Study Effect of Vitamin D on the Immunopathology Responses of the Bronchi in Murine Model of Asthma
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):509-519. doi: 10.18502/ijaai.v20i5.7399.ABSTRACTAllergic asthma is a complicated respiratory problem characterized by airway inflammation, airway hyperresponsiveness (AHR), breathlessness, mucus hyper-secretion, and goblet cell hyperplasia. Asthma is controlled by genetic and environmental factors. Allergy is the main trigger of asthma and is mediated by Th2 cytokines along with IgE production. Vitamin D (Vit D) is the main supplementary factor for the immune system. In the present study, we investigated the effect of Vit D on the exacerbation of allergic asthma. A murine mo...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Linlin Feng Tingting Meng Yunyun Qi Seyyed Shamsadin Athari Xiaoyun Chen Source Type: research

Atopy Patch Test in the Diagnosis of Food Allergens in Infants with Allergic Proctocolitis Compared with Elimination/Introduction C
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):520-524. doi: 10.18502/ijaai.v20i5.7402.ABSTRACTAllergic proctocolitis is a cell-dependent food allergy that is present in both breast and formula-fed infants. The presence of blood with different amounts in the stool is the main manifestation of the disease. Different results have been published on the accuracy and specificity of the atopic patch test (APT). The purpose of this study was to evaluate the results of the APT and compare them with those obtained in the food elimination/introduction (E/I) challenge, as the gold standard of confirming the allergy. Twenty-eight pa...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Saba Arshi Majid Khoshmirsafa Maryam Khalife Mohammad Nabavi Mohammad Hasan Bemanian Sima Shokri Farhad Seif Azizollah Yousefi Morteza Fallahpour Source Type: research

Designing of DNA Vaccine Based on a Secretory Form of Major Capsid Protein of Human Papillomavirus Type 18
In conclusion, pVAX1-tPA-PADRE-L1 recombinant plasmid is a highly immunogenic construct and suggests as a promising candidate for vaccine development against HPV type 18 in low-middle-income countries.PMID:34664812 | DOI:10.18502/ijaai.v20i5.7403 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Somayeh Shokri Shahab Mahmoudvand Manoochehr Makvandi Reza Taherkhani Mohammad Rashno Farid Azizi Jalilian Kambiz Ahmadi Angali Mohammad Ali Foroughi Source Type: research

Evaluationof the New Outer Membrane Protein A Epitope-based Vaccines for Mice Model of Acinetobacter baumannii Associated Pneumonia and Sepsis Infection
In conclusion, findings indicated that peptides derived from outer membrane protein-A can be used as a promising tool for designing the epitope-based vaccines against infections caused by A. baumannii.PMID:34664813 | DOI:10.18502/ijaai.v20i5.7404 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Kobra Mehdinejadiani Ali Hashemi Mojgan Bandehpour Hoda Rahmani Mohammad Mehdi Ranjbar Vahid Yardel Seyed Amir Jalali Nariman Mosaffa Source Type: research

Immunomodulatory Effects of Adipose-derived Mesenchymal Stem Cells on Epithelial Cells Function in Response to Vibrio cholera in a Co-culture Model
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):550-562. doi: 10.18502/ijaai.v20i5.7405.ABSTRACTInflammation-induced by the interaction of the Vibrio cholerae with the epithelial cells is considered as a main cause of bacteria spreading through the gastrointestinal tract and its consequences. Because of the immunomodulatory and antibacterial properties of adipose-derived mesenchymal stem cells (AD-MSCs), this study aimed to investigate the effect of AD-MSCs on the interaction of the bacterial-epithelial cell. Caco-2 differentiated to intestinal epithelial cells co-cultured with AD-MSCs in a 1:1 ratio of the surface area o...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Alireza Moulazadeh Sara Soudi Bita Bakhshi Source Type: research

Evaluation of the Ankylosing Spondylitis Transcriptome for Oxidative Phosphorylation Pathway: The Shared Pathway with Neurodegenerative Diseases
In this study, enriched pathways and differentially expressed genes (DEGs) were identified in whole blood transcription data of AS patients obtained from the gene expression omnibus (GEO) database; using gene set enrichment analysis (GSEA) and differential expression analysis. Four pathways, including oxidative phosphorylation, Alzheimer's, Parkinson's, and Huntington's diseases were significantly enriched in AS patients compared to the controls. We identified 22 common genes among the pathways that showed an increasing trend in AS compared to the controls. Five of them including COX7B, NDUFB3, ATP5PF, UQCRB, and NDUFS4 we...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Arezou Lari Hamid Gholami Pourbadie Ali Sharifi-Zarchi Saeed Aslani Leila Nejatbakhsh Samimi Ahmadreza Jamshidi Mahdi Mahmoudi Source Type: research

