A lower frequency of inflammatory back pain in male patients with ankylosing spondylitis compared with female patients
AbstractIn routine rheumatology practice, we noticed that a significant number of male ankylosing spondylitis (AS) patients did not experience inflammatory back pain (IBP). Based on this observation, we aimed to investigate the prevalence of IBP in male AS patients and compare it to that in female patients. Patients with AS who fulfilled the modified New York criteria were subjected to a face-to-face interview with a standardized questionnaire that addressed the IBP components based on the Berlin criteria. The study also included 63 patients with chronic mechanical back pain (MBP). Erythrocyte sedimentation rate (ESR) and ...
Source: Rheumatology International - February 18, 2024 Category: Rheumatology Source Type: research
Predictors of treatment failure of non-steroidal anti-inflammatory drugs in patients with axial spondyloarthritis with focus on haptoglobin, haptoglobin polymorphism and zonulin
AbstractAccording to the Assessment of SpondyloArthritis International Society-European Alliance of Associations for Rheumatology (ASAS-EULAR) recommendations for the management of axial spondyloarthritis (axSpA), patients should undergo at least two courses of non-steroidal anti-inflammatory drugs (NSAIDs) therapy. In our study, we enrolled axSpA patients both at onset and in a flare who had already been treated with NSAIDs ineffectively. Subsequently, according to the recommendations, they received modified NSAID treatment as another attempt to the first-line drug therapy and were monitored from there. We aimed to identi...
Source: Rheumatology International - February 18, 2024 Category: Rheumatology Source Type: research
A potential role of protein extractions from Metagonimus yokogawai in amelionating inflammation in patients with ankylosing spondylitis
This study aimed to investigate the potential of Metagonimus yokogawai-derived proteins (MYp) to provide protection against ankylosing spondylitis (AS) through modulation of immune responses. The cytotoxicity of MYp at various doses was first assessed using MTS and flow cytometry. Peripheral blood mononuclear cells (PBMCs) were collected from AS patients, and the production of inflammatory cytokines was analyzed through flow cytometry. In the experiments with SKG mice, MYp or vehicle was administered and inflammation was evaluated through immunohistochemistry and enzyme-linked immunosorbent assay. The results showed that M...
Source: Experimental Parasitology - February 18, 2024 Category: Parasitology Authors: Eun Jeong Won Yu Jeong Lee Moon-Ju Kim Hae-In Lee Hyun Hee Jang Seong Hoon Kim Hee Min Yoo Namki Cho Seung Cheol Shim Tae-Jong Kim Source Type: research
A potential role of protein extractions from Metagonimus yokogawai in amelionating inflammation in patients with ankylosing spondylitis
This study aimed to investigate the potential of Metagonimus yokogawai-derived proteins (MYp) to provide protection against ankylosing spondylitis (AS) through modulation of immune responses. The cytotoxicity of MYp at various doses was first assessed using MTS and flow cytometry. Peripheral blood mononuclear cells (PBMCs) were collected from AS patients, and the production of inflammatory cytokines was analyzed through flow cytometry. In the experiments with SKG mice, MYp or vehicle was administered and inflammation was evaluated through immunohistochemistry and enzyme-linked immunosorbent assay. The results showed that M...
Source: Experimental Parasitology - February 18, 2024 Category: Parasitology Authors: Eun Jeong Won Yu Jeong Lee Moon-Ju Kim Hae-In Lee Hyun Hee Jang Seong Hoon Kim Hee Min Yoo Namki Cho Seung Cheol Shim Tae-Jong Kim Source Type: research
A potential role of protein extractions from Metagonimus yokogawai in amelionating inflammation in patients with ankylosing spondylitis
This study aimed to investigate the potential of Metagonimus yokogawai-derived proteins (MYp) to provide protection against ankylosing spondylitis (AS) through modulation of immune responses. The cytotoxicity of MYp at various doses was first assessed using MTS and flow cytometry. Peripheral blood mononuclear cells (PBMCs) were collected from AS patients, and the production of inflammatory cytokines was analyzed through flow cytometry. In the experiments with SKG mice, MYp or vehicle was administered and inflammation was evaluated through immunohistochemistry and enzyme-linked immunosorbent assay. The results showed that M...
