Brain Motor Region Diffusion Tensor Imaging in Patients with Catatonic Schizophrenia: A Case-Control Study
CONCLUSIONS: Catatonic schizophrenia is associated with dysregulation of the connectivity in specific motoric brain regions and corresponding circuits. Future DTI studies are needed to address the neural correlates of motor abnormalities in schizophrenia-related catatonia during the acute and remitted state of the illness to identify the specific pathophysiology of this disorder.PMID:34672443 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Amir Krivoy Shai Shrot Matan Avrahami Tsvi Fischel Abraham Weizman Yael Mardor David Guez Dianne Daniels Athos Katelaris David Last Chen Hoffmann Source Type: research

Surgical Management of Ureteral Endometriosis with Stenosis and Hydronephrosis: A Third Way?
Isr Med Assoc J. 2021 Oct;23(10):670-671.NO ABSTRACTPMID:34672452 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Benita Knox Charlotte Reddington Martin Healey Uri Dior Claudia Cheng Source Type: research

Calcinosis Cutis Universalis in an Inactive Systemic Lupus Erythematosus Patient
Isr Med Assoc J. 2021 Oct;23(10):674-675.NO ABSTRACTPMID:34672454 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Joz élio Freire de Carvalho Source Type: research

COVID-19 Seropositive Rates between the Waves, Israel
CONCLUSIONS: Adult seropositive rates of infection were low relative to other countries. The findings suggest that early initiatives to limit infection entry and spread were effective.PMID:34672439 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Anat Ekka Zohar Jennifer Kertes Erica Cohen-Lunger Ilya Novikov Naama Shamir Stein Sharon Hermoni Alon Miri Mizrahi Reuveni Source Type: research

Candida Bloodstream Infection, a Dire Complication in Hospitalized COVID-19 Patients: Three Cases from a Single Center in Northern Israel
CONCLUSIONS: Our small sample suggests a much higher incidence of candidemia among COVID-19 patients compared to a historical cohort of non-COVID-19 controls. All clinicians treating COVID-19 patients in GICU should be aware of this complication.PMID:34672440 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Shay Brikman Guy Dori Carmel Kasher Anna Yanovskay Merav Strauss Raul Colodner Naiel Bisharat Bibiana Chazan Source Type: research

COVID-19: adrenal response and molecular mimicry
Isr Med Assoc J. 2021 Oct;23(10):618-619.NO ABSTRACTPMID:34672441 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Leonid P Churilov Darja Kanduc Varvara A Ryabkova Source Type: research

Early Neonatal C-Reactive Protein Levels and Periventricular Leukomalacia
Isr Med Assoc J. 2021 Oct;23(10):620-624.ABSTRACTBACKGROUND: Cystic periventricular leukomalacia (cPVL) is a strong indicator of subsequent motor and developmental impairments in premature infants. There is a paucity of publications on biomarkers of cPVL.OBJECTIVES: To determine C-reactive protein (CRP) levels during the first week of life of preterm infants who later developed cPVL and to identify the association between CRP levels with perinatal factors.METHODS: We retrospectively included infants ≤ 32 weeks gestation and/or birth weights ≤ 1500 grams; 17 with a cranial ultrasound diagnosis of cPVL and 54 with norm...
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Mor Cohen-Eilig Noa Bar Lis Ayelet Livneh Haim Bassan Source Type: research

Robotic-assisted Heller Myotomy Is a Safe Operation
CONCLUSIONS: Robotic-assisted Heller myotomy is a safe technique with a low incidence of intra-operative esophageal perforation compared to the laparoscopic approach. We believe that robotic-assisted surgery should be the procedure of choice to treat achalasia.PMID:34672444 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Ilan Schrier Yael Feferman Yael Berger Dafna Yahav Eran Sadot Omri Sulimani Michael Stein Hanoch Kashtan Source Type: research

Is There a Predictive Value of High Mean Platelet Volume in Early Diagnosis of Venous Thromboembolism?
CONCLUSIONS: Although MPV can be a useful diagnostic marker in many diseases, we found no definite association between low MPV and VTE.PMID:34672445 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Andrei Braester Galia Stemer Sahar Khouri Bennidor Raviv Masad Barhoum Source Type: research

