Successful treatment of PASS syndrome with IVIG and anti ‐IL‐1 treatment: A case report
AbstractPASS syndrome is a rare autoinflammatory disease characterized by acne vulgaris, hidradenitis suppurativa, pyoderma gangrenosum, and ankylosing spondylitis. Unlike other autoinflammatory disorders such as PAPA and PASH syndrome, there is no documented gene mutation link. Although there are no established treatment guidelines due to the rarity of these diseases, systemic corticosteroids, biologics, and immunosuppressive drugs are used currently. In our report, we presented a case of PASS syndrome who was unresponsive to adalimumab and in whom we observed improvement in both skin and joint manifestations with intrave...
Source: International Journal of Rheumatic Diseases - March 11, 2024 Category: Rheumatology Authors: Gizem K ırmızıer,
Elif Altunel Kılınç,
Nurdan Oruçoğlu Yıldırım,
Ümit Türsen Tags: LETTER TO THE EDITOR Source Type: research
Intravenous cyclophosphamide therapy for patients with severe ocular inflammatory diseases who failed other immunomodulatory therapies
AbstractBackgroundOcular inflammatory diseases, including scleritis and uveitis, have been widely treated with immunomodulatory therapies (IMTs) as a steroid-sparing approach. Such strategy includes conventional therapies (antimetabolites, alkylating agents, and calcineurin inhibitors) as well as biologic agents like adalimumab, infliximab, rituximab, and tocilizumab. Cyclophosphamide (CP) is an alkylating agent and mainly inhibits the functioning of both T and B cells. Though known to have potential adverse events, including bone marrow suppression, hemorrhagic cystitis, and sterility, CP has been shown to be efficacious,...
Source: Journal of Ophthalmic Inflammation and Infection - March 11, 2024 Category: Opthalmology Source Type: research
Developing International Classification of Disease code definitions for the study of enteric infection sequelae in Canada
CONCLUSION: The multi-step design to derive ICD code definitions provided flexibility to identify existing definitions, to improve their sensitivity and PPV and adapt them to the Canadian context.PMID:38455876 | PMC:PMC10917133 | DOI:10.14745/ccdr.v49i78a01 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 8, 2024 Category: Infectious Diseases Authors: Eleni Galanis Azita Goshtasebi Yuen Wai Hung Jonathan Chan Douglas Matsell Kristine Chapman Gilaad Kaplan David Patrick Bei Yuan Zhang Marsha Taylor Dimitra Panagiotoglou Shannon Majowicz Source Type: research
Developing International Classification of Disease code definitions for the study of enteric infection sequelae in Canada
CONCLUSION: The multi-step design to derive ICD code definitions provided flexibility to identify existing definitions, to improve their sensitivity and PPV and adapt them to the Canadian context.PMID:38455876 | PMC:PMC10917133 | DOI:10.14745/ccdr.v49i78a01 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 8, 2024 Category: Infectious Diseases Authors: Eleni Galanis Azita Goshtasebi Yuen Wai Hung Jonathan Chan Douglas Matsell Kristine Chapman Gilaad Kaplan David Patrick Bei Yuan Zhang Marsha Taylor Dimitra Panagiotoglou Shannon Majowicz Source Type: research
Developing International Classification of Disease code definitions for the study of enteric infection sequelae in Canada
CONCLUSION: The multi-step design to derive ICD code definitions provided flexibility to identify existing definitions, to improve their sensitivity and PPV and adapt them to the Canadian context.PMID:38455876 | PMC:PMC10917133 | DOI:10.14745/ccdr.v49i78a01 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 8, 2024 Category: Infectious Diseases Authors: Eleni Galanis Azita Goshtasebi Yuen Wai Hung Jonathan Chan Douglas Matsell Kristine Chapman Gilaad Kaplan David Patrick Bei Yuan Zhang Marsha Taylor Dimitra Panagiotoglou Shannon Majowicz Source Type: research
Progression of subclinical atherosclerosis in ankylosing spondylitis: a 10-year prospective study
AbstractChronic systemic inflammation contributes to increased CVD burden in Ankylosing Spondylitis (AS). Since long-term follow-up data on subclinical atherosclerosis acceleration are lacking, we examined its progression in contemporary AS patients during 10 years. Fifty-three (89% male, aged 50.4 (36.3–55.9) years,) non-diabetic, CVD-free AS patients and 53 age-sex-matched non-diabetic, control individuals were re-evaluated after 9.2–10.2 years by ultrasonography for carotid/femoral atheromatosis, pulse wave velocity (PWV) and intima-media thick ness (IMT), performed by the same operator/protocol. New atheromatic ...
