MicroRNAs in Human Disease: Commentary
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):259-262. doi: 10.18502/ijaai.v20i3.6341.ABSTRACTThis letter to the editor has not an abstract.PMID:34134446 | DOI:10.18502/ijaai.v20i3.6341 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Ian M Adcock Sharon Mumby Source Type: research

The Prevalence of Allergic Rhinitis in Southwestern Iran and Its Association with Chronic Rhinosinusitis: A GA2LEN Study
This study aimed to assess the prevalence of AR and its association with chronic rhinosinusitis (CRS) in the adult population living in Bushehr, southwestern part of Iran. In this population-based study, a total of 5420 individuals aged 15-65 years were selected through a multi-stage, cluster, random sampling method from which 5201 of them completed the Global Allergy and Asthma Network of Excellence (GA2LEN) questionnaire (Response rate=96.1%). The prevalence of AR, based on Allergic Rhinitis and Its Impact on Asthma (ARIA) classification (mild or moderate; intermittent or persistent) was calculated and the association of...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Afshin Ostovar Safoora Pordel Ali Movahed Reza Kaboodkhani Allahkaram Akhlaghi Amirhossein Darabi Farzaneh Ghaderi Shokrollah Farrokhi Source Type: research

Prevalence of Allergic Rhinitis and Eczema in Adolescents Living in Yazd City: Part of Global Asthma Network Survey
This study aimed to investigate the prevalence and severity of allergic rhinitis and eczema in adolescents living in Yazd city. Using an electronic questionnaire based on the Global Asthma Network (GAN) core questionnaire, 5141 adolescents aged 13-14 years were cross-sectionally surveyed. The prevalence of current symptoms of rhinitis turned out to be 36.3%, proving significantly higher in boys (p=0.009). Moreover, the prevalence of allergic rhinitis and rhinoconjunctivitis in the past year leveled at 12.4% and 10.5%, respectively; however, the former was significantly higher in females (p=0.014). Additionally, severe rhin...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Zahra Nafei Nasrin Behniafard Mohsen Mirzaei Mehran Karimi Elahe Akbarian Source Type: research

Assessment of Carotid Artery Distensibility and Elasticity in Patients with Asthma
This study aimed to determine the possibility of a higher risk of atherosclerosis in asthma patients compared with healthy controls by measuring carotid elasticity and distensibility. This was a cross-sectional study on 326 participants including 221 patients (129 [58.37%] females) with persistent asthma, aged 46.47±11.58 years, body mass index (BMI) of 29.74±3.99, and 105 healthy control subjects (60 [57.14%] females) aged 46.08±11.35 years, and BMI of 29.42±3.76. Of the 221 patients with asthma, 75 (33.93%) had mild, 74 (33.48%) had moderate and 72 (32.57%) had severe asthma. The carotid diste...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Hatice Eyl ül Bozkurt Yılmaz Mustafa Y ılmaz Source Type: research

The Effect of Aspirin on Moderate to Severe Asthmatic Patients with Aspirin Hypersensitivity, Chronic Rhinosinusitis, and Nasal Polyposis
This study aimed to evaluate the effect and outcome of daily low-dose aspirin in the treatment of moderate to severe asthma in patients with concomitant aspirin hypersensitivity and chronic rhinosinusitis with nasal polyposis (CRSwNP). This clinical trial was conducted from February 2014 to February 2015 on 46 adult patients with moderate to severe asthma accompanied by CRSwNP. Patients with a positive aspirin challenge were blindly randomized in three groups receiving placebo/day (A); aspirin 100 mg/day (B); and aspirin 325mg/day (C), respectively. Clinical findings, FEV1 and ACT scores were recorded and compared before, ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Saba Arshi Sepideh Darougar Mohammad Nabavi Mohammad Hassan Bemanian Morteza Fallahpour Sima Shokri Javad Ahmadian Rasool Molatefi Mahsa Rekabi Zeinab Moinfar Paniz Hashemitari Narges Eslami Source Type: research

Airborne Pollens and Their Association with Meteorological Parameters in the Atmosphere of Shiraz, Southwest Iran
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):294-302. doi: 10.18502/ijaai.v20i3.6332.ABSTRACTAirborne pollen is considered one of the causative agents of hay fever, allergic rhinitis, conjunctivitis, and asthma. We aimed to investigate airborne pollens in the context of Shiraz located in the southwest of Iran and find their association with meteorological parameters. The survey was conducted from October 2017 to September 2018, using seven days of volumetric Burkard spore trap, located in the center of the city. A total of 5810 pollen grains/m3 belonging to 15 taxa were identified and recorded. Among them, 73.8% was the...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Heidar Ali Kafashan Ahmad Reza Khosravi Soheila Alyasin Najmeh Sepahi Zahra Kanannejad Farzaneh Mohammad Ali Zadeh Shirazi Sahar Karami Source Type: research

Investigation of rs531564 Polymorphism in the Primary MicroRNA-124 Gene in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: Association with Disease Susceptibility and Clinical Characteristics
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):303-313. doi: 10.18502/ijaai.v20i3.6336.ABSTRACTMicroRNA-124 (miR-124) is known as an important regulator of the immune system and inflammatory response. Studies have reported that this miRNA is dysregulated in autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). A functional analysis demonstrated that rs531564 (C>G) affects the biogenesis of primary microRNA transcript-124 (pri-miR-124) and changes the expression of mature miR-124. In the present study, for the first time, we intended to evaluate the possible association between r...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Mehdi Hassani Mohammad Dehani Maryam Zare Rafie Emran Esmaeilzadeh Saeideh Davar Bahram Pakzad Meysam Mosallaei Seyyed Mohamad Hoseini Hadi Bayat Mohsen Soosanabadi Source Type: research