Extra Peritoneal Packing for Exsanguinating Pelvic Hemorrhage: Should We Do It in the Emergency Department?
Isr Med Assoc J. 2021 Oct;23(10):639-645.ABSTRACTBACKGROUND: Extra peritoneal packing (EPP) is a quick and highly effective method to control pelvic hemorrhage.OBJECTIVES: To determine whether EPP can be as safely and efficiently performed in the emergency department (ED) as in the operating room (OR).METHODS: Retrospective study of 29 patients who underwent EPP in the ED or OR in two trauma centers in Israel 2008-2018.RESULTS: Our study included 29 patients, 13 in the ED-EPP group and 16 in the OR-EPP group. The mean injury severity score (ISS) was 34.9 ± 11.8. Following EPP, hemodynamic stability was successfully ...
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Michael Goldenshluger Hen Chaushu Guy Ron Haya Fogel-Grinvald Shay Mandler Liron Miller Nir Horesh Batia Segal Uri Rimon Yoram Klein Source Type: research

ACPA Antibodies Titer at the Time of Rheumatoid Arthritis Diagnosis Is Not Associated with Disease Severity
Isr Med Assoc J. 2021 Oct;23(10):646-650.ABSTRACTBACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease with the presence of autoantibodies, rheumatoid factor (RF), and anti-citrullinated protein antibodies (ACPA). The presence of RF or ACPA predicts RA severity. Data on the influence of ACPA titer on RA course are limited.OBJECTIVES: To determine the correlation between ACPA titers at the time of RA diagnosis to RA features and severity during 3 years of follow-up.METHODS: We performed a retrospective study of RA patients treated at our institution during the years 2006-2015 with kno...
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Rotem Shpatz Yolanda Braun-Moscovici Alexandra Balbir-Gurman Source Type: research

Autonomic Nervous System Indices in Patients with Systemic Sclerosis without Overt Cardiac Disease
CONCLUSIONS: SSc patients may manifest cardiac autonomic dysfunction, while their autonomic pupillary function is seemingly spared. The role of certain medications, the significance of differential organ involvement, as well as the prognostic value of our findings should be evaluated in future studies.PMID:34672448 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Udi Nussinovitch Omer Gendelman Shiri Rubin Yair Levy Viktoria Vishnevskia-Dai Avi Livneh Merav Lidar Source Type: research

Natural Anti-Endothelial Cell Antibodies in Patients Undergoing Coronary Angiography
Isr Med Assoc J. 2021 Oct;23(10):657-661.ABSTRACTBACKGROUND: Anti-endothelial cell antibodies (AECA) are a known biomarker of endothelial dysfunction and damage in clinical practice, especially in autoimmune disease.OBJECTIVES: To determine the relation between natural AECA levels and prognosis related to coronary artery disease.METHODS: Candidates for coronary angiography were prospectively enrolled. AECA levels were determined by ELISA assay. Mortality was evaluated after more than 5 years follow-up.RESULTS: Of a total 857 patients, 445 had high AECA levels (group 1) and 412 had low levels (
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Nicholay Teodorovich Michael Jonas Dan Haberman Haitham Abu Khadija Omar Ayyad Gera Gandelman Lion Poles Jacob George Alex Blatt Source Type: research

Oral Iron Absorption Test: A Simple Test with Relevance in the Clinical Setting
CONCLUSIONS: The oral iron absorption test, although not clearly standardized, is easy to conduct in any outpatient clinic. This test can readily and clearly determine absorption or nonabsorption of iron. This test can have major implications on the need of oral or intravenous iron therapy and can also determine the need for further gastrointestinal evaluation of the small intestine, where iron absorption takes place and the success of therapy on subsequent iron absorption.PMID:34672450 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Joseph Gardyn Noa Chapal Sharon Floru Source Type: research