Source: Experimental Parasitology - February 18, 2024 Category: Parasitology Authors: Eun Jeong Won Yu Jeong Lee Moon-Ju Kim Hae-In Lee Hyun Hee Jang Seong Hoon Kim Hee Min Yoo Namki Cho Seung Cheol Shim Tae-Jong Kim Source Type: research
A potential role of protein extractions from Metagonimus yokogawai in amelionating inflammation in patients with ankylosing spondylitis
This study aimed to investigate the potential of Metagonimus yokogawai-derived proteins (MYp) to provide protection against ankylosing spondylitis (AS) through modulation of immune responses. The cytotoxicity of MYp at various doses was first assessed using MTS and flow cytometry. Peripheral blood mononuclear cells (PBMCs) were collected from AS patients, and the production of inflammatory cytokines was analyzed through flow cytometry. In the experiments with SKG mice, MYp or vehicle was administered and inflammation was evaluated through immunohistochemistry and enzyme-linked immunosorbent assay. The results showed that M...
Source: Experimental Parasitology - February 18, 2024 Category: Parasitology Authors: Eun Jeong Won Yu Jeong Lee Moon-Ju Kim Hae-In Lee Hyun Hee Jang Seong Hoon Kim Hee Min Yoo Namki Cho Seung Cheol Shim Tae-Jong Kim Source Type: research
A potential role of protein extractions from Metagonimus yokogawai in amelionating inflammation in patients with ankylosing spondylitis
This study aimed to investigate the potential of Metagonimus yokogawai-derived proteins (MYp) to provide protection against ankylosing spondylitis (AS) through modulation of immune responses. The cytotoxicity of MYp at various doses was first assessed using MTS and flow cytometry. Peripheral blood mononuclear cells (PBMCs) were collected from AS patients, and the production of inflammatory cytokines was analyzed through flow cytometry. In the experiments with SKG mice, MYp or vehicle was administered and inflammation was evaluated through immunohistochemistry and enzyme-linked immunosorbent assay. The results showed that M...
Source: Experimental Parasitology - February 18, 2024 Category: Parasitology Authors: Eun Jeong Won Yu Jeong Lee Moon-Ju Kim Hae-In Lee Hyun Hee Jang Seong Hoon Kim Hee Min Yoo Namki Cho Seung Cheol Shim Tae-Jong Kim Source Type: research
Evaluation of interleukins (IL-1 α, IL-1Ra, IL-12, IL-17A, IL-31, and IL-33) and chemokines (CXCL10 and CXCL16) in the serum of male patients with ankylosing spondylitis
CONCLUSIONS: Among the eight cytokines examined, IL-17A, CXCL10, and CXCL16 were up-regulated in the serum of AS patients, while IL-31 was down-regulated. The levels of IL-1α, IL-1Ra, IL-12, and IL-33 showed no significant differences between patients and controls. Serum levels of all cytokines were not affected by disease duration, HLA-B27 positivity, or disease activity.PMID:38364743 | DOI:10.1016/j.intimp.2024.111697 (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 16, 2024 Category: Allergy & Immunology Authors: Hanan Y Muhsin Ali Q Khazaal Haneen M Ismaeel Mohammed H Alosami Ali H Ad'hiah Source Type: research
Regulation mechanisms of disulfidptosis-related genes in ankylosing spondylitis and inflammatory bowel disease
In this study, 11 DE-DAGs were obtained. Functional enrichment analysis revealed their involvement in cytokine production and fatty acid biosynthesis. Latterly, AS/CD/UC -feature genes were derived, and they all had decent diagnostic performance. Through evaluation, the performance of the nomogram was decent for three diseases. Then, 2 co-feature genes (S100A12 and LILRA5) were obtained. The GSEA enrichment results indicated that the co-feature genes were mainly enriched in the cytokine-cytokine receptor interaction and drug metabolism cytochrome P450. As shown by functional experiments, there was a correlation between the...
