Extensive colitis associated with ixekizumab
We present the clinical case of a 56-year-old former smoker female, with a family history of maternal ulcerative colitis and personal history of ankylosing spondylitis treated with Ixekizumab for 3 months, who was admitted for fever, left iliac fossa pain and diarrhea without pathological products of 2 weeks of evolution. Abdominopelvic computed tomography scan identified pancolitis. Complete colonoscopy revealed continuous involvement of the proximal colon (right and transverse colon presented deep ulcerations and mucosal friability) with preservation of the terminal ileum. After many complementary tests and according to ...
Source: Revista Espanola de Enfermedades Digestivas - April 18, 2024 Category: Gastroenterology Authors: Mar ía Luisa López García Mar ía Paz Arreba González Leire Irusta Olano Carmen Mu ñoz Villafranca Source Type: research
Exploring the Effects of Ixekizumab on Pain in Patients with Ankylosing Spondylitis Based on Objective Measures of Inflammation: Post Hoc Analysis from a Large Randomized Clinical Trial
ConclusionThis post hoc analysis is supportive of the hypothesis that ixekizumab reduces pain in AS by additional mechanisms other than the reduction of measurable inflammation.Trial Registration NumberNCT02696785. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - April 18, 2024 Category: Rheumatology Source Type: research
Crucial role of lncRNA NONHSAG037054.2 and GABPA, and their related functional networks, in ankylosing spondylitis
In conclusion, NONHSAG037054.2 and GABPA are associated with AS. GABPA was downregulated in AS, and it could serve as a novel diagnostic factor for AS.PMID:38628657 | PMC:PMC11019654 | DOI:10.3892/etm.2024.12525 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Penglei Cui Yanzhuo Zhang Chao Wang Bin Xiao Qianqian Wang Liang Zhang Hongchao Li Chengai Wu Wei Tian Source Type: research
Angiogenesis-related immune response may be the prelude to the syndesmophyte formation in Ankylosing spondylitis
CONCLUSIONS: We explored the intimate relationship between local inflammation and bone formation in AS from the perspective of nascent vascularisation. Hence, our study lays the foundation for elucidating a unified AS pathogenesis through the immune-angiogenesis-osteogenesis axis.PMID:38631220 | DOI:10.1016/j.intimp.2024.112040 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 17, 2024 Category: Allergy & Immunology Authors: Chunmei Cai Yuye Huang Liyan Li Kai Kei Miu Zhangting Wang Yujie Deng Yanzhen Cai Jinxiu Li Liang Wu Hepeng Zhu Yang Gao Jun Chen Wende Xiao Li Lu Source Type: research
Crucial role of lncRNA NONHSAG037054.2 and GABPA, and their related functional networks, in ankylosing spondylitis
In conclusion, NONHSAG037054.2 and GABPA are associated with AS. GABPA was downregulated in AS, and it could serve as a novel diagnostic factor for AS.PMID:38628657 | PMC:PMC11019654 | DOI:10.3892/etm.2024.12525 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Penglei Cui Yanzhuo Zhang Chao Wang Bin Xiao Qianqian Wang Liang Zhang Hongchao Li Chengai Wu Wei Tian Source Type: research
Angiogenesis-related immune response may be the prelude to the syndesmophyte formation in Ankylosing spondylitis
CONCLUSIONS: We explored the intimate relationship between local inflammation and bone formation in AS from the perspective of nascent vascularisation. Hence, our study lays the foundation for elucidating a unified AS pathogenesis through the immune-angiogenesis-osteogenesis axis.PMID:38631220 | DOI:10.1016/j.intimp.2024.112040 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 17, 2024 Category: Allergy & Immunology Authors: Chunmei Cai Yuye Huang Liyan Li Kai Kei Miu Zhangting Wang Yujie Deng Yanzhen Cai Jinxiu Li Liang Wu Hepeng Zhu Yang Gao Jun Chen Wende Xiao Li Lu Source Type: research
Exploring the Link Between Ankylosing Spondylitis and Inflammatory Bowel Disease: A Retrospective Cohort Study
CONCLUSIONS: AS patients exhibit a markedly increased risk of developing IBD. These findings advocate for heightened clinical vigilance for IBD symptoms in AS patients and suggest the need for a multidisciplinary approach to patient care. Further research into the shared pathogenic pathways is needed to develop personalized treatment strategies and improve patient management.PMID:38616667 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: Kassem Sharif Adi Lahat Yonatan Shneor Patt Niv Ben-Shabat Mahmud Omar Abdulla Watad Howard Amital Omer Gendelman Source Type: research
ASDAS-CRP and ASDAS-ESR cut-offs for disease activity states in axial spondyloarthritis - Are they interchangeable?
