Arthritis in the hands of saints
(Source: Rheumatology International)
Source: Rheumatology International - January 20, 2021 Category: Rheumatology Source Type: research

Adherence to best practice consensus guidelines for familial Mediterranean fever: a modified Delphi study among paediatric rheumatologists in Turkey
ConclusionA consensus was achieved regarding the routine diagnosis and screening and treatment of FMF patients. The definition of colchicine resistance was made and a protocol was created for prolongation of treatment intervals of biologic agents. We anticipate that the results of the study reveal real-life data on the approach to patients in clinical practice. (Source: Rheumatology International)
Source: Rheumatology International - January 16, 2021 Category: Rheumatology Source Type: research

Telemedicine for patients with rheumatic and musculoskeletal diseases during the COVID-19 pandemic; a positive experience in the Netherlands
AbstractTo describe the delivery of care for patients with rheumatic and musculoskeletal diseases (RMDs) from the perspective of rheumatologists in the Netherlands during the first months of the COVID-19 pandemic. A mixed methods design was used with quantitative and qualitative data from a cross-sectional survey sent to all members of the Dutch Rheumatology Society in May 2020. The survey contained questions on demographics, the current way of care delivery, and also on usage, acceptance, facilitators and barriers of telemedicine. Quantitative data were analyzed descriptively. The answers to the open questions were catego...
Source: Rheumatology International - January 15, 2021 Category: Rheumatology Source Type: research

Performance of diagnostic criteria in pediatric Beh çet’s disease
AbstractBeh çet's disease is an inflammatory vasculitic disease of unknown etiology characterized by recurrent oral and genital ulcers, ocular findings, and multiple organ involvement. Mucocutaneous findings are the most common symptoms. The most used diagnostic criteria are International Criteria for BD (ICBD ), International Study Group (ISG) criteria and pediatric Behçet’s disease criteria (PEDBD). Although diagnostic criteria have been defined, the diagnosis is still difficult due to clinical findings developed in pediatric patients. The aim of this study was to evaluate the clinical findings, phen ...
Source: Rheumatology International - January 15, 2021 Category: Rheumatology Source Type: research

Successful use of tofacitinib in the treatment of diffuse systemic sclerosis and axial spondyloarthritis: a case-based review
AbstractSystemic sclerosis (SSc) is an autoimmune rheumatic disease characterised by vasculopathy, inflammation and fibrosis in multiple organs and occasionally coexists with rheumatic conditions, such as axial spondyloarthritis (axSpA). The aim of this study was to demonstrate the successful use of tofacitinib in SSc and axial spondylarthritis (axSpa), as a novel therapeutic agent; however, further studies are needed to elucidate the role of JAK inhibition in the treatment of both conditions. In this paper, we report a case of a 58-year-old woman with diffuse SSc who developed axSpA. The patient had a 10-year history of S...
Source: Rheumatology International - January 12, 2021 Category: Rheumatology Source Type: research

Indian SLE Inception cohort for Research (INSPIRE): the design of a multi-institutional cohort
AbstractSystemic lupus erythematosus (SLE) cohorts across the world have allowed better understanding of SLE, including its bimodal mortality, and the impact of social factors and ethnicity on outcomes. The representation of patients from South Asia has been poor in the existing SLE cohorts across the world. Hence, we planned to initiate an inception cohort to understand the diversity of lupus in India. Indian SLE Inception cohort for REsearch (INSPIRE), planned over 5 years is a multi-centric cohort of adult and childhood lupus patients of Indian origin, fulfilling the SLICC-2012 classification criteria, with an aim to pr...
Source: Rheumatology International - January 12, 2021 Category: Rheumatology Source Type: research

Disease-modifying drug retention rate according to patient age in patients with early rheumatoid arthritis: analysis of the ESPOIR cohort
AbstractPhysicians are sometimes hesitant to use disease-modifying antirheumatic drugs (DMARDs) in elderly patients with rheumatoid arthritis (RA), as they are deemed too fragile, although there are no sufficient scientific evidence. We aimed to compare DMARD treatment retention in early RA patients from the ESPOIR cohort, according to age upon inclusion. Overall, treatment retention was evaluated as the percentage of patients whose DMARDs were not stopped, with stratification by age group:  65 years. Survival curves were measured using the Kaplan–Meier method. Of the entire ESPOIR cohort (n =&thin...
Source: Rheumatology International - January 12, 2021 Category: Rheumatology Source Type: research

