Association between Graves' disease and risk of incident systemic lupus erythematosus: A nationwide population ‐based cohort study
ConclusionThis study shows that Graves' disease is associated with an increased risk of incident SLE. Further studies on the underlying pathogenesis linking Graves' disease and SLE are warranted. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - November 19, 2020 Category: Rheumatology Authors: Cho Lee, Shih ‐Fen Chen, Yu‐Cih Yang, Chung Y. Hsu, Yu‐Chih Shen Tags: ORIGINAL ARTICLE Source Type: research

MiR ‐221‐5p is involved in the regulation of inflammatory responses in acute gouty arthritis by targeting IL‐1β
ConclusionsThis study confirmed that miR ‐221‐5p regulates the production of inflammatory cytokines during the pathogenesis of AGA. These results suggested that miR‐221‐5p could be used as a potential therapeutic target for the treatment of AGA. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - November 17, 2020 Category: Rheumatology Authors: Guangwen Li, Huihui Zhang, Hong Ma, Shiping Qu, Qian Xing, Ge Wang Tags: ORIGINAL ARTICLE Source Type: research

Is being barefoot, wearing shoes and physical activity associated with knee osteoarthritis pain flares? Data from a usually barefoot Sri Lankan cohort
AbstractAimTo identify the association between hours of being barefoot/wearing footwear, physical activity (PA) and knee osteoarthritis pain flares (KOAF).MethodsPersons with a diagnosis of knee osteoarthritis, who reported previous KOAF, were followed up in a 3  months long telephone‐based case‐crossover study. Exposures to risk factors were assessed every 10 days and whenever the participants experienced a KOAF. Conditional logistic regression examined associations of KOAF with following: hours of being barefoot/using footwear and PA performed (P 
Source: International Journal of Rheumatic Diseases - November 16, 2020 Category: Rheumatology Authors: Inoshi Atukorala, Arunasalam Pathmeswaran, Nishamani Batuwita, Nimesha Rajapaksha, Vishmi Ratnasiri, Lalith Wijayaratne, Monika De Silva, Thashi Chang, Yuqing Zhang, David John Hunter Tags: ORIGINAL ARTICLE Source Type: research

Effect of radiographic disease severity in high ‐resolution quantitative computed tomography assessment of metacarpophalangeal joint erosion and cysts
ConclusionThe detection of cortical interruptions is only minimally affected by the degree of erosive damage, whereas the distinction between erosions and cysts is more complex in patients with extensive erosive disease. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - November 10, 2020 Category: Rheumatology Authors: Anne ‐Birgitte Garm Blavnsfeldt, Rasmus Klose‐Jensen, Jesper Thygesen, Philip Therkildsen, Bente Lomholdt Langdahl, Kresten Krarup Keller, Ellen‐Margrethe Hauge Tags: ORIGINAL ARTICLE Source Type: research

Joint damage in rheumatoid arthritis: Lessons learned from an extended 36 ‐joint ultrasonography and 28‐joint Disease Activity Score assessments
AbstractAimTo study joint damage severity in rheumatoid arthritis (RA) patients classified using ultrasound power Doppler (PD) and gray ‐scale (GS) joint inflammation outcomes and the 28‐joint Disease Activity Score (DAS28).MethodUltrasound erosion scores were compared between (a) patients in group 1 (PD positive and GS  ≥ median score), group 2 (PD negative and GS ≥ median score) and group 3 (PD positive and GS 
Source: International Journal of Rheumatic Diseases - November 7, 2020 Category: Rheumatology Authors: York Kiat Tan, HuiHua Li, John Carson Allen, Julian Thumboo Tags: ORIGINAL ARTICLE Source Type: research

Role of exosome in autoimmunity, with a particular emphasis on rheumatoid arthritis
AbstractCell ‐derived exosomes are identified as carriers of lipids, proteins, and genetic materials that participate in cell‐cell signal communication, biological process, and cell signaling. Also, their involvement has been reported in a vast array of disorders and inflammatory conditions such as autoimmun e diseases. Rheumatoid arthritis (RA), a common cause of joint disorder, is an inflammation‐based disease in which the precise understanding of its pathogenesis needs to be further investigated. Also, there is only a palliative care approach for the alleviation of RA symptoms. This paper discusses the recent adva...
Source: International Journal of Rheumatic Diseases - November 7, 2020 Category: Rheumatology Authors: Alireza Hejrati, Bahare Hasani, Mozhgan Esmaili, Davood Bashash, Naeimeh Tavakolinia, Parisa Zafari Tags: REVIEW Source Type: research

