Forkhead box O3 protein (FOXO3) genes and longevity
Approximately 25 –32% of the overall variation in adult lifespan is accounted for by genetic differences that become particularly important for survivalafter the age of 60.Forkhead box O3 protein (FOXO3) is a transcription factor involved in the regulation of genes involved in many cellular processes, including DNA repair, tumor suppression, immune function, and resistance to oxidative stress. Some variants of FOXO3 are associated with longevity in humans.FOXO3 is onchromosome 6. FOXO3A encodes a keyregulator of the insulin –IGF1 signaling pathway that is known to influence metabolism and lifespan. A study of...
Source: Clinical Cases and Images - Blog - April 15, 2023 Category: Universities & Medical Training Tags: Genetics Source Type: blogs

Apolipoprotein E (ApoE) genes: rs429358 and rs7412
The apolipoprotein E (ApoE) gene makes a protein which, when combined with fat, becomes a lipoprotein.The lipoprotein ApoE is a very low-density lipoprotein, responsible in part for removing cholesterol from the bloodstream. Variations in ApoE affect cholesterol metabolism, which in turn alter your chances of having heart disease and in particular a heart attack or a stroke. Variations in ApoE are also associated with altered odds of having Alzheimer's disease and other diseases.There are3 allelic variants of ApoE, as defined by two SNPs,rs429358 and rs7412 known as:- ApoE- ε2- ApoE- ε3- ApoE- ε4The proteins produced by...
Source: Clinical Cases and Images - Blog - April 14, 2023 Category: Universities & Medical Training Tags: Genetics Source Type: blogs

Where does your state rank in terms of life expectancy? Only Hawaii is over 80 years
People in some southern states can expect to die 8 years younger than the average American, according to a data compilation that highlights the disparities in US life expectancy.While Americans lived for 79 years on average in 2020, those in Mississippi can expect to reach just 71.For comparison, people in Hawaii — which has the highest life expectancy — live to 80 on average. The Daily Mail credits the summary to an online pharmacy, NiceRx, it's probably just a compilation of publicly available data. References:https://www.dailymail.co.uk/health/article-11627841/Where-does-state-rank-terms-life-expectancy.ht...
Source: Clinical Cases and Images - Blog - January 13, 2023 Category: Universities & Medical Training Source Type: blogs

New option for H pylori treatment: Voquezna
 The Food and Drug Administration (FDA) has approved the following new medication for the treatment of Helicobacter pylori (H. pylori) infection in adults.:- Voquezna Triple Pak(vonoprazan, amoxicillin, clarithromycin)-Voquezna Dual Pak (vonoprazan, amoxicillin)Vonoprazan, which gives the name of the medication, is an oral small molecule potassium-competitive acid blocker.H. pylori eradication rates were84.7% and 78.5% with Voquezna Triple and Dual Pak, respectively.Voquezna Triple Pak is supplied as a carton containing 56-tablets and 56-capsules divided into 14 daily dose blister cards. Each daily blister card contai...
Source: Clinical Cases and Images - Blog - January 13, 2023 Category: Universities & Medical Training Tags: Infectious Diseases Source Type: blogs

Physiological Effects of Ancient Religious Chants
Several studies have explore the effects of religious changes, such as OM, on physiological parameters such as heart rate, blood pressure and heat rate variability (HRV). Overall, the effects were considered beneficial.For example, a brief chanting of OM (5 min) might enhance parasympathetic nervous system activity, promote relaxation, and provide calmness. Rhythm formulas that involve breathing at 6 breaths per minute induced favorable psychological and possibly physiological effects. Breathing at 6 breaths per minute is very close to so called resonance frequency breathing for most people.References:Physiologic...
Source: Clinical Cases and Images - Blog - December 4, 2022 Category: Universities & Medical Training Tags: HRV Source Type: blogs

Understand risk better by using "micromort" unit
A micromort (from micro- and mortality) is a unit of risk defined as a one-in-a-million chance of death.Micromorts can be used to measure the riskiness of various day-to-day activities.Activities that increase the death risk by roughly one micromort, and their associated cause of death:Traveling 250 miles by car (collision) Travelling 1,000 miles (1,600 km) by jet (collision) Travelling 6,000 miles (9,656 km) by train (collision) Increase in death risk for other activities on a per event basis:Giving birth (vaginal) – 120 micromortsGiving birth (caesarean) – 170 micromortsAstraZeneca vaccination against COVID-19 â...
Source: Clinical Cases and Images - Blog - October 27, 2022 Category: Universities & Medical Training Source Type: blogs