CONCLUSION: We estimated the optimal ASDAS-ESR values corresponding to the established ASDAS-CRP cut-off values. However, applying the estimated cut-offs did not increase the level of agreement between ASDAS-ESR and ASDAS-CRP disease activity states to a relevant degree. Our findings did not provide evidence to reject the established cut-off values for ASDAS-ESR.PMID:38621792 | DOI:10.3899/jrheum.2023-1217 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - April 15, 2024 Category: Rheumatology Authors: Stylianos Georgiadis Lykke Midtb øll Ørnbjerg Brigitte Michelsen Tore K Kvien Daniela Di Giuseppe Johan K Wallman Jakub Z ávada Sella A Provan Eirik Klami Kristianslund Ana Maria Rodrigues Maria Jos é Santos Žiga Rotar Katja Perdan Pirkmajer Dan Nord Source Type: research
When Should I Get My Next COVID Vaccine? Data from the SUrveillance of responses to COVID-19 vaCcines in systEmic immunE mediated inflammatory Diseases (SUCCEED)study
CONCLUSION: Ours is the first pan-Canadian IMID assessment of how vaccine history and other factors affect serologic COVID-19 vaccine responses. These findings may help individuals personalize vaccination decisions, including consideration of additional vaccination when >6 months has elapsed since last COVID vaccination/infection.PMID:38621797 | DOI:10.3899/jrheum.2023-1214 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - April 15, 2024 Category: Rheumatology Authors: Dawn M E Bowdish Vinod Chandran Carol A Hitchon Gilaad G Kaplan J Antonio Avina-Zubieta Paul R Fortin Maggie J Larch é Gilles Boire Anne-Claude Gingras Roya M Dayam Ines Colmegna Luck Lukusa Jennifer L F Lee Dawn P Richards Daniel Pereira Tania H Watts M Source Type: research
ASDAS-CRP and ASDAS-ESR cut-offs for disease activity states in axial spondyloarthritis - Are they interchangeable?
CONCLUSION: We estimated the optimal ASDAS-ESR values corresponding to the established ASDAS-CRP cut-off values. However, applying the estimated cut-offs did not increase the level of agreement between ASDAS-ESR and ASDAS-CRP disease activity states to a relevant degree. Our findings did not provide evidence to reject the established cut-off values for ASDAS-ESR.PMID:38621792 | DOI:10.3899/jrheum.2023-1217 (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2024 Category: Rheumatology Authors: Stylianos Georgiadis Lykke Midtb øll Ørnbjerg Brigitte Michelsen Tore K Kvien Daniela Di Giuseppe Johan K Wallman Jakub Z ávada Sella A Provan Eirik Klami Kristianslund Ana Maria Rodrigues Maria Jos é Santos Žiga Rotar Katja Perdan Pirkmajer Dan Nord Source Type: research
When Should I Get My Next COVID Vaccine? Data from the SUrveillance of responses to COVID-19 vaCcines in systEmic immunE mediated inflammatory Diseases (SUCCEED)study
CONCLUSION: Ours is the first pan-Canadian IMID assessment of how vaccine history and other factors affect serologic COVID-19 vaccine responses. These findings may help individuals personalize vaccination decisions, including consideration of additional vaccination when >6 months has elapsed since last COVID vaccination/infection.PMID:38621797 | DOI:10.3899/jrheum.2023-1214 (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2024 Category: Rheumatology Authors: Dawn M E Bowdish Vinod Chandran Carol A Hitchon Gilaad G Kaplan J Antonio Avina-Zubieta Paul R Fortin Maggie J Larch é Gilles Boire Anne-Claude Gingras Roya M Dayam Ines Colmegna Luck Lukusa Jennifer L F Lee Dawn P Richards Daniel Pereira Tania H Watts M Source Type: research
