The complement factor H-related protein-5 (CFHR5) exacerbates pathological bone formation in ankylosing spondylitis
In this study, we revealed that CFHR5 and proinflammatory cytokines (TNF, IL-6, IL-17A, and IL-23) were elevated in the AS group compared to the HC group. Correlation analysis revealed that CFHR5 levels were not significantly associated with proinflammatory cytokines, while CFHR5 levels in AS were only positively correlated with the high CRP group. Notably, treatment with soluble CFHR5 has no effect on clinical arthritis scores and thickness at hind paw in curdlan-injected SKG, but significantly increased the ectopic bone formation at the calcaneus and tibia bones of the ankle as revealed by micro-CT image and quantificati...
Source: Journal of Molecular Medicine - February 29, 2024 Category: Molecular Biology Source Type: research
The complement factor H-related protein-5 (CFHR5) exacerbates pathological bone formation in ankylosing spondylitis
In this study, we revealed that CFHR5 and proinflammatory cytokines (TNF, IL-6, IL-17A, and IL-23) were elevated in the AS group compared to the HC group. Correlation analysis revealed that CFHR5 levels were not significantly associated with proinflammatory cytokines, while CFHR5 levels in AS were only positively correlated with the high CRP group. Notably, treatment with soluble CFHR5 has no effect on clinical arthritis scores and thickness at hind paw in curdlan-injected SKG, but significantly increased the ectopic bone formation at the calcaneus and tibia bones of the ankle as revealed by micro-CT image and quantificati...
Source: Molecular Medicine - February 28, 2024 Category: Molecular Biology Authors: Ji-Hyun Lee Seung Hoon Lee Chanhyeok Jeon Jinil Han Sang-Hyon Kim Jeehee Youn Ye-Soo Park Tae-Jong Kim Jong-Seo Kim Sungsin Jo Tae-Hwan Kim Chang-Nam Son Source Type: research
The complement factor H-related protein-5 (CFHR5) exacerbates pathological bone formation in ankylosing spondylitis
In this study, we revealed that CFHR5 and proinflammatory cytokines (TNF, IL-6, IL-17A, and IL-23) were elevated in the AS group compared to the HC group. Correlation analysis revealed that CFHR5 levels were not significantly associated with proinflammatory cytokines, while CFHR5 levels in AS were only positively correlated with the high CRP group. Notably, treatment with soluble CFHR5 has no effect on clinical arthritis scores and thickness at hind paw in curdlan-injected SKG, but significantly increased the ectopic bone formation at the calcaneus and tibia bones of the ankle as revealed by micro-CT image and quantificati...
Source: Molecular Medicine - February 28, 2024 Category: Molecular Biology Authors: Ji-Hyun Lee Seung Hoon Lee Chanhyeok Jeon Jinil Han Sang-Hyon Kim Jeehee Youn Ye-Soo Park Tae-Jong Kim Jong-Seo Kim Sungsin Jo Tae-Hwan Kim Chang-Nam Son Source Type: research
Association between Sj ögren syndrome, sociodemographic factors, comorbid conditions, and optic neuritis: a Taiwanese population-based study
DiscussionOur findings strongly support the existence of an association between Sjögren syndrome, rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, systemic lupus erythematosus, granulomatous vasculitis, human herpes viral infection, tuberculosis, and optic neuritis. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 27, 2024 Category: Neurology Source Type: research
Pattern and Predictors of Infection Among Patients With Rheumatological Disease on Immunosuppressive Medications: A Retrospective Study in a Tertiary Care Hospital in Bangladesh
Conclusion COVID-19 pneumonia, urinary tract infections, fungal infection, tuberculosis, herpes zoster, and community-acquired pneumonia were commonly occurring infections among patients receiving different immunosuppressive medications. Factors like poor nutritional status, presence of anemia, leucopenia, hypoalbuminemia, hyperglycemia, and hypovitaminosis D had a significant association with infection. Moreover, inadequate counseling of steroid side effects and history of daily intake of prednisolone (>10mg/day) were also significant factors associated with infection.PMID:38406079 | PMC:PMC10883793 | DOI:10.7759/cureu...
Source: Herpes - February 26, 2024 Category: Infectious Diseases Authors: S K Jakaria Been Sayeed Md Moniruzzaman A K M Humayon Kabir Md Uzzwal Mallik Bikas Chandra Mondal Shahin Mahmud Fahim T Rahman Mehrin Rahman Md Mujibur Rahman Source Type: research
Pattern and Predictors of Infection Among Patients With Rheumatological Disease on Immunosuppressive Medications: A Retrospective Study in a Tertiary Care Hospital in Bangladesh
Conclusion COVID-19 pneumonia, urinary tract infections, fungal infection, tuberculosis, herpes zoster, and community-acquired pneumonia were commonly occurring infections among patients receiving different immunosuppressive medications. Factors like poor nutritional status, presence of anemia, leucopenia, hypoalbuminemia, hyperglycemia, and hypovitaminosis D had a significant association with infection. Moreover, inadequate counseling of steroid side effects and history of daily intake of prednisolone (>10mg/day) were also significant factors associated with infection.PMID:38406079 | PMC:PMC10883793 | DOI:10.7759/cureu...