Inflammation in an Animal Model of Multiple Sclerosis Leads to MicroRNA-25-3p Dysregulation Associated with Inhibition of Pten and Klf4
In this study, we investigated the expression of miR-25-3p and its targets in the central nervous system (CNS) tissue from mice with experimental autoimmune encephalomyelitis (EAE). We also analyzed the expression of miR-25 and its targets in activated macrophages and splenocytes. EAE was induced in 12-week old female C57BL/6 mice; using myelin oligodendrocyte glycoprotein 35-55/complete Freund's adjuvant (MOG35-55/CFA) protocol. The expression of miR-25-3p and its targets, as well as the expression of inflammatory cytokines, were analyzed. We next established primary macrophage cultures as well as splenocyte cultures and ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Ameneh Zare-Chahoki Meysam Ahmadi-Zeidabadi Saeid Azadarmaki Samira Ghorbani Farshid Noorbakhsh Source Type: research

Plasma Levels of MicroRNA-146a-5p, MicroRNA-24-3p, and MicroRNA-125a-5p as Potential Diagnostic Biomarkers for Rheumatoid Arthris
This study aims to evaluate the expression of microRNA (miR)-146a-5p, miR-24-3p, and miR-125a-5p in the plasma of RA patients and compare them with those of healthy controls to obtain a specific expression profile for earlier diagnosis and assistance in treating patients. This study was performed on 50 RA patients and 50 healthy controls. Five microliters of blood were taken from each patient/control. Plasma RNA was extracted using the Trisol solution. cDNAs were synthesized; using moloney murine leukemia virus (MMLV) and deoxynucleoside triphosphate (dNTP). Real-time PCR was performed using SYBR green kit. The mean expres...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Fatemeh Safari Elia Damavandi Abdol-Rahman Rostamian Shafieh Movassaghi Zeinab Imani-Saber Mojtaba Saffari Majid Kabuli Mohsen Ghadami Source Type: research

Role of Fibroblast Activation Protein Alpha in Fibroblast-like Synoviocytes of Rheumatoid Arthritis
This study aimed to investigate the role of fibroblast activation protein-alpha (FAP-α) in the regulation of genes involved in the transformation and pathogenic activity of RA FLSs. Synovial FLSs were isolated from RA patients and non-arthritic individuals (n=10 in both groups) and characterized; using immunocytochemistry and flow cytometry analysis. FLSs were divided into un-treated and Talabostat-treated groups to evaluate the FAP-α effect on the selected genes involved in cell cycle regulation (p21, p53, CCND1), apoptosis (Bcl-2, PUMA), and inflammatory and destructive behavior of FLSs (IL-6, TGF-β1, MM...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Mohammad Javad Mousavi Elham Farhadi Mohammad Vodjgani Jafar Karami Mohammad Naghi Tahmasebi Arash Sharafat Vaziri Marzieh Asgari Nima Rezaei Shayan Mostafaei Ahmadreza Jamshidi Mahdi Mahmoudi Source Type: research

Genotyping of Human Platelet Antigen-1 to -5 and -15 by Polymerase Chain Reaction with Sequence-specific Primers (PCR-SSP) and Real-time PCR in Azeri Blood Donors
This study aimed to compare allelic and genotype frequencies of human platelet antigens in the Azeri ethnicity by TaqMan Real-time and polymerase chain reaction with sequence-specific primers (PCR-SSP) methods. DNA was extracted from the whole blood of 100 Azeri blood donors in the Ardabil Blood Transfusion Center. Genotyping of HPA-1 to -5 and -15 was performed by TaqMan Real-time PCR, and PCR-SSP and consistency of results were evaluated. The results of PCR-SSP and TaqMan Real-time PCR showed complete consistency. The allele frequencies were 91.5% and 8.5% for HPA-1a and -1b; 88% and 12% for HPA-2a and -2b; 58% and 42 % ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Seyed Ghader Azizi Shahram Samiee Mojgan Shaiegan Maryam Zadsar Source Type: research

The Effect of Antigen Dose and Antigen Presenting Process on T Cell Stimulation: A Method for Enrichment of TB10.4 Antigen-specific T-cell Clones
We described a method for inducing, enriching, and replicating Ag-specific poly-clonal T-cells from BALB/c mice infected with live Bacillus Calmette Guérin (BCG) bacterium. During a 7-8 days procedure, T-lymphocytes were purified from immune cells of lymph nodes stimulated with immunodominant Ag of BCG, TB10.4, and expanded by interleukin -2 cytokine. We evaluated the effect of Ag doses (1, 10, and 100 μg/mL) and exposure method of Ag presenting cells (APCs) to T-cells, on T-cells' proliferation, viability, and Interferon-gamma (IFN-γ) secretion at 2, 5, and 7 days after Ag stimulation. Increasing Ag concen...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Mahdieh Motiee Ahmad Zavaran Hosseini Sara Soudi Seyed Mehdi Hassanzadeh Source Type: research

