Validity of the Patient ‐Rated Wrist Evaluation questionnaire in rheumatoid arthritis
This study aims to test the validity of PRWE in patients with RA.MethodSeventy ‐five patients with RA from a single outpatient clinic participated in the study. Patients filled out the Michigan Hand Outcomes Questionnaire (MHOQ) and grip strength of both hands were measured. Patients filled out the PRWE questionnaire consecutively once for the dominant and once for the non‐ dominant hand. Correlations between PRWE and MHOQ and grip strength scores were analyzed by Spearman's correlation method.ResultsOur results demonstrated that there was a very strong correlation between the PRWE and the MHOQ and a moderate correlati...
Source: International Journal of Rheumatic Diseases - July 17, 2019 Category: Rheumatology Authors: Zeynep Tuna, Oguzhan Mete, Gizem Tore, Songul Baglan Yentur, Özkan Varan, Berna Göker, Deran Oskay Tags: ORIGINAL ARTICLE Source Type: research

Efficacy of uric acid ‐lowering therapy on hypercholesterolemia and hypertriglyceridemia in gouty patients
ConclusionUric acid ‐lowering therapy benefits hyperlipidemia in gouty patients. Febuxostat effectively improved serum cholesterol and triglyceride levels compared to allopurinol and benzbromarone in patients with gout. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - July 17, 2019 Category: Rheumatology Authors: Jing Wu, Yu ‐Ping Zhang, Yuan Qu, Li‐Gang Jie, Jia‐Xin Deng, Qing‐Hong Yu Tags: ORIGINAL ARTICLE Source Type: research

Serum level of soluble triggering receptor expressed on myeloid cells ‐1 (sTREM‐1) is a biomarker of synovitis in rheumatoid arthritis
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - July 16, 2019 Category: Rheumatology Authors: Cl émence Gorlier, Jacques‐Eric Gottenberg, Ludivine Laurans, Tabassome Simon, Hafid Ait-Oufella, Jérémie Sellam Tags: NOVEL HYPOTHESIS Source Type: research

Ultrasound power Doppler and gray scale joint inflammation: What they reveal in rheumatoid arthritis
ConclusionUltrasound PD joint inflammation is associated with disease activity and is correlated with DAS28. In contrast, GS joint inflammation is associated with structural damage and is correlated with ultrasound ‐detected bone erosion. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - July 15, 2019 Category: Rheumatology Authors: York Kiat Tan, HuiHua Li, John Carson Allen Jr, Julian Thumboo Tags: ORIGINAL ARTICLE Source Type: research

Sustained clinical remission of rheumatoid arthritis and its predictive factors in an unselected adult Chinese population from 2009 to 2018
ConclusionsAchieving 6 ‐month SR was not uncommon in daily practice. Male, early RA, treatment‐naïve, T2T application, shorter time to remission, and lower disease activity scores in remission increased the occurrence of SR, while increasing age, longer disease duration, and higher baseline disease activity reduced t he chance of remission sustainability. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - July 12, 2019 Category: Rheumatology Authors: Wenhui Xie, Ji Li, Xiaohui Zhang, Xiaoying Sun, Zhuoli Zhang Tags: ORIGINAL ARTICLE Source Type: research

Incidence and patterns of malignancies in a multi ‐ethnic cohort of rheumatoid arthritis patients
ConclusionThere is a trend toward an overall increased malignancy risk in our RA patients compared to the general population. Specifically, there is an increased risk of lymphomas in all RA patients, lung malignancy in male patients, and cervical malignancy in female patients, compared to the general population. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - July 11, 2019 Category: Rheumatology Authors: Xin Rong Lim, Wenwei Xiang, Justina Wei Lynn Tan, Li Wearn Koh, Tsui Yee Lian, Khai Pang Leong, Ee ‐Tzun Koh, TTSH Rheumatoid Arthritis Study Group, Grace Yin Lai Chan, Madelynn Tsu‐Li Chan, Faith Li‐Ann Chia, Hwee Siew Howe, Kok Ooi Kon Tags: ORIGINAL ARTICLE Source Type: research

