Goodbye to the term 'ankylosing spondylitis, hello 'axial spondyloarthritis: time to embrace the ASAS-defined nomenclature
Ankylosing spondylitis (AS) is the historic term used for decades for the HLA-B27-associated inflammatory disease affecting mainly the sacroiliac joints (SIJ) and spine. Classification criteria for AS have radiographic sacroiliitis as a dominant characteristic. However, with the availability of MRI of SIJ, it could be demonstrated that the disease starts long before definite SIJ changes become visible on radiographs. The Assessment of SpondyloArthritis international Society, representing a worldwide group of experts reached consensus on changes in the nomenclature pertaining to axial spondyloarthritis (axSpA), such as the ...
Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: van der Heijde, D., Molto, A., Ramiro, S., Braun, J., Dougados, M., van Gaalen, F. A., Gensler, L. S., Inman, R. D., Landewe, R. B. M., Marzo-Ortega, H., Navarro-Compan, V., Phoka, A., Poddubnyy, D., Protopopov, M., Reveille, J., Rudwaleit, M., Sampaio-Ba Tags: ARD Viewpoint Source Type: research
Multiple sclerosis associated with adalimumab use in ankylosing spondylitis
(Source: Neurological Sciences)
Source: Neurological Sciences - April 10, 2024 Category: Neurology Source Type: research
Incidence and disease burden of autoimmune inflammatory rheumatic diseases after non ‐pharmaceutical interventions in the COVID‐19 era: A nationwide observational study in Korea
ConclusionImplementation of NPIs to contain the pandemic led to a reduction in the incidence of SLE and changed patterns of medical care utilization and treatment cost for most AIRDs. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 9, 2024 Category: Rheumatology Authors: Je Hee Shin,
Jung Yoon Pyo,
Minkyung Han,
Myeongjee Lee,
Sung Min Lim,
Jee Yeon Baek,
Ji Young Lee,
Ji ‐Man Kang,
InKyung Jung,
Jong Gyun Ahn Tags: ORIGINAL ARTICLE Source Type: research
Clinical Characteristics of “Severe” Peripheral Psoriatic Arthritis: A Retrospective Analysis of a Longitudinal Cohort
ConclusionsOur study showed that severe patients with PsA had more disease activity, pain, and impact of disease than non-severe patients. Furthermore, we demonstrated that severity and disease activity are not interchangeable concepts. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - April 9, 2024 Category: Rheumatology Source Type: research
Coexistence of ankylosing spondylitis and Beh çet's disease: Successful treatment with upadacitinib
ConclusionThis case fulfills diagnostic criteria for both AS and BD, emphasizing their coexistence. Notably, treatment with upadacitinib exhibited promising efficacy, underscoring its potential as a therapeutic option in patients with contraindications for conventional treatments. Our findings illuminate the intricate management of patients presenting with these two diverse systemic conditions and advocate for further exploration of JAK inhibitors in similar cases. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 5, 2024 Category: Allergy & Immunology Authors: Krasimir Kraev,
Petar Uchikov,
Bozhidar Hristov,
Maria Kraeva,
Yordanka Basheva ‐Kraeva,
Stanislava Popova‐Belova,
Milena Sandeva,
Dzhevdet Chakarov,
Snezhanka Dragusheva,
Mariela Geneva‐Popova Tags: ORIGINAL ARTICLE Source Type: research
Cytokines and chemokines involved in HLA-B27-positive ankylosing spondylitis-associated acute anterior uveitis
CONCLUSIONS: Significant differences were detected in the levels of several cytokines and chemokines in the serum of HLA-B27+ AS-associated AAU compared with HCs. Some novel differential cytokines and chemokines that have not been reported in other kinds of uveitis were also identified. These results reveal the underlying pathogenesis of HLA-B27+ AS-associated AAU and could potentially aid in clinical diagnosis.PMID:38577559 | PMC:PMC10994677 (Source: Molecular Vision)
Source: Molecular Vision - April 5, 2024 Category: Molecular Biology Authors: Huan Li Zhaoxia He Bolin Deng Chen Yang Liang Wang Jialing Xiao Weijia Wu Xiangmei Li Lixin Zhang Yutong Wei Siyu Zhu Huining Yang Huanyue Hai Jiarui Hu Lin Li Yi Shi Man Yu Ping Shuai Yuping Liu Xueming Ju Gang Wu Yu Zhou Jing Zhu Bo Gong Source Type: research