Disseminated Mycobacterium simiae Infection in a Patient with Complete IL-12p40 Deficiency
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):376-381. doi: 10.18502/ijaai.v20i3.6339.ABSTRACTMendelian susceptibility to mycobacterial disease (MSMD) is a rare group of genetic disorders characterized by infections with weakly virulent environmental mycobacteria (EM) or Mycobacterium bovis bacillus Calmette-Guérin (BCG). Herein, we described the case of a 4.5-year-old boy with protein-losing enteropathy, lymphoproliferation, and candidiasis, who was found to have disseminated Mycobacterium simiae infection. A homozygous mutation in the IL12B gene, c.527_528delCT (p.S176Cfs*12) was identified, responsible for the ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Seyed Alireza Mahdaviani Majid Marjani Mahnaz Jamee Armin Khavandegar Hosseinali Ghaffaripour Golnaz Eslamian Mehdi Ghaini Shabnam Eskandarzadeh Jean-Laurent Casanova Jacinta Bustamante Davood Mansouri Ali Akbar Velayati Source Type: research

COVID-19 Pandemic and Influenza Season in Hospitalized Patients: Concerns and Suggestions
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):382-383. doi: 10.18502/ijaai.v20i3.6340.ABSTRACTThis is a letter to the editor.PMID:34134459 | DOI:10.18502/ijaai.v20i3.6340 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Amir Hossein Norooznezhad Source Type: research

MicroRNAs in Human Disease: Commentary
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):259-262. doi: 10.18502/ijaai.v20i3.6341.ABSTRACTThis letter to the editor has not an abstract.PMID:34134446 | DOI:10.18502/ijaai.v20i3.6341 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Ian M Adcock Sharon Mumby Source Type: research

The Prevalence of Allergic Rhinitis in Southwestern Iran and Its Association with Chronic Rhinosinusitis: A GA2LEN Study
This study aimed to assess the prevalence of AR and its association with chronic rhinosinusitis (CRS) in the adult population living in Bushehr, southwestern part of Iran. In this population-based study, a total of 5420 individuals aged 15-65 years were selected through a multi-stage, cluster, random sampling method from which 5201 of them completed the Global Allergy and Asthma Network of Excellence (GA2LEN) questionnaire (Response rate=96.1%). The prevalence of AR, based on Allergic Rhinitis and Its Impact on Asthma (ARIA) classification (mild or moderate; intermittent or persistent) was calculated and the association of...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Afshin Ostovar Safoora Pordel Ali Movahed Reza Kaboodkhani Allahkaram Akhlaghi Amirhossein Darabi Farzaneh Ghaderi Shokrollah Farrokhi Source Type: research

Prevalence of Allergic Rhinitis and Eczema in Adolescents Living in Yazd City: Part of Global Asthma Network Survey
This study aimed to investigate the prevalence and severity of allergic rhinitis and eczema in adolescents living in Yazd city. Using an electronic questionnaire based on the Global Asthma Network (GAN) core questionnaire, 5141 adolescents aged 13-14 years were cross-sectionally surveyed. The prevalence of current symptoms of rhinitis turned out to be 36.3%, proving significantly higher in boys (p=0.009). Moreover, the prevalence of allergic rhinitis and rhinoconjunctivitis in the past year leveled at 12.4% and 10.5%, respectively; however, the former was significantly higher in females (p=0.014). Additionally, severe rhin...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Zahra Nafei Nasrin Behniafard Mohsen Mirzaei Mehran Karimi Elahe Akbarian Source Type: research

Assessment of Carotid Artery Distensibility and Elasticity in Patients with Asthma
This study aimed to determine the possibility of a higher risk of atherosclerosis in asthma patients compared with healthy controls by measuring carotid elasticity and distensibility. This was a cross-sectional study on 326 participants including 221 patients (129 [58.37%] females) with persistent asthma, aged 46.47±11.58 years, body mass index (BMI) of 29.74±3.99, and 105 healthy control subjects (60 [57.14%] females) aged 46.08±11.35 years, and BMI of 29.42±3.76. Of the 221 patients with asthma, 75 (33.93%) had mild, 74 (33.48%) had moderate and 72 (32.57%) had severe asthma. The carotid diste...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Hatice Eyl ül Bozkurt Yılmaz Mustafa Y ılmaz Source Type: research

The Effect of Aspirin on Moderate to Severe Asthmatic Patients with Aspirin Hypersensitivity, Chronic Rhinosinusitis, and Nasal Polyposis
This study aimed to evaluate the effect and outcome of daily low-dose aspirin in the treatment of moderate to severe asthma in patients with concomitant aspirin hypersensitivity and chronic rhinosinusitis with nasal polyposis (CRSwNP). This clinical trial was conducted from February 2014 to February 2015 on 46 adult patients with moderate to severe asthma accompanied by CRSwNP. Patients with a positive aspirin challenge were blindly randomized in three groups receiving placebo/day (A); aspirin 100 mg/day (B); and aspirin 325mg/day (C), respectively. Clinical findings, FEV1 and ACT scores were recorded and compared before, ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Saba Arshi Sepideh Darougar Mohammad Nabavi Mohammad Hassan Bemanian Morteza Fallahpour Sima Shokri Javad Ahmadian Rasool Molatefi Mahsa Rekabi Zeinab Moinfar Paniz Hashemitari Narges Eslami Source Type: research