Study of the Effects of N-acetylcysteine on Inflammatory Biomarkers and Disease Activity Score in Patients with Rheumatoid Arthritis
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):574-583. doi: 10.18502/ijaai.v20i5.7407.ABSTRACTRheumatoid arthritis (RA) is considered as an autoimmune-related condition in which the overproduction of pro-inflammatory cytokines leads to an inflammatory cascade. N-acetylcysteine (NAC) is a potent anti-inflammatory and anti-oxidant agent. We aimed to explore the impact of oral NAC on cytokines activities and clinical indicators in RA patients. In this placebo-controlled randomized double-blind clinical trial, 41 active RA patients were allocated in either NAC (600 mg, twice a day) or placebo group, as add-on therapy to the...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Faezeh Jamali Arman Ahmadzadeh Zahra Sahraei Jamshid Salamzadeh Source Type: research

Induction of Systemic Lupus Erythematosus-like Syndrome in BALB/c Mice Leads to Disturbance in Splenic T Cell Subpopulations
In this study, we evaluated the balance of T cell subsets in BALB/c mice model of SLE induced; using Con A and polyamines as DNA immunogenicity modifiers. BALB/c mice were immunized subcutaneously with 50 µg extracted DNA from cells cultured in different conditions: splenocytes+ polyamines (group P), splenocytes+ Con A (group A), splenocytes+ polyamines+ Con A (group PA) and splenocytes only (control). Anti-double-stranded DNA -(ds-DNA) antibodies, proteinuria, and antinuclear autoantibodies were assessed by enzyme-linked immunosorbent assay, Bradford method, and immunofluorescence respectively. Transcription factors...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Parisa Rahimzadeh Sahar Mortezagholi Mojgan Ghayedi Haideh Namdari Mitra Rahimzadeh Roobina Boghozian Maryam Azimi Eisa Salehi Source Type: research

Investigating the Correlation between Growth Differentiation Factor 15 Serum Level and Its Gene Expression with Psoriasis and Its Severity
This study aimed to evaluate the relationship between GDF-15 serum levels as well as gene expression with psoriasis and its severity. This case-control study was performed on 45 patients with psoriasis Vulgaris and 45 healthy individuals. The severity of the disease was determined based on the psoriasis area and severity index (PASI score). Serum levels of GDF-15 were measured by enzyme-linked immunosorbent assay (ELISA) and its gene expression in peripheral blood mononuclear cells was quantified by real-time polymerase chain reaction (RT-PCR). The mean serum levels of GDF-15 in patients and controls were 1.98±1.57 ...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Hossein Akbari Rezvan Talaee Seyedeh Fatemeh Zaker Hassan Nikoueinejad Source Type: research

Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):600-613. doi: 10.18502/ijaai.v20i5.7410.ABSTRACTMetformin, cimetidine, and ibuprofen separately exhibit immunomodulatory and anti-tumorigenic effects. Herein, the impacts of metformin alone and in combination with cimetidine/ibuprofen on some Th1- and regulatory T (Treg) cell-related parameters were evaluated using a breast cancer (BC) model. For establishing the BC model, four groups of Balb/c mice were challenged with the carcinoma cell line. After 11-30 days post-induction, they were treated intraperitoneally (with metformin (200 mg/kg), "metformin plus cimetidine (2...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Fereshteh Taghipour Omolbanin Oladpour Mohammad Taghi Rezayati Hossain Khorramdelazad Maryam Nemati Zahra Taghipour Javad Masoumi Zuhair Mohammad Hassan Abdollah Jafarzadeh Source Type: research

Alterations in Mitochondrial and Inflammasome Homeostasis by 2-Chloroethyl Ethyl Sulfide and Their Mitigation by Curcumin: An in Vitro Study
In conclusion, we suggest curcumin alleviates the disturbance of mitochondrial dynamics and downregulates the inflammasome genes exposed to the CEES.PMID:34664820 | DOI:10.18502/ijaai.v20i5.7411 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Azam Kia Mona Nadi Vahideh Hajhasan Jafar Salimian Source Type: research