Are down ‐titration and discontinuation strategies of tumour necrosis factor–blocking agents for rheumatoid arthritis in patients with low disease activity possible? ‐ A Cochrane Review summary with commentary
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - November 6, 2020 Category: Rheumatology Authors: Giovanni Morone Tags: COCHRANE CORNER Source Type: research

Did Sejong the Great have ankylosing spondylitis? The oldest documented case of ankylosing spondylitis
ConclusionsBased on the analysis of official documentation, the author argues that there is a high probability that Sejong suffered from ankylosing spondylitis, making this the oldest officially documented case of the disease. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - November 6, 2020 Category: Rheumatology Authors: JiHwan Lee Tags: ORIGINAL ARTICLE Source Type: research

Incidence of giant cell arteritis after bisphosphonate exposure: A retrospective cohort study
ConclusionThe incidence of GCA after bisphosphonate injection was not increased compared to the generally reported incidence in the USA. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - November 5, 2020 Category: Rheumatology Authors: Salman Bin Mahmood, Yuanyuan Ji, Yi Peng, Zaki Abou Zahr Tags: ORIGINAL ARTICLE Source Type: research

A practical guide to interpreting and applying systematic reviews of qualitative studies in rheumatology
AbstractWhile patient ‐centered care is widely advocated in the management of rheumatic diseases, it can be challenging to implement, particularly for patients with complex systemic conditions. Patient‐centered care involves identifying and integrating the patient's experiences, attitudes, and preferences in decision ‐making. Qualitative research is used to describe patient perspectives and priorities that may not always be expressed in clinical settings. Systematic reviews of qualitative studies can provide new and more comprehensive evidence of patients' beliefs and priorities across different populations an d heal...
Source: International Journal of Rheumatic Diseases - November 5, 2020 Category: Rheumatology Authors: Daniel Sumpton, Ayano Kelly, David Tunnicliffe, Jonathan C. Craig, Chandana Guha, Geraldine Hassett, Allison Tong Tags: REVIEW Source Type: research

Clinical implications of synovial fluid specimen handling for crystal associated arthritides: A systematic review
ConclusionMonosodium urate crystals remain stable over time independent of storage time, temperature and preservative. CPP crystals are mostly stable for 24 ‐48 hours but can deteriorate with time. Overall, SF crystal examination should ideally be done within 24‐48 hours. They may be stored at room temperature without any preservative. Otherwise, refrigeration (4°C/39°F) and EDTA preservation is reasonable. Stored SF re‐examination, at 24 hou rs, helps identify a small number of additional MSU and CPP cases. Centrifugation techniques allow better and easier crystal identification, particularly ...
Source: International Journal of Rheumatic Diseases - November 5, 2020 Category: Rheumatology Authors: Megan M. Meyer, Lisa A. Marks, Fawad Aslam Tags: REVIEW ARTICLE Source Type: research

Anti ‐carbamylated protein and peptide antibodies as potential inflammatory joint biomarkers in the relatives of rheumatoid arthritis patients
ConclusionThe presence of anti ‐FCS‐Carp, anti‐Ca‐Fib3 and anti‐Ca‐Fib2 antibodies may have a role for these antibodies as early biomarkers in the development of RA, probably including additional mechanisms related with other non‐SE alleles; the anti‐peptide antibodies proposed in the present study may represent a simpler way to identify antibodies directed to a specific target. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - November 4, 2020 Category: Rheumatology Authors: Lorena Chila ‐Moreno, Luz‐Stella Rodríguez, Wilson Bautista‐Molano, Juan‐Manuel Bello‐Gualtero, Alejandro Ramos‐Casallas, Consuelo Romero‐Sánchez Tags: ORIGINAL ARTICLE Source Type: research