Airborne Pollens and Their Association with Meteorological Parameters in the Atmosphere of Shiraz, Southwest Iran
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):294-302. doi: 10.18502/ijaai.v20i3.6332.ABSTRACTAirborne pollen is considered one of the causative agents of hay fever, allergic rhinitis, conjunctivitis, and asthma. We aimed to investigate airborne pollens in the context of Shiraz located in the southwest of Iran and find their association with meteorological parameters. The survey was conducted from October 2017 to September 2018, using seven days of volumetric Burkard spore trap, located in the center of the city. A total of 5810 pollen grains/m3 belonging to 15 taxa were identified and recorded. Among them, 73.8% was the...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Heidar Ali Kafashan Ahmad Reza Khosravi Soheila Alyasin Najmeh Sepahi Zahra Kanannejad Farzaneh Mohammad Ali Zadeh Shirazi Sahar Karami Source Type: research

Investigation of rs531564 Polymorphism in the Primary MicroRNA-124 Gene in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: Association with Disease Susceptibility and Clinical Characteristics
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):303-313. doi: 10.18502/ijaai.v20i3.6336.ABSTRACTMicroRNA-124 (miR-124) is known as an important regulator of the immune system and inflammatory response. Studies have reported that this miRNA is dysregulated in autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). A functional analysis demonstrated that rs531564 (C>G) affects the biogenesis of primary microRNA transcript-124 (pri-miR-124) and changes the expression of mature miR-124. In the present study, for the first time, we intended to evaluate the possible association between r...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Mehdi Hassani Mohammad Dehani Maryam Zare Rafie Emran Esmaeilzadeh Saeideh Davar Bahram Pakzad Meysam Mosallaei Seyyed Mohamad Hoseini Hadi Bayat Mohsen Soosanabadi Source Type: research

Inflammation in an Animal Model of Multiple Sclerosis Leads to MicroRNA-25-3p Dysregulation Associated with Inhibition of Pten and Klf4
In this study, we investigated the expression of miR-25-3p and its targets in the central nervous system (CNS) tissue from mice with experimental autoimmune encephalomyelitis (EAE). We also analyzed the expression of miR-25 and its targets in activated macrophages and splenocytes. EAE was induced in 12-week old female C57BL/6 mice; using myelin oligodendrocyte glycoprotein 35-55/complete Freund's adjuvant (MOG35-55/CFA) protocol. The expression of miR-25-3p and its targets, as well as the expression of inflammatory cytokines, were analyzed. We next established primary macrophage cultures as well as splenocyte cultures and ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Ameneh Zare-Chahoki Meysam Ahmadi-Zeidabadi Saeid Azadarmaki Samira Ghorbani Farshid Noorbakhsh Source Type: research

Plasma Levels of MicroRNA-146a-5p, MicroRNA-24-3p, and MicroRNA-125a-5p as Potential Diagnostic Biomarkers for Rheumatoid Arthris
This study aims to evaluate the expression of microRNA (miR)-146a-5p, miR-24-3p, and miR-125a-5p in the plasma of RA patients and compare them with those of healthy controls to obtain a specific expression profile for earlier diagnosis and assistance in treating patients. This study was performed on 50 RA patients and 50 healthy controls. Five microliters of blood were taken from each patient/control. Plasma RNA was extracted using the Trisol solution. cDNAs were synthesized; using moloney murine leukemia virus (MMLV) and deoxynucleoside triphosphate (dNTP). Real-time PCR was performed using SYBR green kit. The mean expres...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Fatemeh Safari Elia Damavandi Abdol-Rahman Rostamian Shafieh Movassaghi Zeinab Imani-Saber Mojtaba Saffari Majid Kabuli Mohsen Ghadami Source Type: research

Role of Fibroblast Activation Protein Alpha in Fibroblast-like Synoviocytes of Rheumatoid Arthritis
This study aimed to investigate the role of fibroblast activation protein-alpha (FAP-α) in the regulation of genes involved in the transformation and pathogenic activity of RA FLSs. Synovial FLSs were isolated from RA patients and non-arthritic individuals (n=10 in both groups) and characterized; using immunocytochemistry and flow cytometry analysis. FLSs were divided into un-treated and Talabostat-treated groups to evaluate the FAP-α effect on the selected genes involved in cell cycle regulation (p21, p53, CCND1), apoptosis (Bcl-2, PUMA), and inflammatory and destructive behavior of FLSs (IL-6, TGF-β1, MM...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Mohammad Javad Mousavi Elham Farhadi Mohammad Vodjgani Jafar Karami Mohammad Naghi Tahmasebi Arash Sharafat Vaziri Marzieh Asgari Nima Rezaei Shayan Mostafaei Ahmadreza Jamshidi Mahdi Mahmoudi Source Type: research

Genotyping of Human Platelet Antigen-1 to -5 and -15 by Polymerase Chain Reaction with Sequence-specific Primers (PCR-SSP) and Real-time PCR in Azeri Blood Donors
This study aimed to compare allelic and genotype frequencies of human platelet antigens in the Azeri ethnicity by TaqMan Real-time and polymerase chain reaction with sequence-specific primers (PCR-SSP) methods. DNA was extracted from the whole blood of 100 Azeri blood donors in the Ardabil Blood Transfusion Center. Genotyping of HPA-1 to -5 and -15 was performed by TaqMan Real-time PCR, and PCR-SSP and consistency of results were evaluated. The results of PCR-SSP and TaqMan Real-time PCR showed complete consistency. The allele frequencies were 91.5% and 8.5% for HPA-1a and -1b; 88% and 12% for HPA-2a and -2b; 58% and 42 % ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Seyed Ghader Azizi Shahram Samiee Mojgan Shaiegan Maryam Zadsar Source Type: research

