Comparison of safety, efficacy and cost between oral pulse cyclophosphamide versus intravenous cyclophosphamide pulse therapy in severe systemic lupus erythematosus
AbstractObjectivesThe aim of this study is to compare efficacy, toxicity and cost between oral and intravenous cyclophosphamide (CYC) pulse therapy in inducing remission (Systemic Lupus Erythematosus Disease Activity Index [SLEDAI]
Source: International Journal of Rheumatic Diseases - May 25, 2020 Category: Rheumatology Authors: Shivraj Padiyar, Suvrat Arya, Ajit Surin, Vishad Viswanath, Debashish Danda Tags: ORIGINAL ARTICLE Source Type: research

Cross ‐cultural adaptation and validation of the Gait, Arms, Legs, Spine locomotor screening test for detecting musculoskeletal disorders in Mexican adults
ConclusionsThe GALS diagnostic test proved valid for detecting MSK disorders among Mexican adults. It can be used by specialized physicians, family doctors, general practitioners and even physicians in training. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - May 19, 2020 Category: Rheumatology Authors: Luis Antonio Moreno ‐Torres, Carmelita Elizabeth Ventura‐Alfaro, Francisco Javier Aceves‐Ávila Tags: ORIGINAL ARTICLE Source Type: research

Clinical characteristics and outcomes of 566 Thais with systemic sclerosis: A cohort study
ConclusiondcSSc is a common SSc subset among Thais. PF was an early complication in SSc and earlier PF detection was associated with a poorer prognosis. Elderly onset, high FC, severe skin tightness, and multiple organ involvements were associated with a greater mortality risk. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - May 18, 2020 Category: Rheumatology Authors: Chingching Foocharoen, Udomlack Peansukwech, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Patnarin Pongkulkiat, Penpiriya Khamphiw, Ratanavadee Nanagara Tags: ORIGINAL ARTICLE Source Type: research

Patient and clinician views on an app for rheumatoid arthritis disease monitoring: Function, implementation and implications
ConclusionPeople with RA and healthcare professionals have clearly identified features, benefits and risks of an app for self ‐assessment of RA and incorporation into clinical care. An app developed informed by these opinions has high usability. Next steps are development and validation of a method of patient‐performed joint counts, and implementation, with evaluation, in the clinical setting. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - May 18, 2020 Category: Rheumatology Authors: Rebecca Grainger, Hermaleigh Roberta Townsley, Catherine Anna Ferguson, Faye Ellen Riley, Tobias Langlotz, William John Taylor Tags: ORIGINAL ARTICLE Source Type: research

Effect of TNF ‐inhibitor therapy on spinal structural progression in ankylosing spondylitis patients: A systematic review and meta‐analysis
AbstractTo review the effect of tumor necrosis factor ‐alpha inhibitor (TNFi) therapies on radiographic progression in ankylosing spondylitis (AS) patients as evaluated by the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). Pubmed, MEDLINE, EMBASE, and the Cochrane Library databases were searched from inception to August 2019. All compara tive and non‐comparative studies that evaluated the clinical effectiveness of TNFi on radiographic progression as assessed by mSASSS change at a minimum follow‐up of 1 year were included. The Newcastle–Ottawa Scale and Cochrane Collaboration Risk of Bias Tool ...
Source: International Journal of Rheumatic Diseases - May 17, 2020 Category: Rheumatology Authors: Prabjit Ajrawat, Zahi Touma, Ismail Sari, Cameron Taheri, Juan Pablo Diaz Martinez, Nigil Haroon Tags: REVIEW Source Type: research

Successful treatment of adalimumab for older Beh çet's disease complicated with pulmonary artery thrombosis: A case report
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - May 13, 2020 Category: Rheumatology Authors: Shuzo Yoshida, Yuko Kimura Tags: CORRESPONDENCE Source Type: research

Quality of English ‐language videos on YouTube as a source of information on systemic lupus erythematosus
ConclusionOur findings highlight an abundance of YouTube videos with useful information on SLE, that are mostly reliable and of high quality. However, in order to effectively educate patients, pitfalls such as misleading content, falsely elevated video characteristics and non ‐professional sources need to be made known to patients. As part of holistic care, healthcare professionals should advise patients to seek information from reputed sources. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - May 13, 2020 Category: Rheumatology Authors: Caitlin Hsuen Ng, Grace Rui Si Lim, Warren Fong Tags: ORIGINAL ARTICLE Source Type: research