A Friend and a Foe: 50 Years of the Apolipoprotein E Research Trail
Isr Med Assoc J. 2021 Oct;23(10):665-669.ABSTRACTAn arginine-rich apolipoprotein was discovered 50 years ago and became known as apolipoprotein E (ApoE) 10 years later. ApoE is associated with triglyceride-rich lipoproteins and mediates the clearance of these lipoproteins from the plasma. The ApoE-deficient hypercholesterolemic mice are an excellent platform for experimental atherosclerosis because they are similar to human pathology with regard to an atherogenic diet. ApoE is mainly produced in the liver and central nervous system cells. Three alleles determine six ApoE phenotypes with different metabolic effects and plas...
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Yishai Levy David Levy Source Type: research

Small Vessel Vasculitis of the Central Nervous System: A Rare Disease with a Challenging Diagnosis
Isr Med Assoc J. 2021 Oct;23(10):672-673.NO ABSTRACTPMID:34672453 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Orr Yahal Yael Halavy Asaf Vivante Noah Gruber Irit Tirosh Omer Bar-Yosef Source Type: research

Science, Anatomy, and Art: Revisiting Leonardo da Vinci, Pioneer of Modern Anatomy
Isr Med Assoc J. 2021 Oct;23(10):676-680.ABSTRACTLeonardo da Vinci, the artist and scientist, was an archetype figure of the Renaissance era. He was an autodidactic polymath in natural sciences, engineering, and physical sciences, imbued with universality, prodigious inventive imagination, and curiosity to know and understand the world around him. Among his myriad activities, anatomy, physiology, and biomechanics of the musculoskeletal system and the underlying systems fully engaged him. Leonardo dissected dozens of human and animal corpses to study. His anatomical illustrations were precise, combining art and science with...
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Baruch Wolach Ofir Wolach Source Type: research

Brain Motor Region Diffusion Tensor Imaging in Patients with Catatonic Schizophrenia: A Case-Control Study
CONCLUSIONS: Catatonic schizophrenia is associated with dysregulation of the connectivity in specific motoric brain regions and corresponding circuits. Future DTI studies are needed to address the neural correlates of motor abnormalities in schizophrenia-related catatonia during the acute and remitted state of the illness to identify the specific pathophysiology of this disorder.PMID:34672443 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Amir Krivoy Shai Shrot Matan Avrahami Tsvi Fischel Abraham Weizman Yael Mardor David Guez Dianne Daniels Athos Katelaris David Last Chen Hoffmann Source Type: research

Surgical Management of Ureteral Endometriosis with Stenosis and Hydronephrosis: A Third Way?
Isr Med Assoc J. 2021 Oct;23(10):670-671.NO ABSTRACTPMID:34672452 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Benita Knox Charlotte Reddington Martin Healey Uri Dior Claudia Cheng Source Type: research

Calcinosis Cutis Universalis in an Inactive Systemic Lupus Erythematosus Patient
Isr Med Assoc J. 2021 Oct;23(10):674-675.NO ABSTRACTPMID:34672454 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Joz élio Freire de Carvalho Source Type: research

COVID-19 Seropositive Rates between the Waves, Israel
CONCLUSIONS: Adult seropositive rates of infection were low relative to other countries. The findings suggest that early initiatives to limit infection entry and spread were effective.PMID:34672439 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Anat Ekka Zohar Jennifer Kertes Erica Cohen-Lunger Ilya Novikov Naama Shamir Stein Sharon Hermoni Alon Miri Mizrahi Reuveni Source Type: research

Candida Bloodstream Infection, a Dire Complication in Hospitalized COVID-19 Patients: Three Cases from a Single Center in Northern Israel
CONCLUSIONS: Our small sample suggests a much higher incidence of candidemia among COVID-19 patients compared to a historical cohort of non-COVID-19 controls. All clinicians treating COVID-19 patients in GICU should be aware of this complication.PMID:34672440 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Shay Brikman Guy Dori Carmel Kasher Anna Yanovskay Merav Strauss Raul Colodner Naiel Bisharat Bibiana Chazan Source Type: research

COVID-19: adrenal response and molecular mimicry
Isr Med Assoc J. 2021 Oct;23(10):618-619.NO ABSTRACTPMID:34672441 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Leonid P Churilov Darja Kanduc Varvara A Ryabkova Source Type: research