Prognosis, complications and treatment response in systemic juvenile idiopathic arthritis patients: A single ‐center experience
ConclusionThe disease is characterized with diverse clinical presentation and possibly severe complications. MAS complicated with multiorgan insufficiency is the major mortality factor. Corticosteroids represent the mainstay of the initial treatment. In patients resistant to classic treatment, biological drugs should be timely introduced. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - July 4, 2019 Category: Rheumatology Authors: Kenan Barut, Amra Adrovic, Sezgin Sahin, Gurkan Tarcin, Gulberk Tahaoglu, Oya Koker, Mehmet Yildiz, Ozgur Kasapcopur Tags: ORIGINAL ARTICLE Source Type: research

Circulating miR ‐99b‐5p as a novel predictor of erosion progression on high‐resolution peripheral quantitative computed tomography in early rheumatoid arthritis: A prospective cohort study
ConclusionsDifferential expressions of circulating miR ‐143‐3p, miR‐145‐5p and miR‐99b‐5p in the plasma of ERA patients may characterize a severe form of the disease. MiR‐99b‐5p, in particular, may serve as a possible predictor for erosion progression. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - July 4, 2019 Category: Rheumatology Authors: Jiang Yue, Terrence C. K. Lau, James F. Griffith, Jiankun Xu, Fan Xiao, Lin Shi, Defeng Wang, Priscilla C. H. Wong, Edmund K. Li, Lydia P. Tam, Martin Li, Tena K. Li, Wah Yan Mak, Vivian Hung, Ling Qin, Lai ‐Shan Tam Tags: ORIGINAL ARTICLE Source Type: research

The associations of TNF ‐α gene polymorphisms with bone mineral density and risk of osteoporosis: A meta‐analysis
AbstractObjectiveFracture is a common consequence of osteoporosis and is associated with high morbidity and mortality. Recently, increasing evidence has suggested that polymorphisms in tumor necrosis factor‐α (TNF ‐α) gene were associated with osteoporosis risk and bone mineral density (BMD), but results remain conflicting. We herein performed a meta ‐analysis based on evidence currently available from the literature to make a more precise estimation of these relationships.MethodsThe PubMed, EMBASE, Cochrane Library, CNKI (China National Knowledge Infrastructure) and Wan Fang databases were searched for e...
Source: International Journal of Rheumatic Diseases - July 4, 2019 Category: Rheumatology Authors: Suo ‐Chao Fu, Ping Wang, Ming‐Xing Qi, Jing‐Ping Peng, Xiao‐Qian Lin, Cai‐Yun Zhang, Gui‐Xin Zhao, Gong‐Hao He Tags: ORIGINAL ARTICLE Source Type: research

Giant calcinosis revealing systemic sclerosis
We report the case of a man who developed severe calcinosis in shoulders and hips occurring before other systemic sclerosis' symptoms. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - July 2, 2019 Category: Rheumatology Authors: Etienne Meriglier, Fran çois Lafourcade, Bruno Gombert, Cedric Landron Tags: APLAR GRAND ROUND CASE Source Type: research

Issue Information
International Journal of Rheumatic Diseases, Volume 22, Issue 6, Page 959-964, June 2019. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 27, 2019 Category: Rheumatology Tags: ISSUE INFORMATION Source Type: research

APLAR Matters
International Journal of Rheumatic Diseases, Volume 22, Issue 6, Page 1167-1168, June 2019. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 27, 2019 Category: Rheumatology Tags: APLAR Matters Source Type: research

Work disability and musculoskeletal disease
International Journal of Rheumatic Diseases, Volume 22, Issue 6, Page 965-966, June 2019. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 27, 2019 Category: Rheumatology Authors: E. Michael Shanahan Tags: EDITORIAL Source Type: research

Comment on APLAR Grand Round: Phenotypes of single mtDNA deletions may unequivocally suggest mitochondrial disease
International Journal of Rheumatic Diseases, Volume 22, Issue 6, Page 1165-1166, June 2019. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 27, 2019 Category: Rheumatology Authors: Josef Finsterer Tags: CORRESPONDENCE Source Type: research

Bilateral brachial synovial cysts in systemic juvenile idiopathic arthritis: Case report and literature review
ConclusionBrachial synovial cyst is a rare manifestation of juvenile idiopathic arthritis. Uncontrolled systemic inflammation inducing chronic damage to joint structure may be the primary cause of synovial cyst formation. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 27, 2019 Category: Rheumatology Authors: Qi Zheng, Meiping Lu Tags: ORIGINAL ARTICLE Source Type: research