Association of MBL2 gene polymorphisms and systemic lupus erythematosus susceptibility: A meta ‐analysis
This study aimed to explore whetherMBL2 A\B, A\C, A\D, A\O, L\H and Y\X polymorphisms affected SLE susceptibility.MethodsA meta ‐analysis was performed on 20 studies, containing allelic contrast, additive, dominant and recessive models. Odds ratio (OR) was calculated to reflect the effect of association.ResultsA total of 64 pooled comparisons were conducted, including 7194 SLE patients and 7401 healthy controls. The meta ‐analysis inducted a significant association between allele B and SLE (OR = 0.766, 95% CI = 0.681‐0.862,P 
Source: International Journal of Rheumatic Diseases - November 4, 2020 Category: Rheumatology Authors: Zhi ‐Chao Yuan, Wang‐Dong Xu, You‐Yu Lan, Jia‐Min Wang, Qian Wu, Jie Zhou, An‐Fang Huang Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
International Journal of Rheumatic Diseases, Volume 23, Issue S1, Page 1-2, October 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - November 2, 2020 Category: Rheumatology Tags: Issue Information Source Type: research

Author Index
International Journal of Rheumatic Diseases, Volume 23, Issue S1, Page 354-367, October 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - November 2, 2020 Category: Rheumatology Tags: Author index Source Type: research

Poster Abstracts
International Journal of Rheumatic Diseases, Volume 23, Issue S1, Page 109-353, October 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - November 2, 2020 Category: Rheumatology Tags: ABSTRACT Source Type: research

Oral Abstracts
International Journal of Rheumatic Diseases, Volume 23, Issue S1, Page 3-108, October 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - November 2, 2020 Category: Rheumatology Tags: ABSTRACT Source Type: research

Cricopharyngeal bar and dermatomyositis: A cause of rapidly progressive dysphagia
ConclusionDysphagia associated with IIM can be multifactorial, and can be due to the involvement of the muscles of swallowing in the inflammatory process, or due to restrictive pharyngeal defects, and determination of the cause of dysphagia can assist with management. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - November 1, 2020 Category: Rheumatology Authors: Cameron Louis Adams, Siobhan Lohan, Alana Bruce, Narainraj Kamalaraj, Shyamini Gunaratne, Ray White Tags: APLAR Grand Round Case Source Type: research

Development of a Bangla version of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Bath Ankylosing Spondylitis Functional Index (BASFI)
ConclusionsBangla version of BASDAI and BASFI may be useful in disease activity and functional ability assessment in AS patients. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - November 1, 2020 Category: Rheumatology Authors: Syed Jamil Abdal, Sabrina Yesmin, Md. Nahiduzzamane Shazzad, Mohammad Abul Kalam Azad, Md. Abu Shahin, Minhaj Rahim Choudhury, Md. Nazrul Islam, Syed Atiqul Haq Tags: ORIGINAL ARTICLE Source Type: research

Does acupuncture improve pain and function in people with hip osteoarthritis? A Cochrane Review summary with commentary
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 29, 2020 Category: Rheumatology Authors: Soo Chin Chan, Julia Patrick Engkasan Tags: COCHRANE CORNER Source Type: research

A letter: Responding to questions from Li and colleagues
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 28, 2020 Category: Rheumatology Authors: Decai Wang Tags: CORRESPONDENCE Source Type: research

Evaluation of cognitive function in adult patients with juvenile idiopathic arthritis
AbstractObjectiveTo evaluate cognitive function in adult patients with juvenile idiopathic arthritis (JIA) and associated factors.Patients and methodsWe performed a cross ‐sectional observational study of adult patients with JIA and a healthy control group (no inflammatory diseases) matched for age, gender, and educational level. Cognitive function was assessed using Wechsler Adult Intelligence Scale‐III. The cognitive domains measured were attention/concentratio n, verbal function, visuospatial organization, working memory, and problem solving (Similarities). Other measures included clinical‐epidemiological characte...
Source: International Journal of Rheumatic Diseases - October 28, 2020 Category: Rheumatology Authors: Natalia Mena ‐Vázquez, Pablo Cabezudo‐García, Fernando Ortiz‐Márquez, Gisela Díaz‐Cordovés Rego, Luis Muñoz‐Becerra, Sara Manrique‐Arija, Antonio Fernández‐Nebro Tags: ORIGINAL ARTICLE Source Type: research