SASDAS: a practical tool to measure disease activity in axSpa patients. Comments on “a prospective study of novel disease activity indices for ankylosing spondylitis”
(Source: Rheumatology International)
Source: Rheumatology International - January 11, 2021 Category: Rheumatology Source Type: research

Advances in imaging technologies for the assessment of peripheral neuropathies in rheumatoid arthritis
AbstractPeripheral neuropathy in patients with rheumatoid arthritis is associated with a maladaptive autoimmune response that may cause chronic pain and disability. Nerve conduction studies are the routine method performed when rheumatologists presume its presence. However, this approach is invasive, may not reveal subtle malfunctions in the early stages of the disease, and does not expose abnormalities in structures surrounding the nerves and muscles, limiting the possibility of a timely diagnosis. This work aims to present a narrative review of new technologies for the clinical assessment of peripheral neuropathy in Rheu...
Source: Rheumatology International - January 11, 2021 Category: Rheumatology Source Type: research

Characteristics and outcomes of overlap myositis: a comparative multigroup cohort study in adults from the MyoCite cohort
AbstractOverlap myositis (OM), an important subset of idiopathic inflammatory myopathies (IIM), is being increasingly recognized with wider myositis-specific autoantibody (MSA) testing. We studied the differences in clinical characteristics and long-term outcomes of OM with Dermatomyositis (DM), Polymyositis (PM), anti-synthetase syndrome (ASSD), and Cancer-associated IIM (CAM). Data from the MyoCite registry (Dec2017 –May2020), a prospective dataset of IIM was extracted for the clinical profile, and MSAs, immunosuppressants received, disease activity (relapses and incomplete response), and treatment-related (drugs A...
Source: Rheumatology International - January 10, 2021 Category: Rheumatology Source Type: research

Comorbidities in psoriatic arthritis: a systematic review and meta-analysis
AbstractThe aims of this systematic review and meta-analysis were to: (1) describe the prevalence of commonly reported comorbidities in psoriatic arthritis (PsA), (2) compare the incidence and/or prevalence of comorbidities between PsA and control populations; and (3) examine the impact of comorbidities on PsA outcomes. We systematically searched Medline, PubMed, Scopus, and Web of Science using a predefined protocol in accordance with PRISMA guidelines. Studies reporting only one comorbidity, or a few closely related diseases within one organ system, were excluded. Where possible, meta-analysis was performed using random-...
Source: Rheumatology International - January 9, 2021 Category: Rheumatology Source Type: research

Comorbidities in rheumatic diseases need special consideration during the COVID-19 pandemic
AbstractComorbidities in rheumatic and musculoskeletal diseases (RMDs) not only increase morbidity and mortality but also confound disease activity, limit drug usage and increase chances of severe infections or drug-associated adverse effects. Most RMDs lead to accelerated atherosclerosis and variable manifestations of the metabolic syndrome. Literature on COVID-19 in patients with RMDs, and the effects of various comorbidities on COVID-19 was reviewed. The initial data of COVID-19 infections in RMDs have not shown an increased risk for severe disease or the use of different immunosuppression. However, there are some emerg...
Source: Rheumatology International - January 3, 2021 Category: Rheumatology Source Type: research

Increased short-term risk of cardiovascular events in inflammatory rheumatic diseases: results from a population-based cohort
AbstractCardiovascular diseases represent the first cause of death globally. Inflammatory rheumatic disease (IRMD) patients, due to their lifelong inflammatory status, are at increased risk of developing premature cardiovascular disease. We aimed to assess the risk for cardiovascular events (CVE) in a population-based study. We followed 10,153 adults from the EpiDoC Cohort, a large Portuguese population-based prospective study (2011 –2016). IRMD patients were identified at baseline and followed during 5 years. CVE were defined as a composite of self-reported myocardial infarction or angina pectoris, arrhythmias,...
Source: Rheumatology International - January 3, 2021 Category: Rheumatology Source Type: research