The Effect of Antigen Dose and Antigen Presenting Process on T Cell Stimulation: A Method for Enrichment of TB10.4 Antigen-specific T-cell Clones
We described a method for inducing, enriching, and replicating Ag-specific poly-clonal T-cells from BALB/c mice infected with live Bacillus Calmette Guérin (BCG) bacterium. During a 7-8 days procedure, T-lymphocytes were purified from immune cells of lymph nodes stimulated with immunodominant Ag of BCG, TB10.4, and expanded by interleukin -2 cytokine. We evaluated the effect of Ag doses (1, 10, and 100 μg/mL) and exposure method of Ag presenting cells (APCs) to T-cells, on T-cells' proliferation, viability, and Interferon-gamma (IFN-γ) secretion at 2, 5, and 7 days after Ag stimulation. Increasing Ag concen...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Mahdieh Motiee Ahmad Zavaran Hosseini Sara Soudi Seyed Mehdi Hassanzadeh Source Type: research

Disseminated Mycobacterium simiae Infection in a Patient with Complete IL-12p40 Deficiency
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):376-381. doi: 10.18502/ijaai.v20i3.6339.ABSTRACTMendelian susceptibility to mycobacterial disease (MSMD) is a rare group of genetic disorders characterized by infections with weakly virulent environmental mycobacteria (EM) or Mycobacterium bovis bacillus Calmette-Guérin (BCG). Herein, we described the case of a 4.5-year-old boy with protein-losing enteropathy, lymphoproliferation, and candidiasis, who was found to have disseminated Mycobacterium simiae infection. A homozygous mutation in the IL12B gene, c.527_528delCT (p.S176Cfs*12) was identified, responsible for the ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Seyed Alireza Mahdaviani Majid Marjani Mahnaz Jamee Armin Khavandegar Hosseinali Ghaffaripour Golnaz Eslamian Mehdi Ghaini Shabnam Eskandarzadeh Jean-Laurent Casanova Jacinta Bustamante Davood Mansouri Ali Akbar Velayati Source Type: research

COVID-19 Pandemic and Influenza Season in Hospitalized Patients: Concerns and Suggestions
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):382-383. doi: 10.18502/ijaai.v20i3.6340.ABSTRACTThis is a letter to the editor.PMID:34134459 | DOI:10.18502/ijaai.v20i3.6340 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Amir Hossein Norooznezhad Source Type: research

MicroRNAs in Human Disease: Commentary
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):259-262. doi: 10.18502/ijaai.v20i3.6341.ABSTRACTThis letter to the editor has not an abstract.PMID:34134446 | DOI:10.18502/ijaai.v20i3.6341 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Ian M Adcock Sharon Mumby Source Type: research

The Prevalence of Allergic Rhinitis in Southwestern Iran and Its Association with Chronic Rhinosinusitis: A GA2LEN Study
This study aimed to assess the prevalence of AR and its association with chronic rhinosinusitis (CRS) in the adult population living in Bushehr, southwestern part of Iran. In this population-based study, a total of 5420 individuals aged 15-65 years were selected through a multi-stage, cluster, random sampling method from which 5201 of them completed the Global Allergy and Asthma Network of Excellence (GA2LEN) questionnaire (Response rate=96.1%). The prevalence of AR, based on Allergic Rhinitis and Its Impact on Asthma (ARIA) classification (mild or moderate; intermittent or persistent) was calculated and the association of...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Afshin Ostovar Safoora Pordel Ali Movahed Reza Kaboodkhani Allahkaram Akhlaghi Amirhossein Darabi Farzaneh Ghaderi Shokrollah Farrokhi Source Type: research

Prevalence of Allergic Rhinitis and Eczema in Adolescents Living in Yazd City: Part of Global Asthma Network Survey
This study aimed to investigate the prevalence and severity of allergic rhinitis and eczema in adolescents living in Yazd city. Using an electronic questionnaire based on the Global Asthma Network (GAN) core questionnaire, 5141 adolescents aged 13-14 years were cross-sectionally surveyed. The prevalence of current symptoms of rhinitis turned out to be 36.3%, proving significantly higher in boys (p=0.009). Moreover, the prevalence of allergic rhinitis and rhinoconjunctivitis in the past year leveled at 12.4% and 10.5%, respectively; however, the former was significantly higher in females (p=0.014). Additionally, severe rhin...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Zahra Nafei Nasrin Behniafard Mohsen Mirzaei Mehran Karimi Elahe Akbarian Source Type: research

Assessment of Carotid Artery Distensibility and Elasticity in Patients with Asthma
This study aimed to determine the possibility of a higher risk of atherosclerosis in asthma patients compared with healthy controls by measuring carotid elasticity and distensibility. This was a cross-sectional study on 326 participants including 221 patients (129 [58.37%] females) with persistent asthma, aged 46.47±11.58 years, body mass index (BMI) of 29.74±3.99, and 105 healthy control subjects (60 [57.14%] females) aged 46.08±11.35 years, and BMI of 29.42±3.76. Of the 221 patients with asthma, 75 (33.93%) had mild, 74 (33.48%) had moderate and 72 (32.57%) had severe asthma. The carotid diste...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Hatice Eyl ül Bozkurt Yılmaz Mustafa Y ılmaz Source Type: research