Vaspin deficiency failed to promote the proliferation of BMSCs in osteoarthritis
This study included 15 non ‐obese elderly patients with severe knee OA and 15 non‐obese controls with femoral neck fracture. Patients all underwent hip or knee arthroplasty surgery to restore joint shape and function. Bone marrow samples were taken during surgery to estimate vaspin and transforming growth factor (TGF)‐β 1 levels by enzyme‐linked immunosorbent assay and to observe the effect of vaspin on BMSCs proliferation by Cell Counting Kit‐8. Real‐time polymerase chain reaction and western blot were performed to evaluate the effect of vaspin on the genes and proteins of Akt involved in the PI3K/AKT sig...
Source: International Journal of Rheumatic Diseases - October 27, 2020 Category: Rheumatology Authors: Junfeng Wang, Zhongqiang Chen, Zhenpeng Guan Tags: ORIGINAL ARTICLE Source Type: research

Diagnostic accuracy of 14 ‐3‐3η protein in rheumatoid arthritis: A meta‐analysis
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 26, 2020 Category: Rheumatology Authors: Linhui Li, Jian Chen, Yongmei Jiang Tags: CORRESPONDENCE Source Type: research

Is methotrexate effective and safe in patients with psoriatic arthritis? A Cochrane Review summary with commentary
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 22, 2020 Category: Rheumatology Authors: Frane Grubi šić Tags: COCHRANE CORNER Source Type: research

Survival and causes of death for Takayasu ’s arteritis in Korea: A retrospective population‐based study
AbstractObjectiveFew studies have evaluated survival of Takayasu's arteritis (TAK; M31.4) in Korea. The purpose of this study was to assess the survival rate (SR) and causes of death for TAK.MethodsNewly diagnosed TAK data (N  = 2731) were collected from the National Health Insurance Service in Korea from 2006 through 2017. The Kaplan‐Meier method was used. Korean death data was used from 2006 through 2018.ResultsThe mean age was 48.1 ( ±16.9) years. The proportion of female patients was 74.4%. The most common cause of death in TAK was diseases of the circulatory system. The 1‐, 3‐, 5‐, and 10‐ye...
Source: International Journal of Rheumatic Diseases - October 22, 2020 Category: Rheumatology Authors: Shin Yi Jang, Taek Kyu Park, Duk ‐Kyung Kim Tags: ORIGINAL ARTICLE Source Type: research

YouTube for information about side effects of biologic therapy: A social media analysis
AbstractObjectiveBiologic therapies are one of the most significant breakthroughs in the treatment of rheumatic diseases, although there is still some uncertainty surrounding long ‐term patient safety. Recently, a growing number of patients browse the Internet as a source of health‐related information. We aimed to assess the quality of information available on YouTube videos regarding the side effects of biologic therapy.MethodsWe used the keywords “biologic therapy side effects,” “biologic therapy risks,” “biologic therapy safety,” “biologic agents side effects,” “...
Source: International Journal of Rheumatic Diseases - October 22, 2020 Category: Rheumatology Authors: Orhan Zengin, Mustafa Erkut Onder Tags: ORIGINAL ARTICLE Source Type: research

Subclinical atherosclerosis in systemic sclerosis: Different risk profiles among patients according to clinical manifestations
AbstractIntroductionLike other autoimmune diseases, systemic sclerosis (SSc) has been described to be associated with accelerated atherosclerosis (ATS). Before clinical manifestations of cardiovascular disease (CVD) occur, subclinical ATS can be investigated in different ways.AimTo evaluate the presence of subclinical ATS in a group of patients with SSc, and to identify different risk profiles among patients.MethodsSubclinical ATS was reviewed in 43 SSc patients and 27 healthy controls, using 2 methods: carotid ultrasound and flow mediated dilation (FMD) of the brachial artery.ResultsPlaques were statistically more frequen...
Source: International Journal of Rheumatic Diseases - October 19, 2020 Category: Rheumatology Authors: Iliana Sciarra, Massimiliano Vasile, Alessia Carboni, Katia Stefanantoni, Nicoletta Iannace, Carlotta Angelelli, Antongiulio G. Scarno, Guido Valesini, Valeria Riccieri Tags: ORIGINAL ARTICLE Source Type: research

