Humira Biosimilar Gross-to-Net Pricing Bubble Was Preceded by the Same Pricing Bubble Burst for Insulin Just Months Ago
Today ' s post is not about diabetes per se, although there IS a diabetes connection. But this morning, the big news was that a biosimilar of Abbvie ' s blockbuster anti-inflammatory biologic Humira will be sold byMark Cuban Cost Plus Drug Company (see the press release athttps://www.globenewswire.com/news-release/2023/06/01/2680351/33333/en/Mark-Cuban-Cost-Plus-Drug-Company-joins-forces-with-Coherus-to-make-YUSIMRY-a-HUMIRA-biosimilar-available-to-patients.html for more) at what amounts to an 85% discount to the innovator drug. Mark Cuban Cost Plus Drug Company announced the Humira biosimilar on social media today. See th...
Source: Scott's Web Log - June 1, 2023 Category: Endocrinology Tags: 2023 Abbvie Biosimilar drug discounts gross-to-net bubble Humira insulin Source Type: blogs
Thought experiment: Would therapists be out of a job if we could “ fix ” persistent pain?
Every few years someone, somewhere, announces that “it won’t be long before we have a treatment to rid the world of persistent pain.” And there’s a hiss and roar to celebrate this momentous finding, and much ado about how wonderful it will be.
I’m still waiting. BUT I thought it might be an interesting thought experiment to wonder what might happen if a “cure” was available for fibromyalgia.
As readers will know, I have lived with what eventually was named “fibromyalgia” since my early 20’s, and probably longer. I’ve dabbled in various treatments ove...
Source: HealthSkills Weblog - October 10, 2021 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Pain conditions Professional topics Research Science in practice biopsychosocial pain management Therapeutic approaches Source Type: blogs
Funtabulously Frivolous Friday Five 283
Dr Neil Long Funtabulously Frivolous Friday Five 283
It's Friday. Boggle your brain with FFFF challenge and some old fashioned trivia. Funtabulously Frivolous Friday Five 283 (Source: Life in the Fast Lane)
Source: Life in the Fast Lane - June 14, 2019 Category: Emergency Medicine Authors: Dr Neil Long Tags: FFFF ankylosing spondylitis ECG Get out of Jail Card HLA inland taipan McGinn McGinn-White narcolepsy PE Pimping S1Q3T3 venom Windkessel effect Source Type: blogs
Ankylosing Spondylitis: MRI
DiscussionAnkylosing spondylitis (also known as Bechterew disease and Marie Str ümpell disease). More common in males with 3:1 ratio.Spondyloarthritis is a group of diseases with common clinical, laboratory, and genetic features& association with human leukocyte antigen HLA-B27. Ankylosing spondylitis is the prototypic disease in the spectrum of spondyloarthritis which usually has axial skeletal manifestations. Other representative disorders in this spectrum of disease which usually have peripheral articular involvement, but axial skeleton manifestations are also frequently seen are --psoriati...
Source: Sumer's Radiology Site - January 11, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs
MKSAP: 25-year-old woman with ankylosing spondylitis
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 25-year-old woman is evaluated during a follow-up visit for an 18-month history of ankylosing spondylitis. She has minimal lower back pain with morning stiffness lasting 20 minutes. She is able to pursue her activities of daily living without any restrictions. […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 5, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > < /span > Tags: Conditions Rheumatology Source Type: blogs
One way of using a biopsychosocial framework in pain management – iv
And yes! There’s more to this series of posts on how I use a biopsychosocial model in practice!
Today’s post is about moving from a conceptual model to a practical model, or how we can use research in our clinical reasoning.
A biopsychosocial model (BPSM) as envisaged by Engel was a framework for clinicians to think about why this person is presenting in this way at this time (and what may be maintaining their situation), as well as what could be done to reduce distress and disability. Engel wanted clinicians to go beyond disease processes, isolated from the people experiencing them, and to explore aspects of h...
Source: HealthSkills Weblog - February 4, 2018 Category: Anesthesiology Authors: adiemusfree Tags: Chronic pain Clinical reasoning Coping strategies Pain conditions Professional topics Research biopsychosocial disability function Health healthcare Low back pain pain management Therapeutic approaches Source Type: blogs
FDA Approves Sixth United States Biosimilar
Recently, the FDA announced that it approved Boehringer Ingelheim’s Cyltezo (adalimumab-adbm), the second biosimilar to AbbVie’s blockbuster Humira and sixth biosimilar in the United States. “Cyltezo is the first biosimilar from Boehringer Ingelheim to be approved by the FDA and marks an important step towards our goal of providing new and more affordable treatment options to healthcare providers and patients,” said Ivan Blanarik, Senior Vice President and Head of Therapeutic Area Biosimilars at Boehringer Ingelheim. “Chronic inflammatory diseases collectively affect 23.5 million people in the U.S., and Cyltezo h...
