Impact and associates of digital pitting in patients with systemic sclerosis: a pilot study.
Abstract Objective: Despite being a cardinal clinical sign of systemic sclerosis (SSc), digital pitting has been little studied. Our objective was to test, in a pilot study, the hypothesis that pitting is painful and associated with digital vascular disease severity.Method: Fifty patients with SSc were recruited: 25 with and 25 without digital pitting. Fingertip pain was assessed on a 0-10 scale. Thermography of both hands assessed surface temperature, allowing calculation of the distal-dorsal difference (temperature gradient) for each finger. Nailfold capillaroscopy was performed in each finger using a dermatosco...
Source: Scandinavian Journal of Rheumatology - January 13, 2020 Category: Rheumatology Authors: Nolan E, Manning J, Heal C, Moore T, Herrick AL Tags: Scand J Rheumatol Source Type: research

Scoring magnetic resonance imaging (MRI) inflammation and structural lesions in sacroiliac joints of patients with axial spondyloarthritis: assessment of all MRI slices of the cartilaginous compartment versus standardized six or five slices.
Conclusion: The standardized 6/5 slices approach showed no relevant differences from the 'all slices' approach and, therefore, is equally suited for monitoring purposes. PMID: 31847676 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - December 17, 2019 Category: Rheumatology Authors: Krabbe S, Kröber G, Pedersen SJ, Østergaard M, Møller JM, Sørensen IJ, Jensen B, Madsen OR, Klarlund M, Weber U Tags: Scand J Rheumatol Source Type: research

Anti-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibody in necrotizing myopathy: treatment outcomes, cancer risk, and role of autoantibody level.
Abstract Objective: To evaluate clinical associations of anti-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibody (Ab) and statin exposure in necrotizing myopathy (NM) patients.Methods: NM without a known myositis-specific autoantibody (MSA) was ascertained from a large single-centre myositis database between 1985 and 2012. A comparison NM cohort included 32 anti-SRP+ autoantibody patients, and other control groups included 74 non-NM myositis patients and 21 non-myositis controls. Sera from all cases and controls were tested using a validated anti-HMGCR enzyme-linked immunosorbent assay. Clinical f...
Source: Scandinavian Journal of Rheumatology - December 5, 2019 Category: Rheumatology Authors: Aggarwal R, Moghadam-Kia S, Lacomis D, Malik A, Qi Z, Koontz D, Burlingame RW, Oddis CV Tags: Scand J Rheumatol Source Type: research

Physical activity in rheumatoid arthritis: relationship to cardiovascular risk factors, subclinical atherosclerosis, and disease activity.
Conclusions: Physical activity was associated with more favourable risk factors for CVD. However, many patients were physically inactive, stressing the importance of promoting physical activity in RA. PMID: 31739706 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - November 19, 2019 Category: Rheumatology Authors: Hörnberg K, Pomeroy J, Sandberg C, Södergren A, Ångström L, Sundström B, Wållberg Jonsson S Tags: Scand J Rheumatol Source Type: research

Prevalence of ankylosing spondylitis in Spain: EPISER2016 Study.
Conclusion: EPISER2016 is the first population-based study to estimate the prevalence of AS in Spain, which has been estimated as being similar to that in other European countries. PMID: 31682163 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - November 4, 2019 Category: Rheumatology Authors: Quilis N, Sivera F, Seoane-Mato D, Antón-Pagés F, Añez G, Medina F, Garrido L, Del Val N, Paniagua I, Ballina J, Brandy-García AM, González B, Casas L, Sánchez-Piedra C, Díaz-González F, Bustabad-Reyes S Tags: Scand J Rheumatol Source Type: research

Integrating transcriptome-wide association study and mRNA expression profiling identified candidate genes and pathways associated with osteomyelitis.
Conclusion: This integrative study of TWAS and mRNA expression profiling detected multiple candidate genes and GO terms for OM. Our results provide novel clues for understanding the pathogenesis of OM. PMID: 31657276 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - October 28, 2019 Category: Rheumatology Authors: Zhang L, Du Y, Wen Y, Ma M, Cheng S, Cheng B, Li P, Qi X, Liang C, Liu L, Liang X, Guo X, Zhang F Tags: Scand J Rheumatol Source Type: research