Early Neonatal C-Reactive Protein Levels and Periventricular Leukomalacia
Isr Med Assoc J. 2021 Oct;23(10):620-624.ABSTRACTBACKGROUND: Cystic periventricular leukomalacia (cPVL) is a strong indicator of subsequent motor and developmental impairments in premature infants. There is a paucity of publications on biomarkers of cPVL.OBJECTIVES: To determine C-reactive protein (CRP) levels during the first week of life of preterm infants who later developed cPVL and to identify the association between CRP levels with perinatal factors.METHODS: We retrospectively included infants ≤ 32 weeks gestation and/or birth weights ≤ 1500 grams; 17 with a cranial ultrasound diagnosis of cPVL and 54 with norm...
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Mor Cohen-Eilig Noa Bar Lis Ayelet Livneh Haim Bassan Source Type: research

Robotic-assisted Heller Myotomy Is a Safe Operation
CONCLUSIONS: Robotic-assisted Heller myotomy is a safe technique with a low incidence of intra-operative esophageal perforation compared to the laparoscopic approach. We believe that robotic-assisted surgery should be the procedure of choice to treat achalasia.PMID:34672444 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Ilan Schrier Yael Feferman Yael Berger Dafna Yahav Eran Sadot Omri Sulimani Michael Stein Hanoch Kashtan Source Type: research

Is There a Predictive Value of High Mean Platelet Volume in Early Diagnosis of Venous Thromboembolism?
CONCLUSIONS: Although MPV can be a useful diagnostic marker in many diseases, we found no definite association between low MPV and VTE.PMID:34672445 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Andrei Braester Galia Stemer Sahar Khouri Bennidor Raviv Masad Barhoum Source Type: research

Extra Peritoneal Packing for Exsanguinating Pelvic Hemorrhage: Should We Do It in the Emergency Department?
Isr Med Assoc J. 2021 Oct;23(10):639-645.ABSTRACTBACKGROUND: Extra peritoneal packing (EPP) is a quick and highly effective method to control pelvic hemorrhage.OBJECTIVES: To determine whether EPP can be as safely and efficiently performed in the emergency department (ED) as in the operating room (OR).METHODS: Retrospective study of 29 patients who underwent EPP in the ED or OR in two trauma centers in Israel 2008-2018.RESULTS: Our study included 29 patients, 13 in the ED-EPP group and 16 in the OR-EPP group. The mean injury severity score (ISS) was 34.9 ± 11.8. Following EPP, hemodynamic stability was successfully ...
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Michael Goldenshluger Hen Chaushu Guy Ron Haya Fogel-Grinvald Shay Mandler Liron Miller Nir Horesh Batia Segal Uri Rimon Yoram Klein Source Type: research

ACPA Antibodies Titer at the Time of Rheumatoid Arthritis Diagnosis Is Not Associated with Disease Severity
Isr Med Assoc J. 2021 Oct;23(10):646-650.ABSTRACTBACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease with the presence of autoantibodies, rheumatoid factor (RF), and anti-citrullinated protein antibodies (ACPA). The presence of RF or ACPA predicts RA severity. Data on the influence of ACPA titer on RA course are limited.OBJECTIVES: To determine the correlation between ACPA titers at the time of RA diagnosis to RA features and severity during 3 years of follow-up.METHODS: We performed a retrospective study of RA patients treated at our institution during the years 2006-2015 with kno...
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Rotem Shpatz Yolanda Braun-Moscovici Alexandra Balbir-Gurman Source Type: research

Autonomic Nervous System Indices in Patients with Systemic Sclerosis without Overt Cardiac Disease
CONCLUSIONS: SSc patients may manifest cardiac autonomic dysfunction, while their autonomic pupillary function is seemingly spared. The role of certain medications, the significance of differential organ involvement, as well as the prognostic value of our findings should be evaluated in future studies.PMID:34672448 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Udi Nussinovitch Omer Gendelman Shiri Rubin Yair Levy Viktoria Vishnevskia-Dai Avi Livneh Merav Lidar Source Type: research