Altered protein levels in bone marrow lesions of hip osteoarthritis: Analysis by proteomics and multiplex immunoassays
ConclusionReduced osteoprotegerin, ACAN and HAPL1 are consistent with osteoclastic activation and high remodeling activity in BMLs. The pronounced increase in angiogenesis markers, hemoglobin and serum albumin support the presence of increased vascularity in subchondral bone affected by BMLs in OA. VEGFs and IL ‐6 are known nociceptive modulators, and increased levels are in keeping with pain being a clinical feature frequently associated with BMLs. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - May 7, 2020 Category: Rheumatology Authors: Maziar Shabestari, Yashar R. Shabestari, Maria A. Landin, Milaim Pepaj, Timothy P. Cleland, Janne E. Reseland, Erik F. Eriksen Tags: ORIGINAL ARTICLE Source Type: research

Recent advances in pediatric rheumatology: October to December 2019
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 28, 2020 Category: Rheumatology Authors: Murugan Sudhakar, Loganathan Sathish Kumar, Surjit Singh Tags: EXPERT COMMENTS Source Type: research

A systematic review of the prophylactic role of chloroquine and hydroxychloroquine in coronavirus disease ‐19 (COVID‐19)
ConclusionAlthough pre ‐clinical results are promising, to date there is a dearth of evidence to support the efficacy of CQ or HCQ in preventing COVID‐19. Considering potential safety issues and the likelihood of imparting a false sense of security, prophylaxis with CQ or HCQ against COVID‐19 needs to be thoroughly evaluated in observational studies or high‐quality randomized controlled studies. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 27, 2020 Category: Rheumatology Authors: Sanket Shah, Saibal Das, Avinash Jain, Durga Prasanna Misra, Vir Singh Negi Tags: ORIGINAL ARTICLE Source Type: research

Interleukin ‐17 in urine and serum of patients with nephritis
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 23, 2020 Category: Rheumatology Authors: Natalia Chebotareva, Anatoliy Vinogradov, Alla Gindis, Wenjing Cao Tags: CORRESPONDENCE Source Type: research

Shared susceptibilities between knee osteoarthritis and hip osteoarthritis
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 21, 2020 Category: Rheumatology Authors: Xin Kang, Hongmou Zhao, Hua Lin, Hongliang Liu, Tuanyun Zhao Tags: CORRESPONDENCE Source Type: research

Intra ‐articular delivery of umbilical cord‐derived mesenchymal stem cells temporarily retard the progression of osteoarthritis in a rat model
ConclusionThese findings indicate that single injection of hUC ‐MSCs can have temporary effects on decelerating the progression of cartilage degeneration in OA rats, but may not inhibit OA progression in the long‐term. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 21, 2020 Category: Rheumatology Authors: Dan Xing, Jun Wu, Bin Wang, Wei Liu, Wenjing Liu, Yu Zhao, Liu Wang, Jiao Jiao Li, Aifeng Liu, Qi Zhou, Jie Hao, Jianhao Lin Tags: ORIGINAL ARTICLE Source Type: research

Shared susceptibilities between knee osteoarthritis and hip osteoarthritis
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 21, 2020 Category: Rheumatology Authors: Xin Kang, Hongmou Zhao, Hua Lin, Hongliang Liu, Tuanyun Zhao Tags: CORRESPONDENCE Source Type: research

Intra ‐articular delivery of umbilical cord‐derived mesenchymal stem cells temporarily retard the progression of osteoarthritis in a rat model
ConclusionThese findings indicate that single injection of hUC ‐MSCs can have temporary effects on decelerating the progression of cartilage degeneration in OA rats, but may not inhibit OA progression in the long‐term. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 21, 2020 Category: Rheumatology Authors: Dan Xing, Jun Wu, Bin Wang, Wei Liu, Wenjing Liu, Yu Zhao, Liu Wang, Jiao Jiao Li, Aifeng Liu, Qi Zhou, Jie Hao, Jianhao Lin Tags: ORIGINAL ARTICLE Source Type: research

Ultrasonography involvement of carotid, upper and lower limb arteries in a large cohort of systemic sclerosis patients
ConclusionsThis study shows that macrovascular involvement is quite common in SSc and that some disease characteristics linked to microvascular involvement are associated with atherosclerotic plaques, which can be present even in early disease. Our study suggests that a complete evaluation of macrocirculation is mandatory for rheumatologists treating SSc patients. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 20, 2020 Category: Rheumatology Authors: Cristian Caimmi, Sergio De Marchi, Silvia Laura Bosello, Dilia Giuggioli, Paola Caramaschi, Angela Di Giorgio, Amelia Spinella, Giulia Astorino, Giovanni Canestrari, Emanuele Cocchiara, Elisa Gremese, Ombretta Viapiana, Maurizio Rossini Tags: ORIGINAL ARTICLE Source Type: research