Assessing recovery after cold challenge and thumb involvement can help to rule out systemic sclerosis in patients presenting with Raynaud's phenomenon.
Conclusions: In patients with RP, when there is restoration of perfusion in all fingers after 10 min or when the thumb is spared, the presence of an underlying SSc is very unlikely. Although these results need to be validated in a clinical setting in a larger prospective study, these signs can help physicians to select additional testing for SSc in RP patients. PMID: 31637927 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - October 22, 2019 Category: Rheumatology Authors: van Roon AM, van Roon AM, Stel AJ, Bootsma H, Smit AJ, Mulder DJ Tags: Scand J Rheumatol Source Type: research

Immunoglobulin G4-related disease as a mimicker of granulomatosis with polyangiitis: a case report.
pe JE PMID: 31631725 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - October 21, 2019 Category: Rheumatology Authors: Jiang Z, Wang D, Jurkiewicz M, Langdon KD, Hammond R, Fernández-Codina A, Pope JE Tags: Scand J Rheumatol Source Type: research

Cardiovascular risk factors are highly overrepresented in Swedish patients with psoriatic arthritis compared with the general population.
Abstract Objectives: We aimed to determine the prevalence of cardiovascular risk factors in patients with psoriatic arthritis (PsA) followed at a large Swedish Rheumatology Clinic, and to compare differences in cardiovascular risk factors between men and women with PsA and with the general population. Method: A questionnaire was sent to patients with PsA registered at the Rheumatology Clinic at Sahlgrenska University Hospital, Gothenburg (n = 982). Comparisons with the general population were made using data from the Swedish National Public Health Survey. Descriptive statistics are presented. Body mass i...
Source: Scandinavian Journal of Rheumatology - October 21, 2019 Category: Rheumatology Authors: Landgren AJ, Bilberg A, Eliasson B, Larsson I, Dehlin M, Jacobsson L, Klingberg E Tags: Scand J Rheumatol Source Type: research

Delayed neutrophil apoptosis in granulomatosis with polyangiitis: dysregulation of neutrophil gene signature and circulating apoptosis-related proteins.
Conclusions: Circulating neutrophils in GPA have anti-apoptotic phenotype involving both intrinsic and extrinsic pathways of apoptosis. This is accompanied by increased levels of circulating pro-survival factors (GM-CSF, TNF-α, sFas), independent of disease activity. Anti-apoptotic phenotype of neutrophils in GPA is reproduced by exposure to low concentrations of TNF-α. PMID: 31610684 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - October 15, 2019 Category: Rheumatology Authors: Surmiak M, Hubalewska-Mazgaj M, Wawrzycka-Adamczyk K, Musiał J, Sanak M Tags: Scand J Rheumatol Source Type: research

Lymphopenia and neutropenia are associated with subsequent incident proteinuria in Danish patients with systemic lupus erythematosus.
Conclusion: Lymphopenia and neutropenia predicted the risk of first-time proteinuria independently of immunosuppressants. PMID: 31612777 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - October 15, 2019 Category: Rheumatology Authors: Tanha N, Hansen RB, Yang J, Lange T, Nielsen CT, Helleberg M, Kamper AL, Faurschou M, Jacobsen S Tags: Scand J Rheumatol Source Type: research

'The feeling of not being entitled to something': fertility, pregnancy, and sexuality among women with systemic lupus erythematosus in South Africa.
Conclusion: A combination of patient-centred care focusing on safe, effective contraception and medication targeting remission state, constant counselling, consistent information, and a pregnancy managed jointly by an obstetrics and rheumatology team could achieve optimum results. PMID: 31583923 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - October 4, 2019 Category: Rheumatology Authors: Phuti A, Hodkinson B, Tikly M, Schneider M Tags: Scand J Rheumatol Source Type: research

Axillary lymph-node metabolic activity assessment on 18F-FDG-PET/CT in rheumatoid arthritis patients treated with biologic therapies.
Abstract Objective: Recent studies have provided new insights into the role of lymph nodes (LNs) in rheumatoid arthritis (RA). The aim of this study was to evaluate the metabolic activity of the axillary LNs in relation to that of the upper limb joints and the clinical assessment of disease activity in RA patients treated with biologic therapies. Method: 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) scans were acquired for 64 patients with RA at baseline and after 6 months of biologic therapy, and the patients' clinical status was evaluated. The maximum standardized ...
Source: Scandinavian Journal of Rheumatology - October 3, 2019 Category: Rheumatology Authors: Dam TT, Okamura K, Nakajima T, Yonemoto Y, Suto T, Arisaka Y, Tomonaga H, Tachibana M, Tajika T, Vu LD, Chikuda H, Tsushima Y Tags: Scand J Rheumatol Source Type: research