Proliferation and Directional Differentiation of iNKT Cells Derived from DBA/1 Mice Thymus
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):623-634. doi: 10.18502/ijaai.v20i5.7412.ABSTRACTThe rates of invariant natural killer T (iNKT) cells in vivo are very low, and the amounts of cells obtained directly from the body are hard enough to fulfill their potential in clinical application. To overcome this problem, we subcutaneously injected alpha-galactosylceramide (α-GalCer) into DBA/1 mice and thymic single cells were isolated and cultured in vitro. Fluorescence-activated cell sorting was used to detect the iNKT cells and their subsets in the thymus after the injection of α-GalCer by different methods....
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Dongzhi Chen Zhao Li Rui Liang Huifang Liu Yuanyuan Wang Hongyun Shi Ming Meng Source Type: research

Meatal Stenosis and Atopic Condition: A Pilot Study Demonstrating a Possible Unidentified Etiology
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):635-640. doi: 10.18502/ijaai.v20i5.7413.ABSTRACTMeatal stenosis (MS) is known as one of the most frequent complications of circumcision. In the present study, we aimed to find any possible relationship between MS and allergic disorders. A total of 36 children with a mean±SD age of 5.84±2.03 years were referred with MS and an atopic background even in themselves or in one of their family members (Group A). There were also age-matched controls with a mean±SD age of 5.70±2.17 years who were referred to our center with allergic symptoms and no urinary...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Nastaran Sabetkish Zahra Pourpak Abdol-Mohammad Kajbafzadeh Raheleh Shokouhi Shoormasti Mahsa Jafari Source Type: research

A Report of Two Patients with Food Protein-induced Enterocolitis Mimicking Bartter Syndrome
This study aims to emphasize the several features of this syndrome that may mimic other diagnoses and sometimes leading to near-death events due to delay in the diagnosis and improper treatment. The first patient was a 30-month-old boy with multiple episodes of profuse vomiting and diarrhea within 1 hour after breastfeeding, beginning from the first month of life progressing to hypokalemia and metabolic alkalosis at the age of 5 months leading to the diagnosis of Bartter syndrome. The second patient had a history of unremitting diarrhea which had been started soon after his first breastfeeding followed by biliary vomiting ...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Sepideh Darougar Arezoo Shirzani Mahboubeh Mansouri Masoumeh Mohkam Source Type: research

Study Effect of Vitamin D on the Immunopathology Responses of the Bronchi in Murine Model of Asthma
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):509-519. doi: 10.18502/ijaai.v20i5.7399.ABSTRACTAllergic asthma is a complicated respiratory problem characterized by airway inflammation, airway hyperresponsiveness (AHR), breathlessness, mucus hyper-secretion, and goblet cell hyperplasia. Asthma is controlled by genetic and environmental factors. Allergy is the main trigger of asthma and is mediated by Th2 cytokines along with IgE production. Vitamin D (Vit D) is the main supplementary factor for the immune system. In the present study, we investigated the effect of Vit D on the exacerbation of allergic asthma. A murine mo...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Linlin Feng Tingting Meng Yunyun Qi Seyyed Shamsadin Athari Xiaoyun Chen Source Type: research

Atopy Patch Test in the Diagnosis of Food Allergens in Infants with Allergic Proctocolitis Compared with Elimination/Introduction C
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):520-524. doi: 10.18502/ijaai.v20i5.7402.ABSTRACTAllergic proctocolitis is a cell-dependent food allergy that is present in both breast and formula-fed infants. The presence of blood with different amounts in the stool is the main manifestation of the disease. Different results have been published on the accuracy and specificity of the atopic patch test (APT). The purpose of this study was to evaluate the results of the APT and compare them with those obtained in the food elimination/introduction (E/I) challenge, as the gold standard of confirming the allergy. Twenty-eight pa...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Saba Arshi Majid Khoshmirsafa Maryam Khalife Mohammad Nabavi Mohammad Hasan Bemanian Sima Shokri Farhad Seif Azizollah Yousefi Morteza Fallahpour Source Type: research

Designing of DNA Vaccine Based on a Secretory Form of Major Capsid Protein of Human Papillomavirus Type 18
In conclusion, pVAX1-tPA-PADRE-L1 recombinant plasmid is a highly immunogenic construct and suggests as a promising candidate for vaccine development against HPV type 18 in low-middle-income countries.PMID:34664812 | DOI:10.18502/ijaai.v20i5.7403 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Somayeh Shokri Shahab Mahmoudvand Manoochehr Makvandi Reza Taherkhani Mohammad Rashno Farid Azizi Jalilian Kambiz Ahmadi Angali Mohammad Ali Foroughi Source Type: research