Proposal of a new nomenclature for the underlying pathogenetic mechanism of severe Coronavirus Disease-19: “Inflammatory Thrombosis with Immune Endotheliitis—ITIE”
(Source: Rheumatology International)
Source: Rheumatology International - January 3, 2021 Category: Rheumatology Source Type: research

One-year direct costs of biological therapy in rheumatoid arthritis and its predictive factors: data from the Moroccan RBSMR registry
AbstractThe aim of the study was to estimate the annual direct costs of biological therapies in rheumatoid arthritis (RA), and to establish possible factors associated with those costs. The main data source was the Moroccan registry of biological therapies in rheumatic diseases (RBSMR Registry). We included patients with available 1-year data. Variables related to socio-economic status, disease and biological therapy were collected. Direct costs included prices of biologics, costs of infusions, and subcutaneous injections. Differences in costs across groups were tested by Mann –Whitney and Kruskal–Wallis tests....
Source: Rheumatology International - January 2, 2021 Category: Rheumatology Source Type: research

High-resolution ultrasound imaging of skin involvement in systemic sclerosis: a systematic review
AbstractTo collect evidence on the application of ultrasound in skin assessment in patients with systemic sclerosis (SSc). The authors carried out a review of the literature via Pubmed MEDLINE database. The search terms were: skin imaging in systemic sclerosis, ultrasound skin imaging in patients with systemic sclerosis. The selection and analysis of articles were performed by two independent evaluators. The authors analyzed 10 studies characterizing 470 patients with systemic sclerosis. The patients were young adults, mainly women. The described methods of ultrasound were: ultrasound elastography (7.14%), ultra-high-frequ...
Source: Rheumatology International - January 2, 2021 Category: Rheumatology Source Type: research

Macrophage activation syndrome in systemic lupus erythematosus and systemic-onset juvenile idiopathic arthritis: a retrospective study of similarities and dissimilarities
AbstractMacrophage activation syndrome (MAS) is a serious complication of rheumatic diseases. Fever and hyperferritinemia are common in active systemic-onset juvenile idiopathic arthritis (sJIA) and cytopenia in active systemic lupus erythematosus (SLE), thus recognizing MAS in them is a challenge. We compared clinical and laboratory parameters, various classification criteria, and outcomes of MAS in SLE and sJIA. Clinical and laboratory data were extracted from case records of patients with clinician diagnosed cases of SLE-MAS (adult and pediatric) and sJIA-MAS, admitted (2004 –2018) at a tertiary care hospital. Rav...
Source: Rheumatology International - January 2, 2021 Category: Rheumatology Source Type: research

The feasibility of an exercise intervention to improve sleep (time, quality and disturbance) in people with rheumatoid arthritis: a pilot RCT
AbstractCurrent rheumatology guidelines recommend exercise as a key component in the management of people with RA, however, what is lacking is evidence on its impact on sleep. Objective is to assess the feasibility of a walking-based intervention on TST, sleep quality, and sleep disturbance and to generate potential effect size estimates for a main trial. Participants were recruited at weekly rheumatology clinics and through social media. Patients with RA were randomized to a walking-based intervention consisting of 28 sessions, spread over 8  weeks (2–5 times/week), with 1 per week being supervised by a physiot...
Source: Rheumatology International - January 2, 2021 Category: Rheumatology Source Type: research

Colchicine as an adjunct to heparin for prophylaxis of venous thromboembolism in patients with COVID-19
(Source: Rheumatology International)
Source: Rheumatology International - January 2, 2021 Category: Rheumatology Source Type: research