Nodular localized primary cutaneous amyloidosis and primary Sj ögren's syndrome.
Nodular localized primary cutaneous amyloidosis and primary Sjögren's syndrome. Scand J Rheumatol. 2019 Oct 03;:1-2 Authors: Davies K, Collins A, Charlton FG, Ng WF PMID: 31578131 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - October 3, 2019 Category: Rheumatology Authors: Davies K, Collins A, Charlton FG, Ng WF Tags: Scand J Rheumatol Source Type: research

Authors' comments to the retraction.
Med - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - October 1, 2019 Category: Rheumatology Authors: Authors' comments to the retraction. Tags: Scand J Rheumatol Source Type: research

Statement of Retraction.
PMID: 31571514 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - October 1, 2019 Category: Rheumatology Authors: Sylvest D Tags: Scand J Rheumatol Source Type: research

Three cases of autoimmune-associated haemophagocytic syndrome in dermatomyositis with anti-MDA5 autoantibody.
PMID: 31571515 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - October 1, 2019 Category: Rheumatology Authors: Honda M, Moriyama M, Kondo M, Kumakura S, Sumita Y, Murakawa Y Tags: Scand J Rheumatol Source Type: research

Etanercept therapy leads to reductions in matrix metalloproteinase-3 in patients with erosive hand osteoarthritis.
PMID: 31566063 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - September 30, 2019 Category: Rheumatology Authors: Kroon F, Bay-Jensen AC, Wittoek R, Verbruggen G, Smolen JS, Kloppenburg M, Ramonda R Tags: Scand J Rheumatol Source Type: research

T cells, natural killer cells, and γδT cells in a large patient cohort with rheumatoid arthritis: influence of age and anti-rheumatic therapy.
Conclusion: Age and TNF-inhibition therapy influence lymphocyte subdifferentiation in patients with RA. It may be prudent to use age- and therapy-adjusted standard values for lymphocyte subsets during clinical trials and treatment of RA. PMID: 31556339 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - September 26, 2019 Category: Rheumatology Authors: Schwaneck EC, Renner R, Junker L, Tony HP, Kleinert S, Gernert M, Schmalzing M, Gadeholt O Tags: Scand J Rheumatol Source Type: research

Pulmonary involvement in primary Sj ögren's syndrome, as measured by the ESSDAI.
Conclusion: In this cross-sectional study in daily clinical practice, pulmonary involvement was present in 10-15% of pSS patients, of which ILD was most common. Of all pSS patients, 6% were scored as active on the pulmonary domain of the ESSDAI. PMID: 31556344 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - September 26, 2019 Category: Rheumatology Authors: Heus A, Arends S, Van Nimwegen JF, Stel AJ, Nossent GD, Bootsma H Tags: Scand J Rheumatol Source Type: research

Peptidylarginine deiminase 4 (PAD4) activity in early rheumatoid arthritis.
Abstract Objectives: Peptidylarginine deiminases (PADs) are a family of calcium-dependent enzymes catalysing the conversion of arginine residues to citrulline, which may constitute a risk factor in rheumatoid arthritis (RA) pathogenesis. We investigated PAD activation by serum (PADAct) in early RA, and the associations between PAD activation and disease characteristics, treatment response, and progression of radiographic damage. Method: Sera from disease-modifying anti-rheumatic drug (DMARD)-naïve early RA patients (n = 225), classified according to the 2010 American College of Rheumatology/European...
Source: Scandinavian Journal of Rheumatology - September 23, 2019 Category: Rheumatology Authors: Jonsson MK, Kantyka T, Falkowski K, Aliko A, Aga AB, Lillegraven S, Sexton J, Fevang BT, Mydel P, Haavardsholm EA Tags: Scand J Rheumatol Source Type: research

Validation and assessment of minimally clinically important difference of the unadjusted Health Assessment Questionnaire in a Danish cohort: uncovering ordinal bias.
Conclusions: The Danish unadjusted version of the HAQ-DI showed acceptable internal construct validity. Application of the logit MCID classified an additional one in six patients as having achieved an MCID compared to the MCID calculated on the ordinal scale, which may have potential implications for the powering of future studies. PMID: 31538511 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - September 20, 2019 Category: Rheumatology Authors: Ørnbjerg LM, Christensen KB, Tennant A, Hetland ML Tags: Scand J Rheumatol Source Type: research