Evaluationof the New Outer Membrane Protein A Epitope-based Vaccines for Mice Model of Acinetobacter baumannii Associated Pneumonia and Sepsis Infection
In conclusion, findings indicated that peptides derived from outer membrane protein-A can be used as a promising tool for designing the epitope-based vaccines against infections caused by A. baumannii.PMID:34664813 | DOI:10.18502/ijaai.v20i5.7404 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Kobra Mehdinejadiani Ali Hashemi Mojgan Bandehpour Hoda Rahmani Mohammad Mehdi Ranjbar Vahid Yardel Seyed Amir Jalali Nariman Mosaffa Source Type: research

Immunomodulatory Effects of Adipose-derived Mesenchymal Stem Cells on Epithelial Cells Function in Response to Vibrio cholera in a Co-culture Model
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):550-562. doi: 10.18502/ijaai.v20i5.7405.ABSTRACTInflammation-induced by the interaction of the Vibrio cholerae with the epithelial cells is considered as a main cause of bacteria spreading through the gastrointestinal tract and its consequences. Because of the immunomodulatory and antibacterial properties of adipose-derived mesenchymal stem cells (AD-MSCs), this study aimed to investigate the effect of AD-MSCs on the interaction of the bacterial-epithelial cell. Caco-2 differentiated to intestinal epithelial cells co-cultured with AD-MSCs in a 1:1 ratio of the surface area o...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Alireza Moulazadeh Sara Soudi Bita Bakhshi Source Type: research

Evaluation of the Ankylosing Spondylitis Transcriptome for Oxidative Phosphorylation Pathway: The Shared Pathway with Neurodegenerative Diseases
In this study, enriched pathways and differentially expressed genes (DEGs) were identified in whole blood transcription data of AS patients obtained from the gene expression omnibus (GEO) database; using gene set enrichment analysis (GSEA) and differential expression analysis. Four pathways, including oxidative phosphorylation, Alzheimer's, Parkinson's, and Huntington's diseases were significantly enriched in AS patients compared to the controls. We identified 22 common genes among the pathways that showed an increasing trend in AS compared to the controls. Five of them including COX7B, NDUFB3, ATP5PF, UQCRB, and NDUFS4 we...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Arezou Lari Hamid Gholami Pourbadie Ali Sharifi-Zarchi Saeed Aslani Leila Nejatbakhsh Samimi Ahmadreza Jamshidi Mahdi Mahmoudi Source Type: research

Study of the Effects of N-acetylcysteine on Inflammatory Biomarkers and Disease Activity Score in Patients with Rheumatoid Arthritis
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):574-583. doi: 10.18502/ijaai.v20i5.7407.ABSTRACTRheumatoid arthritis (RA) is considered as an autoimmune-related condition in which the overproduction of pro-inflammatory cytokines leads to an inflammatory cascade. N-acetylcysteine (NAC) is a potent anti-inflammatory and anti-oxidant agent. We aimed to explore the impact of oral NAC on cytokines activities and clinical indicators in RA patients. In this placebo-controlled randomized double-blind clinical trial, 41 active RA patients were allocated in either NAC (600 mg, twice a day) or placebo group, as add-on therapy to the...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Faezeh Jamali Arman Ahmadzadeh Zahra Sahraei Jamshid Salamzadeh Source Type: research

Induction of Systemic Lupus Erythematosus-like Syndrome in BALB/c Mice Leads to Disturbance in Splenic T Cell Subpopulations
In this study, we evaluated the balance of T cell subsets in BALB/c mice model of SLE induced; using Con A and polyamines as DNA immunogenicity modifiers. BALB/c mice were immunized subcutaneously with 50 µg extracted DNA from cells cultured in different conditions: splenocytes+ polyamines (group P), splenocytes+ Con A (group A), splenocytes+ polyamines+ Con A (group PA) and splenocytes only (control). Anti-double-stranded DNA -(ds-DNA) antibodies, proteinuria, and antinuclear autoantibodies were assessed by enzyme-linked immunosorbent assay, Bradford method, and immunofluorescence respectively. Transcription factors...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Parisa Rahimzadeh Sahar Mortezagholi Mojgan Ghayedi Haideh Namdari Mitra Rahimzadeh Roobina Boghozian Maryam Azimi Eisa Salehi Source Type: research

Investigating the Correlation between Growth Differentiation Factor 15 Serum Level and Its Gene Expression with Psoriasis and Its Severity
This study aimed to evaluate the relationship between GDF-15 serum levels as well as gene expression with psoriasis and its severity. This case-control study was performed on 45 patients with psoriasis Vulgaris and 45 healthy individuals. The severity of the disease was determined based on the psoriasis area and severity index (PASI score). Serum levels of GDF-15 were measured by enzyme-linked immunosorbent assay (ELISA) and its gene expression in peripheral blood mononuclear cells was quantified by real-time polymerase chain reaction (RT-PCR). The mean serum levels of GDF-15 in patients and controls were 1.98±1.57 ...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Hossein Akbari Rezvan Talaee Seyedeh Fatemeh Zaker Hassan Nikoueinejad Source Type: research

Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):600-613. doi: 10.18502/ijaai.v20i5.7410.ABSTRACTMetformin, cimetidine, and ibuprofen separately exhibit immunomodulatory and anti-tumorigenic effects. Herein, the impacts of metformin alone and in combination with cimetidine/ibuprofen on some Th1- and regulatory T (Treg) cell-related parameters were evaluated using a breast cancer (BC) model. For establishing the BC model, four groups of Balb/c mice were challenged with the carcinoma cell line. After 11-30 days post-induction, they were treated intraperitoneally (with metformin (200 mg/kg), "metformin plus cimetidine (2...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Fereshteh Taghipour Omolbanin Oladpour Mohammad Taghi Rezayati Hossain Khorramdelazad Maryam Nemati Zahra Taghipour Javad Masoumi Zuhair Mohammad Hassan Abdollah Jafarzadeh Source Type: research

Alterations in Mitochondrial and Inflammasome Homeostasis by 2-Chloroethyl Ethyl Sulfide and Their Mitigation by Curcumin: An in Vitro Study
In conclusion, we suggest curcumin alleviates the disturbance of mitochondrial dynamics and downregulates the inflammasome genes exposed to the CEES.PMID:34664820 | DOI:10.18502/ijaai.v20i5.7411 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Azam Kia Mona Nadi Vahideh Hajhasan Jafar Salimian Source Type: research

Proliferation and Directional Differentiation of iNKT Cells Derived from DBA/1 Mice Thymus
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):623-634. doi: 10.18502/ijaai.v20i5.7412.ABSTRACTThe rates of invariant natural killer T (iNKT) cells in vivo are very low, and the amounts of cells obtained directly from the body are hard enough to fulfill their potential in clinical application. To overcome this problem, we subcutaneously injected alpha-galactosylceramide (α-GalCer) into DBA/1 mice and thymic single cells were isolated and cultured in vitro. Fluorescence-activated cell sorting was used to detect the iNKT cells and their subsets in the thymus after the injection of α-GalCer by different methods....
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Dongzhi Chen Zhao Li Rui Liang Huifang Liu Yuanyuan Wang Hongyun Shi Ming Meng Source Type: research

Meatal Stenosis and Atopic Condition: A Pilot Study Demonstrating a Possible Unidentified Etiology
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):635-640. doi: 10.18502/ijaai.v20i5.7413.ABSTRACTMeatal stenosis (MS) is known as one of the most frequent complications of circumcision. In the present study, we aimed to find any possible relationship between MS and allergic disorders. A total of 36 children with a mean±SD age of 5.84±2.03 years were referred with MS and an atopic background even in themselves or in one of their family members (Group A). There were also age-matched controls with a mean±SD age of 5.70±2.17 years who were referred to our center with allergic symptoms and no urinary...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Nastaran Sabetkish Zahra Pourpak Abdol-Mohammad Kajbafzadeh Raheleh Shokouhi Shoormasti Mahsa Jafari Source Type: research

A Report of Two Patients with Food Protein-induced Enterocolitis Mimicking Bartter Syndrome
This study aims to emphasize the several features of this syndrome that may mimic other diagnoses and sometimes leading to near-death events due to delay in the diagnosis and improper treatment. The first patient was a 30-month-old boy with multiple episodes of profuse vomiting and diarrhea within 1 hour after breastfeeding, beginning from the first month of life progressing to hypokalemia and metabolic alkalosis at the age of 5 months leading to the diagnosis of Bartter syndrome. The second patient had a history of unremitting diarrhea which had been started soon after his first breastfeeding followed by biliary vomiting ...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Sepideh Darougar Arezoo Shirzani Mahboubeh Mansouri Masoumeh Mohkam Source Type: research

Study Effect of Vitamin D on the Immunopathology Responses of the Bronchi in Murine Model of Asthma
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):509-519. doi: 10.18502/ijaai.v20i5.7399.ABSTRACTAllergic asthma is a complicated respiratory problem characterized by airway inflammation, airway hyperresponsiveness (AHR), breathlessness, mucus hyper-secretion, and goblet cell hyperplasia. Asthma is controlled by genetic and environmental factors. Allergy is the main trigger of asthma and is mediated by Th2 cytokines along with IgE production. Vitamin D (Vit D) is the main supplementary factor for the immune system. In the present study, we investigated the effect of Vit D on the exacerbation of allergic asthma. A murine mo...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Linlin Feng Tingting Meng Yunyun Qi Seyyed Shamsadin Athari Xiaoyun Chen Source Type: research