Recent advances in pediatric rheumatology: January to March 2019
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 27, 2019 Category: Rheumatology Authors: Pratap Kumar Patra, Aaqib Zaffar Banday, Surjit Singh Tags: EXPERT COMMENTS Source Type: research

Validity and reliability of the Assessment of Spondyloarthritis International Society Health Index in English ‐speaking patients with axial spondyloarthritis in Singapore
ConclusionsThis study supports the ASAS HI as a valid and reliable measure of health status for use in patients with axSpA in Singapore. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 27, 2019 Category: Rheumatology Authors: Yu Heng Kwan, Fang Fang Aw, Warren Fong, Jie Kie Phang, Uta Kiltz, Ka Keat Lim, Eng Hui Chew, Nai Lee Lui, Chuen Seng Tan, Julian Thumboo, Truls Østbye, Ying Ying Leung Tags: ORIGINAL ARTICLE Source Type: research

Body mass index associates with disease relapse in patients with giant cell arteritis
AbstractObjectiveTo identify risk factors associated with disease relapse in giant cell arteritis (GCA).MethodsWe reviewed data from 30 consecutive, newly diagnosed patients with GCA. The patients were divided according to relapse or non ‐relapse status, and their baseline characteristics were compared.ResultsAmong the 30 patients, 8 relapsed at a median of 28  weeks from GCA diagnosis. Patients with relapse were male‐dominant (male: 88% vs female: 41%,P = 0.02) and showed a higher body mass index (BMI, 23 kg/m2 vs 19  kg/m2,P 
Source: International Journal of Rheumatic Diseases - June 27, 2019 Category: Rheumatology Authors: Kotaro Matsumoto, Yuko Kaneko, Tsutomu Takeuchi Tags: ORIGINAL ARTICLE Source Type: research

Cross ‐cultural adaptation of the Hamilton axial spondyloarthritis questionnaire and development of a Chinese version in a multi‐ethnic Asian population
ConclusionThe adapted axial SpA questionnaire demonstrated good sensitivity in the pilot ‐testing and appears to be a promising tool for facilitating early identification of axial SpA cases in the multi‐ethnic Asian population. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 27, 2019 Category: Rheumatology Authors: Ling Xiang, Edmund Pek Siang Teo, Andrea Hsiu Ling Low, Ying Ying Leung, Warren Fong, Xiaohui Xin, Mihir Gandhi, Yu Heng Kwan, Elenore J. B. Uy, Louise Hamilton, Julian Thumboo Tags: ORIGINAL ARTICLE Source Type: research

Performance evaluation of a line blot assay system for detection of anti ‐PM‐Scl antibody in Japanese patients with systemic sclerosis
ConclusionDetection of anti ‐PM‐Scl Ab assessed with a commercial LB assay requires extreme caution since it may yield false‐positive data. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 27, 2019 Category: Rheumatology Authors: Yasuhito Hamaguchi, Masataka Kuwana, Kazuhiko Takehara Tags: ORIGINAL ARTICLE Source Type: research

Efficacy and safety of iguratimod plus corticosteroid as bridge therapy in treating mild IgG4 ‐related diseases: A prospective clinical trial
ConclusionIguratimod plus corticosteroid as bridge therapy is effective for the treatment of mild IgG4 ‐RD, it can improve the clinical symptoms, reduce serum IgG and IgG4 levels, especially plasmablasts/plasma cells and memory B cells. In addition, the metabolite profiling became similar to normal controls after treatment. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 27, 2019 Category: Rheumatology Authors: Panpan Zhang, Yiyi Gong, Zheng Liu, Yanying Liu, Wei Lin, Jieqiong Li, Mu Wang, Xiaowei Liu, Yunyun Fei, Hua Chen, Linyi Peng, Jing Li, Jiaxin Zhou, Qun Shi, Xuan Zhang, Min Shen, Xiaofeng Zeng, Fengchun Zhang, Yongzhe Li, Yan Zhao, We Tags: ORIGINAL ARTICLE Source Type: research