Exploring the Link Between Ankylosing Spondylitis and Inflammatory Bowel Disease: A Retrospective Cohort Study
CONCLUSIONS: AS patients exhibit a markedly increased risk of developing IBD. These findings advocate for heightened clinical vigilance for IBD symptoms in AS patients and suggest the need for a multidisciplinary approach to patient care. Further research into the shared pathogenic pathways is needed to develop personalized treatment strategies and improve patient management.PMID:38616667 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - April 15, 2024 Category: General Medicine Authors: Kassem Sharif Adi Lahat Yonatan Shneor Patt Niv Ben-Shabat Mahmud Omar Abdulla Watad Howard Amital Omer Gendelman Source Type: research
ASDAS-CRP and ASDAS-ESR cut-offs for disease activity states in axial spondyloarthritis - Are they interchangeable?
CONCLUSION: We estimated the optimal ASDAS-ESR values corresponding to the established ASDAS-CRP cut-off values. However, applying the estimated cut-offs did not increase the level of agreement between ASDAS-ESR and ASDAS-CRP disease activity states to a relevant degree. Our findings did not provide evidence to reject the established cut-off values for ASDAS-ESR.PMID:38621792 | DOI:10.3899/jrheum.2023-1217 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - April 15, 2024 Category: Rheumatology Authors: Stylianos Georgiadis Lykke Midtb øll Ørnbjerg Brigitte Michelsen Tore K Kvien Daniela Di Giuseppe Johan K Wallman Jakub Z ávada Sella A Provan Eirik Klami Kristianslund Ana Maria Rodrigues Maria Jos é Santos Žiga Rotar Katja Perdan Pirkmajer Dan Nord Source Type: research
When Should I Get My Next COVID Vaccine? Data from the SUrveillance of responses to COVID-19 vaCcines in systEmic immunE mediated inflammatory Diseases (SUCCEED)study
CONCLUSION: Ours is the first pan-Canadian IMID assessment of how vaccine history and other factors affect serologic COVID-19 vaccine responses. These findings may help individuals personalize vaccination decisions, including consideration of additional vaccination when >6 months has elapsed since last COVID vaccination/infection.PMID:38621797 | DOI:10.3899/jrheum.2023-1214 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - April 15, 2024 Category: Rheumatology Authors: Dawn M E Bowdish Vinod Chandran Carol A Hitchon Gilaad G Kaplan J Antonio Avina-Zubieta Paul R Fortin Maggie J Larch é Gilles Boire Anne-Claude Gingras Roya M Dayam Ines Colmegna Luck Lukusa Jennifer L F Lee Dawn P Richards Daniel Pereira Tania H Watts M Source Type: research
ASDAS-CRP and ASDAS-ESR cut-offs for disease activity states in axial spondyloarthritis - Are they interchangeable?
CONCLUSION: We estimated the optimal ASDAS-ESR values corresponding to the established ASDAS-CRP cut-off values. However, applying the estimated cut-offs did not increase the level of agreement between ASDAS-ESR and ASDAS-CRP disease activity states to a relevant degree. Our findings did not provide evidence to reject the established cut-off values for ASDAS-ESR.PMID:38621792 | DOI:10.3899/jrheum.2023-1217 (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2024 Category: Rheumatology Authors: Stylianos Georgiadis Lykke Midtb øll Ørnbjerg Brigitte Michelsen Tore K Kvien Daniela Di Giuseppe Johan K Wallman Jakub Z ávada Sella A Provan Eirik Klami Kristianslund Ana Maria Rodrigues Maria Jos é Santos Žiga Rotar Katja Perdan Pirkmajer Dan Nord Source Type: research