Atopy Patch Test in the Diagnosis of Food Allergens in Infants with Allergic Proctocolitis Compared with Elimination/Introduction C
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):520-524. doi: 10.18502/ijaai.v20i5.7402.ABSTRACTAllergic proctocolitis is a cell-dependent food allergy that is present in both breast and formula-fed infants. The presence of blood with different amounts in the stool is the main manifestation of the disease. Different results have been published on the accuracy and specificity of the atopic patch test (APT). The purpose of this study was to evaluate the results of the APT and compare them with those obtained in the food elimination/introduction (E/I) challenge, as the gold standard of confirming the allergy. Twenty-eight pa...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Saba Arshi Majid Khoshmirsafa Maryam Khalife Mohammad Nabavi Mohammad Hasan Bemanian Sima Shokri Farhad Seif Azizollah Yousefi Morteza Fallahpour Source Type: research

Designing of DNA Vaccine Based on a Secretory Form of Major Capsid Protein of Human Papillomavirus Type 18
In conclusion, pVAX1-tPA-PADRE-L1 recombinant plasmid is a highly immunogenic construct and suggests as a promising candidate for vaccine development against HPV type 18 in low-middle-income countries.PMID:34664812 | DOI:10.18502/ijaai.v20i5.7403 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Somayeh Shokri Shahab Mahmoudvand Manoochehr Makvandi Reza Taherkhani Mohammad Rashno Farid Azizi Jalilian Kambiz Ahmadi Angali Mohammad Ali Foroughi Source Type: research

Evaluationof the New Outer Membrane Protein A Epitope-based Vaccines for Mice Model of Acinetobacter baumannii Associated Pneumonia and Sepsis Infection
In conclusion, findings indicated that peptides derived from outer membrane protein-A can be used as a promising tool for designing the epitope-based vaccines against infections caused by A. baumannii.PMID:34664813 | DOI:10.18502/ijaai.v20i5.7404 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Kobra Mehdinejadiani Ali Hashemi Mojgan Bandehpour Hoda Rahmani Mohammad Mehdi Ranjbar Vahid Yardel Seyed Amir Jalali Nariman Mosaffa Source Type: research

Immunomodulatory Effects of Adipose-derived Mesenchymal Stem Cells on Epithelial Cells Function in Response to Vibrio cholera in a Co-culture Model
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):550-562. doi: 10.18502/ijaai.v20i5.7405.ABSTRACTInflammation-induced by the interaction of the Vibrio cholerae with the epithelial cells is considered as a main cause of bacteria spreading through the gastrointestinal tract and its consequences. Because of the immunomodulatory and antibacterial properties of adipose-derived mesenchymal stem cells (AD-MSCs), this study aimed to investigate the effect of AD-MSCs on the interaction of the bacterial-epithelial cell. Caco-2 differentiated to intestinal epithelial cells co-cultured with AD-MSCs in a 1:1 ratio of the surface area o...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Alireza Moulazadeh Sara Soudi Bita Bakhshi Source Type: research

Evaluation of the Ankylosing Spondylitis Transcriptome for Oxidative Phosphorylation Pathway: The Shared Pathway with Neurodegenerative Diseases
In this study, enriched pathways and differentially expressed genes (DEGs) were identified in whole blood transcription data of AS patients obtained from the gene expression omnibus (GEO) database; using gene set enrichment analysis (GSEA) and differential expression analysis. Four pathways, including oxidative phosphorylation, Alzheimer's, Parkinson's, and Huntington's diseases were significantly enriched in AS patients compared to the controls. We identified 22 common genes among the pathways that showed an increasing trend in AS compared to the controls. Five of them including COX7B, NDUFB3, ATP5PF, UQCRB, and NDUFS4 we...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Arezou Lari Hamid Gholami Pourbadie Ali Sharifi-Zarchi Saeed Aslani Leila Nejatbakhsh Samimi Ahmadreza Jamshidi Mahdi Mahmoudi Source Type: research

Study of the Effects of N-acetylcysteine on Inflammatory Biomarkers and Disease Activity Score in Patients with Rheumatoid Arthritis
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):574-583. doi: 10.18502/ijaai.v20i5.7407.ABSTRACTRheumatoid arthritis (RA) is considered as an autoimmune-related condition in which the overproduction of pro-inflammatory cytokines leads to an inflammatory cascade. N-acetylcysteine (NAC) is a potent anti-inflammatory and anti-oxidant agent. We aimed to explore the impact of oral NAC on cytokines activities and clinical indicators in RA patients. In this placebo-controlled randomized double-blind clinical trial, 41 active RA patients were allocated in either NAC (600 mg, twice a day) or placebo group, as add-on therapy to the...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Faezeh Jamali Arman Ahmadzadeh Zahra Sahraei Jamshid Salamzadeh Source Type: research