Immunoglobulin G galactosylation levels are decreased in systemic sclerosis patients and differ according to disease subclassification.
Conclusion: IgG-Gal ratios were abnormal in SSc patients and were associated with disease severity. The IgG-Gal ratio therefore shows potential as a biomarker for the diagnosis of SSc. PMID: 31538512 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - September 20, 2019 Category: Rheumatology Authors: Liu Q, Lin J, Han J, Zhang Y, Lu J, Tu W, Zhao Y, Guo G, Chu H, Pu W, Liu J, Ma Y, Chen X, Zhang R, Gu J, Zou H, Jin L, Wu W, Ren S, Wang J Tags: Scand J Rheumatol Source Type: research

Evaluation of choroidal substructure perfusion in patients affected by systemic sclerosis: an optical coherence tomography angiography study.
Conclusion: Choroidal microcirculation is impaired in SSc, even in patients without ophthalmological symptoms. Choroidal OCT and OCTA may offer additional biomarkers for SSc activity. PMID: 31526060 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - September 17, 2019 Category: Rheumatology Authors: Ranjbar M, Rothe M, Klapa S, Lange T, Prasuhn M, Grisanti S, Riemekasten G, Humrich JY Tags: Scand J Rheumatol Source Type: research

Responsiveness of different dynamic contrast-enhanced magnetic resonance imaging approaches: a post-hoc analysis of a randomized controlled trial of certolizumab pegol in rheumatoid arthritis.
ard M Abstract Objective: The aim was to explore dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as an early marker of therapeutic response in patients with rheumatoid arthritis (RA) starting treatment with certolizumab pegol (CZP). Method: In 40 RA patients initiating CZP (27 patients) or 2 weeks of placebo (PCB) followed by CZP (13 patients), DCE-MRI of the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints was performed at weeks 0, 1, 2, 4, 8, and 16. Using semi-automated software, three methods for drawing volume regions of interest (ROIs) in MCP2-5 and PIP2-5 were applied:...
Source: Scandinavian Journal of Rheumatology - September 16, 2019 Category: Rheumatology Authors: Axelsen MB, Boesen M, Bliddal H, Jacobsson L, Hansen MS, Østergaard M Tags: Scand J Rheumatol Source Type: research

Frequency, characteristics, and clinical determinants of 'prodrome' in familial Mediterranean fever patients.
Conclusions: All FMF patients, particularly males and patients who had peritonitis or arthritis at any time, should be questioned about prodrome. Prodrome should be analysed in terms of elucidating the pathogenesis of FMF and as an opportunity for a secondary prevention strategy for impending attacks. This study may shed light on prodrome for future cytokine or drug studies with the purpose of developing new cost-effective treatment protocols irrespective of colchicine resistance. PMID: 31478409 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - September 3, 2019 Category: Rheumatology Authors: Babaoglu H, Atas N, Varan O, Satis H, Bilici Salman R, Guler A, Karadeniz H, Ozturk MA, Haznedaroglu S, Goker B, Tufan A Tags: Scand J Rheumatol Source Type: research

Unexpectedly lower proportion of placental transferred tocilizumab relative to whole immunoglobulin G: a case report.
PMID: 31436129 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - August 22, 2019 Category: Rheumatology Authors: Moriyama M, Wada Y, Minamoto T, Kondo M, Honda M, Murakawa Y Tags: Scand J Rheumatol Source Type: research

Lower serum levels of transforming growth factor- β1 and disease activity in Takayasu arteritis.
Lower serum levels of transforming growth factor-β1 and disease activity in Takayasu arteritis. Scand J Rheumatol. 2019 Aug 21;:1-2 Authors: Savioli B, Salu BR, de Brito MV, Oliva M, de Souza A PMID: 31432731 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - August 21, 2019 Category: Rheumatology Authors: Savioli B, Salu BR, de Brito MV, Oliva M, de Souza A Tags: Scand J Rheumatol Source Type: research