Natural Anti-Endothelial Cell Antibodies in Patients Undergoing Coronary Angiography
Isr Med Assoc J. 2021 Oct;23(10):657-661.ABSTRACTBACKGROUND: Anti-endothelial cell antibodies (AECA) are a known biomarker of endothelial dysfunction and damage in clinical practice, especially in autoimmune disease.OBJECTIVES: To determine the relation between natural AECA levels and prognosis related to coronary artery disease.METHODS: Candidates for coronary angiography were prospectively enrolled. AECA levels were determined by ELISA assay. Mortality was evaluated after more than 5 years follow-up.RESULTS: Of a total 857 patients, 445 had high AECA levels (group 1) and 412 had low levels (
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Nicholay Teodorovich Michael Jonas Dan Haberman Haitham Abu Khadija Omar Ayyad Gera Gandelman Lion Poles Jacob George Alex Blatt Source Type: research

Oral Iron Absorption Test: A Simple Test with Relevance in the Clinical Setting
CONCLUSIONS: The oral iron absorption test, although not clearly standardized, is easy to conduct in any outpatient clinic. This test can readily and clearly determine absorption or nonabsorption of iron. This test can have major implications on the need of oral or intravenous iron therapy and can also determine the need for further gastrointestinal evaluation of the small intestine, where iron absorption takes place and the success of therapy on subsequent iron absorption.PMID:34672450 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Joseph Gardyn Noa Chapal Sharon Floru Source Type: research

A Friend and a Foe: 50 Years of the Apolipoprotein E Research Trail
Isr Med Assoc J. 2021 Oct;23(10):665-669.ABSTRACTAn arginine-rich apolipoprotein was discovered 50 years ago and became known as apolipoprotein E (ApoE) 10 years later. ApoE is associated with triglyceride-rich lipoproteins and mediates the clearance of these lipoproteins from the plasma. The ApoE-deficient hypercholesterolemic mice are an excellent platform for experimental atherosclerosis because they are similar to human pathology with regard to an atherogenic diet. ApoE is mainly produced in the liver and central nervous system cells. Three alleles determine six ApoE phenotypes with different metabolic effects and plas...
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Yishai Levy David Levy Source Type: research

Small Vessel Vasculitis of the Central Nervous System: A Rare Disease with a Challenging Diagnosis
Isr Med Assoc J. 2021 Oct;23(10):672-673.NO ABSTRACTPMID:34672453 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Orr Yahal Yael Halavy Asaf Vivante Noah Gruber Irit Tirosh Omer Bar-Yosef Source Type: research

Science, Anatomy, and Art: Revisiting Leonardo da Vinci, Pioneer of Modern Anatomy
Isr Med Assoc J. 2021 Oct;23(10):676-680.ABSTRACTLeonardo da Vinci, the artist and scientist, was an archetype figure of the Renaissance era. He was an autodidactic polymath in natural sciences, engineering, and physical sciences, imbued with universality, prodigious inventive imagination, and curiosity to know and understand the world around him. Among his myriad activities, anatomy, physiology, and biomechanics of the musculoskeletal system and the underlying systems fully engaged him. Leonardo dissected dozens of human and animal corpses to study. His anatomical illustrations were precise, combining art and science with...
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Baruch Wolach Ofir Wolach Source Type: research

Brain Motor Region Diffusion Tensor Imaging in Patients with Catatonic Schizophrenia: A Case-Control Study
CONCLUSIONS: Catatonic schizophrenia is associated with dysregulation of the connectivity in specific motoric brain regions and corresponding circuits. Future DTI studies are needed to address the neural correlates of motor abnormalities in schizophrenia-related catatonia during the acute and remitted state of the illness to identify the specific pathophysiology of this disorder.PMID:34672443 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Amir Krivoy Shai Shrot Matan Avrahami Tsvi Fischel Abraham Weizman Yael Mardor David Guez Dianne Daniels Athos Katelaris David Last Chen Hoffmann Source Type: research

Surgical Management of Ureteral Endometriosis with Stenosis and Hydronephrosis: A Third Way?
Isr Med Assoc J. 2021 Oct;23(10):670-671.NO ABSTRACTPMID:34672452 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Benita Knox Charlotte Reddington Martin Healey Uri Dior Claudia Cheng Source Type: research