Similar lipid level changes in early rheumatoid arthritis patients following 1-year treat-to-target strategy with adalimumab plus methotrexate versus placebo plus methotrexate: secondary analyses from the randomised controlled OPERA trial
AbstractTo compare changes in low-density lipoprotein cholesterol and other lipids in patients with rheumatoid arthritis (RA) randomised to a 1-year treat-to-target strategy with either adalimumab plus methotrexate or placebo plus methotrexate. Prespecified secondary analyses from the OPERA trial, where 180 early and treatment-na ïve RA patients received methotrexate 20 mg once weekly in combination with either placebo or subcutaneous adalimumab 40 mg every other week. Serum lipid levels were measured at baseline and after 1 year. Changes in lipid levels were analysed using mixed linear models based on ...
Source: Rheumatology International - January 2, 2021 Category: Rheumatology Source Type: research

How to define disease severity accurately in patients with familial Mediterranean fever
(Source: Rheumatology International)
Source: Rheumatology International - January 1, 2021 Category: Rheumatology Source Type: research

Response to ‘How to define disease severity accurately in patients with familial Mediterranean fever’
(Source: Rheumatology International)
Source: Rheumatology International - January 1, 2021 Category: Rheumatology Source Type: research

COVID-19 in Italian Sj ögren's syndrome patients: a monocentric study
(Source: Rheumatology International)
Source: Rheumatology International - January 1, 2021 Category: Rheumatology Source Type: research

Think twice before submitting your precious articles for publication!
(Source: Rheumatology International)
Source: Rheumatology International - January 1, 2021 Category: Rheumatology Source Type: research

COVID-19, hydroxychloroquine and sudden cardiac death: implications for clinical practice in patients with rheumatic diseases
AbstractSudden cardiac death is commonly seen due to arrhythmias, which is a common cardiac manifestation seen in COVID-19 patients, especially those with underlying cardiovascular disease (CVD). Administration of hydroxychloroquine (HCQ) as a potential treatment option during SARS-CoV-2, initially gained popularity, but later, its safe usage became questionable due to its cardiovascular safety, largely stemming from instances of cardiac arrhythmias in COVID-19. Moreover, in the setting of rheumatic diseases, in which  patients are usually on HCQ for their primary disease, there is a need to scale the merits and demer...
Source: Rheumatology International - January 1, 2021 Category: Rheumatology Source Type: research

Opening the black box of non-pharmacological care in systemic sclerosis: a cross-sectional online survey of Dutch health professionals
The objective is to describe the spectrum of the health professional (HP) treatment approach for systemic sclerosis (SSc) from the perspective of Dutch HPs, including alignment of treatment goals set by HPs with self-reported referral reasons, coverage of patient-reported unmet care needs, and quality of communication between HPs and rheumatologists. Dutch HPs were invited through their patients with SSc to complete an anonymous online survey. The survey covered referral reasons, treatment goals, and interventions of the last patient treated, as well as the perceived quality of communication between HPs and rheumatologists...
Source: Rheumatology International - December 23, 2020 Category: Rheumatology Source Type: research

Correction to: Concomitant onset of systemic lupus erythematosus and disseminated histoplasmosis: a case-based review
The original article can be found online. (Source: Rheumatology International)
Source: Rheumatology International - December 21, 2020 Category: Rheumatology Source Type: research

Analysis of a single-institution cohort of patients with Felty's syndrome and T-cell large granular lymphocytic leukemia in the setting of rheumatoid arthritis
AbstractT-cell large granular lymphocytic leukemia (T-LGLL) is a lymphoproliferative disorder characterized by a persistent increase in the number of large granular lymphocytes (LGLs), neutropenia, and splenomegaly. Clinical manifestations of T-LGLL in the setting of rheumatoid arthritis (RA) are often identical to those in which one would suspect Felty's syndrome (FS). These disorders are distinguished by the presence of T-cell clonality, which is present in T-LGLL but not in FS. Mutations in the signal transducer and activator of transcription 3 (STAT3) and 5b (STAT5b) genes can be used as molecular markers of T-LGLL, bu...
Source: Rheumatology International - December 5, 2020 Category: Rheumatology Source Type: research

