The Role of H3K27me3-Mediated Th17 Differentiation in Ankylosing Spondylitis
The objective of this study was to investigate the expression of H3K27me3 in patients with AS and to explore its epigenetic regulation mechanism of Th17 differentiation during AS inflammation. We collected serum samples from 45 patients with AS at various stages and 10 healthy controls to measure their Interleukin-17 (IL-17) levels using ELISA. A quantitative polymerase chain reaction was used to quantify the mRNA levels of RORc and the signaling molecules of the JAK2/STAT3 pathway, JMJD3, and EZH2. Additionally, Western blot analysis was performed to quantify the protein levels of H3K27me3, ROR γt, JAK2, STAT3, JMJD3, an...
Source: Inflammation - March 22, 2024 Category: Allergy & Immunology Source Type: research
Upadacitinib in Crohn's disease
Expert Opin Pharmacother. 2024 Mar 21. doi: 10.1080/14656566.2024.2333964. Online ahead of print.ABSTRACTINTRODUCTION: The small molecule and oral selective and reversible Janus kinase (JAK) inhibitor upadacitinib has been approved for the treatment of moderate to severe active Crohn's disease (CD) in adult patients since April 2023 by EMA/FDA.AREAS COVERED: The approval is based on the two induction studies a maintenance study showing that upadacitinib induction and maintenance therapy was superior to placebo. The approval of upadacitinib in CD expands the therapeutic armamentarium for the management of inflammatory bowel...
Source: Expert Opinion on Pharmacotherapy - March 21, 2024 Category: Drugs & Pharmacology Authors: Axel Dignass Philip Esters Cathrin Flauaus Source Type: research
An updated advancement of bifunctional IL-27 in inflammatory autoimmune diseases
Interleukin-27 (IL-27) is a member of the IL-12 family. The gene encoding IL-27 is located at chromosome 16p11. IL-27 is considered as a heterodimeric cytokine, which consists of Epstein–Barr virus (EBV)-induced gene 3 (Ebi3) and IL-27p28. Based on the function of IL-27, it binds to receptor IL-27rα or gp130 and then regulates downstream cascade. To date, findings show that the expression of IL-27 is abnormal in different inflammatory autoimmune diseases (including systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome, Behcet’s disease, inflammatory bowel disease, multiple sclerosis, systemic sclerosis,...
Source: Frontiers in Immunology - March 19, 2024 Category: Allergy & Immunology Source Type: research
Proteome-wide Mendelian randomization identifies therapeutic targets for ankylosing spondylitis
ConclusionOur investigation examined the causal connections between six plasma proteins and AS, providing a comprehensive understanding of potential therapeutic targets. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 19, 2024 Category: Allergy & Immunology Source Type: research
Targeting osteoblast ‐specific transcription factor: A common approach for ankylosing spondylitis and the tumor microenvironment
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 15, 2024 Category: Rheumatology Authors: Po ‐Hung Chen,
Su‐Boon Yong,
Wan‐Ting Liao,
Meng‐Yu Wu,
Chia‐Jung Li,
I‐Ming Jou Tags: LETTER TO THE EDITOR Source Type: research
Association between Sj ögren syndrome, sociodemographic factors, comorbid conditions, and optic neuritis: a Taiwanese population-based study
DISCUSSION: Our findings strongly support the existence of an association between Sjögren syndrome, rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, systemic lupus erythematosus, granulomatous vasculitis, human herpes viral infection, tuberculosis, and optic neuritis.PMID:38476197 | PMC:PMC10927792 | DOI:10.3389/fneur.2024.1353326 (Source: Herpes)
Source: Herpes - March 13, 2024 Category: Infectious Diseases Authors: Ren-Long Jan Chung-Han Ho Cheng-Hao Sung Jhi-Joung Wang Han-Yi Jan Wei-Yu Chen Yuh-Shin Chang Source Type: research
A Case of Insidious Onset of Kimura Disease-associated Immunoglobulin A Nephropathy without Eosinophil Infiltration in the Renal Tissue
In this study, we report a case of KD combined with immunoglobulin A nephropathy that first presented as a mass in the inguinal region, followed by recurrent renal involvement. Previous reports suggested that renal involvement caused by KD was due to direct infiltration of eosinophils; however, in this case, no eosinophil infiltration was found in the renal tissue after renal biopsy. This observation reminds us to approach the case from an immune-related molecular perspective to investigate the exact cause of renal damage due to KD.PMID:38477957 | DOI:10.18502/ijaai.v22i6.14649 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Linxin Liu Haoxian Gou Yongfa Liu Shuai Hu Xiaoli Yang Bo Li Source Type: research
Association between Sj ögren syndrome, sociodemographic factors, comorbid conditions, and optic neuritis: a Taiwanese population-based study
DISCUSSION: Our findings strongly support the existence of an association between Sjögren syndrome, rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, systemic lupus erythematosus, granulomatous vasculitis, human herpes viral infection, tuberculosis, and optic neuritis.PMID:38476197 | PMC:PMC10927792 | DOI:10.3389/fneur.2024.1353326 (Source: Herpes)
Source: Herpes - March 13, 2024 Category: Infectious Diseases Authors: Ren-Long Jan Chung-Han Ho Cheng-Hao Sung Jhi-Joung Wang Han-Yi Jan Wei-Yu Chen Yuh-Shin Chang Source Type: research
A Case of Insidious Onset of Kimura Disease-associated Immunoglobulin A Nephropathy without Eosinophil Infiltration in the Renal Tissue
In this study, we report a case of KD combined with immunoglobulin A nephropathy that first presented as a mass in the inguinal region, followed by recurrent renal involvement. Previous reports suggested that renal involvement caused by KD was due to direct infiltration of eosinophils; however, in this case, no eosinophil infiltration was found in the renal tissue after renal biopsy. This observation reminds us to approach the case from an immune-related molecular perspective to investigate the exact cause of renal damage due to KD.PMID:38477957 | DOI:10.18502/ijaai.v22i6.14649 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Linxin Liu Haoxian Gou Yongfa Liu Shuai Hu Xiaoli Yang Bo Li Source Type: research
A Comprehensive Review on the Role of Interleukin-40 as a Biomarker for Diagnosing Inflammatory Diseases
Autoimmune Dis. 2024 Mar 1;2024:3968767. doi: 10.1155/2024/3968767. eCollection 2024.ABSTRACTInterleukins are a group of proteins that have a wide range of complex functions and are believed to be involved in several diseases and conditions. In particular, interleukin-40 (IL-40) is a recently identified cytokine associated with B cells that was first introduced by Catalan et al. in 2017. This cytokine has several roles in the body, including functioning in the formation of B cells in the bone marrow, IgA production, and expression in the intestinal microbiome. Moreover, IL-40 appears to be involved in numerous autoimmune a...
Source: Autoimmune Diseases - March 11, 2024 Category: Allergy & Immunology Authors: Feryal Dabbagh-Gorjani Source Type: research