Prevalence of methotrexate intolerance among patients with rheumatoid arthritis using the Arabic version of the methotrexate intolerance severity score
ConclusionThe Arabic MISS showed validity and good reliability in detecting MTX intolerance in RA patients. MTX intolerance is prevalent among RA patients. Larger studies are needed to confirm these findings. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 27, 2019 Category: Rheumatology Authors: Jawza Albaqami, Rawan Alshalhoub, Haya Almalag, Maha Dessougi, Amal Al Harthi, Mohamed K. Bedaiwi, Mohammed A. Omair Tags: ORIGINAL ARTICLE Source Type: research

Potential benefits of biologics on stroke and mortality in patients with rheumatoid arthritis: A nationwide population ‐based cohort study in Taiwan
ConclusionBiologics used in RA patients have been shown to have a beneficial impact on improving clinical outcomes, including decreased risks of death and stroke. The economic burden from costs of biologics may be alleviated by improving outcomes. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 25, 2019 Category: Rheumatology Authors: Chao ‐Hsiun Tang, Fun Yu, Ching‐Ya Huang, Der‐Yuan Chen Tags: ORIGINAL ARTICLE Source Type: research

Authors reply to comment on axial SpA recommendations
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 21, 2019 Category: Rheumatology Authors: Lai ‐Shan Tam, Chak‐Sing Lau, on behalf of the APLAR Axial Spondyloarthritis Recommendations Working Group Tags: CORRESPONDENCE Source Type: research

Associations between blood lead, cadmium, and mercury levels with hyperuricemia in the Korean general population: A retrospective analysis of population ‐based nationally representative data
ConclusionFurther studies are necessary to clarify the observed association, and public health strategies to reduce heavy metal exposure may be necessary for decreasing the potential harmful effects of hyperuricemia. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 19, 2019 Category: Rheumatology Authors: Wonkil Jung, Yunkyung Kim, Hoseob Lihm, Jihun Kang Tags: ORIGINAL ARTICLE Source Type: research

The first case of idiopathic inflammatory myopathy complicated by Epstein ‐Barr virus‐associated smooth muscle tumor and lymphoma
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 18, 2019 Category: Rheumatology Authors: Ho So, Victor Tak Lung Wong, Hin Ting Pang, Virginia Wen Nga Lao, Ronald Man Lung Yip Tags: CORRESPONDENCE Source Type: research

Low levels of pannexin ‐1 in Behçet’s syndrome
AbstractObjectiveBeh çet's syndrome (BS) is a chronic, multisystemic and inflammatory syndrome. In our study, we aimed to compare the initiator, effector and inflammatory caspases and pannexin channel protein, which is thought to have an activity in inflammation, in the inflammatory process of BS, with healthy subjects , to investigate their level in patients and their relationship with the clinical findings.MethodForty ‐six patients who were under follow‐up for BS in the Sivas Cumhuriyet University Medical Faculty Department of Internal Diseases, Rheumatology Unit, between January 2017 and June 2017 and 44 heal...
Source: International Journal of Rheumatic Diseases - June 18, 2019 Category: Rheumatology Authors: Ali Şahin, Abdullah İlhan, Mehmet Emin Derin, Halef Okan Doğan, Mehtap Şahin Tags: ORIGINAL ARTICLE Source Type: research

Anti ‐drug antibodies and low serum trough infliximab levels correlate with disease activity measures in spondyloarthritis patients on an as‐needed infliximab treatment
AbstractAimIn India, many centers use infliximab at lower doses of 3 ‐5 mg/kg without the loading dose for spondyloarthritis (SpA) patients. It is then continued on an as‐required basis, rather than a fixed schedule. Our study was undertaken to see if the trough drug levels and anti‐drug antibodies in patients with SpA treated with as‐needed infliximab dosin g correlated with the disease activity measures.MethodsThirty ‐five adult SpA patients in the age group 18‐70 years were recruited. They had received three or more infusions of infliximab at 3‐5 mg/kg over the past 6 to 12 months. Pati...
Source: International Journal of Rheumatic Diseases - June 18, 2019 Category: Rheumatology Authors: Abhishek Patil, Sundeep Upadhyaya, Reetika Dawar, Nikunjkumar Dadhaniya, Isha Sood, Sirinder J. Gupta, Rohini Handa Tags: ORIGINAL ARTICLE Source Type: research

