Ballet foot in a boy
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 8, 2021 Category: Rheumatology Authors: Teresa Giani, Maurizio Gattinara, Rolando Cimaz Tags: APLAR GRAND ROUND CASE Source Type: research

Your help is needed in the fight against COVID ‐19: Please contribute to the COVID‐19 Global rheumatology alliance registry
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 6, 2021 Category: Rheumatology Tags: APLAR MATTERS Source Type: research

Issue Information
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 5, 2021 Category: Rheumatology Tags: ISSUE INFORMATION Source Type: research

Cardiovascular comorbidity in rheumatic and musculoskeletal diseases: Where we are and how can we move forward?
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 5, 2021 Category: Rheumatology Authors: George D. Kitas, Theodoros Dimiroulas Tags: EDITORIAL Source Type: research

The pathophysiological effects of exercise in the management of idiopathic inflammatory myopathies: A scoping review
AbstractIdiopathic inflammatory myopathy (IIM) is a term used for a heterogeneous group of diseases characterized by severe muscle weakness. In addition to pharmacological treatment options, non ‐pharmacological methods such as exercising are essential for proper management of myositis. The present article aimed to provide an insight into the potential pathophysiological mechanisms underlying exercise‐related benefits in myositis. A systematic search was performed on PubMed/MEDLINE, Sco pus, Web of Science, and Google Scholar using the following keywords and their combinations: “idiopathic inflammatory myopathy&r...
Source: International Journal of Rheumatic Diseases - April 1, 2021 Category: Rheumatology Authors: Ilke Coskun Benlidayi, Latika Gupta Tags: REVIEW ARTICLE Source Type: research

Is denosumab associated with an increased risk for infection in patients with low bone mineral density? A systematic review and meta ‐analysis of randomized controlled trials
ConclusionDenosumab ‐treated patients with low bone mineral density have slightly increased incidence of SAEI compared with placebo, but not when compared with bisphosphonates. Application of these results requires consideration of the entire body of data available regarding denosumab safety. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 1, 2021 Category: Rheumatology Authors: Brett Catton, Salman Surangiwala, Tanveer Towheed Tags: ORIGINAL ARTICLE Source Type: research

Clinical characteristics of Vietnamese patients with idiopathic inflammatory myopathies and autoantibodies to aminoacyl ‐transfer RNA synthetases
ConclusionsDifferent aaRS autoantibody specificities may vary between different ethnic populations for reasons that still need to be clarified. Furthermore, the high frequency of pulmonary hypertension is noteworthy but otherwise clinical manifestations associated with aaRS autoantibodies did not differ from other ethnic populations. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 1, 2021 Category: Rheumatology Authors: Thuy Nguyen Thi Phuong, Lan Nguyen Thi Ngoc, Johan R önnelid, Leonid Padyukov, Ingrid E. Lundberg Tags: ORIGINAL ARTICLE Source Type: research

Polymorphism of genes involved in methotrexate pathway: Predictors of response to methotrexate therapy in Indian rheumatoid arthritis patients
ConclusionPolymorphisms ofATIC andITPA genes alone or with clinical variables were associated with response to MTX therapy in Indian RA patients. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 29, 2021 Category: Rheumatology Authors: Ankita Singh, Harikrishnan Gangadharan, Vikas Gupta, Pradeepta S. Patro, Ramnath Misra, Amita Aggarwal Tags: ORIGINAL ARTICLE Source Type: research

Association of F11R polymorphisms and gene expression with primary Sj ögren’s syndrome patients
ConclusionThe result indicated that G allele of ‐436A/G genotype has the potential protective effect against SS disease condition. F11R mRNA was expressed significantly lower in SS patients. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 29, 2021 Category: Rheumatology Authors: Tzu ‐Jung Fang, Ruei‐Nian Li, Yuan‐Zhao Lin, Chia‐Hui Lin, Chia‐Chun Tseng, Wan‐Yu Sung, Tsan‐Teng Ou, Cheng‐Chin Wu, Jeng‐Hsien Yen Tags: ORIGINAL ARTICLE Source Type: research

Increased malignancies in our Waikato cohort of patients with systemic sclerosis
ConclusionThis study found an increased risk of malignancy for patients within the Waikato SSc cohort. Risk was greater in male patients and the mean age of patients with malignancies was approximately 8  years older than those without malignancy. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 22, 2021 Category: Rheumatology Authors: Monique S. Rees, Chris Frampton, Douglas H. N. White, Kamal K. Solanki Tags: ORIGINAL ARTICLE Source Type: research