Kawasaki-like disease in children with COVID-19
In this study, we investigated children with typical and atypical Kawasaki disease (KD) likely to be associated with COVID-19. We have reported four children with Kawasaki-like disease probably associated with COVID-19. The clinical features were consistent with incomplete KD in three patients. SARS-CoV-2 RT-PCR was positive in one and the serology was positive in one patient with negative RT-PCR. Corticosteroids, anakinra, intravenous immunoglobulin (IVIG), and acetylsalicylic acid were used in the treatment. Three patients recovered after the treatment while one patient died. The literature review revealed 36 articles de...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Scholarly publishing and journal targeting in the time of the Coronavirus Disease 2019 (COVID-19) pandemic: a cross-sectional survey of rheumatologists and other specialists
AbstractThe evolving research landscape in the time of the Coronavirus disease 2019 (COVID-19) pandemic calls for greater understanding of the perceptions of scholars regarding the current state and future of publishing. An anonymised and validated e-survey featuring 30 questions was circulated among rheumatologists and other specialists over social media to understand preferences while choosing target journals, publishing standards, commercial editing services, preprint archiving, social media and alternative publication activities. Of 108 respondents, a significant proportion were clinicians (68%), researchers (60%) and ...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Adrenocorticotropic hormone: an effective “natural” biologic therapy for acute gout?
AbstractTreatment of acute gout consists of non-steroidal anti-inflammatory drugs (NSAIDs), colchicine and steroids. However, the typical patient with gout has multiple comorbidities such as cardiovascular disease, hypertension, renal dysfunction or diabetes/metabolic syndrome that represent contraindications to these therapeutic options. The aim of this study is to review the available evidence regarding the use of ACTH as an alternative therapeutic option for acute gout and explore potential mechanisms of action. We performed an electronic search (MEDLINE, Scopus and Web of Science) using the keywords ACTH or adrenocorti...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

High rates of severe disease and death due to SARS-CoV-2 infection in rheumatic disease patients treated with rituximab: a descriptive study
The objective of this study is to describe the characteristics and outcomes of rheumatic and musculoskeletal disease (RMD) patients who were treated with rituximab and had suspected or confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this descriptive study, RMD patients who were treated with rituximab in the last 12  months at the Rheumatology Department of our hospital were screened for SARS-CoV-2 infection via telephone interview and a comprehensive review of clinical health records (01/02/2020–26/05/2020). Those with probable or confirmed SARS-CoV-2 infection were included....
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

#Covid4Rheum: an analytical twitter study in the time of the COVID-19 pandemic
This study examined the content and stakeholders associated with the Twitter hashtag #Covid4Rheum during the COVID-19 pandemic. The content analysis shows that Twitter connects stakeholders of the rheumatology community on a global level, reaching millions of users. Specifically, the use of hashtags on Twitter assists digital crowdsourcing projects and scientific collaboration, as exemplified by the COVID-19 Global Rheumatology Alliance registry. Moreover, Twitter facilitates the distribution of scientific content, such as guidelines or publications. Finally, digital data mining enables the identification of hot topics wit...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Bone turnover biomarkers, disease activity, and MRI changes of sacroiliac joints in patients with spondyloarthritis
AbstractThe lack of valid biomarkers in patients with spondyloarthritis (SpA) requires searching for additional options to increase sacroiliac joint (SIJ) evaluation effectiveness. We assessed the serum levels of bone turnover markers and their relationships with active and chronic changes in SIJs using magnetic resonance imaging (MRI), indices, and laboratory parameters of disease activity in SpA patients. 102 patients with SpA and 15 healthy subjects were included. Testing of serum levels of transforming growth factor-beta (TGF- β1), Wnt3, sclerostin, and Dickkopf-1 (Dkk-1) was conducted. Active inflammatory lesions...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Reduction of biologics in rheumatoid arthritis: a systematic review and meta-analysis
AbstractThe effects of dose reduction or spacing of all types of biologics in rheumatoid arthritis has not been consistently assessed in systematic reviews. We aimed to assess the effects of biologics reduction compared with dose maintenance in patients with rheumatoid arthritis in low disease activity or remission. We performed a systematic review with meta-analysis according to a previously registered protocol (PROSPERO registration: CRD42017069080); and searched MEDLINE, Embase, Scopus, Cochrane Library and trial registers up to July, 2020. Two researchers selected, extracted and assessed the risk of bias of controlled ...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Familial aggregation of longevity in giant cell arteritis and polymyalgia rheumatica
AbstractThe long-term mortality in giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) is unexpectedly decreased or at least not increased regardless of several mortality risk factors that these diseases share with other chronic immune-mediated rheumatic diseases. The genetic and immunological profile of PMR/GCA patients is unique, therefore, the hypothesis that this profile provides some survival advantage to PMR/GCA patients should be considered. The longevity is a phenomenon that was demonstrated to be familial. The familial aggregation of longevity can be studied by analysis of life expectancy in family members...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