The utility of fluorine ‐18‐fluorodeoxyglucose positron emission tomography in the diagnosis and monitoring of large vessel vasculitis: A South Australian retrospective audit
ConclusionFluorine ‐18‐labelled deoxyglucose positron emission tomography has a role in the diagnosis of large vessel vasculitis, particularly in patients with a high suspicion of active large vessel vasculitis who do not meet the ACR criteria. FDG‐PET may have a role in monitoring disease activity in selected p atients with large vessel vasculitis especially in identifying occult sites of large vessel inflammation or to titrate prednisolone therapy. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 18, 2019 Category: Rheumatology Authors: Ai Duyen Nguyen, Thomas Crowhurst, Susan Lester, Rachael Dobson, Dylan Bartholomeusz, Catherine Hill Tags: ORIGINAL ARTICLE Source Type: research

A cost per responder analysis of secukinumab vs adalimumab for the treatment of ankylosing spondylitis from the Korean perspective
ConclusionThe costs per responder associated with ASAS 20 and 40 response rates were consistently lower for secukinumab compared with adalimumab. The treatment with secukinumab for patients with AS could be a cost ‐saving treatment option in South Korea. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 18, 2019 Category: Rheumatology Authors: Dam Kim, Hyojin Kim, SeongHa Cho, Min ‐Chan Park Tags: ORIGINAL ARTICLE Source Type: research

Comparison of the efficacy and safety of tofacitinib and upadacitinib in patients with active rheumatoid arthritis: A Bayesian network meta ‐analysis of randomized controlled trials
ConclusionsIn RA patients with an inadequate response to cs ‐ or b‐DMARDs, upadacitinib 15 mg + MTX and upadacitinib 30 mg + MTX were the most efficacious interventions and were not associated with significant risks of serious adverse events. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 18, 2019 Category: Rheumatology Authors: Gwan Gyu Song, Sung Jae Choi, Young Ho Lee Tags: ORIGINAL ARTICLE Source Type: research

Identification of 6 dermatomyositis subgroups using principal component analysis ‐based cluster analysis
ConclusionWe applied cluster analysis to a large group of DM patients and identified 6 clinical subgroups, underscoring the need for better phenotypic characterization to help develop individualized treatments and improve prognosis. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 9, 2019 Category: Rheumatology Authors: Huiyi Zhu, Chanyuan Wu, Nan Jiang, Yanhong Wang, Jiuliang Zhao, Dong Xu, Qian Wang, Mengtao Li, Xiaofeng Zeng Tags: ORIGINAL ARTICLE Source Type: research

Serum and urine interleukin ‐17A levels as biomarkers of disease activity in systemic lupus erythematosus
This study examined the correlations of both serum and urine interleukin ‐17A (IL‐17A) levels with disease activity in systemic lupus erythematosus (SLE). This study was also aimed at determining their sensitivity and specificity as biomarkers of disease activity in SLE.MethodsA cross ‐sectional study was performed involving SLE patients (n = 120 patients) from Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Serum and urinary IL‐17A levels were determined by immunoassay while disease activity was assessed using Systemic Lupus Erythematosus Disease Activity Index‐20 00 (SLEDAI‐2K) and British Is...
Source: International Journal of Rheumatic Diseases - June 9, 2019 Category: Rheumatology Authors: Fariz Nordin, Syahrul Sazliyana Shaharir, Asrul Abdul Wahab, Ruslinda Mustafar, Abdul Halim Abdul Gafor, Mohd Shahrir Mohamed Said, Sakthiswary Rajalingham, Shamsul Azhar Shah Tags: ORIGINAL ARTICLE Source Type: research

Association of HLA class II alleles/haplotypes and amino acid variations in the peptide binding pockets with rheumatoid arthritis
ConclusionsAlleles DRB1*04:06 and*04:01 showed strong susceptible and DRB1*13:01 and *14:01 showed protective associations in RA patients. The amino acid variations in DQ β molecules revealed significant molecular markers for susceptibility to and protection from RA in south India. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 6, 2019 Category: Rheumatology Authors: Rathika Chinniah, Meenakshi Sundari Rajendran, Ramgopal Sivanadham, Muthu Lakshmi Adaikalam, Padma Malini Ravi, Murali Vijayan, Seerala Boopathy, Sasiharan Pandi, Vandit Sevak, Balakrishnan Karuppiah Tags: ORIGINAL ARTICLE Source Type: research