Association of serum CCL20 levels with pulmonary vascular involvement and primary biliary cholangitis in patients with systemic sclerosis
ConclusionSerum CCL20 levels may be involved in the development of pulmonary vascular involvement leading to pulmonary arterial hypertension and asymptomatic PBC in SSc patients. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 22, 2021 Category: Rheumatology Authors: Tetsuya Ikawa, Takuya Miyagawa, Yuki Fukui, Shun Minatsuki, Hisataka Maki, Toshiro Inaba, Masaru Hatano, Satoshi Toyama, Jun Omatsu, Kentaro Awaji, Yuta Norimatsu, Yusuke Watanabe, Ayumi Yoshizaki, Shinichi Sato, Yoshihide Asano Tags: ORIGINAL ARTICLE Source Type: research

Evaluating the strength of spinal and proximal girdle muscles in patients with axial spondyloarthritis: Correlation with activity, disability, and functionality
ConclusionAll muscle strengths were lower in patients compared to healthy volunteers. Strengthening specific muscle groups for the desired goal can be a reasonable strategy. The study is prospectively registered and available atwww.clinicaltrials.gov (NCT04435860). (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 22, 2021 Category: Rheumatology Authors: Ozan Volkan Yurdakul, Ozlenen Eylul Ince, Fatih Bagcier, Mert Kara, Esra Kultur, Teoman Aydin Tags: ORIGINAL ARTICLE Source Type: research

Joint hypermobility and its association with self ‐reported knee health: A cross‐sectional study of healthy Australian adults
AbstractAimThe primary aim of this study was to determine the association between generalized joint hypermobility (GJH), knee ‐specific hypermobility (KSH) and self‐reported knee health in an Australian population. Secondary aims included elucidating ethnic/gender differences in GJH/KSH prevalence and knee health, and identifying KSH using a novel knee extension range of motion cut‐off method.MethodKnee extension range, Beighton score, and 5 domains of the Knee Injury and Osteoarthritis Outcome Score (KOOS) were collected from adults aged 18 ‐101 years self‐identifying as healthy, and were grouped by ethnici...
Source: International Journal of Rheumatic Diseases - March 17, 2021 Category: Rheumatology Authors: Cliffton Chan, Haiwei H. Qi, Jennifer N. Baldwin, Marnee J. McKay, Joshua Burns, Leslie L. Nicholson Tags: ORIGINAL ARTICLE Source Type: research

High cost of illness in fibromyalgia patients in Iran, irrespective of disease severity: A prospective cost study
ConclusionFibromyalgia is associated with high health ‐related and non‐health‐related costs in our country, irrespective of its severity. This study warrants urgent consideration in managing the disease burden on both patients and society. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 17, 2021 Category: Rheumatology Authors: Faeze Gharibpoor, Elaheh Nasrollahzadeh, Banafshesh Gavidel ‐Parsa, Mohammad Ebrahim Ghaffari, Ali Bidari Tags: ORIGINAL ARTICLE Source Type: research

Are non ‐steroidal anti‐inflammatory drugs effective for acute low back pain? A Cochrane Review summary with commentary
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 16, 2021 Category: Rheumatology Authors: Farooq Azam Rathore, Ayesha Afridi Tags: COCHRANE CORNER Source Type: research

Left ventricular hypertrophy predicts poorer cardiovascular outcome in normotensive normoglycemic patients with rheumatoid arthritis
This study was designed to assess prevalence, predictors and prognostic role of LV hypertrophy (LVH) in a selected group of RA patients with normal blood pressure and glycemia who should be at low risk for LVH.MethodsWe prospectively analyzed 241 normotensive normoglycemic RA patients (mean age 53  ± 12 years, 61% women) involved in a primary prevention program for cardiovascular diseases who were followed‐up for 40 (24‐56) months. LVH was detected by echocardiography and defined as LV mass ≥49.2 g/m2.7 for men and ≥46.7 g/m2.7 for women. Primary outcome was a composite of cardiova...
Source: International Journal of Rheumatic Diseases - March 15, 2021 Category: Rheumatology Authors: Giovanni Cioffi, Ombretta Viapiana, Giovanni Orsolini, Federica Ognibeni Sonographer, Andrea Dalbeni, Davide Gatti, Giovanni Adami, Angelo Fassio, Maurizio Rossini, Alessandro Giollo Tags: ORIGINAL ARTICLE Source Type: research

