Pathogenesis of gout: Exploring more therapeutic target
AbstractGout is a chronic metabolic and immune disease, and its specific pathogenesis is still unclear. When the serum uric acid exceeds its saturation in the blood or tissue fluid, it is converted to monosodium urate crystals, which lead to acute arthritis of varying degrees, urinary stones, or irreversible peripheral joint damage, and in severe cases, impairment of vital organ function. Gout flare is a clinically significant state of acute inflammation in gout. The current treatment is mostly anti-inflammatory analgesics, which have numerous side effects with limited treatment methods. Gout pathogenesis involves many asp...
Source: International Journal of Rheumatic Diseases - April 22, 2024 Category: Rheumatology Authors: Niqin Xiao, Zhaohu Xie, Zhiyan He, Yundong Xu, Shuyu Zhen, Yuanyuan Wei, Xiaoyu Zhang, Jiayan Shen, Jian Wang, Yadan Tian, Jinlian Zuo, Jiangyun Peng, Zhaofu Li Tags: REVIEW Source Type: research

Construct validity, reliability, and threshold value for treatment goals of the Thai version of the 12 ‐item Psoriatic Arthritis Impact of Disease Questionnaire for patients with psoriatic arthritis
ConclusionsThe Thai-PsAID is a valid, reliable, and feasible tool for measuring PsA prognosis. A cutoff of 2.7 accurately discriminates MDA and PASS and indicates no need for medication escalation. The Thai-PsAID may be used as a standalone measure. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 13, 2024 Category: Rheumatology Authors: Praveena Chiowchanwisawakit, Annop Orawongpaisarn, Wanruchada Katchamart Tags: ORIGINAL ARTICLE Source Type: research

Incidence and disease burden of autoimmune inflammatory rheumatic diseases after non ‐pharmaceutical interventions in the COVID‐19 era: A nationwide observational study in Korea
ConclusionImplementation of NPIs to contain the pandemic led to a reduction in the incidence of SLE and changed patterns of medical care utilization and treatment cost for most AIRDs. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 9, 2024 Category: Rheumatology Authors: Je Hee Shin, Jung Yoon Pyo, Minkyung Han, Myeongjee Lee, Sung Min Lim, Jee Yeon Baek, Ji Young Lee, Ji ‐Man Kang, InKyung Jung, Jong Gyun Ahn Tags: ORIGINAL ARTICLE Source Type: research

Routine biomarker profile for the prediction of clinical phenotypes of adult ‐onset Still's disease using unsupervised clustering algorithm
ConclusionThe study demonstrates the potential of integrating traditional biomarkers with unsupervised clustering algorithms in understanding the heterogeneity of AoSD. These findings suggest new avenues for developing personalized treatment strategies, though further validation in larger, prospective studies is necessary. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 5, 2024 Category: Rheumatology Authors: Antonio Gallardo ‐Pizarro, Valerio Campos‐Rodríguez, Daniel Martín‐Iglesias, Guillermo Ruiz‐Irastorza Tags: ORIGINAL ARTICLE Source Type: research

The role of rheumatologist in the assessment of hemophilic arthropathy using head ‐us in patients with hemophilia
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 5, 2024 Category: Rheumatology Authors: Emine Y ılmaz, Zühre Kaya, Hasan Satış, Merve Yazol, Serap Kirkiz, Ülker Koçak Tags: LETTER TO THE EDITOR Source Type: research

In memoriam: Professor Debashish Danda —A Beacon of excellence and humanity
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 5, 2024 Category: Rheumatology Authors: James Cheng ‐Chung Wei Tags: OBITUARY Source Type: research

Areas of further research in splint therapy for temporomandibular disorders
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 4, 2024 Category: Rheumatology Authors: Anish Poorna  T, Bobby John, Joshna E K, Arun Rao Tags: LETTER TO THE EDITOR Source Type: research

Case report: Other autoinflammatory mutations in a patient with atypical familial Mediterranean fever symptoms
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 4, 2024 Category: Rheumatology Authors: Ervanur Hac ıoglu, Ozan Er, Sejla Karup, Serdal Ugurlu Tags: LETTER TO THE EDITOR Source Type: research

Association between genetically proxied PCSK9 inhibition and systemic lupus erythematosus risk: A mendelian randomization study
ConclusionsThis Mendelian randomization study showed that PCSK9 was associated with SLE pathogenesis, and its inhibition was associated with a reduced risk of SLE. This study has offered a prospective therapeutic avenue for intervening in the progression of SLE by inhibiting PCSK9 levels. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 3, 2024 Category: Rheumatology Authors: Xincan Ji, Hao ‐Yang Guo, Mengqi Han, Hui Peng, Hui Yuan Tags: ORIGINAL ARTICLE Source Type: research

Risk factors for initial and recurrent severe infections in first hospitalized patients with systemic lupus erythematosus: A retrospective study of a Chinese cohort
ConclusionIn this cohort of SLE, patients with severe infection had a higher risk of reinfection, and low immunoglobulin, anti-dsDNA antibody positivity, and cyclophosphamide use were independent risk factors for recurrent severe infection. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 2, 2024 Category: Rheumatology Authors: Ying Zhu, Kexin Zhu, Xueyi Zhang, Zhijie Qian, Qingqing Guo, Xuefeng Xu, Genhong Yao, Xiaojun Tang, Dandan Wang, Huayong Zhang, Xuebing Feng, Ziyi Jin, Lingyun Sun Tags: ORIGINAL ARTICLE Source Type: research

A bibliometric analysis of miRNAs in rheumatoid arthritis from 2001 to 2022: Research hotspots and trends
ConclusionsIn the past two decades, extensive and continuous research has been conducted to investigate the role of miRNAs in RA, and miRNAs are widely recognized in the pathogenesis of RA. Related research has mainly focused on miR-146a and miR-155 that have shown promising results as key factors in RA experimental models. Focusing on clinical applications and translational research may be the future research direction and hotspot based on molecular biology basic research and mechanism exploration. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 2, 2024 Category: Rheumatology Authors: Xuezhi Ma, Wumiti Taxi, Yang Guo, Hasiteer Jiaerken, Yafeng Zhang, Jianwei Wang, Haitao Sun, Lining Wang, Yong Ma Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 2, 2024 Category: Rheumatology Tags: ISSUE INFORMATION Source Type: research

Causal association between several gender ‐driven factors and gout: A bidirectional Mendelian randomization study
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 23, 2024 Category: Rheumatology Authors: Yanshuang Ren, Yuqing Jiang, Huifang Peng, Hongwei Jiang Tags: LETTER TO THE EDITOR Source Type: research

A child with Kawasaki disease and acute pancreatitis: Atypical presentation
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 23, 2024 Category: Rheumatology Authors: Reva Tyagi, Disha Nagaraj, Suprit Basu, Pankaj Gupta, Manphool Singhal, Rakesh Kumar Pilania Tags: LETTER TO THE EDITOR Source Type: research

Challenging diagnosis and successful management of phosphaturic mesenchymal tumor mimicking ankylosing spondylitis: A case report
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 23, 2024 Category: Rheumatology Authors: Yuan Zhang, Jiang Zhu, Xuemeng Chen, Ganping Bai, Yu Du, Qinghua Zou Tags: LETTER TO THE EDITOR Source Type: research