Fibromyalgia in patients with psoriatic arthritis: Impact on disease activity indices, fatigue and health ‐related quality of life
ConclusionThese results might highlight the importance of considering FM as a contextual factor in disease activity assessment in patients with PsA, especially in those with discrepancies in tender joint count/patient ‐reported outcomes vs SJC/inflammatory markers and those with persistently high disease activity indices. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 19, 2020 Category: Rheumatology Authors: Noha A. Elsawy, Abdel ‐Moneim H. Helal, Hala A. Abd ElHamid, Yousra Hisham Abdel‐Fattah Tags: ORIGINAL ARTICLE Source Type: research

Investigation of the relationship between the pelvic floor and sexual dysfunction in women with Sj ögren’s syndrome
ConclusionAccording to the study results, as the disease duration increases, the distress increases and this distress has a negative effect on the health ‐related quality of life of these women. Pelvic floor distress was associated with poor sexual function and pain. From these results, it can be recommended that the methods of pharmacology, education, exercise, relaxation, lifestyle change, and so on for pelvic floor dysfunction and pain in women with SS should be applied together with a multidisciplinary approach. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 17, 2020 Category: Rheumatology Authors: Sebahat Yaprak Cetin, Alime Buyuk, Ayse Ayan Tags: ORIGINAL ARTICLE Source Type: research

Delay in seeking medical help in patients with rheumatoid arthritis in India: A qualitative study
ConclusionThis is the first qualitative study which explored perceptions and experiences of RA patients in India resulting in delay. Improved provision of rheumatology care, effective referral system and greater involvement of government at local and national levels are needed to improve the delay in seeking medical help for Indian patients. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 17, 2020 Category: Rheumatology Authors: Avinash Jain, Amita Aggarwal, Jo Adams, Rachel E. Jordan, Steven Sadhra, Shirish Dubey, Kerry Allen, Kanta Kumar Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
International Journal of Rheumatic Diseases, Volume 23, Issue 10, Page 1265-1268, October 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 15, 2020 Category: Rheumatology Tags: ISSUE INFORMATION Source Type: research

APLAR Matters
International Journal of Rheumatic Diseases, Volume 23, Issue 10, Page 1433-1434, October 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 15, 2020 Category: Rheumatology Tags: APLAR Matters Source Type: research

Controversies and advances in connective tissue disease ‐related pulmonary arterial hypertension
International Journal of Rheumatic Diseases, Volume 23, Issue 10, Page 1269-1275, October 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 15, 2020 Category: Rheumatology Authors: Kathleen Morrisroe, Mandana Nikpour Tags: EDITORIAL Source Type: research

Are corticosteroids effective as adjunctive therapy in children with septic arthritis? A Cochrane Review summary with commentary
International Journal of Rheumatic Diseases, Volume 23, Issue 10, Page 1426-1429, October 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 15, 2020 Category: Rheumatology Authors: Alessandro Sire, Tags: COCHRANE CORNER Source Type: research

Your help is needed in the fight against COVID ‐19: Please contribute to the COVID‐19 Global Rheumatology Alliance Registry
International Journal of Rheumatic Diseases, Volume 23, Issue 10, Page 1432-1432, October 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 15, 2020 Category: Rheumatology Tags: APLAR MATTERS Source Type: research

Elevation of cytomegalovirus antigenemia predicts serious infection and death in patients receiving immunosuppressive therapies for autoimmune diseases
ConclusionWe suggest that the counts of CMV Ag MAX can reflect the extent of compromise in the immune system, and can be a predictive marker for serious infections and death. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 14, 2020 Category: Rheumatology Authors: Risa Yoshihara, Toshihiko Komai, Hirofumi Shoda, Keishi Fujio Tags: ORIGINAL ARTICLE Source Type: research

Neutrophil to lymphocyte ratio predicts glucocorticoid resistance in polymyalgia rheumatica
ConclusionBaseline NLR can predict glucocorticoid resistance in newly diagnosed PMR patients. Both NLR and PLR may be reliable biomarkers of disease activity in PMR. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 12, 2020 Category: Rheumatology Authors: Claire E. Owen, Christopher McMaster, David F. L. Liew, Jessica L. Leung, Andrew M. Scott, Russell R. C. Buchanan Tags: ORIGINAL ARTICLE Source Type: research