The influence of perioperative interventions targeting psychological distress on clinical outcome after total knee arthroplasty
AbstractOur aim was to assess the effect of perioperative interventions targeting psychological distress on clinical outcome after total knee arthroplasty (TKA). We searched studies on the effect of perioperative interventions focused on psychological distress used in conjunction with TKA on pain, function, and quality of life (QoL) on PubMed, Embase.com, PsycINFO/OVID, CENTRAL, the Cochrane Database of Systematic Reviews, Scopus, and Web of Science. We included 40 studies (22 RCTs, ten cohort studies, and eight quasi-experimental studies) with a total of 3846 patients. We graded the quality of evidence as low for pain and...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Cardiovascular risk assessment in patients with rheumatoid arthritis using carotid ultrasound B-mode imaging
AbstractRheumatoid arthritis (RA) is a systemic chronic inflammatory disease that affects synovial joints and has various extra-articular manifestations, including atherosclerotic cardiovascular disease (CVD). Patients with RA experience a higher risk of CVD, leading to increased morbidity and mortality. Inflammation is a common phenomenon in RA and CVD. The pathophysiological association between these diseases is still not clear, and, thus, the risk assessment and detection of CVD in such patients is of clinical importance. Recently, artificial intelligence (AI) has gained prominence in advancing healthcare and, therefore...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Comparison of the efficacy and safety of biologic agents between elderly-onset and young-onset RA patients: the ANSWER cohort study
The objective of the study was to compare the efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) between elderly-onset rheumatoid arthritis (EORA) and young-onset rheumatoid arthritis (YORA) patients. Patients with rheumatoid arthritis (RA) aged ≧18 years enrolled in a Japanese multicenter observational registry between 2009 and 2018 who had moderate or high disease activity when initiating bDMARDs were included. EORA was defined as RA with onset at 60 or over. After propensity score weighting for differences in confounding factors, gene ralized estimating equations were used to assess...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Subclinical atherosclerosis in systemic sclerosis and rheumatoid arthritis: a comparative matched-cohort study
AbstractSystemic autoimmune inflammatory disorders confer a higher risk of cardiovascular (CV) disease leading to increased morbidity and mortality and reduced life expectancy compared to the general population. CV risk in systemic sclerosis (SSc) has not been studied extensively but surrogate markers of atherosclerosis namely carotid intima media thickness (cIMT) and pulse wave velocity (PWV) are impaired in some but not all studies in SSc patients. The aim of this study was to investigate the prevalence of subclinical atherosclerosis assessed by cIMT and PWV between two well-characterized SSc and Rheumatoid Arthritis (RA...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Utility of the neutrophil-to-lymphocyte ratio for predicting bacterial infection in patients with rheumatoid arthritis receiving Tocilizumab
This study aimed to describe the utility of the neutrophil-to-lymphocyte ratio (NLR) for predicting bacterial infections in patients with rheumatoid arthritis (RA) treated with Tocilizumab (TCZ). We extracted RA patients treated with TCZ in whom an infection developed between April 2008 and March 2018 from our hospital database. We divided these patients into the bacterial infection and non-bacterial infection groups and compared their background, C-reactive protein (CRP) values, white blood cell count (WBC), the NLR at the time of infection diagnosis, and the ratio of the NLR at the time of infection diagnosis (post-NLR) ...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Adaptation and validation of the Rheumatoid Arthritis Quality of Life (RAQoL) questionnaire for use in Bulgaria
AbstractRheumatoid arthritis (RA) is a chronic disease with an enormous impact on patients ’ quality of life. The Rheumatoid Arthritis Quality of Life (RAQoL) questionnaire is a disease-specific measure of QoL for individuals with rheumatoid arthritis. Our aim was to adapt and validate the RAQoL for use in Bulgaria. The development of a new language version of the RAQoL consisted of thr ee stages: translation, field testing and psychometric evaluation. The dual-panel methodology, requiring two independent panels of Bulgarian speakers, was applied to translate the UK English version of the RAQoL into Bulgarian. Face a...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Association between hip extensor muscle weakness and disability of activities of daily living in patients with early-stage knee osteoarthritis