Effect of secukinumab versus adalimumab biosimilar on radiographic progression in patients with radiographic axial spondyloarthritis: Results from a head ‐to‐head randomized phase IIIb study
ConclusionsSpinal radiographic progression over 2 years was low with no significant difference between secukinumab and SDZ-ADL arms. The safety of both treatments was consistent with previous reports. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 1, 2024 Category: Rheumatology Authors: Xenofon Baraliakos,
Mikkel Østergaard,
Denis Poddubnyy,
Désirée van der Heijde,
Atul Deodhar,
Pedro M. Machado,
Victoria Navarro‐Compán,
Kay Geert A. Hermann,
Mitsumasa Kishimoto,
Eun Young Lee,
Lianne S. Gensler,
Uta Kiltz,
Marco F. Eig Tags: Full Length Source Type: research
Modelling Treatment Sequences in Immunology: Optimizing Patient Outcomes
CONCLUSIONS: Prescribing more efficacious treatments earlier provides a greater opportunity to improve patient outcomes and minimizes treatment failures.PMID:38554238 | DOI:10.1007/s12325-023-02766-w (Source: Adv Data)
Source: Adv Data - March 30, 2024 Category: Epidemiology Authors: Rose J Hart Fareen Hassan Sarah Alulis Karl W Patterson Jennifer Norma Barthelmes Jennifer H Boer Dawn Lee Source Type: research
Modelling Treatment Sequences in Immunology: Optimizing Patient Outcomes
CONCLUSIONS: Prescribing more efficacious treatments earlier provides a greater opportunity to improve patient outcomes and minimizes treatment failures.PMID:38554238 | DOI:10.1007/s12325-023-02766-w (Source: Adv Data)
Source: Adv Data - March 30, 2024 Category: Epidemiology Authors: Rose J Hart Fareen Hassan Sarah Alulis Karl W Patterson Jennifer Norma Barthelmes Jennifer H Boer Dawn Lee Source Type: research
Role of endoplasmic reticulum aminopeptidase-1 gene polymorphism (rs13167972) in occurrence susceptibility of ankylosing spondylitis in a sample of Iraqi male patients
CONCLUSION: The AS occurred in young overweight males with blood group O-. The AG and GG genotypes are risk factors for AS development while the G allele is a risk factor that increases the chances for disease incidence.PMID:38551779 | DOI:10.1007/s11033-024-09438-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 29, 2024 Category: Molecular Biology Authors: Sumyah Hussein Hassan Ibtesam Ghadban Auda Ekhlass N Ali Mohammed Hadi Alosami Ranya H Hussein Source Type: research
Role of endoplasmic reticulum aminopeptidase-1 gene polymorphism (rs13167972) in occurrence susceptibility of ankylosing spondylitis in a sample of Iraqi male patients
CONCLUSION: The AS occurred in young overweight males with blood group O-. The AG and GG genotypes are risk factors for AS development while the G allele is a risk factor that increases the chances for disease incidence.PMID:38551779 | DOI:10.1007/s11033-024-09438-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 29, 2024 Category: Molecular Biology Authors: Sumyah Hussein Hassan Ibtesam Ghadban Auda Ekhlass N Ali Mohammed Hadi Alosami Ranya H Hussein Source Type: research
Natural Autoantibodies in Biologic-Treated Rheumatoid Arthritis and Ankylosing Spondylitis Patients: Associations with Vascular Pathophysiology
Int J Mol Sci. 2024 Mar 18;25(6):3429. doi: 10.3390/ijms25063429.ABSTRACTCardiovascular (CV) morbidity and mortality have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Natural autoantibodies (nAAb) are involved in innate immunity, as well as autoimmunity, inflammation, and atherosclerosis. There have not been any studies assessing the effects of biologics on nAAbs in RA and AS, also in relation to vascular pathophysiology. Fifty-three anti-TNF-treated RA and AS patients were included in a 12-month follow-up study. Anti-citrate synthase (CS) and anti-topoisomerase I fragment 4 (TOPO-F4) IgM...
Source: Atherosclerosis - March 28, 2024 Category: Cardiology Authors: Di ána Simon Dorottya Kacs ándi Anita Pusztai Bogl árka Soós Edit V égh Gy örgy Kerekes Monika Bodoki Szilvia Szamosi Gabriella Sz űcs Zolt án Prohászka P éter Németh T ímea Berki Zolt án Szekanecz Source Type: research