Rosmarinic acid attenuates inflammation in experimentally induced arthritis in Wistar rats, using Freund ’s complete adjuvant
AbstractAimThe purpose of our investigation is to evaluate the anti ‐arthritic potential of isolated rosmarinic acid from the rind ofPunica granatum.MethodRosmarinic acid was isolated by bioactivity ‐guided isolation from butanolic fraction ofPunica granatum and acute toxicity of rosmarinic acid was carried out. The experiment was conducted at doses of 25 and 50  mg/kg, in Freund's complete adjuvant (FCA)‐induced arthritic rats. Various parameters, that is arthritic score, paw volume, thickness of paw, hematological, antioxidant and inflammatory parameters such as glutathione (GSH), superoxide dismutase (SOD), m...
Source: International Journal of Rheumatic Diseases - June 2, 2019 Category: Rheumatology Authors: Rupesh Kumar Gautam, Gaurav Gupta, Sanjay Sharma, Ketan Hatware, Kiran Patil, Komal Sharma, Swapnil Goyal, Dinesh Kumar Chellappan, Kamal Dua Tags: ORIGINAL ARTICLE Source Type: research

Assessing the construct validity of clinical tests to identify sacroiliac joint inflammation in patients with non ‐radiographic axial spondyloarthritis
ConclusionsSacroiliac joint pain provocation tests correlate modestly with inflammation. The Patrick's Faber test showed the greater LR to identify SIJ inflammation in patients with nrAxSpA. SIJ pain provocation tests may offer a simple and cost ‐effective way of identifying patients with nrAxSpA who are most likely to have MRI evidence of inflammation. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - May 27, 2019 Category: Rheumatology Authors: Marcelo P. Castro, Simon M. Stebbings, Stephan Milosavljevic, Susanne J. Pedersen, Melanie D. Bussey Tags: ORIGINAL ARTICLE Source Type: research

Efficacy and safety of leflunomide in psoriatic arthritis treatment: A single ‐arm meta‐analysis
ConclusionsLeflunomide is an effective and well ‐tolerated treatment for PsA, and would be a safe and convenient option. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - May 27, 2019 Category: Rheumatology Authors: Qiaoding Dai, Liping Xu, Xiali Yu Tags: ORIGINAL ARTICLE Source Type: research

Clinical features and new diagnostic criteria for the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis
ConclusionOur new criteria are useful for diagnosing PFAPA. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - May 27, 2019 Category: Rheumatology Authors: Yusuke Takeuchi, Tomonari Shigemura, Norimoto Kobayashi, Haruo Nagumo, Masahiro Furumoto, Kyo Ogasawara, Hitomi Fujii, Masahiro Takizawa, Takashi Soga, Hisanori Matoba, Junya Masumoto, Keitaro Fukushima, Kiyoshi Migita, Toshiyuki Ojima, Yoh Tags: ORIGINAL ARTICLE Source Type: research

Clinical significance of CCN2/connective tissue growth factor in Beh çet's disease patients
ConclusionBeh çet's disease patients showed a significant increase of CCN2 levels, especially in the group of patients with major organ involvement. A significant reduction of these levels was found in patients who received steroids or cyclophosphamide. Larger studies with further investigations of the precise r ole of CCN2 in BD pathogenesis might lead to novel therapies for the clinical management of this disease. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - May 23, 2019 Category: Rheumatology Authors: Iman Hamed Bassyouni, Wafaa Hob Sharkawy Mohammed, Fatma M. Taha, Rasha M. El Refai Tags: ORIGINAL ARTICLE Source Type: research

Validation of 2017 classification criteria for adult and juvenile idiopathic inflammatory myopathies proposed by EULAR/ACR in Chinese patients
AbstractObjectivesTo evaluate the ability of 2017 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) to classify IIM in comparison with the 1975 Bohan and Peter criteria in Chinese patients.MethodsTwo hundred and twenty ‐one inpatients with suspected IIM (including 40 children) were retrospectively included in this study. The performance of the 2017 EULAR/ACR criteria was evaluated by sensitivity, specificity, positive predictive value, negative predictive value and classification rate, in comparison to th...
Source: International Journal of Rheumatic Diseases - May 23, 2019 Category: Rheumatology Authors: Xiaohui Zhang, Xinlei Yang, Lanlan Ji, Zhuoli Zhang Tags: ORIGINAL ARTICLE Source Type: research