High levels of cathepsin S and cystatin C in patients with fibromyalgia syndrome
ConclusionSerum CatS and CysC levels were found to be higher in FM patients. However, there was no correlation between the functional status of FM patients and serum CatS and CysC levels. These results can be of guidance for further clinical studies of the etiopathogenesis and treatment of FM. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 19, 2020 Category: Rheumatology Authors: Ibrahim Kocak, Sami Hizmetli, Ay ça Tas, Ahmet Karadag, Cemile Zontul, Yavuz Silig Tags: ORIGINAL ARTICLE Source Type: research

Update on disease pathogenesis, diagnosis, and management of primary Sj ögren’s syndrome
AbstractPrimary Sj ögren's syndrome (pSS) is a typical multisystem disease, characterized by lymphocytic infiltration of the exocrine glands leading to glandular dysfunction. Multiple systemic manifestations occur in those of serious conditions, with different courses and outcomes. Its pathogenesis is complex, and i ts diagnosis and management are being constantly updated and improved. We have failed to have much progress in targeted immunotherapy for pSS, and as yet this is still based on empirical treatment. Many studies have tried to define pSS more accurately, to study its pathogenesis, to find effective...
Source: International Journal of Rheumatic Diseases - April 16, 2020 Category: Rheumatology Authors: Jing Wang, Lingyan Zhou, Bin Liu Tags: REVIEW ARTICLE Source Type: research

Distinct HLA and non ‐HLA associations in different subtypes of ANCA‐associated vasculitides in North India
ConclusionThe study indicated strong genetic associations were linked with PR3 antineutrophil cytoplasmic antibody specificity and it appears that PR3 ‐AAV and MPO‐AAV have distinct genetic backgrounds. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 16, 2020 Category: Rheumatology Authors: Jagdeep Singh, Aman Sharma, Lekha Rani, Navchetan Kaur, Shashi Anand, Biman Saikia, Saket Jha, Ritambhra Nada, Ranjana Walker Minz Tags: ORIGINAL ARTICLE Source Type: research

Update on disease pathogenesis, diagnosis, and management of primary Sj ögren’s syndrome
AbstractPrimary Sj ögren's syndrome (pSS) is a typical multisystem disease, characterized by lymphocytic infiltration of the exocrine glands leading to glandular dysfunction. Multiple systemic manifestations occur in those of serious conditions, with different courses and outcomes. Its pathogenesis is complex, and i ts diagnosis and management are being constantly updated and improved. We have failed to have much progress in targeted immunotherapy for pSS, and as yet this is still based on empirical treatment. Many studies have tried to define pSS more accurately, to study its pathogenesis, to find effective...
Source: International Journal of Rheumatic Diseases - April 16, 2020 Category: Rheumatology Authors: Jing Wang, Lingyan Zhou, Bin Liu Tags: REVIEW ARTICLE Source Type: research

Distinct HLA and non ‐HLA associations in different subtypes of ANCA‐associated vasculitides in North India
ConclusionThe study indicated strong genetic associations were linked with PR3 antineutrophil cytoplasmic antibody specificity and it appears that PR3 ‐AAV and MPO‐AAV have distinct genetic backgrounds. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 16, 2020 Category: Rheumatology Authors: Jagdeep Singh, Aman Sharma, Lekha Rani, Navchetan Kaur, Shashi Anand, Biman Saikia, Saket Jha, Ritambhra Nada, Ranjana Walker Minz Tags: ORIGINAL ARTICLE Source Type: research

Are exercises beneficial for patients with rheumatoid arthritis of the hand? ‐ A Cochrane review summary with commentary
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 15, 2020 Category: Rheumatology Authors: Frane Grubi šić Tags: COCHRANE CORNER Source Type: research