Diagnostic value of anti ‐citrullinated α‐enolase peptide 1 antibody in patients with rheumatoid arthritis: A systematic review and meta‐analysis
ConclusionsThe anti ‐CEP 1 antibody had moderate RA diagnostic value with relatively low sensitivity and high specificity. An ELISA may increase the RA diagnostic sensitivity. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 13, 2021 Category: Rheumatology Authors: Haolong Li, Liubing Li, Chenxi Liu, Linlin Cheng, Songxin Yan, Haizhen Chen, Yongzhe Li Tags: REVIEW ARTICLE Source Type: research

Issue Information
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 12, 2021 Category: Rheumatology Tags: ISSUE INFORMATION Source Type: research

Slowly melting the urate snow in joints: Explaining gout attacks to patients
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 12, 2021 Category: Rheumatology Authors: Toru Shimizu, Matthew John Rooks Tags: EDITORIAL Source Type: research

Costs of disease: The perspective matters
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 12, 2021 Category: Rheumatology Authors: Casper Webers, Annelies Boonen, Bart Spaetgens Tags: EDITORIAL Source Type: research

Evaluation of an ankylosing spondylitis education and self ‐management program: Beneficial effects on ankylosing spondylitis specific outcomes
AbstractBackgroundSelf ‐management programs have demonstrated significant health benefits in people with musculoskeletal diseases.AimTo examine the benefits of a tailored ankylosing spondylitis self ‐management program (ASSMP) delivered by trained health professionals for people with ankylosing spondylitis (AS) relative to health status, quality of life and disease activity.MethodsASSMP was developed within a continuous quality improvement framework following a needs assessment and focus group discussions. Formal feedback from the group after each 6  week program cycle group by questionnaire helped refine the ASSM...
Source: International Journal of Rheumatic Diseases - March 12, 2021 Category: Rheumatology Authors: Charles A. Inderjeeth, Emma Boland, Clara Connor, Christina Johnson, Angela Jacques, Jean McQuade Tags: ORIGINAL ARTICLE Source Type: research

What is the effect of shock wave therapy in rotator cuff disease with or without calcification? A Cochrane Review summary with commentary
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 12, 2021 Category: Rheumatology Authors: Elena Ilieva, Aleksandra Ilieva Tags: COCHRANE CORNER Source Type: research

Your help is needed in the fight against COVID ‐19: Please contribute to the COVID‐19 Global Rheumatology Alliance Registry
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 12, 2021 Category: Rheumatology Tags: APLAR MATTERS Source Type: research

Issue Information
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 12, 2021 Category: Rheumatology Tags: APLAR MATTERS Source Type: research

Prevalence and risk factors for falls in patients with spondyloarthritis: A systematic review
ConclusionWe identified potentially modifiable risk factors associated with increased risk of falls in patients with SpA, including functional limitation, poor balance and mobility, fear of falling and active disease. Clinicians should recognize these factors and address them in the holistic management of patients with SpA, thereby reducing falls and their complications. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 11, 2021 Category: Rheumatology Authors: Grace Rui Si Lim, Caitlin Hsuen Ng, Yu Heng Kwan, Warren Fong Tags: ORIGINAL ARTICLE Source Type: research

Recent advances in pediatric rheumatology: October to December 2020
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 9, 2021 Category: Rheumatology Authors: Gummadi Anjani, Himanshi Chaudhary, Surjit Singh Tags: REVIEW Source Type: research

MiR ‐223‐3p and miR‐22‐3p inhibit monosodium urate‐induced gouty inflammation by targeting NLRP3
AbstractBackgroundMicroRNAs (miRNAs) have been shown to play a crucial role in inflammation regulation; however, their relationship with inflammation in acute gouty arthritis has not been fully elucidated. Herein, we conducted a study to explore the regulatory roles of miR ‐223‐3p and miR‐22‐3p in gouty‐associated inflammation.MethodsIn vitro and in vivo experiments were conducted to examine the molecular mechanisms of miRNA regulation in gouty inflammation. Dual ‐luciferase reporter assay was used to verify the direct target of miR‐223‐3p and miR‐22‐3p.ResultsWe found that miR ‐223‐3p and miR‐22...
Source: International Journal of Rheumatic Diseases - March 2, 2021 Category: Rheumatology Authors: Xiang Wang, Jingwei Chi, Bingzi Dong, Lili Xu, Yue Zhou, Yajing Huang, Shengnan Sun, Fanxiang Wei, Yuzhao Liu, Chuanfeng Liu, Kui Che, Wenshan Lv, Ying Chen, Yangang Wang Tags: ORIGINAL ARTICLE Source Type: research