Ultrasound detected changes in joint cartilage thickness in juvenile idiopathic arthritis
AbstractAimThe purpose of this study was to investigate the changes in joint cartilage thickness in different subtypes of juvenile idiopathic arthritis (JIA) using ultrasound, comparing them with healthy children and to evaluate the relationship with disease duration and inflammatory markers.MethodsWe conducted a cross ‐sectional study comprising of 27 cases of JIA and 54 age‐ and sex‐matched healthy children. Bilateral wrist, knee and ankle joint cartilage thicknesses were measured by ultrasound as per European League Against Rheumatism standard guidelines and compared them between JIA subtypes as well as b etween c...
Source: International Journal of Rheumatic Diseases - May 22, 2019 Category: Rheumatology Authors: Sonali Mitra, Partha Pratim Samui, Moumita Samanta, Rakesh Kumar Mondal, Avijit Hazra, Kalyanbrata Mandal, Tapas Kumar Sabui Tags: ORIGINAL ARTICLE Source Type: research

Reactivation of hepatitis B virus infection following rituximab treatment in HBsAg ‐negative, HBcAb‐positive rheumatoid arthritis patients: A long‐term, real‐world observation
This study aimed to investigate the temporal course of rHBV development in rheumatoid arthritis (RA) patients undergoing long‐term rituximab therapy.MethodsThe occurrence of rHBV was examined in 157 RA patients during rituximab therapy. Serum levels of HBV surface antigen (HBsAg), HBV core antibody (HBcAb), and HBsAb were determined by electrochemiluminescence immunoassays, and viral loads by real ‐time polymerase chain reaction assay.ResultsAmong 157 patients undergoing rituximab therapy, 103 (65.6%) were HBsAg ‐negative and HBcAb‐positive. Before rituximab therapy, 20 (19.4%) of these 103 patients were HBsAb‐ne...
Source: International Journal of Rheumatic Diseases - May 22, 2019 Category: Rheumatology Authors: Yi ‐Ming Chen, Hsin‐Hua Chen, Wen‐Nan Huang, Yi‐Hsing Chen, Tsu‐Yi Hsieh, Sheng‐Shun Yang, Joung‐Liang Lan, Der‐Yuan Chen Tags: ORIGINAL ARTICLE Source Type: research

Headache and vision changes in an elderly man with rheumatoid arthritis
We present a case of an elderly, immunosuppressed patient with rheumatoid arthritis who was not appropriately vaccinated, and subsequently developed herpes zoster ophthalmicus, which initially presented similar to giant cell arteritis. Evidence ‐based vaccinations are integral in decreasing the incidence of preventable diseases and promoting optimal health at the individual and population level. Although the patient ultimately did not suffer any long‐term adverse sequelae, this case highlights the importance of vaccination in the rheum atology setting, and to consider both inflammatory and infectious causes of headache...
Source: International Journal of Rheumatic Diseases - May 22, 2019 Category: Rheumatology Authors: Timothy S.H. Kwok, Nick Daneman, Shirley L. Lake Tags: POSTGRADUATE QUIZ Source Type: research

Clinical characteristics and risk factors of ulceration over tophi in patients with gout
ConclusionsGout patients with ulceration(s) over tophi present several different aspects of clinical characteristics compared with those without ulceration. The ulcerations are most commonly seen in feet and they are mainly categorized as stages I and II. Glucocorticoid overuse, prolonged duration with tophi and greater numbers of tophi are risk factors for ulceration over tophi. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - May 22, 2019 Category: Rheumatology Authors: Zhengping Huang, Xiuqi Liu, Yuqi Liu, Guowei Li, Xia Pan, Zhixiang Huang, Yukai Huang, Qidang Huang, Shaoling Zheng, Tianwang Li Tags: ORIGINAL ARTICLE Source Type: research