State ‐of‐the‐art treatment of systemic lupus erythematosus
AbstractAs glucocorticoids and immunosuppressive drugs are non ‐specific therapeutic agents that cause many adverse reactions, the development of biologicals aiming to control specific molecular targets is anticipated for the treatment of systemic lupus erythematosus (SLE). The antibody targeting B cell‐activating factor belonging to the tumor necrosis fact or family (BAFF) belimumab was the first biological approved for SLE. At present, many biologicals, such as anifrolumab (anti‐type I interferon receptor antibody) and ustekinumab (antibody against interleukin 12/23 [p40]), are in clinical trials. Thus, successful ...
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Yoshiya Tanaka Tags: INVITED REVIEW Source Type: research

Issue Information
International Journal of Rheumatic Diseases, Volume 23, Issue 4, Page 459-464, April 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Tags: ISSUE INFORMATION Source Type: research

APLAR Matters
International Journal of Rheumatic Diseases, Volume 23, Issue 4, Page 602-603, April 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Tags: APLAR Matters Source Type: research

Is paracetamol better than placebo for knee and hip osteoarthritis? A Cochrane review summary with commentary
International Journal of Rheumatic Diseases, Volume 23, Issue 4, Page 595-596, April 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Francesco Negrini, Stefano Negrini Tags: COCHRANE CORNER Source Type: research

Pleural effusion: An uncommon manifestation of SAPHO syndrome?
International Journal of Rheumatic Diseases, Volume 23, Issue 4, Page 599-601, April 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Patricia Mor án‐Álvarez, Javier Bachiller‐Corral, José Luis Morell‐Hita, Carmen Larena‐Grijalba, Luis Gorospe‐Sarasúa Tags: CORRESPONDENCE Source Type: research

Comment on “Prevalence of undifferentiated inflammatory arthropathy in patients with Hashimoto's thyroiditis in an endocrinology clinic” by Luis M. Valderrama‐Hinds and co‐workers. Int J Rheum Dis 2019; 22: 1985‐1989
International Journal of Rheumatic Diseases, Volume 23, Issue 4, Page 597-598, April 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Giuseppe Giuffrida, Alfredo Campenn ì, Francesco Trimarchi, Rosaria Maddalena Ruggeri Tags: CORRESPONDENCE Source Type: research

The additive effects of hydroxychloroquine to maintenance therapy with standard of care in patients with systemic lupus erythematosus
ConclusionsThe use of HCQ effectively improved SLEDAI scores and was a predictive factor for the prevention of SLEDAI flare. Therefore, HCQ may be considered a potential mainstay of maintenance therapy. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Ippei Miyagawa, Kazuhisa Nakano, Shingo Nakayamada, Shigeru Iwata, Kentaro Hanami, Shunsuke Fukuyo, Satoshi Kubo, Akio Kawabe, Yusuke Miyazaki, Yoshino Inoue, Masanobu Ueno, Naoaki Ohkubo, Yuya Fujita, Yoshiya Tanaka Tags: ORIGINAL ARTICLE Source Type: research

Association between MRI findings and patient ‐reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse
AbstractObjectiveTo investigate whether magnetic resonance imaging (MRI) pathologies in the wrist/hand of rheumatoid arthritis (RA) patients are associated with patient ‐reported outcomes (PROs) at clinical remission and relapse.MethodsWrist/hand MRIs and wrists/hands/feet radiographs were obtained in 114 established RA patients in clinical remission, before tapering their biologic disease ‐modifying antirheumatic drugs. MRIs were assessed according to the Outcome Measures in Rheumatology (OMERACT) RA MRI score (RAMRIS) for inflammation (synovitis/tenosynovitis/bone marrow edema) and damage (bone erosion/joint space na...
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Daniel Glinatsi, Cecilie H. Brahe, Merete L. Hetland, Lykke Ørnbjerg, Simon Krabbe, Joshua F. Baker, Mikael Boesen, Zoreh Rastiemadabadi, Lone Morsel‐Carlsen, Henrik Røgind, Annette Hansen, Jesper Nørregaard, Søren Jacobsen, Lene Tersle Tags: ORIGINAL ARTICLE Source Type: research

Correlation between serological biomarkers of extracellular matrix turnover and lung fibrosis and pulmonary artery hypertension in patients with systemic sclerosis
ConclusionOur study indicated that collagen turnover abnormality, especially type VI collagen, is not only important pathologically in skin sclerosis but also in organ involvement. These biomarkers of collagen turnover are potentially clinically useful as biomarkers of organ involvement in SSc. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Satoshi Kubo, Anne Sofie Siebuhr, Anne ‐C. Bay‐Jensen, Pernille Juhl, Morten A. Karsdal, Yurie Satoh, Yasuyuki Todoroki, Kazuhisa Nakano, Shingo Nakayamada, Yoshiya Tanaka Tags: ORIGINAL ARTICLE Source Type: research