Chinese registry of rheumatoid arthritis (CREDIT): III. The transition of disease activity during follow ‐ups and predictors of achieving treatment target
This study aimed at presenting disease activities transition during follow‐ups and identifying predictors to treatment response.MethodPatients who had baseline, 3 ‐ and 6‐month follow‐up data from November 2016 to April 2018 were recruited. Then, we selected patients who did not reach remission (REM)/low disease activity (LDA) at baseline to investigate the predictors for treatment response.ResultsThere were 979 patients included (83.00% female, mean age 51.8 and median duration 3.84  years). REM/LDA rate at baseline, 3‐, and 6‐month follow‐up were 34.02%, 59.35% and 68.23%. Additionally, early RA has mo...
Source: International Journal of Rheumatic Diseases - October 9, 2020 Category: Rheumatology Authors: Yirong Xiang, Qian Wang, Hongbin Li, Xinwang Duan, Yongfei Fang, Pingting Yang, Qin Li, Rui Wu, Yuehong Huo, Xiaofei Shi, Zhenbiao Wu, Yanhong Wang, Nan Jiang, Evelyn Hsieh, Mengtao Li, Xinping Tian, Xiaofeng Zeng, Chinese Registry of Rhe Tags: ORIGINAL ARTICLE Source Type: research

Disease severity affects myocardial functions in patients with treatment ‐naive early rheumatoid arthritis
AbstractObjectivesThe cross ‐sectional study aimed to assess myocardial functions using global longitudinal strain (GLS) echocardiography and arrhythmia parameters with treatment naive newly diagnosed rheumatoid arthritis (RA) and no clinical evidence of cardiovascular disease (CVD).MethodsSeventy seven newly diagnosed treatment ‐naive RA patients were enrolled. Disease severity was evaluated according to rheumatoid factor (RF) and anti‐citrullinated protein antibodies (ACPA) positivity, and Disease Activity Score 28 C‐reactive protein (DAS28 CRP). Myocardial functions were assessed using conventional echocardiogra...
Source: International Journal of Rheumatic Diseases - October 7, 2020 Category: Rheumatology Authors: Ender Özgün Çakmak, Uğur Fındıkçıoğlu, Mehmet Engin Tezcan Tags: ORIGINAL ARTICLE Source Type: research

Somatosensory dysfunction related neuropathic pain component affects disease activity, functional status and quality of life in ankylosing spondylitis
ConclusionsOur results revealed that the presence of NP component in patients with AS is associated with various disease ‐related variables, including pain, high disease activity, reduced mobility of the axial skeleton, depression and poor quality of life. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 7, 2020 Category: Rheumatology Authors: Emel Atar, Ayhan Askin Tags: ORIGINAL ARTICLE Source Type: research

Recognition of spondyloarthritis lesions on magnetic resonance imaging: Results of an educational intervention
ConclusionMRI training workshops in SpA allow rheumatologists to improve recognition of acute inflammatory and structural lesions. The long ‐term effects of such training need further evaluation. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 5, 2020 Category: Rheumatology Authors: Rodrigo Garcia Salinas, Josefina Marin, Gabriel Aguilar, Santiago Ruta, Dario Aguerre, Xenofon Baraliakos Tags: Original Article Source Type: research

Interleukin ‐17A biomarker as a predictor for detection of early axial spondyloarthritis changes in patients with psoriasis
ConclusionOur study can imply that IL ‐17A is a valuable, useful and low‐cost biomarker in detecting early axial SpA changes in asymptomatic and nonradiographic axial SpA (nr‐axial SpA) psoriatic patients that helps early management and prevent progressive axial involvement and disabilities. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 4, 2020 Category: Rheumatology Authors: Dalia S. Saif, Mohamed A. El Tabl, Naglaa Afifi, Mahmoud S. Abdallah, Sally M. El Hefnawy, Shimaa A. Hassanein Tags: ORIGINAL ARTICLE Source Type: research

Prevalence of patients with rheumatoid arthritis and age ‐stratified trends in clinical characteristics and treatment, based on the National Database of Health Insurance Claims and Specific Health Checkups of Japan
ConclusionThe estimated prevalence of patients with RA in Japan was 0.65%. Age ‐stratified treatment trends and clinical characteristics have been described in a super‐aged society for the first time. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 4, 2020 Category: Rheumatology Authors: Ayako Nakajima, Ryoko Sakai, Eisuke Inoue, Masayoshi Harigai Tags: ORIGINAL ARTICLE Source Type: research