The efficacy of manual soft ‐tissue mobilization in ankylosing spondylitis: A randomized controlled study
ConclusionWe recommend the use of soft ‐tissue mobilization in addition to the exercises to treat AS patients. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 1, 2021 Category: Rheumatology Authors: Elif Gur Kabul, Bilge Basakci Calik, Mucahit Oztop, Veli Cobankara Tags: ORIGINAL ARTICLE Source Type: research

Identification of serum interleukin ‐13 and interleukin‐13 receptor subunit expressions: Rheumatoid arthritis–associated interstitial lung disease
AbstractAim of the workTo identify the role of serum IL ‐13, and its receptor subunit expressions as a serologic marker of rheumatoid arthritis (RA)‐associated ILD (RA‐ILD).Patients and MethodsFifty RA patients with ILD and 50 RA patients without ILD were examined, in addition to 50 controls. Disease Activity Score in 28 joints (DAS ‐28), the Health Assessment Questionnaire (HAQ), and medication history were evaluated. ESR, CRP, RF, Anti‐CCP, Serum Krebs von den Lungen‐6 (KL‐6), surfactant protein D (SP‐D) levels, Interleukin 13 and its receptors (IL‐13 Rα1 and L‐13 Rα2), and mRNA relative e...
Source: International Journal of Rheumatic Diseases - February 27, 2021 Category: Rheumatology Authors: Manal Shawky Hussein, Amal Mohamad El ‐Barbary, Doaa Waseem Nada, Rasha Ahmad Gaber, Reham Mohamed Elkolaly, Marwa Ahmed Aboelhawa Tags: ORIGINAL ARTICLE Source Type: research

Comparison of relapse rates in Beh çet’s disease with venous involvement on different doses of azathioprine therapy, a retrospective observational study
AbstractAimThe aim of this study was to investigate relapse rates in azathioprine (AZA) maintenance therapy at different doses in Beh çet's disease (BD) with venous involvement.MethodClinical records of patients who met the diagnostic criteria of International Study Group (ISG) for BD, were diagnosed with venous involvement of BD for at least 6  months and sustained clinical remission with AZA for at least 3 months were analyzed retrospectively. The analysis cohort was divided into 2 groups based on AZA dose (Group A: ≥ 2 mg/kg/d and Group B:
Source: International Journal of Rheumatic Diseases - February 27, 2021 Category: Rheumatology Authors: Sinem Girgin, Seda Yurumez, Ahmet Omma, Selda Celik, Ozan Cemal Icacan, Cemal Bes, Nilufer Alpay ‐Kanitez Tags: ORIGINAL ARTICLE Source Type: research

Epigenetics of ankylosing spondylitis: Recent developments
AbstractAnkylosing spondylitis (AS) is a chronic inflammatory autoimmune disease which mainly affects the spine, sacroiliac joint and peripheral joints. To date, the exact causes and pathogenesis of AS still remain unknown. It is considered that the pathogenesis of AS is associated with genetic, infection, environment, immunity and other factors. Among them, the role of genetic factors in the pathogenesis of AS has been studied most deeply. However, over the past few years, the function of environmental predisposition and epigenetic modification in the pathogenesis of AS has received extensive attention. This paper summari...
Source: International Journal of Rheumatic Diseases - February 20, 2021 Category: Rheumatology Authors: Hui Yang, Yuting Chen, Wei Xu, Ming Shao, Jixiang Deng, Shanshan Xu, Xing Gao, Shiyang Guan, Jinian Wang, Shengqian Xu, Zongwen Shuai, Faming Pan Tags: REVIEW Source Type: research

Erratum
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - February 12, 2021 Category: Rheumatology Tags: ERRATUM Source Type: research

