Ankylosing Spondylitis Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Natural Autoantibodies in Biologic-Treated Rheumatoid Arthritis and Ankylosing Spondylitis Patients: Associations with Vascular Pathophysiology
Int J Mol Sci. 2024 Mar 18;25(6):3429. doi: 10.3390/ijms25063429.ABSTRACTCardiovascular (CV) morbidity and mortality have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Natural autoantibodies (nAAb) are involved in innate immunity, as well as autoimmunity, inflammation, and atherosclerosis. There have not been any studies assessing the effects of biologics on nAAbs in RA and AS, also in relation to vascular pathophysiology. Fifty-three anti-TNF-treated RA and AS patients were included in a 12-month follow-up study. Anti-citrate synthase (CS) and anti-topoisomerase I fragment 4 (TOPO-F4) IgM...
Source: Atherosclerosis - March 28, 2024 Category: Cardiology Authors: Di ána Simon Dorottya Kacs ándi Anita Pusztai Bogl árka Soós Edit V égh Gy örgy Kerekes Monika Bodoki Szilvia Szamosi Gabriella Sz űcs Zolt án Prohászka P éter Németh T ímea Berki Zolt án Szekanecz Source Type: research

Genes, Vol. 15, Pages 426: Investigating the Influence of ANTXR2 Gene Mutations on Protective Antigen Binding for Heightened Anthrax Resistance
This study delves into the genetic landscape of ANTXR2, aiming to comprehend its associations with diverse disorders, elucidate the impacts of its mutations, and pinpoint minimal non-pathogenic mutations capable of reducing the binding affinity of the ANTXR2 gene with the protective antigen. Recognizing the pivotal role of single-nucleotide polymorphisms (SNPs) in shaping genetic diversity, we conducted computational analyses to discern highly deleterious and tolerated non-synonymous SNPs (nsSNPs) in the ANTXR2 gene. The Mutpred2 server determined that the Arg465Trp alteration in the ANTXR2 gene leads to altered DNA bindin...
Source: Genes - March 28, 2024 Category: Genetics & Stem Cells Authors: Chamalapura Ashwathama Archana Yamini Sri Sekar Kuralayanapalya Puttahonnappa Suresh Saravanan Subramaniam Ningegowda Sagar Swati Rani Jayashree Anandakumar Rajan Kumar Pandey Nagendra Nath Barman Sharanagouda S. Patil Tags: Article Source Type: research

The Association Between Epidermal Growth Factor rs3756261 A/G Gene Polymorphism and the Risk of Ankylosing Spondylitis in a Chinese Han Population
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - March 27, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research

Efficacy of denosumab against osteoporosis determined using quantitative computed tomography in treatment-na ïve male patients with ankylosing spondylitis: case series of six patients
Scand J Rheumatol. 2024 Mar 26:1-3. doi: 10.1080/03009742.2024.2316960. Online ahead of print.NO ABSTRACTPMID:38529827 | DOI:10.1080/03009742.2024.2316960 (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - March 26, 2024 Category: Rheumatology Authors: S H Kim S-H Lee R Song Source Type: research

Decreasing incidence of cervical spine fractures in patients with ankylosing spondylitis: A population-based study in Southeast Norway
Individuals diagnosed with ankylosing spondylitis (AS) face an increased risk of spine fractures, specifically cervical spine fractures (CS-Fxs). In the past two decades, biological disease-modifying antirheumatic drugs (bDMARDs) have provided considerable relief from pain and an enhanced sense of wellbeing for a large segment of AS patients. Despite these improvements, it remains unclear whether extended use of bDMARDs can indeed reduce the risk of spine fractures. (Source: The Spine Journal)
Source: The Spine Journal - March 26, 2024 Category: Orthopaedics Authors: P ål Nicolay Fougner Rydning, Hege Linnerud, Jalal Mirzamohammadi, Tor Brommeland, Pål Andre Rønning, Magnus Evjensvold, Mads Aarhus, Gunnstein Bakland, Eirik Helseth Tags: Clinical Study Source Type: research

Challenging diagnosis and successful management of phosphaturic mesenchymal tumor mimicking ankylosing spondylitis: A case report
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 23, 2024 Category: Rheumatology Authors: Yuan Zhang, Jiang Zhu, Xuemeng Chen, Ganping Bai, Yu Du, Qinghua Zou Tags: LETTER TO THE EDITOR Source Type: research

Additional Data in Expanded Patient Populations and New Indications Support the Practice of Biosimilar-to-Biosimilar Switching
AbstractAs of 31 December, 2023, 31 observational studies have been published, including a total of 6081 patients who underwent a switch from one biosimilar to another biosimilar of the same reference biologic. Most studies evaluated infliximab, while a smaller number evaluated adalimumab, rituximab or etanercept. Indications studied now include sarcoidosis, as well as the indications previously reported of rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis/ankylosing spondylitis and inflammatory bowel disease (Crohn ’s disease and ulcerative colitis). This updated data set includes eight additional studi...
Source: BioDrugs - March 23, 2024 Category: Drugs & Pharmacology Source Type: research

Innovate therapeutic targets for autoimmune diseases: insights from proteome-wide mendelian randomization and Bayesian colocalization
CONCLUSIONS: Our integrated study identified 12 potential therapeutic targets for ADs and provided novel insights into future drug development for ADs.PMID:38515381 | DOI:10.1080/08916934.2024.2330392 (Source: Autoimmunity)
Source: Autoimmunity - March 22, 2024 Category: Allergy & Immunology Authors: Qiubai Jin Feihong Ren Ping Song Source Type: research