Source: Rheumatology International - March 5, 2024 Category: Rheumatology Source Type: research
Prediction of the activity of early ankylosing spondylitis using radiomics texture analysis on STIR
CONCLUSIONS: Radiomics analysis based on STIR texture analysis has a good prediction for the evaluation of bone marrow oedema activity of sacroiliac joints in AS. It can be a new non-invasive and objective evaluation method for AS activity.PMID:38436270 | DOI:10.55563/clinexprheumatol/99pc16 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 4, 2024 Category: Rheumatology Authors: Zhaojuan Shi Zhe Yang Datian Su Juan Cheng Zhaoxia Shi Mei Wang Hui Zheng Jiankui Han Changqin Li Jian Qin Source Type: research
IL-17-producing cells in ankylosing spondylitis patients show gender-based differences in gene expression
CONCLUSIONS: Transcriptomic analysis revealed that male AS patients exhibit distinct expression patterns of IL-17 pro-inflammatory genes, which may contribute to the phenotypic differences observed between genders in AS.PMID:38436300 | DOI:10.55563/clinexprheumatol/do7osn (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 4, 2024 Category: Rheumatology Authors: Chan Mi Lee Ernest Ricky Chan Darerian Schueller Maya Breitman Maricela Haghiac Marina Magrey Source Type: research
Prediction of the activity of early ankylosing spondylitis using radiomics texture analysis on STIR
CONCLUSIONS: Radiomics analysis based on STIR texture analysis has a good prediction for the evaluation of bone marrow oedema activity of sacroiliac joints in AS. It can be a new non-invasive and objective evaluation method for AS activity.PMID:38436270 | DOI:10.55563/clinexprheumatol/99pc16 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 4, 2024 Category: Rheumatology Authors: Zhaojuan Shi Zhe Yang Datian Su Juan Cheng Zhaoxia Shi Mei Wang Hui Zheng Jiankui Han Changqin Li Jian Qin Source Type: research
IL-17-producing cells in ankylosing spondylitis patients show gender-based differences in gene expression
CONCLUSIONS: Transcriptomic analysis revealed that male AS patients exhibit distinct expression patterns of IL-17 pro-inflammatory genes, which may contribute to the phenotypic differences observed between genders in AS.PMID:38436300 | DOI:10.55563/clinexprheumatol/do7osn (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 4, 2024 Category: Rheumatology Authors: Chan Mi Lee Ernest Ricky Chan Darerian Schueller Maya Breitman Maricela Haghiac Marina Magrey Source Type: research
Prediction of the activity of early ankylosing spondylitis using radiomics texture analysis on STIR
CONCLUSIONS: Radiomics analysis based on STIR texture analysis has a good prediction for the evaluation of bone marrow oedema activity of sacroiliac joints in AS. It can be a new non-invasive and objective evaluation method for AS activity.PMID:38436270 | DOI:10.55563/clinexprheumatol/99pc16 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 4, 2024 Category: Rheumatology Authors: Zhaojuan Shi Zhe Yang Datian Su Juan Cheng Zhaoxia Shi Mei Wang Hui Zheng Jiankui Han Changqin Li Jian Qin Source Type: research
IL-17-producing cells in ankylosing spondylitis patients show gender-based differences in gene expression
CONCLUSIONS: Transcriptomic analysis revealed that male AS patients exhibit distinct expression patterns of IL-17 pro-inflammatory genes, which may contribute to the phenotypic differences observed between genders in AS.PMID:38436300 | DOI:10.55563/clinexprheumatol/do7osn (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 4, 2024 Category: Rheumatology Authors: Chan Mi Lee Ernest Ricky Chan Darerian Schueller Maya Breitman Maricela Haghiac Marina Magrey Source Type: research