Calcinosis Cutis Universalis in an Inactive Systemic Lupus Erythematosus Patient
Isr Med Assoc J. 2021 Oct;23(10):674-675.NO ABSTRACTPMID:34672454 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Joz élio Freire de Carvalho Source Type: research

COVID-19 Seropositive Rates between the Waves, Israel
CONCLUSIONS: Adult seropositive rates of infection were low relative to other countries. The findings suggest that early initiatives to limit infection entry and spread were effective.PMID:34672439 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Anat Ekka Zohar Jennifer Kertes Erica Cohen-Lunger Ilya Novikov Naama Shamir Stein Sharon Hermoni Alon Miri Mizrahi Reuveni Source Type: research

Candida Bloodstream Infection, a Dire Complication in Hospitalized COVID-19 Patients: Three Cases from a Single Center in Northern Israel
CONCLUSIONS: Our small sample suggests a much higher incidence of candidemia among COVID-19 patients compared to a historical cohort of non-COVID-19 controls. All clinicians treating COVID-19 patients in GICU should be aware of this complication.PMID:34672440 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Shay Brikman Guy Dori Carmel Kasher Anna Yanovskay Merav Strauss Raul Colodner Naiel Bisharat Bibiana Chazan Source Type: research

COVID-19: adrenal response and molecular mimicry
Isr Med Assoc J. 2021 Oct;23(10):618-619.NO ABSTRACTPMID:34672441 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Leonid P Churilov Darja Kanduc Varvara A Ryabkova Source Type: research

Early Neonatal C-Reactive Protein Levels and Periventricular Leukomalacia
Isr Med Assoc J. 2021 Oct;23(10):620-624.ABSTRACTBACKGROUND: Cystic periventricular leukomalacia (cPVL) is a strong indicator of subsequent motor and developmental impairments in premature infants. There is a paucity of publications on biomarkers of cPVL.OBJECTIVES: To determine C-reactive protein (CRP) levels during the first week of life of preterm infants who later developed cPVL and to identify the association between CRP levels with perinatal factors.METHODS: We retrospectively included infants ≤ 32 weeks gestation and/or birth weights ≤ 1500 grams; 17 with a cranial ultrasound diagnosis of cPVL and 54 with norm...
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Mor Cohen-Eilig Noa Bar Lis Ayelet Livneh Haim Bassan Source Type: research

Robotic-assisted Heller Myotomy Is a Safe Operation
CONCLUSIONS: Robotic-assisted Heller myotomy is a safe technique with a low incidence of intra-operative esophageal perforation compared to the laparoscopic approach. We believe that robotic-assisted surgery should be the procedure of choice to treat achalasia.PMID:34672444 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Ilan Schrier Yael Feferman Yael Berger Dafna Yahav Eran Sadot Omri Sulimani Michael Stein Hanoch Kashtan Source Type: research

Is There a Predictive Value of High Mean Platelet Volume in Early Diagnosis of Venous Thromboembolism?
CONCLUSIONS: Although MPV can be a useful diagnostic marker in many diseases, we found no definite association between low MPV and VTE.PMID:34672445 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Andrei Braester Galia Stemer Sahar Khouri Bennidor Raviv Masad Barhoum Source Type: research

Extra Peritoneal Packing for Exsanguinating Pelvic Hemorrhage: Should We Do It in the Emergency Department?
Isr Med Assoc J. 2021 Oct;23(10):639-645.ABSTRACTBACKGROUND: Extra peritoneal packing (EPP) is a quick and highly effective method to control pelvic hemorrhage.OBJECTIVES: To determine whether EPP can be as safely and efficiently performed in the emergency department (ED) as in the operating room (OR).METHODS: Retrospective study of 29 patients who underwent EPP in the ED or OR in two trauma centers in Israel 2008-2018.RESULTS: Our study included 29 patients, 13 in the ED-EPP group and 16 in the OR-EPP group. The mean injury severity score (ISS) was 34.9 ± 11.8. Following EPP, hemodynamic stability was successfully ...
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Michael Goldenshluger Hen Chaushu Guy Ron Haya Fogel-Grinvald Shay Mandler Liron Miller Nir Horesh Batia Segal Uri Rimon Yoram Klein Source Type: research