The Effect of Aspirin on Moderate to Severe Asthmatic Patients with Aspirin Hypersensitivity, Chronic Rhinosinusitis, and Nasal Polyposis
This study aimed to evaluate the effect and outcome of daily low-dose aspirin in the treatment of moderate to severe asthma in patients with concomitant aspirin hypersensitivity and chronic rhinosinusitis with nasal polyposis (CRSwNP). This clinical trial was conducted from February 2014 to February 2015 on 46 adult patients with moderate to severe asthma accompanied by CRSwNP. Patients with a positive aspirin challenge were blindly randomized in three groups receiving placebo/day (A); aspirin 100 mg/day (B); and aspirin 325mg/day (C), respectively. Clinical findings, FEV1 and ACT scores were recorded and compared before, ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Saba Arshi Sepideh Darougar Mohammad Nabavi Mohammad Hassan Bemanian Morteza Fallahpour Sima Shokri Javad Ahmadian Rasool Molatefi Mahsa Rekabi Zeinab Moinfar Paniz Hashemitari Narges Eslami Source Type: research

Airborne Pollens and Their Association with Meteorological Parameters in the Atmosphere of Shiraz, Southwest Iran
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):294-302. doi: 10.18502/ijaai.v20i3.6332.ABSTRACTAirborne pollen is considered one of the causative agents of hay fever, allergic rhinitis, conjunctivitis, and asthma. We aimed to investigate airborne pollens in the context of Shiraz located in the southwest of Iran and find their association with meteorological parameters. The survey was conducted from October 2017 to September 2018, using seven days of volumetric Burkard spore trap, located in the center of the city. A total of 5810 pollen grains/m3 belonging to 15 taxa were identified and recorded. Among them, 73.8% was the...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Heidar Ali Kafashan Ahmad Reza Khosravi Soheila Alyasin Najmeh Sepahi Zahra Kanannejad Farzaneh Mohammad Ali Zadeh Shirazi Sahar Karami Source Type: research

Investigation of rs531564 Polymorphism in the Primary MicroRNA-124 Gene in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: Association with Disease Susceptibility and Clinical Characteristics
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):303-313. doi: 10.18502/ijaai.v20i3.6336.ABSTRACTMicroRNA-124 (miR-124) is known as an important regulator of the immune system and inflammatory response. Studies have reported that this miRNA is dysregulated in autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). A functional analysis demonstrated that rs531564 (C>G) affects the biogenesis of primary microRNA transcript-124 (pri-miR-124) and changes the expression of mature miR-124. In the present study, for the first time, we intended to evaluate the possible association between r...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Mehdi Hassani Mohammad Dehani Maryam Zare Rafie Emran Esmaeilzadeh Saeideh Davar Bahram Pakzad Meysam Mosallaei Seyyed Mohamad Hoseini Hadi Bayat Mohsen Soosanabadi Source Type: research

Inflammation in an Animal Model of Multiple Sclerosis Leads to MicroRNA-25-3p Dysregulation Associated with Inhibition of Pten and Klf4
In this study, we investigated the expression of miR-25-3p and its targets in the central nervous system (CNS) tissue from mice with experimental autoimmune encephalomyelitis (EAE). We also analyzed the expression of miR-25 and its targets in activated macrophages and splenocytes. EAE was induced in 12-week old female C57BL/6 mice; using myelin oligodendrocyte glycoprotein 35-55/complete Freund's adjuvant (MOG35-55/CFA) protocol. The expression of miR-25-3p and its targets, as well as the expression of inflammatory cytokines, were analyzed. We next established primary macrophage cultures as well as splenocyte cultures and ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Ameneh Zare-Chahoki Meysam Ahmadi-Zeidabadi Saeid Azadarmaki Samira Ghorbani Farshid Noorbakhsh Source Type: research

Plasma Levels of MicroRNA-146a-5p, MicroRNA-24-3p, and MicroRNA-125a-5p as Potential Diagnostic Biomarkers for Rheumatoid Arthris
This study aims to evaluate the expression of microRNA (miR)-146a-5p, miR-24-3p, and miR-125a-5p in the plasma of RA patients and compare them with those of healthy controls to obtain a specific expression profile for earlier diagnosis and assistance in treating patients. This study was performed on 50 RA patients and 50 healthy controls. Five microliters of blood were taken from each patient/control. Plasma RNA was extracted using the Trisol solution. cDNAs were synthesized; using moloney murine leukemia virus (MMLV) and deoxynucleoside triphosphate (dNTP). Real-time PCR was performed using SYBR green kit. The mean expres...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Fatemeh Safari Elia Damavandi Abdol-Rahman Rostamian Shafieh Movassaghi Zeinab Imani-Saber Mojtaba Saffari Majid Kabuli Mohsen Ghadami Source Type: research

