculosis treatment?
In this report, we presented clinical features of two cases with GPA who had been diagnosed as tuberculosis (TBC) and well treated with anti-tuberculosis (anti-TBC) drugs. However, one of two cases had ear–nose–throat (ENT) manifestations before the diagnosis of TBC and her extrapulmonary findings related with GPA have added to clinical features in the following years. In the second case, the manifestations of GPA appeared after 13 months of anti-TBC treatment. We speculated that lung invol vement in these cases may be due to GPA rather than TBC. Our aim was to highlight difficulties in the differenti...
Source: Rheumatology International - April 9, 2018 Category: Rheumatology Source Type: research

Clinical connection between rheumatoid arthritis and liver damage
AbstractWhen liver damage is present in rheumatoid arthritis (RA) patients, it is sometimes difficult to determine whether it is a hepatic manifestation of RA, associated primary liver disease or hepatotoxic liver disease which developed during the treatment of RA. Liver damage during RA is most common in the form of asymptomatic abnormal liver tests. Occasionally, liver damage may progress to cirrhosis. Patients with RA are more susceptible to an associated autoimmune liver disease. Medications used in rheumatology are often hepatotoxic and it is difficult to differentiate between hepatic manifestations of the primary dis...
Source: Rheumatology International - April 7, 2018 Category: Rheumatology Source Type: research

Association between memory B-cells and clinical and immunological features of primary Sj ögren’s syndrome and Sicca patients
AbstractB-cells play a pivotal role in primary Sj ögren’s syndrome (pSS) pathogenesis. We aim to (1) evaluate the distribution of B-lymphocyte subpopulations in pSS and Sicca patients, (2) establish cut-off points that discriminate pSS from controls, (3) evaluate the association between memory B-cells and phenotypic features in pSS. We included 57 pSS patients, 68 Sicca and 24 healthy controls. Circulating B-cells were characterized by flow cytometry as naïve and memory subsets and classified from Bm1 to Bm5. Compared to controls, pSS patients had lower percentages (29.5 vs 44.4%) and absolute numbers (47 v...
Source: Rheumatology International - April 6, 2018 Category: Rheumatology Source Type: research

Measuring hand grip strength in rheumatoid arthritis
AbstractRheumatoid arthritis (RA) is a systemic inflammatory disease with a particular predilection for causing pain, deformity and functional limitation affecting the hands. Measures of the severity of RA, such as the disease activity score with 28 joint count may not fully reflect the regional impact of RA on the hands. Hand grip strength measurements are a form of objective assessment that focuses specifically on the hands in RA. This review explores what is currently known about the assessment of hand grip strength; what it may indicate, how it is measured, some of the practical aspects and challenges associated with p...
Source: Rheumatology International - April 6, 2018 Category: Rheumatology Source Type: research

The role of genetics and epigenetics in rheumatic diseases: are they really a target to be aimed at?
AbstractTo date, numerous genetic and epigenetic studies have been performed and provided a crucial step forward in our understanding of the pathogenesis of rheumatic diseases. However, most of the recent advances in the treatment of rheumatic diseases including biological therapies are not based on or even discrepant from these genetic and epigenetic findings. For example, tumor necrosis factor inhibitors are quite successful in the treatment of rheumatoid arthritis (RA), Beh çet’s disease (BD), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) but not in that of systemic lupus erythematosus (SLE), sy...
Source: Rheumatology International - April 5, 2018 Category: Rheumatology Source Type: research

Serum drug levels of biologic agents in the management of rheumatoid arthritis and spondyloarthritis: a systematic review
The objective was to study relevant clinical questions on the topic, i.e., (1) whether drug levels predict relapse in patients whose biologic was optimized because of remission or low disease activity; (2) whether information about drug levels influences the prognosis of patients with primary or secondary failure to a biological therapy; and (3) whether methotrexate (MTX) influences the association between drug levels and response. Medline, Embase, Cochrane databases were screened, from inception to December 2016 in search for all studies related to the three research questions about. Overall characteristics and outcomes o...
Source: Rheumatology International - April 3, 2018 Category: Rheumatology Source Type: research

The Swiss French version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)
In conclusion, the Swiss French version of the JAMAR is a valid tool for the assessment of children with JIA and is suitable for use both in routine clinical practice and clinical research. (Source: Rheumatology International)
Source: Rheumatology International - April 1, 2018 Category: Rheumatology Source Type: research

The Croatian version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)
In conclusion, the Croatian version o f the JAMAR is a valid tool for the assessment of children with JIA and is suitable for use both in routine clinical practice and clinical research. (Source: Rheumatology International)
Source: Rheumatology International - April 1, 2018 Category: Rheumatology Source Type: research

The Slovene version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)
In conclusion, the Slovene version of the JAMAR is a valid tool for the assessment of childre n with JIA and is suitable for use both in routine clinical practice and clinical research. (Source: Rheumatology International)
Source: Rheumatology International - April 1, 2018 Category: Rheumatology Source Type: research

The Greek version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)
In conclusion, the Greek version of the JAMAR is a valid tool for the assessment of children with JIA and is suitable for use both in routine clinical practice and in clinical research. (Source: Rheumatology International)
Source: Rheumatology International - April 1, 2018 Category: Rheumatology Source Type: research

The Portuguese version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)
In conclusion, the Portuguese version of the JAMAR is a valid tool for the assessm ent of children with JIA and is suitable for use both in routine clinical practice and clinical research. (Source: Rheumatology International)
Source: Rheumatology International - April 1, 2018 Category: Rheumatology Source Type: research

The Ecuadorian Spanish version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)
In conclusion, the Ecuadorian Spanish version of the JAMAR is a valid tool for the assessment of children with JIA and is suitable for use both in routine clinical practice and clinical research. (Source: Rheumatology International)
Source: Rheumatology International - April 1, 2018 Category: Rheumatology Source Type: research

The Mexican Spanish version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)
In conclusion, the Mexican Spanish version of the JAMAR is a valid tool for the assessment of children with JIA and is suitable for use both in routine clinical practice and clinical research. (Source: Rheumatology International)
Source: Rheumatology International - April 1, 2018 Category: Rheumatology Source Type: research

The Lithuanian version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)
In conclusion, the Lithuanian version of the JAMAR is a valid tool for the assessment of children with JIA and is suitable for use both in routine clinical practice and clinical research. (Source: Rheumatology International)
Source: Rheumatology International - April 1, 2018 Category: Rheumatology Source Type: research