Dopamine elevation after a cold bath
Dopamine elevation after cold bath is due to stimulation of pain receptors in the skin, at 2 minutes in the video below: https://www.youtube.com/watch?v=QmOF0crdyRU Norepi, Epi and dopamine were all increased with cold water exposure. Dopamine increased 250% over baseline and that increase was sustained after the exposure for up to 3 hours. The sweet spot is alert but calm. That was achieved via the cold exposure. Calm/alert state. Cold exposure can be equivalent to coffee without the jitters. Mnemonics: D Dopamine Drives Determination and motivation C Cold water exposure Calm/alert state At 42 minutes. Chocolate increases...
Source: Clinical Cases and Images - Blog - October 27, 2022 Category: Universities & Medical Training Tags: Wim Hof Method Source Type: blogs

First use of the hastag #MedTwitter was in 2009
The first use of the hastag #MedTwitter was in 2009 by one of my accounts @DrVes, did not know about this until this year. @blogborygmi"should the Twitter awards be a series of tweets" -Twitter structure is not suitable for that, although#MedTwitter can be used— Ves Dimov, M.D. (@DrVes)January 6, 2009 More: Did you know that the first medical journal club on Twitter was started by an allergist/immunologist@DrVes?#MedTwitter: If you ’re interested in connecting with the allergy& immunology community, try:#AIMedEd. We ’d love to interact& learn from other specialtieshttps://t.co/Xbl...
Source: Clinical Cases and Images - Blog - October 21, 2022 Category: Universities & Medical Training Source Type: blogs

Tom Jones at 81, sings about aging on his new album
NPR and Bob Boilen | June 7, 2021: "We're publishing this Tom Jones Tiny Desk (home) concert on his 81st birthday. It's a poignant moment in the life of a singer whose career spans 56 years and more than 100 million records sold; the passing of his wife, Linda, in 2016 after 59 years of marriage was devastating and resulted in the longest break between recordings of his career. But now Tom Jones is back with a new album, Surrounded By Time, and ready to share his deepest feelings, channeling songs by others with a voice still rich and muscular.The songs on the album (and for this Tiny Desk) deal so eloquently with time and...
Source: Clinical Cases and Images - Blog - June 27, 2021 Category: Universities & Medical Training Tags: Geriatrics Longevity Music Psychology Source Type: blogs

Tome Jones at 81, sings about aging on his new album
NPR and Bob Boilen | June 7, 2021: "We're publishing this Tom Jones Tiny Desk (home) concert on his 81st birthday. It's a poignant moment in the life of a singer whose career spans 56 years and more than 100 million records sold; the passing of his wife, Linda, in 2016 after 59 years of marriage was devastating and resulted in the longest break between recordings of his career. But now Tom Jones is back with a new album, Surrounded By Time, and ready to share his deepest feelings, channeling songs by others with a voice still rich and muscular.The songs on the album (and for this Tiny Desk) deal so eloquently with time and...
Source: Clinical Cases and Images - Blog - June 27, 2021 Category: Universities & Medical Training Tags: Geriatrics Longevity Music Psychology Source Type: blogs

Middlescence = time between adolescence and senescence
Middlescence is defined as the time between adolescence and senescence. "It is a paradox of life that we do not begin to live until we begin to die. Death begins at thirty, that is, deterioration of the muscle cells sets in."https://royalsocietypublishing.org/doi/pdf/10.1098/rsnr.2020.0008 From the video below: Life begins at 40: the biological and cultural roots of the midlife crisis | The Royal Society. In this lecture, Professor Mark Jackson, winner of the 2018 Wilkins-Bernal-Medawar Medal, explores a rich range of historical sources to argue that the midlife crisis emerged as a result of demographic changes, ...
Source: Clinical Cases and Images - Blog - June 26, 2021 Category: Universities & Medical Training Tags: Psychology Source Type: blogs

How to give a talk/present a lecture - by MIT/Patrick Winston
 Some goods points in the video below.Quality = f (K P t) -- explained at beginning: Patrick Winston's How to Speak talk has been an MIT tradition for over 40 years. Offered every January, the talk is intended to improve your speaking ability in critical situations by teaching you a few heuristic rules.00:16 - Introduction03:11 - Rules of Engagement04:15 - How to Start05:38 - Four Sample Heuristics10:17 - The Tools: Time and Place13:24 - The Tools: Boards, Props, and Slides36:30 - Informing: Promise, Inspiration, How To Think41:30 - Persuading: Oral Exams, Job Talks, Getting Famous53:06  - How to Stop: Final...
Source: Clinical Cases and Images - Blog - June 25, 2021 Category: Universities & Medical Training Tags: Education Psychology Source Type: blogs