Induction of Systemic Lupus Erythematosus-like Syndrome in BALB/c Mice Leads to Disturbance in Splenic T Cell Subpopulations
In this study, we evaluated the balance of T cell subsets in BALB/c mice model of SLE induced; using Con A and polyamines as DNA immunogenicity modifiers. BALB/c mice were immunized subcutaneously with 50 µg extracted DNA from cells cultured in different conditions: splenocytes+ polyamines (group P), splenocytes+ Con A (group A), splenocytes+ polyamines+ Con A (group PA) and splenocytes only (control). Anti-double-stranded DNA -(ds-DNA) antibodies, proteinuria, and antinuclear autoantibodies were assessed by enzyme-linked immunosorbent assay, Bradford method, and immunofluorescence respectively. Transcription factors...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Parisa Rahimzadeh Sahar Mortezagholi Mojgan Ghayedi Haideh Namdari Mitra Rahimzadeh Roobina Boghozian Maryam Azimi Eisa Salehi Source Type: research

Investigating the Correlation between Growth Differentiation Factor 15 Serum Level and Its Gene Expression with Psoriasis and Its Severity
This study aimed to evaluate the relationship between GDF-15 serum levels as well as gene expression with psoriasis and its severity. This case-control study was performed on 45 patients with psoriasis Vulgaris and 45 healthy individuals. The severity of the disease was determined based on the psoriasis area and severity index (PASI score). Serum levels of GDF-15 were measured by enzyme-linked immunosorbent assay (ELISA) and its gene expression in peripheral blood mononuclear cells was quantified by real-time polymerase chain reaction (RT-PCR). The mean serum levels of GDF-15 in patients and controls were 1.98±1.57 ...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Hossein Akbari Rezvan Talaee Seyedeh Fatemeh Zaker Hassan Nikoueinejad Source Type: research

Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):600-613. doi: 10.18502/ijaai.v20i5.7410.ABSTRACTMetformin, cimetidine, and ibuprofen separately exhibit immunomodulatory and anti-tumorigenic effects. Herein, the impacts of metformin alone and in combination with cimetidine/ibuprofen on some Th1- and regulatory T (Treg) cell-related parameters were evaluated using a breast cancer (BC) model. For establishing the BC model, four groups of Balb/c mice were challenged with the carcinoma cell line. After 11-30 days post-induction, they were treated intraperitoneally (with metformin (200 mg/kg), "metformin plus cimetidine (2...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Fereshteh Taghipour Omolbanin Oladpour Mohammad Taghi Rezayati Hossain Khorramdelazad Maryam Nemati Zahra Taghipour Javad Masoumi Zuhair Mohammad Hassan Abdollah Jafarzadeh Source Type: research

Alterations in Mitochondrial and Inflammasome Homeostasis by 2-Chloroethyl Ethyl Sulfide and Their Mitigation by Curcumin: An in Vitro Study
In conclusion, we suggest curcumin alleviates the disturbance of mitochondrial dynamics and downregulates the inflammasome genes exposed to the CEES.PMID:34664820 | DOI:10.18502/ijaai.v20i5.7411 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Azam Kia Mona Nadi Vahideh Hajhasan Jafar Salimian Source Type: research

Proliferation and Directional Differentiation of iNKT Cells Derived from DBA/1 Mice Thymus
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):623-634. doi: 10.18502/ijaai.v20i5.7412.ABSTRACTThe rates of invariant natural killer T (iNKT) cells in vivo are very low, and the amounts of cells obtained directly from the body are hard enough to fulfill their potential in clinical application. To overcome this problem, we subcutaneously injected alpha-galactosylceramide (α-GalCer) into DBA/1 mice and thymic single cells were isolated and cultured in vitro. Fluorescence-activated cell sorting was used to detect the iNKT cells and their subsets in the thymus after the injection of α-GalCer by different methods....
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Dongzhi Chen Zhao Li Rui Liang Huifang Liu Yuanyuan Wang Hongyun Shi Ming Meng Source Type: research