Source: Herpes - February 26, 2024 Category: Infectious Diseases Authors: S K Jakaria Been Sayeed Md Moniruzzaman A K M Humayon Kabir Md Uzzwal Mallik Bikas Chandra Mondal Shahin Mahmud Fahim T Rahman Mehrin Rahman Md Mujibur Rahman Source Type: research
Sulfasalazine promotes ferroptosis through AKT-ERK1/2 and P53-SLC7A11 in rheumatoid arthritis
ConclusionsSulfasalazine promoted ferroptosis of FLSs in rheumatoid arthritis, and the PI3K-AKT-ERK1/2 pathway and P53-SLC7A11 pathway play an important role in this process. (Source: Inflammopharmacology)
Source: Inflammopharmacology - February 26, 2024 Category: Drugs & Pharmacology Source Type: research
Thoracic vertebra chance fracture with spinal epidural hematoma in patient with ankylosing spondylitis
Asian J Surg. 2024 Feb 22:S1015-9584(24)00291-4. doi: 10.1016/j.asjsur.2024.02.033. Online ahead of print.NO ABSTRACTPMID:38395708 | DOI:10.1016/j.asjsur.2024.02.033 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - February 23, 2024 Category: Surgery Authors: Pingan Liu Hao Zhu Jingjing Xie Source Type: research
Disposcope endoscope for orotracheal intubation in ankylosing spondylitis patients with restricted mouth opening
Asian J Surg. 2024 Feb 20:S1015-9584(24)00343-9. doi: 10.1016/j.asjsur.2024.02.083. Online ahead of print.NO ABSTRACTPMID:38383191 | DOI:10.1016/j.asjsur.2024.02.083 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - February 21, 2024 Category: Surgery Authors: Duo Yang Renzhe Lin Jinxin Lan Longsheng Zhang Source Type: research
Andersson lesion can be healed with sagittal alignment improved in kyphosis deformity secondary to ankylosing spondylitis
Asian J Surg. 2024 Feb 19:S1015-9584(24)00355-5. doi: 10.1016/j.asjsur.2023.08.236. Online ahead of print.NO ABSTRACTPMID:38378413 | DOI:10.1016/j.asjsur.2023.08.236 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - February 20, 2024 Category: Surgery Authors: Guohui Zheng Wen Yin Yunlei Zhai Haiyang Yu Source Type: research
How to Monitor Disease Activity of Axial Spondyloarthritis in Clinical Practice
Curr Rheumatol Rep. 2024 Feb 19. doi: 10.1007/s11926-024-01141-0. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Treatment guided by periodic and quantitative data assessment results in better outcomes compared to using clinical gestalt. While validated generic as well as specific disease activity measures for axial spondyloarthritis (axSpA) are available, there is vast scope to improve their actual utilization in routine clinical practice. In this review, we discuss available disease activity measures for axSpA, describe results from the survey conducted among general rheumatologists as well as Spondyloarthritis Researc...
Source: Pain Physician - February 19, 2024 Category: Anesthesiology Authors: Anand Kumthekar Nirali Sanghavi Anuya Natu Abhijeet Danve Source Type: research
How to Monitor Disease Activity of Axial Spondyloarthritis in Clinical Practice
Curr Rheumatol Rep. 2024 Feb 19. doi: 10.1007/s11926-024-01141-0. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Treatment guided by periodic and quantitative data assessment results in better outcomes compared to using clinical gestalt. While validated generic as well as specific disease activity measures for axial spondyloarthritis (axSpA) are available, there is vast scope to improve their actual utilization in routine clinical practice. In this review, we discuss available disease activity measures for axSpA, describe results from the survey conducted among general rheumatologists as well as Spondyloarthritis Researc...
Source: Pain Physician - February 19, 2024 Category: Anesthesiology Authors: Anand Kumthekar Nirali Sanghavi Anuya Natu Abhijeet Danve Source Type: research
Identification of a Novel Gene Expression Signature Associated with Amino Acid Metabolism (AAM) in Ankylosing Spondylitis (AS)
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - February 19, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
How to Monitor Disease Activity of Axial Spondyloarthritis in Clinical Practice
AbstractPurpose of ReviewTreatment guided by periodic and quantitative data assessment results in better outcomes compared to using clinical gestalt. While validated generic as well as specific disease activity measures for axial spondyloarthritis (axSpA) are available, there is vast scope to improve their actual utilization in routine clinical practice. In this review, we discuss available disease activity measures for axSpA, describe results from the survey conducted among general rheumatologists as well as Spondyloarthritis Research and Treatment Network (SPARTAN) members about disease activity measurement in daily prac...
Source: Current Rheumatology Reports - February 19, 2024 Category: Rheumatology Source Type: research