Musculoskeletal sarcoidosis: A single center experience over 15 years
ConclusionWe identified a large cohort of MSK sarcoidosis and determined the prevalence of all 4 subtypes. In patients who do develop MSK manifestations of sarcoidosis, they are commonly a part of the initial presentation of sarcoidosis. There is an unmet need to establish standardized classification criteria for the 4 MSK sarcoidosis syndromes. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - February 11, 2021 Category: Rheumatology Authors: Sanjeev Patil, Carolyn A. Hilliard, Masumi Arakane, Sreedevi Koppisetti Jenigiri, Elizabeth H. Field, Namrata Singh Tags: ORIGINAL ARTICLE Source Type: research

Comparison of baseline laboratory findings of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis and multisystem inflammatory syndrome in children
AbstractAimsRecently, multisystem inflammatory syndrome in children (MIS ‐C) has been recognized in association with coronavirus disease 2019 as a cytokine storm syndrome. MIS‐C presents with symptoms similar to Kawasaki disease and macrophage activation syndrome (MAS). We aimed to better understand this cytokine storm syndrome by comparing the initial laboratory fin dings of MIS‐C and MAS.MethodsPatients who were diagnosed with MAS due to systemic juvenile idiopathic arthritis in our clinic between March 2002 and November 2020 and with MIS ‐C between 20 September and 20 October 2020 were enrolled into the study. T...
Source: International Journal of Rheumatic Diseases - February 7, 2021 Category: Rheumatology Authors: Fatma Ayd ın, Elif Çelikel, Zahide Ekici Tekin, Serkan Coşkun, Müge Sezer, Cüneyt Karagöl, Melike Mehveş Kaplan, Nilüfer Tekgöz, Tuba Kurt, Serhan Özcan, Ahmet Vedat Kavurt, Aslınur Özkaya Parlakay, Banu Çelikel Acar Tags: ORIGINAL ARTICLE Source Type: research

Association of the genetic variants in the endoplasmic reticulum aminopeptidase 2 gene with ankylosing spondylitis susceptibility
ConclusionsERAP2 gene rs2287988 and rs17408150 SNPs are associated with susceptibility to AS, but they are probably not determining the levels of IL ‐17A, IL‐23, and IL‐10 in this disease. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - February 7, 2021 Category: Rheumatology Authors: Mehrdad Ebrazeh, Fatemeh Ezzatifar, Shahram Torkamandi, Fatemeh Sadat Mohammadi, Sevda Salimifard, Arezoo Gowhari Shabgah, Maryam Hemmatzadeh, Saeed Aslani, Farhad Babaie, Farhad Jadidi ‐Niaragh, Jamshid Gholizadeh Navashenaq, Hamed Mohammadi Tags: ORIGINAL ARTICLE Source Type: research

Autoantibodies in severe COVID ‐19‐related acute respiratory distress syndrome: Just innocent bystanders?
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - February 4, 2021 Category: Rheumatology Authors: Michele Umbrello, Stefano Nespoli, Eleonora Pisano, Cecilia Bonino, Stefano Muttini Tags: CORRESPONDENCES Source Type: research

Utility of magnetic resonance imaging in Crohn's associated sacroiliitis: A cross ‐sectional study
ConclusionThere were 12% ‐18% of CD patients who had MRI evidence of sacroiliitis, which was not associated with back pain, CD activity or serologic measures. This data suggests that MRI is a useful modality to identify subclinical sacroiliitis in CD patients. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - February 2, 2021 Category: Rheumatology Authors: Fardina Malik, Ellen Scherl, Ulrich Weber, John A. Carrino, Madeline Epsten, Stephanie Wichuk, Susanne J. Pedersen, Joel Paschke, Sergio Schwartzman, Georg Kroeber, Walter P. Maksymowych, Randy Longman, Lisa A. Mandl Tags: ORIGINAL ARTICLE Source Type: research

Assessment of the anti ‐rheumatoid arthritis activity of Gastrodia elata (tian‐ma) and Radix aconitic lateralis preparata (fu‐zi) via network pharmacology and untargeted metabolomics analyses
ConclusionsThe anti ‐RA properties of Tian‐Ma and Fu‐Zi are associated with the inhibition of arachidonic acid metabolism pathway. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - February 1, 2021 Category: Rheumatology Authors: Jie Yang, Yu Zhang, Wei ‐Hong Li, Bu‐Fa Guo, Qi‐Lun Peng, Wei‐Yi Yao, Di‐Hong Gong, Wei‐Jun Ding Tags: ORIGINAL ARTICLE Source Type: research