Source: Frontiers in Immunology - February 16, 2024 Category: Allergy & Immunology Source Type: research
CD_99 G1 neutrophils modulate osteogenic differentiation of mesenchymal stem cells in the pathological process of ankylosing spondylitis
Conclusions
Our results revealed the dynamics of cell subpopulations, gene expression and intercellular interactions during AS pathogenesis. These findings provide new insights into the cellular and molecular mechanisms of osteogenesis and will benefit the development of novel therapeutic strategies. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Feng, X., Wang, C., Ji, B., Qiao, J., Xu, Y., Zhu, S., Ji, Z., Zhou, B., Tong, W., Xu, W. Tags: Open access, ARD, Spondyloarthritis Source Type: research
Correction: Proteomic and genomic profiling of plasma exosomes from patients with ankylosing spondylitis
Tavasolian F, Lively S, Pastrello C, et al. Proteomic and genomic profiling of plasma exosomes from patients with ankylosing spondylitis. Ann Rheum Dis 2023;82:1429-43.
The Patient and public involvement statement should read:
An ongoing longitudinal AS cohort was used for the study with the approval of the UHN research ethics board (REB# 21–5565). All patients and healthy controls (HC) provided written consent to participate. AS patients fulfilled the modified New York AS criteria.30 31 AS patients (n=40) had an average age of 47±10 years, while HC (n=28) had an average age of 37±11 years. Table 1 prov...
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Tags: ARD Correction Source Type: research
A lower frequency of inflammatory back pain in male patients with ankylosing spondylitis compared with female patients
AbstractIn routine rheumatology practice, we noticed that a significant number of male ankylosing spondylitis (AS) patients did not experience inflammatory back pain (IBP). Based on this observation, we aimed to investigate the prevalence of IBP in male AS patients and compare it to that in female patients. Patients with AS who fulfilled the modified New York criteria were subjected to a face-to-face interview with a standardized questionnaire that addressed the IBP components based on the Berlin criteria. The study also included 63 patients with chronic mechanical back pain (MBP). Erythrocyte sedimentation rate (ESR) and ...
Source: Rheumatology International - February 14, 2024 Category: Rheumatology Source Type: research
Predictors of treatment failure of non-steroidal anti-inflammatory drugs in patients with axial spondyloarthritis with focus on haptoglobin, haptoglobin polymorphism and zonulin
AbstractAccording to the Assessment of SpondyloArthritis International Society-European Alliance of Associations for Rheumatology (ASAS-EULAR) recommendations for the management of axial spondyloarthritis (axSpA), patients should undergo at least two courses of non-steroidal anti-inflammatory drugs (NSAIDs) therapy. In our study, we enrolled axSpA patients both at onset and in a flare who had already been treated with NSAIDs ineffectively. Subsequently, according to the recommendations, they received modified NSAID treatment as another attempt to the first-line drug therapy and were monitored from there. We aimed to identi...
Source: Rheumatology International - February 14, 2024 Category: Rheumatology Source Type: research
Exercise Therapy Research in Ankylosing Spondylitis-Induced Back Pain: A Bibliometric Study (2004-2023)
CONCLUSIONS Exercise therapy for AS-induced back pain is a growing research area, necessitating further exploration in clinical management and rehabilitation strategies. The relationship between ET and osteoimmunological mechanisms remains a focal point for future research, with a trend towards personalized and interdisciplinary treatment approaches.PMID:38347712 | DOI:10.12659/MSM.943196 (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 13, 2024 Category: Research Authors: Jiang-Xia Zheng Xi-Feng Zhang Sheng-Hui Liu Feng Ye Sen-Guo Ji Xiu-Zhen Wen Source Type: research
GSE243689 Ankylosing spondylitis patients present a distinct CD8 T-cell subset with osteogenic and cytotoxic potential
Contributors : Veronica Martini ; Valentina Cecchinato ; Ylenia Silvestri ; Andrea Rinaldi ; Mariagrazia UguccioniSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnkylosing Spondylitis (AS) is a chronic inflammatory rheumatic disease affecting mainly the axial skeleton. Peripheral involvement (arthritis, enthesitis and dactylitis) and extra-musculoskeletal manifestations including uveitis, psoriasis and bowel inflammation occur in a relevant proportion of patients. AS is responsible for chronic and severe back pain caused by local inflammation that can lead to osteoproliferation ...
Source: GEO: Gene Expression Omnibus - February 13, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