Subclinical atherosclerosis and endothelial dysfunction in patients with polymyalgia rheumatica: a pilot study.
Conclusions: PMR is characterized by an important chronic subclinical inflammatory component. This pilot study demonstrates that affected patients show endothelial dysfunction that slowly responds to steroid therapy. Further studies are needed to investigate the clinical relevance of these observations and, in particular, to monitor the cardiovascular risk profile of PMR patients. PMID: 31418315 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - August 16, 2019 Category: Rheumatology Authors: Santoro L, Birra D, Bosello S, Nesci A, Di Giorgio A, Peluso G, Giupponi B, Zaccone V, Gasbarrini A, Zoli A, Santoliquido A Tags: Scand J Rheumatol Source Type: research

Differences between females and males in axial spondyloarthritis: data from a real-life cross-sectional cohort.
Conclusions: In this real-life cohort of patients with axSpA, although males more often had structural damage on X-rays, females had similar disease with regard to SpA features and at least equal disease activity parameters compared to males. PMID: 31418321 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - August 16, 2019 Category: Rheumatology Authors: de Jong H, Paramarta JE, de Winter J, Baeten D, van de Sande M Tags: Scand J Rheumatol Source Type: research

Anti-citrullinated protein antibody titre as a predictor of abatacept treatment persistence in patients with rheumatoid arthritis: a prospective cohort study in Japan.
Conclusions: Persistence with abatacept and sustained therapeutic response are associated with an early reduction in ACPA titre. Prediction of abatacept continuation and efficacy will facilitate the optimal design of therapy in the early stages of RA. PMID: 31402744 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - August 12, 2019 Category: Rheumatology Authors: Endo Y, Koga T, Kawashiri SY, Morimoto S, Nishino A, Okamoto M, Eguchi M, Tsuji S, Takatani A, Shimizu T, Sumiyoshi R, Igawa T, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Ueki Y, Yoshitama T, Eiraku N, Matsuoka N, Okada A, Fujikawa K, Hamada Tags: Scand J Rheumatol Source Type: research

Pedunculoside attenuates pathological phenotypes of fibroblast-like synoviocytes and protects against collagen-induced arthritis.
Conclusion: These results demonstrate that PE exerts an inhibitory role in FLSs and CIA rats, and therefore may have therapeutic value for the treatment of RA. PMID: 31354003 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - July 29, 2019 Category: Rheumatology Authors: Ma X, Chen G, Wang J, Xu J, Zhao F, Hu M, Xu Z, Yang B, Guo J, Sun S, Liu M Tags: Scand J Rheumatol Source Type: research

Incidence of ankylosing spondylitis and spondyloarthritis in 2000-2013: a nationwide Danish cohort study.
Conclusion: The incidence of both AS and SpA in Denmark increased from 2000 to 2013. However, the proportion of patients diagnosed with SpA rather than AS was significantly higher in 2010-2013. This may be due to increased awareness of SpA and new treatment options, but possibly also misclassification of patients with SpA. PMID: 31354008 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - July 29, 2019 Category: Rheumatology Authors: Nygaard A, Ljungdalh PS, Iachina M, Nikolov TN, Schiøttz-Christensen B Tags: Scand J Rheumatol Source Type: research

Distribution characteristics of elevated serum immunoglobulin G4 (IgG4) and its relationship with IgG4-related disease.
Conclusions: Elevated serum IgG4 may be present in multiple non-IgG4-RD conditions. However, a high serum IgG4 concentration is of great value for IgG4-RD diagnosis, and there appears to be a positive relationship between serum IgG4 levels and organ involvement in patients with IgG4-RD. Examining the IgG4/IgG ratio and serum IgG does not improve the ability of IgG4-RD diagnosis. PMID: 31354076 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - July 29, 2019 Category: Rheumatology Authors: Yang H, Li J, Wang Y, Ye S, Li J Tags: Scand J Rheumatol Source Type: research

Increased risk of osteoporotic fractures in Swedish patients with rheumatoid arthritis despite early treatment with potent disease-modifying anti-rheumatic drugs: a prospective general population-matched cohort study.
ersson M Abstract Objective: To study the difference in incidence and risk of fragility fractures between rheumatoid arthritis (RA) patients followed up early in the disease and the general population in Sweden; and the fracture risk changes in RA patients diagnosed in the 1990s and 2000s because of earlier, more potent pharmacological treatment in the later period. Method: Patients with early RA were recruited from the BARFOT cohort, a Swedish multicentre observational study of early RA patients (n = 2557). All patients fulfilled 1987 American College of Rheumatology criteria and were included between 1...
Source: Scandinavian Journal of Rheumatology - July 19, 2019 Category: Rheumatology Authors: Nyhäll-Wåhlin BM, Ajeganova S, Petersson IF, Andersson M Tags: Scand J Rheumatol Source Type: research