Role of Fibroblast Activation Protein Alpha in Fibroblast-like Synoviocytes of Rheumatoid Arthritis
This study aimed to investigate the role of fibroblast activation protein-alpha (FAP-α) in the regulation of genes involved in the transformation and pathogenic activity of RA FLSs. Synovial FLSs were isolated from RA patients and non-arthritic individuals (n=10 in both groups) and characterized; using immunocytochemistry and flow cytometry analysis. FLSs were divided into un-treated and Talabostat-treated groups to evaluate the FAP-α effect on the selected genes involved in cell cycle regulation (p21, p53, CCND1), apoptosis (Bcl-2, PUMA), and inflammatory and destructive behavior of FLSs (IL-6, TGF-β1, MM...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Mohammad Javad Mousavi Elham Farhadi Mohammad Vodjgani Jafar Karami Mohammad Naghi Tahmasebi Arash Sharafat Vaziri Marzieh Asgari Nima Rezaei Shayan Mostafaei Ahmadreza Jamshidi Mahdi Mahmoudi Source Type: research

Genotyping of Human Platelet Antigen-1 to -5 and -15 by Polymerase Chain Reaction with Sequence-specific Primers (PCR-SSP) and Real-time PCR in Azeri Blood Donors
This study aimed to compare allelic and genotype frequencies of human platelet antigens in the Azeri ethnicity by TaqMan Real-time and polymerase chain reaction with sequence-specific primers (PCR-SSP) methods. DNA was extracted from the whole blood of 100 Azeri blood donors in the Ardabil Blood Transfusion Center. Genotyping of HPA-1 to -5 and -15 was performed by TaqMan Real-time PCR, and PCR-SSP and consistency of results were evaluated. The results of PCR-SSP and TaqMan Real-time PCR showed complete consistency. The allele frequencies were 91.5% and 8.5% for HPA-1a and -1b; 88% and 12% for HPA-2a and -2b; 58% and 42 % ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Seyed Ghader Azizi Shahram Samiee Mojgan Shaiegan Maryam Zadsar Source Type: research

The Effect of Antigen Dose and Antigen Presenting Process on T Cell Stimulation: A Method for Enrichment of TB10.4 Antigen-specific T-cell Clones
We described a method for inducing, enriching, and replicating Ag-specific poly-clonal T-cells from BALB/c mice infected with live Bacillus Calmette Guérin (BCG) bacterium. During a 7-8 days procedure, T-lymphocytes were purified from immune cells of lymph nodes stimulated with immunodominant Ag of BCG, TB10.4, and expanded by interleukin -2 cytokine. We evaluated the effect of Ag doses (1, 10, and 100 μg/mL) and exposure method of Ag presenting cells (APCs) to T-cells, on T-cells' proliferation, viability, and Interferon-gamma (IFN-γ) secretion at 2, 5, and 7 days after Ag stimulation. Increasing Ag concen...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Mahdieh Motiee Ahmad Zavaran Hosseini Sara Soudi Seyed Mehdi Hassanzadeh Source Type: research

Disseminated Mycobacterium simiae Infection in a Patient with Complete IL-12p40 Deficiency
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):376-381. doi: 10.18502/ijaai.v20i3.6339.ABSTRACTMendelian susceptibility to mycobacterial disease (MSMD) is a rare group of genetic disorders characterized by infections with weakly virulent environmental mycobacteria (EM) or Mycobacterium bovis bacillus Calmette-Guérin (BCG). Herein, we described the case of a 4.5-year-old boy with protein-losing enteropathy, lymphoproliferation, and candidiasis, who was found to have disseminated Mycobacterium simiae infection. A homozygous mutation in the IL12B gene, c.527_528delCT (p.S176Cfs*12) was identified, responsible for the ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Seyed Alireza Mahdaviani Majid Marjani Mahnaz Jamee Armin Khavandegar Hosseinali Ghaffaripour Golnaz Eslamian Mehdi Ghaini Shabnam Eskandarzadeh Jean-Laurent Casanova Jacinta Bustamante Davood Mansouri Ali Akbar Velayati Source Type: research

COVID-19 Pandemic and Influenza Season in Hospitalized Patients: Concerns and Suggestions
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):382-383. doi: 10.18502/ijaai.v20i3.6340.ABSTRACTThis is a letter to the editor.PMID:34134459 | DOI:10.18502/ijaai.v20i3.6340 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Amir Hossein Norooznezhad Source Type: research

MicroRNAs in Human Disease: Commentary
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):259-262. doi: 10.18502/ijaai.v20i3.6341.ABSTRACTThis letter to the editor has not an abstract.PMID:34134446 | DOI:10.18502/ijaai.v20i3.6341 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Ian M Adcock Sharon Mumby Source Type: research

The Prevalence of Allergic Rhinitis in Southwestern Iran and Its Association with Chronic Rhinosinusitis: A GA2LEN Study
This study aimed to assess the prevalence of AR and its association with chronic rhinosinusitis (CRS) in the adult population living in Bushehr, southwestern part of Iran. In this population-based study, a total of 5420 individuals aged 15-65 years were selected through a multi-stage, cluster, random sampling method from which 5201 of them completed the Global Allergy and Asthma Network of Excellence (GA2LEN) questionnaire (Response rate=96.1%). The prevalence of AR, based on Allergic Rhinitis and Its Impact on Asthma (ARIA) classification (mild or moderate; intermittent or persistent) was calculated and the association of...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Afshin Ostovar Safoora Pordel Ali Movahed Reza Kaboodkhani Allahkaram Akhlaghi Amirhossein Darabi Farzaneh Ghaderi Shokrollah Farrokhi Source Type: research