C1QTNF4 gene p.His198Gln mutation is correlated with early ‐onset systemic lupus erythematosus in Iranian patients
ConclusionOur results suggest that this mutation (p.His198Gln) potentially has an important role in SLE risk in the Iranian population. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 1, 2020 Category: Rheumatology Authors: Bahram Pakzad, Reza Shirpour, Maryam Mousavi, Hadi Karimzadeh, Amirhossein Salehi, Mehdi Kazemi, Guilda Amini, Mojtaba Akbari, Rasoul Salehi Tags: ORIGINAL ARTICLE Source Type: research

Relationship of Wnt pathway activity and organ involvement in scleroderma types
ConclusionWnt ‐1 and Wnt‐2 were found higher in scleroderma and organ involvement. They may play a role in the pathogenesis of the disease. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - September 29, 2020 Category: Rheumatology Authors: Ay şe Koçak, Duygu Harmancı, Gül Güner Akdoğan, Merih Birlik Tags: ORIGINAL ARTICLE Source Type: research

Risk factors correlated with immunosuppressant discontinuation in antineutrophil cytoplasmic antibody ‐associated vasculitis patients
AbstractAimThe use of an immunosuppressant is recommended as a treatment for remission induction in anti ‐neutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV). However, the immunosuppressant is sometimes discontinued due to an adverse event. We sought to identify the cause and risk factors for immunosuppressant discontinuation in patients with AAV receiving remission induction treatment.MethodsWe retrospectively analyzed the cases of AAV patients treated in 2005 ‐2016 with immunosuppressants to induce remission. We defined “discontinuation” as stopping, switching, or delaying immunosuppressa...
Source: International Journal of Rheumatic Diseases - September 29, 2020 Category: Rheumatology Authors: Takamasa Murosaki, Takeo Sato, Katsuya Nagatani, Kojiro Sato, Seiji Minota Tags: ORIGINAL ARTICLE Source Type: research

Evaluation of inflammatory rheumatic diseases from an emergency medicine perspective
ConclusionsOur study found that visits to the ED by patients with inflammatory rheumatic diseases were classified as urgent or less urgent. Patients with rheumatoid arthritis were the most numerous ED visitors. Vasculitis was the most common cause of hospitalization in the wards and scleroderma was the most common cause of hospitalization in the ICU and death. This suggests that ED physicians should be aware of these patients. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - September 29, 2020 Category: Rheumatology Authors: Ishak San, Abdulsamet Erden, Emin Gemcioglu, Orhan K ücüksahin Tags: ORIGINAL ARTICLE Source Type: research

Predictors of glucocorticoid ‐free remission in patients with polymyalgia rheumatica treated with prednisolone
ConclusionThe normalization of CRP within 1  month from baseline predicted GC‐free remission in PMR patients treated with PSL, and resulted in a lower cumulative PSL dose. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - September 29, 2020 Category: Rheumatology Authors: Kyosuke Hattori, Yuji Hirano, Toshihisa Kojima Tags: ORIGINAL ARTICLE Source Type: research

Sarcopenia in rheumatoid arthritis: Is it a common manifestation?
AbstractObjectiveTo evaluate the presence of sarcopenia in patients with rheumatoid arthritis (RA).MethodThis cross ‐sectional study included 100 patients with RA and 100 gender‐matched healthy individuals. Sarcopenia was assessed by performing tests evaluating muscle strength, muscle mass, and physical performance, using the criteria determined by The European Working Group on Sarcopenia. Sarcopenia is defin ed as a decrease in muscle strength and muscle mass. On the other hand, presarcopenia is defined as a decrease in muscle strength with a normal muscle mass.ResultsThe participants comprised of 70 females and 30 ma...
Source: International Journal of Rheumatic Diseases - September 25, 2020 Category: Rheumatology Authors: Emre Tekgoz, Seda Colak, Funda Seher Ozalp Ates, Ilknur Sonaeren, Sedat Yilmaz, Muhammet Cinar Tags: Original Article Source Type: research