Source: Policy and Medicine - November 17, 2017 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs
Ankylosing Spondylitis : Carrot Stick Fracture
In Ankylsoing spondylitis : Carrot Stick fractures usually occur through the disco-vertebral junction in the lower cervical or upper thoracic spine. When several contiguous segments of the spine are fused, the fused column acts as a lever arm. These fractures often occur following minimal trauma due to the altered biomechanics of the spineFamous Radiology Blog http://www.sumerdoc.blogspot.com
TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - September 7, 2017 Category: Radiology Authors: Sumer Sethi Source Type: blogs
The Age of the Personal Clinical Trial
We have arrived at what I call “The Age of the Personal Clinical Trial.” We now have the ability to collaborate, ask questions on health, then obtain answers within days to weeks, all on our own.
Let’s say, for example, you or a loved one has ankylosing spondylitis and are experiencing progressive back pain, as your spine is essentially becoming “frozen,” severely limiting your ability to bend and twist. You suspect that vitamin D restoration may play an important positive role. You therefore collaborate with, say, 30 other people with the same condition (through one of the Undoctored online t...
Source: Wheat Belly Blog - July 6, 2017 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Wheat Belly Lifestyle diy health diy healthcare Dr. Davis gluten gluten-free grains personal clinical trial wellness Source Type: blogs
If you have low back pain try these steps first
Low back pain, the scourge of mankind: it is the second leading cause of disability here in the United States, and the fourth worldwide. It’s also one of the top five medical problems for which people see doctors. Almost every day that I see patients, I see someone with back pain. It’s one of the top reasons for lost wages due to missed work, as well as for healthcare dollars spent, hence, a very expensive problem.
Looking at two kinds of back pain
Let’s talk about the most common forms of back pain: acute (which lasts less than four weeks) and subacute (which lasts four to 12 weeks). Most of these cases (approximate...
Source: Harvard Health Blog - April 3, 2017 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Back Pain Managing your health care Pain Management Source Type: blogs
Wheat Belly: Self-Directed Health?
Director chair, film slate and load horn.
Here’s a proposal for you: If, by following the Wheat Belly lifestyle, a long list of conditions are reduced or reversed at no risk, almost no cost, reversing even chronic and potentially fatal conditions . . . does that mean that the notion of self-directed health might be on the horizon, i.e., putting control over health back in our own hands?
I think it does. No, we will never implant our own defibrillators or take out our own gallbladders. But so many chronic health conditions afflicting modern humans recede that I believe that it is entirely reasonable to start talking a...
Source: Wheat Belly Blog - February 16, 2016 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle arthritis autoimmune diabetes eating disorder gluten grains Inflammation joint Weight Loss Source Type: blogs
Fab Mab? Look Beyond the Lab.
As we move ahead in the US with more biosimilars being submitted for approval – and for interchangeability – attention must be paid to patient outcomes. Case in point is research presented at the 2013 ACR/ARHP Annual Meeting that hasn’t as yet received the attention it deserves: Efficacy and Safety of CT-P13 (Infliximab Biosimilar) over Two Years in Patients with Ankylosing Spondylitis: Comparison Between Continuing with CT-P13 and Switching from Infliximab to CT-P13. Biosimilarity and measurement of efficacy is only one dimension. Attention must be paid to effectiveness relative to real-world patient outcomes data. ...
Source: drugwonks.com Blog - January 11, 2016 Category: Pharmaceuticals Source Type: blogs
Ankylosing spondylitis (AS) - NHSChoices video
NHSChoices: Ankylosing spondylitis is a type of arthritis that affects parts of the spine. In this video, an expert describes the long-term effects of the condition, its most common symptoms and the different treatments available.http://www.youtube.com/watch?v=1cYuwDkykoA
Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook. (Source: Clinical Cases and Images - Blog)
Source: Clinical Cases and Images - Blog - July 21, 2015 Category: Universities & Medical Training Source Type: blogs
LITFL Review 184
Welcome to the 184th LITFL Review. Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chuck of FOAM.
The Most Fair Dinkum Ripper Beauts of the Week
Here’s an awesome new echo resource from the Nepean Hospital ICU in Penrith, NSW, Australia, containing basic and advanced physics and scanning resources. [SO]
The Best of #FOAMed Emergency Medicine
Boring EM reviews the relevance of IN...
Source: Life in the Fast Lane - May 31, 2015 Category: Emergency Medicine Authors: Marjorie Lazoff, MD Tags: Education LITFL review Source Type: blogs
Top stories in health and medicine, April 7, 2015
From MedPage Today:
Nicotine Replacement in Pregnancy: How Risky? The absolute risk of major congenital anomalies was similar among infants born to smokers and those born to women on nicotine replacement therapy (NRT), but respiratory problems were worse in the latter group.
AS Activity Tied to Future Risk for Heart Disease. Early inflammation and disease activity predicted future elevations in arterial stiffness in ankylosing spondylitis (AS).
Medicare Is Stingy in First Year of Doctor Bonuses. Dr. Michael Kitchell initially welcomed the federal government’s new quality incentives for doctors. His medical group in...
Source: Kevin, M.D. - Medical Weblog - April 7, 2015 Category: Journals (General) Authors: MedPage Today Tags: News Emergency Heart OB/GYN Source Type: blogs