Prevalence of Allergic Rhinitis and Eczema in Adolescents Living in Yazd City: Part of Global Asthma Network Survey
This study aimed to investigate the prevalence and severity of allergic rhinitis and eczema in adolescents living in Yazd city. Using an electronic questionnaire based on the Global Asthma Network (GAN) core questionnaire, 5141 adolescents aged 13-14 years were cross-sectionally surveyed. The prevalence of current symptoms of rhinitis turned out to be 36.3%, proving significantly higher in boys (p=0.009). Moreover, the prevalence of allergic rhinitis and rhinoconjunctivitis in the past year leveled at 12.4% and 10.5%, respectively; however, the former was significantly higher in females (p=0.014). Additionally, severe rhin...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Zahra Nafei Nasrin Behniafard Mohsen Mirzaei Mehran Karimi Elahe Akbarian Source Type: research

Assessment of Carotid Artery Distensibility and Elasticity in Patients with Asthma
This study aimed to determine the possibility of a higher risk of atherosclerosis in asthma patients compared with healthy controls by measuring carotid elasticity and distensibility. This was a cross-sectional study on 326 participants including 221 patients (129 [58.37%] females) with persistent asthma, aged 46.47±11.58 years, body mass index (BMI) of 29.74±3.99, and 105 healthy control subjects (60 [57.14%] females) aged 46.08±11.35 years, and BMI of 29.42±3.76. Of the 221 patients with asthma, 75 (33.93%) had mild, 74 (33.48%) had moderate and 72 (32.57%) had severe asthma. The carotid diste...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Hatice Eyl ül Bozkurt Yılmaz Mustafa Y ılmaz Source Type: research

The Effect of Aspirin on Moderate to Severe Asthmatic Patients with Aspirin Hypersensitivity, Chronic Rhinosinusitis, and Nasal Polyposis
This study aimed to evaluate the effect and outcome of daily low-dose aspirin in the treatment of moderate to severe asthma in patients with concomitant aspirin hypersensitivity and chronic rhinosinusitis with nasal polyposis (CRSwNP). This clinical trial was conducted from February 2014 to February 2015 on 46 adult patients with moderate to severe asthma accompanied by CRSwNP. Patients with a positive aspirin challenge were blindly randomized in three groups receiving placebo/day (A); aspirin 100 mg/day (B); and aspirin 325mg/day (C), respectively. Clinical findings, FEV1 and ACT scores were recorded and compared before, ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Saba Arshi Sepideh Darougar Mohammad Nabavi Mohammad Hassan Bemanian Morteza Fallahpour Sima Shokri Javad Ahmadian Rasool Molatefi Mahsa Rekabi Zeinab Moinfar Paniz Hashemitari Narges Eslami Source Type: research

Airborne Pollens and Their Association with Meteorological Parameters in the Atmosphere of Shiraz, Southwest Iran
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):294-302. doi: 10.18502/ijaai.v20i3.6332.ABSTRACTAirborne pollen is considered one of the causative agents of hay fever, allergic rhinitis, conjunctivitis, and asthma. We aimed to investigate airborne pollens in the context of Shiraz located in the southwest of Iran and find their association with meteorological parameters. The survey was conducted from October 2017 to September 2018, using seven days of volumetric Burkard spore trap, located in the center of the city. A total of 5810 pollen grains/m3 belonging to 15 taxa were identified and recorded. Among them, 73.8% was the...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Heidar Ali Kafashan Ahmad Reza Khosravi Soheila Alyasin Najmeh Sepahi Zahra Kanannejad Farzaneh Mohammad Ali Zadeh Shirazi Sahar Karami Source Type: research

Investigation of rs531564 Polymorphism in the Primary MicroRNA-124 Gene in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: Association with Disease Susceptibility and Clinical Characteristics
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):303-313. doi: 10.18502/ijaai.v20i3.6336.ABSTRACTMicroRNA-124 (miR-124) is known as an important regulator of the immune system and inflammatory response. Studies have reported that this miRNA is dysregulated in autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). A functional analysis demonstrated that rs531564 (C>G) affects the biogenesis of primary microRNA transcript-124 (pri-miR-124) and changes the expression of mature miR-124. In the present study, for the first time, we intended to evaluate the possible association between r...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Mehdi Hassani Mohammad Dehani Maryam Zare Rafie Emran Esmaeilzadeh Saeideh Davar Bahram Pakzad Meysam Mosallaei Seyyed Mohamad Hoseini Hadi Bayat Mohsen Soosanabadi Source Type: research

Inflammation in an Animal Model of Multiple Sclerosis Leads to MicroRNA-25-3p Dysregulation Associated with Inhibition of Pten and Klf4
In this study, we investigated the expression of miR-25-3p and its targets in the central nervous system (CNS) tissue from mice with experimental autoimmune encephalomyelitis (EAE). We also analyzed the expression of miR-25 and its targets in activated macrophages and splenocytes. EAE was induced in 12-week old female C57BL/6 mice; using myelin oligodendrocyte glycoprotein 35-55/complete Freund's adjuvant (MOG35-55/CFA) protocol. The expression of miR-25-3p and its targets, as well as the expression of inflammatory cytokines, were analyzed. We next established primary macrophage cultures as well as splenocyte cultures and ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 17, 2021 Category: Allergy & Immunology Authors: Ameneh Zare-Chahoki Meysam Ahmadi-Zeidabadi Saeid Azadarmaki Samira Ghorbani Farshid Noorbakhsh Source Type: research