This study aimed to investigate the association between hip extensor muscle weakness and performance of activities of daily living (ADL) including stair ambulation, sit-to-stand (STS), and walking in patients with early-stage knee osteoarthritis (OA).MethodsCommunity-dwelling older individuals (age  ≥ 65 years and Kellgren–Lawrence grade 1–2) were recruited in this cross-sectional study. The ability to perform stair ambulation, STS, and walking was measured using the Japanese Knee Osteoarthritis Measure. The maximum isometric knee extensor and hip extensor muscle strengths were eval uated....
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Comparing quality and readability of online English language information to patient use and perspectives for common rheumatologic conditions
AbstractEvaluate quality and readability of online information for common rheumatologic diseases. Compare rheumatology patients ’ internet use and preferences to an objective evaluation of internet quality and readability. Five common rheumatologic diseases were searched on the web browser Google using English language. The first twenty websites from each of the five searches were evaluated for internet quality (e.g. conte nt that is current, balanced, has specific aims, and is appropriately cited) using the DISCERN criteria and readability using the Flesch–Kincaid Grade Level (FKGL). The results were contraste...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Insights into the knowledge, attitude and practices for the treatment of idiopathic inflammatory myopathy from a cross-sectional cohort survey of physicians
AbstractThe idiopathic inflammatory myopathies (IIM) are heterogeneous and lead to high morbidity and mortality. Knowledge deficits among healthcare professionals could be detrimental to clinical care. Identifying areas of deficient Knowledge, Attitude and Practice (KAP) of IIM can improve physician education and patient outcomes. To assess the proportion of physicians treating IIM with poor KAP and identify the key areas of deficit. An anonymised and validated e-survey (57 questions) was circulated among physicians treating IIM (purposive sampling). Responses were evaluated using the Likert scale for good (>  70...
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Acknowledgement to referees
(Source: Rheumatology International)
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Use of rituximab and the risk of adverse clinical outcomes in COVID-19 patients with systemic rheumatic disease
(Source: Rheumatology International)
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Correction to: Osteoporosis in patients with rheumatoid arthritis: trends in the German National Database 2007 –2017
The original article can be found online. (Source: Rheumatology International)
Source: Rheumatology International - October 28, 2020 Category: Rheumatology Source Type: research

Prevalence and variables associated with fatigue in psoriatic arthritis: a cross-sectional study
ConclusionPsA-associated fatigue is prevalent in this Asian PsA cohort and is associated with disease activity, impact and chronicity. (Source: Rheumatology International)
Source: Rheumatology International - September 26, 2020 Category: Rheumatology Source Type: research

Benefits and adverse effects of hydroxychloroquine, methotrexate and colchicine: searching for repurposable drug candidates
AbstractRepurposing of antirheumatic drugs has garnered global attention. The aim of this article is to overview available evidence on the use of widely used antirheumatic drugs hydroxychloroquine, methotrexate and colchicine for additional indications. Hydroxychloroquine has endothelial stabilizing and anti-thrombotic effects. Its use has been explored as an adjunctive therapy in refractory thrombosis in antiphospholipid syndrome. It may also prevent recurrent pregnancy losses in the absence of antiphospholipid antibodies. Hydroxychloroquine favourably modulates atherogenic lipid and glycaemic profiles. Methotrexate has b...
Source: Rheumatology International - September 26, 2020 Category: Rheumatology Source Type: research