Alteration of the gut microbiota in tumor necrosis factor ‐α antagonist‐treated collagen‐induced arthritis mice
ConclusionOur results revealed that TNF ‐α antagonist treatment can reduce the abundance and diversity of gut microbiota in CIA mice. Targeted gut microbiota may be a new therapeutic strategy for the treatment of RA. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Binglong Wang, Yujue He, Jifeng Tang, Qishui Ou, Jinpiao Lin Tags: ORIGINAL ARTICLE Source Type: research

Determinants of generalized fatigue in individuals with symptomatic knee osteoarthritis: The MOST Study
AbstractAimThe aim of the study was to identify sociodemographic, disease ‐related, physical and mental health‐related determinants of fatigue at 2‐year follow‐up in individuals with symptomatic knee osteoarthritis (OA).MethodsA longitudinal analysis of participants with symptomatic knee OA from the Multicenter Osteoarthritis Study (MOST) was conducted to identify predictors of fatigue at 2 ‐year follow‐up. Participants self‐reported fatigue at baseline for the first time in the MOST cohort and at follow‐up using a 0‐10 visual analog scale. At baseline, questionnaires on sociodemographics, disease‐relat...
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Henrietta O. Fawole, Jody L. Riskowski, Andrea Dell'Isola, Martijn P. Steultjens, Michael C. Nevitt, James C. Torner, Cora E. Lewis, David T. Felson, Sebastien F. M. Chastin Tags: ORIGINAL ARTICLE Source Type: research

The relationship of serum SCUBE ‐1, ‐2 and ‐3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients
ConclusionIn this study, a correlation was observed between serum SCUBE levels and some clinical and laboratory parameters (FEV1, FVC, PAP, C4, and Duru öz Hand Index) in SSc patients. New clinical studies are needed to better understand the contribution of these molecules in the progression and pathogenesis of SSc. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: İbrahim Gündüz, İbrahim Batmaz, Turgut Bozan, Aysun Ekinci, Remzi Cevik Tags: ORIGINAL ARTICLE Source Type: research

Ultrasonographic evaluation of Achilles tendon: Is there any difference between ankylosing spondylitis, non ‐radiographic axial spondyloarthropathy and controls?
AbstractPurposeThe aim is to evaluate Achilles tendon enthesopathy with ultrasound (US) in ankylosing spondylitis (AS) and non ‐radiographic axial SpA (nr‐axSpA) patients and controls, and compare these groups in terms of associations between disease activity parameters and ultrasonographic Achilles enthesitis signs.MethodsA total of 24 AS and 20 nr ‐axSpA patients fulfilling the Assessment in Spondyloarthritis International Working Group criteria for axSpA and 30 controls were enrolled. Demographic characteristics, erythrocyte sedimentation rate, C‐reactive protein (CRP), human leukocyte antigen (HLA)‐B27, Bath ...
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Shahla Vahidfar, İsmihan Sunar, Şebnem Ataman, Gürkan Yılmaz, Javid M. Azarabadi, Ayşe Bölükbaşı Tags: ORIGINAL ARTICLE Source Type: research

Association of rs27044 and rs30187 polymorphisms in endoplasmic reticulum aminopeptidase 1 gene and ankylosing spondylitis susceptibility: A meta ‐analysis
AbstractBackgroundThe findings regarding association ofendoplasmic reticulum aminopeptidase 1 (ERAP1) gene polymorphisms and ankylosing spondylitis (AS) susceptibility are inconsistent. Our aim is to appraise and merge the existing evidence on the relationship ofrs27044 andrs30187 polymorphisms inERAP1 gene and susceptibility to AS.MethodsElectronic databases of PubMed, Web of Science, EMBASE, Cochrane Library, Wanfang, and CNKI were retrieved for relevant publications. The search was conducted from inception to 10 June, 2019. Studies on the association ofrs27044 andrs30187 polymorphisms and risk of AS were included. Quali...
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Shutao Gao, Tao Xu, Weidong Liang, Chuanhui Xun, Qiang Deng, Hailong Guo, Weibin Sheng Tags: ORIGINAL ARTICLE Source Type: research