Personalized Rheumatic Medicine through Dose Reduction Reduces the Cost of Biological Treatment - a retrospective intervention analysis.
Conclusions: The results suggest that dose reduction can be safely performed in patients in treatment remission on a group level without compromising treatment efficacy. Subcutaneous bDMARDs, including abatacept, adalimumab, and etanercept, were observed to be well suited to customizing dosage. This study highlights the potential for individualized and personalized rheumatic medicine by providing dose reduction to individual patients, while monitoring disease activity. PMID: 31322029 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - July 19, 2019 Category: Rheumatology Authors: Meyer MK, Andersen M, Ring T, Andersen GN, Ehlers LH, Rasmussen C, Stensballe A Tags: Scand J Rheumatol Source Type: research

Addition or removal of concomitant methotrexate alters adalimumab effectiveness in rheumatoid arthritis but not psoriatic arthritis.
Conclusion: Addition of MTX to adalimumab confers further therapeutic benefit in patients with RA, but not in those with PsA, suggesting differences in MTX effects in these two patient populations. Clinicaltrials.gov NCT01078090, NCT01077258, NCT01111240. PMID: 31311386 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - July 16, 2019 Category: Rheumatology Authors: Behrens F, Koehm M, Schwaneck EC, Schmalzing M, Wittig BM, Gnann H, Greger G, Tony HP, Burkhardt H Tags: Scand J Rheumatol Source Type: research

Delayed onset of metronidazole-induced encephalopathy in a patient with systemic sclerosis accompanied by intestinal pseudo-obstruction.
PMID: 31307267 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - July 16, 2019 Category: Rheumatology Authors: Azuma N, Ohta M, Kageyama Y, Kawanaka Y, Matsui K Tags: Scand J Rheumatol Source Type: research

Repair of bone erosions in rheumatoid arthritis: a systematic literature review.
Conclusion: Repair of erosions does occur in RA. The definition and frequency of repair vary and the possible clinical relevance is unclear, motivating further studies. PMID: 31309850 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - July 16, 2019 Category: Rheumatology Authors: Forslind K, Svensson B Tags: Scand J Rheumatol Source Type: research

Dynamics of immunocyte activation during intravenous immunoglobulin treatment in Kawasaki disease.
Conclusions: Our results suggest that insufficient control of monocyte suppression and T-cell activation, especially in terms of the CD8-related immune system, are associated with IVIG resistance. The restoration of T-cell suppression may be important for KD recovery. These findings provide insight into the mechanism of IVIG resistance. PMID: 31272272 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - July 5, 2019 Category: Rheumatology Authors: Matsuguma C, Wakiguchi H, Suzuki Y, Okada S, Furuta T, Ohnishi Y, Azuma Y, Ohga S, Hasegawa S Tags: Scand J Rheumatol Source Type: research

New onset of psoriasis induced by secukinumab in a patient with ankylosing spondylitis: a case report.
PMID: 31262212 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - July 2, 2019 Category: Rheumatology Authors: Currado D, Margiotta D, Conforti C, Coppola R, Panasiti V, Afeltra A, Navarini L Tags: Scand J Rheumatol Source Type: research

Predictive values of anti-cyclic citrullinated peptide antibodies and rheumatoid factor in relation to serological aspects of the ACR/EULAR 2010 classification criteria for rheumatoid arthritis.
Conclusion: The PPV of ACPAs is higher than the PPV of IgM RF at 3 × UNL. These findings are not reflected in the ACR/EULAR 2010 classification criteria for RA. PMID: 31264518 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - July 2, 2019 Category: Rheumatology Authors: Tenstad HB, Nilsson AC, Dellgren CD, Lindegaard HM, Rubin KH, Lillevang ST Tags: Scand J Rheumatol Source Type: research

Effectiveness and safety of belimumab in patients with systemic lupus erythematosus in a real-world setting.
era R Abstract Objective: To investigate the effectiveness and safety of belimumab in patients with active systemic lupus erythematosus (SLE) in a real-life setting. Methods: All SLE patients treated with belimumab in the Department of Autoimmune Diseases of the Hospital Clinic of Barcelona were retrospectively analysed. The Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) score, clinical SLEDAI-2K, levels of anti-double-stranded DNA (anti-dsDNA) antibody, complement components C3 and C4, and 50% haemolytic complement activity (CH50) were recorded at baseline and at 6, 12, and 24 months. A...
Source: Scandinavian Journal of Rheumatology - July 2, 2019 Category: Rheumatology Authors: Anjo C, Mascaró JM, Espinosa G, Cervera R Tags: Scand J Rheumatol Source Type: research