Bad bites? A case report of rapidly progressive painful necrotic lower limb lesions from propylthiouracil ‐associated vasculitis
International Journal of Rheumatic Diseases, EarlyView. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - May 22, 2019 Category: Rheumatology Authors: Queenie Luu, John Riordan Tags: CORRESPONDENCE Source Type: research

Predictive clinical ‐genetic model of long‐term non‐response to tumor necrosis factor‐alpha inhibitor therapy in spondyloarthritis
This study aimed to determine clinical and genetic predictors of non‐response to TNFi treatment in 118 spondyloarthritis patients diagnosed according to Assessment in SpondyloArthritis International Society (ASAS) cr iteria.MethodFrom the literature, 41 single nucleotide polymorphisms (SNPs) were selected that had previously been associated with TNFi treatment response in spondyloarthropathies, rheumatoid arthritis and psoriasis. A clinical non ‐response was defined as a decrease of
Source: International Journal of Rheumatic Diseases - May 22, 2019 Category: Rheumatology Authors: Jessica Polo y La Borda, Jos é Campos, Jesús Sanz, José Luis Andréu, Juan Mulero, Alejandra Sánchez Tags: ORIGINAL ARTICLE Source Type: research

Initial assessment of the early arthritis for psoriatic patients diagnostic questionnaire in dermatology clinics in Australia, Korea and China
ConclusionThe Australian, Korean, and Chinese versions of the EARP questionnaire are suitable for the early detection of PsA symptoms in patients with psoriasis by dermatologists working in specialist dermatology clinics. Trial registration: NCT02470481. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - May 22, 2019 Category: Rheumatology Authors: Seong ‐Jin Jo, Peter Foley, Stephen Philip Oakley, Jianzhong Zhang, Min Zheng, Kichul Shin, Dennis McGonagle, Paolo Gisondi, Ilaria Tinazzi, Belinda E. Butcher, Malcolm Handel Tags: ORIGINAL ARTICLE Source Type: research

Evaluation of risk factors for atherosclerosis using carotid ultrasonography in Japanese patients with rheumatoid arthritis
ConclusionDisease Activity Score of 28 joints —erythrocyte sedimentation rate was related to the size and number of plaques, whereas only traditional risk factors were related to max cIMT. This indicated that the inflammatory conditions of RA could affect the formation of atherosclerotic plaques. For the management of CVD in patients with RA, it may be important to control not only traditional risk factors, but also RA disease activity. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - May 17, 2019 Category: Rheumatology Authors: Hiroko Yamamoto, Toshiki Nakajima, Rie Kawahara, Shuichiro Nakabo, Motomu Hashimoto, Wataru Yamamoto, Izuru Masuda, Hiromu Ito, Tsuneyo Mimori, Yasutomo Fujii Tags: ORIGINAL ARTICLE Source Type: research

Beh çet’s disease presentations and care outcomes in a tertiary hospital in south‐western Saudi Arabia
AbstractAimTo study the clinical presentations of Beh çet's disease in patients visiting a tertiary hospital in south‐western Saudi Arabia.Patients and methodsForty ‐seven patients with Behçet's disease attending the Rheumatology Department at Asser Central Hospital, Saudi Arabia were recruited into the study. The study was conducted over a period of 5 years from January 2012 to July 2017. Medical records of the patients were reviewed to analyze the frequen cy of different clinical manifestations.ResultsThe study had 26 men and 21 women. The mean age of the patients was 37.11  ± 11.9 years (range
Source: International Journal of Rheumatic Diseases - May 17, 2019 Category: Rheumatology Authors: Fares M. Al Zahrani, Bashayer Alsultan, Hana Alahmari, Ali Almannaa, Malak Asseri, Shahad Alhayaza, Fatimah Aljaser, Alwaleed Alamri, Ali Alasmari, Mansour Somaily, Abdullah Alsabaani Tags: ORIGINAL ARTICLE Source Type: research

Infection risks of rituximab versus non ‐rituximab treatment for rheumatoid arthritis: A systematic review and meta‐analysis
ConclusionIn patients with RA, RTX treatment has no additional risks for infections over non ‐RTX treatment. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - May 17, 2019 Category: Rheumatology Authors: Yuhong Shi, Yanbin Wu, Yafei Ren, Yanan Jiang, Yiqiang Chen Tags: ORIGINAL ARTICLE Source Type: research