Knee synovial fluid complement C3 ‐β chain levels correlate with clinical symptoms of knee osteoarthritis
ConclusionWe present first ‐hand evidence that the clinical symptoms of OA are mainly associated with C3 in the local SF rather than systemic circulation, suggesting local factors in the etiopathogenesis. Future local targeted therapies for pain management may be more effective and safer. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Tzu Hsuan Cheng, Seung Ho Yoon, Philip Lee, Dennis Dimaculangan, Aditya Vikram Maheshwari, Ming Zhang Tags: ORIGINAL ARTICLE Source Type: research

Association between radiographic anterior cruciate ligament tear and joint symptoms: Data from the osteoarthritis initiative
ConclusionIndividuals did not report an increase in knee pain, stiffness or disability in their ACL ‐deficient knee. Only disability was associated with worsening severity of radiographic OA in ACL‐deficient knees. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Victoria L. Johnson, Ali Guermazi, Frank W. Roemer, David J. Hunter Tags: ORIGINAL ARTICLE Source Type: research

Cranial and large vessel activity on positron emission tomography scan at diagnosis and 6 months in giant cell arteritis
AbstractAimPositron emission tomography/computed tomography (PET/CT) can detect cranial and large vessel inflammation in giant cell arteritis (GCA). We aimed to determine the change and significance of vascular activity at diagnosis and 6  months.MethodNewly diagnosed GCA patients underwent time ‐of‐flight fluorine‐18‐fluoro‐2‐deoxyglucose PET/CT from vertex to diaphragm within 72 hours of commencing corticosteroids and were followed for 12 months. A 6 months scan was performed in patients with inflammatory features on biopsy or CT aortitis. Vascular uptake was visually grade d by 2 blinded ...
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Anthony M. Sammel, Edward Hsiao, Geoffrey Schembri, Elizabeth Bailey, Katherine Nguyen, Janice Brewer, Leslie Schrieber, Beatrice Janssen, Peter Youssef, Clare L. Fraser, Rodger Laurent Tags: ORIGINAL ARTICLE Source Type: research

Adherence to subcutaneous anti ‐TNFα agents in patients with rheumatoid arthritis is largely influenced by pain and skin sensations at the injection site
ConclusionAdherence is influenced by both demographic characteristics (age) and clinical factors (disease activity, comorbidity burden and injection site pain and skin perception) in RA patients. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Fausto Salaffi, Marco Di Carlo, Sonia Farah, Marina Carotti Tags: ORIGINAL ARTICLE Source Type: research

Validity and reliability of Work Productivity and Activity Impairment among patients with axial spondyloarthritis in Singapore
AbstractObjectivesTo assess the validity and reliability of the Work Productivity and Activity Impairment (WPAI) questionnaire in patients with axSpA.MethodsEnglish ‐speaking patients seen at a dedicated axSpA clinic in a Singapore tertiary referral hospital were recruited from 2017 to 2019. Content validity of the WPAI was assessed through cognitive debriefing interviews (CDIs). Construct validity was assessed by a priori hypotheses regarding the correlation s of the WPAI outcomes (absenteeism, presenteeism, overall work productivity loss, and activity impairment) with Bath Ankylosing Spondylitis Functional Index (BASFI...
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Jie Kie Phang, Yu Heng Kwan, Warren Fong, Chuen Seng Tan, Nai Lee Lui, Julian Thumboo, Ying Ying Leung Tags: ORIGINAL ARTICLE Source Type: research

Characteristics of diffuse large B ‐cell lymphoma in patients with primary Sjögren's syndrome
ConclusionThese results indicate that DLBCL tends to occur late in pSS cases and is mainly related to the non ‐GCB subtype of DLBCL. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Vadim Romanovich Gorodetskiy, Natalya Alexandrovna Probatova, Vladimir Ivanovich Vasilyev Tags: ORIGINAL ARTICLE Source Type: research

Phenobarbital rheumatism —A fresh look at an old malady: Case report and systematic review of literature
International Journal of Rheumatic Diseases, Volume 23, Issue 4, Page 589-594, April 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Authors: Saket Jha, Amal Basnet, Rajiv Ranjan Kumar, Aadhaar Dhooria, Venkata Subramanian Krishnaraju, Sanjay Jain, Varun Dhir Tags: APLAR GRAND ROUND CASE Source Type: research

Issue Information
International Journal of Rheumatic Diseases, Volume 23, Issue 4, Page 459-464, April 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Tags: ISSUE INFORMATION Source Type: research

APLAR Matters
International Journal of Rheumatic Diseases, Volume 23, Issue 4, Page 602-603, April 2020. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 14, 2020 Category: Rheumatology Tags: APLAR Matters Source Type: research