Successful treatment with tocilizumab for massive ascites due to secondary amyloidosis complicating rheumatoid arthritis: a case report.
PMID: 31244353 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - June 27, 2019 Category: Rheumatology Authors: Shimagami H, Katada Y Tags: Scand J Rheumatol Source Type: research

Association of female sex and positive rheumatoid factor with low serum infliximab and anti-drug antibodies, related to treatment failure in early rheumatoid arthritis: results from the SWEFOT trial population.
Abstract Objective: Infliximab-treated patients with rheumatoid arthritis (RA) may respond insufficiently due to low serum infliximab (sIFX) levels, caused by anti-drug antibodies (ADAs). However, monitoring of sIFX and ADAs is not routinely implemented, and levels for optimal outcome have not been validated. We searched for predictors for sIFX  0.2 μg/mL]. The primary and secondary outcome measures were low disease activity [LDA = 28-joint Disease Activity Score (DAS28) ≤ 3.2] and remission (DAS28 
Source: Scandinavian Journal of Rheumatology - June 27, 2019 Category: Rheumatology Authors: Hambardzumyan K, Hermanrud C, Marits P, Vivar N, Ernestam S, Wallman JK, van Vollenhoven RF, Fogdell-Hahn A, Saevarsdottir S, SWEFOT study group Tags: Scand J Rheumatol Source Type: research

Risk factors for development and persistence of chronic widespread pain in spondyloarthritis: a population-based two-year follow-up study.
Conclusion: The prevalence of CWP remained high over time, but with individual transitions between the pain groups. The development and persistence of CWP were predicted by more pain and worse health, with the addition of female gender and higher age for persistent CWP. Special attention and treatment alternatives for patients with SpA and concomitant CWP are essential in the clinic. PMID: 31244357 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - June 27, 2019 Category: Rheumatology Authors: Mogard E, Lindqvist E, Bremander A, Bergman S Tags: Scand J Rheumatol Source Type: research

Effectiveness of resistance exercise in functional fitness in women with primary Sj ögren's syndrome: randomized clinical trial.
Effectiveness of resistance exercise in functional fitness in women with primary Sjögren's syndrome: randomized clinical trial. Scand J Rheumatol. 2019 Jun 27;:1-10 Authors: Minali PA, Pimentel C, de Mello MT, Lima G, Dardin LP, Garcia A, Goñi T, Trevisani V Abstract Objective: The purpose of this study was to analyse the effectiveness of resistance exercise in functional fitness in women with primary Sjögren's syndrome (pSS). Method: This is a randomized controlled clinical trial with 51 volunteers: 26 allocated to the exercise group (GEX) and 25 to the control group. The GEX underwe...
Source: Scandinavian Journal of Rheumatology - June 27, 2019 Category: Rheumatology Authors: Minali PA, Pimentel C, de Mello MT, Lima G, Dardin LP, Garcia A, Goñi T, Trevisani V Tags: Scand J Rheumatol Source Type: research

Complete atrioventricular block in a patient with systemic sclerosis.
PMID: 31220990 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - June 21, 2019 Category: Rheumatology Authors: Yang X, Qu L, Li Y, Li X Tags: Scand J Rheumatol Source Type: research

Cost-effectiveness of five different anti-tumour necrosis factor tapering strategies in rheumatoid arthritis: a modelling study.
Conclusion: Because our study showed a comparable iNMB for tapering in four or five steps (including discontinuation), we recommend a choice between these strategies, based on shared decision making. PMID: 31220991 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - June 21, 2019 Category: Rheumatology Authors: Verhoef LM, Bos D, van den Ende C, van den Hoogen F, Fautrel B, Hulscher ME, Kievit W, den Broeder AA Tags: Scand J Rheumatol Source Type: research

Hyperphosphataemic familial tumoral calcinosis: case report of a rare and challenging disease.
PMID: 31213107 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - June 19, 2019 Category: Rheumatology Authors: Guerra MG, Videira T, de Fonseca D, Vieira R, Dos Santos J, Pinto S Tags: Scand J Rheumatol Source Type: research