ACPA Antibodies Titer at the Time of Rheumatoid Arthritis Diagnosis Is Not Associated with Disease Severity
Isr Med Assoc J. 2021 Oct;23(10):646-650.ABSTRACTBACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease with the presence of autoantibodies, rheumatoid factor (RF), and anti-citrullinated protein antibodies (ACPA). The presence of RF or ACPA predicts RA severity. Data on the influence of ACPA titer on RA course are limited.OBJECTIVES: To determine the correlation between ACPA titers at the time of RA diagnosis to RA features and severity during 3 years of follow-up.METHODS: We performed a retrospective study of RA patients treated at our institution during the years 2006-2015 with kno...
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Rotem Shpatz Yolanda Braun-Moscovici Alexandra Balbir-Gurman Source Type: research

Autonomic Nervous System Indices in Patients with Systemic Sclerosis without Overt Cardiac Disease
CONCLUSIONS: SSc patients may manifest cardiac autonomic dysfunction, while their autonomic pupillary function is seemingly spared. The role of certain medications, the significance of differential organ involvement, as well as the prognostic value of our findings should be evaluated in future studies.PMID:34672448 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Udi Nussinovitch Omer Gendelman Shiri Rubin Yair Levy Viktoria Vishnevskia-Dai Avi Livneh Merav Lidar Source Type: research

Natural Anti-Endothelial Cell Antibodies in Patients Undergoing Coronary Angiography
Isr Med Assoc J. 2021 Oct;23(10):657-661.ABSTRACTBACKGROUND: Anti-endothelial cell antibodies (AECA) are a known biomarker of endothelial dysfunction and damage in clinical practice, especially in autoimmune disease.OBJECTIVES: To determine the relation between natural AECA levels and prognosis related to coronary artery disease.METHODS: Candidates for coronary angiography were prospectively enrolled. AECA levels were determined by ELISA assay. Mortality was evaluated after more than 5 years follow-up.RESULTS: Of a total 857 patients, 445 had high AECA levels (group 1) and 412 had low levels (
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Nicholay Teodorovich Michael Jonas Dan Haberman Haitham Abu Khadija Omar Ayyad Gera Gandelman Lion Poles Jacob George Alex Blatt Source Type: research

Oral Iron Absorption Test: A Simple Test with Relevance in the Clinical Setting
CONCLUSIONS: The oral iron absorption test, although not clearly standardized, is easy to conduct in any outpatient clinic. This test can readily and clearly determine absorption or nonabsorption of iron. This test can have major implications on the need of oral or intravenous iron therapy and can also determine the need for further gastrointestinal evaluation of the small intestine, where iron absorption takes place and the success of therapy on subsequent iron absorption.PMID:34672450 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Joseph Gardyn Noa Chapal Sharon Floru Source Type: research

A Friend and a Foe: 50 Years of the Apolipoprotein E Research Trail
Isr Med Assoc J. 2021 Oct;23(10):665-669.ABSTRACTAn arginine-rich apolipoprotein was discovered 50 years ago and became known as apolipoprotein E (ApoE) 10 years later. ApoE is associated with triglyceride-rich lipoproteins and mediates the clearance of these lipoproteins from the plasma. The ApoE-deficient hypercholesterolemic mice are an excellent platform for experimental atherosclerosis because they are similar to human pathology with regard to an atherogenic diet. ApoE is mainly produced in the liver and central nervous system cells. Three alleles determine six ApoE phenotypes with different metabolic effects and plas...
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Yishai Levy David Levy Source Type: research

Small Vessel Vasculitis of the Central Nervous System: A Rare Disease with a Challenging Diagnosis
Isr Med Assoc J. 2021 Oct;23(10):672-673.NO ABSTRACTPMID:34672453 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - October 21, 2021 Category: General Medicine Authors: Orr Yahal Yael Halavy Asaf Vivante Noah Gruber Irit Tirosh Omer Bar-Yosef Source Type: research