Meatal Stenosis and Atopic Condition: A Pilot Study Demonstrating a Possible Unidentified Etiology
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):635-640. doi: 10.18502/ijaai.v20i5.7413.ABSTRACTMeatal stenosis (MS) is known as one of the most frequent complications of circumcision. In the present study, we aimed to find any possible relationship between MS and allergic disorders. A total of 36 children with a mean±SD age of 5.84±2.03 years were referred with MS and an atopic background even in themselves or in one of their family members (Group A). There were also age-matched controls with a mean±SD age of 5.70±2.17 years who were referred to our center with allergic symptoms and no urinary...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Nastaran Sabetkish Zahra Pourpak Abdol-Mohammad Kajbafzadeh Raheleh Shokouhi Shoormasti Mahsa Jafari Source Type: research

A Report of Two Patients with Food Protein-induced Enterocolitis Mimicking Bartter Syndrome
This study aims to emphasize the several features of this syndrome that may mimic other diagnoses and sometimes leading to near-death events due to delay in the diagnosis and improper treatment. The first patient was a 30-month-old boy with multiple episodes of profuse vomiting and diarrhea within 1 hour after breastfeeding, beginning from the first month of life progressing to hypokalemia and metabolic alkalosis at the age of 5 months leading to the diagnosis of Bartter syndrome. The second patient had a history of unremitting diarrhea which had been started soon after his first breastfeeding followed by biliary vomiting ...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Sepideh Darougar Arezoo Shirzani Mahboubeh Mansouri Masoumeh Mohkam Source Type: research

Study Effect of Vitamin D on the Immunopathology Responses of the Bronchi in Murine Model of Asthma
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):509-519. doi: 10.18502/ijaai.v20i5.7399.ABSTRACTAllergic asthma is a complicated respiratory problem characterized by airway inflammation, airway hyperresponsiveness (AHR), breathlessness, mucus hyper-secretion, and goblet cell hyperplasia. Asthma is controlled by genetic and environmental factors. Allergy is the main trigger of asthma and is mediated by Th2 cytokines along with IgE production. Vitamin D (Vit D) is the main supplementary factor for the immune system. In the present study, we investigated the effect of Vit D on the exacerbation of allergic asthma. A murine mo...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Linlin Feng Tingting Meng Yunyun Qi Seyyed Shamsadin Athari Xiaoyun Chen Source Type: research

Atopy Patch Test in the Diagnosis of Food Allergens in Infants with Allergic Proctocolitis Compared with Elimination/Introduction C
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):520-524. doi: 10.18502/ijaai.v20i5.7402.ABSTRACTAllergic proctocolitis is a cell-dependent food allergy that is present in both breast and formula-fed infants. The presence of blood with different amounts in the stool is the main manifestation of the disease. Different results have been published on the accuracy and specificity of the atopic patch test (APT). The purpose of this study was to evaluate the results of the APT and compare them with those obtained in the food elimination/introduction (E/I) challenge, as the gold standard of confirming the allergy. Twenty-eight pa...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Saba Arshi Majid Khoshmirsafa Maryam Khalife Mohammad Nabavi Mohammad Hasan Bemanian Sima Shokri Farhad Seif Azizollah Yousefi Morteza Fallahpour Source Type: research

Designing of DNA Vaccine Based on a Secretory Form of Major Capsid Protein of Human Papillomavirus Type 18
In conclusion, pVAX1-tPA-PADRE-L1 recombinant plasmid is a highly immunogenic construct and suggests as a promising candidate for vaccine development against HPV type 18 in low-middle-income countries.PMID:34664812 | DOI:10.18502/ijaai.v20i5.7403 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Somayeh Shokri Shahab Mahmoudvand Manoochehr Makvandi Reza Taherkhani Mohammad Rashno Farid Azizi Jalilian Kambiz Ahmadi Angali Mohammad Ali Foroughi Source Type: research

Evaluationof the New Outer Membrane Protein A Epitope-based Vaccines for Mice Model of Acinetobacter baumannii Associated Pneumonia and Sepsis Infection
In conclusion, findings indicated that peptides derived from outer membrane protein-A can be used as a promising tool for designing the epitope-based vaccines against infections caused by A. baumannii.PMID:34664813 | DOI:10.18502/ijaai.v20i5.7404 (Source: Iranian Journal of Allergy, Asthma and Immunology)
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Kobra Mehdinejadiani Ali Hashemi Mojgan Bandehpour Hoda Rahmani Mohammad Mehdi Ranjbar Vahid Yardel Seyed Amir Jalali Nariman Mosaffa Source Type: research

Immunomodulatory Effects of Adipose-derived Mesenchymal Stem Cells on Epithelial Cells Function in Response to Vibrio cholera in a Co-culture Model
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):550-562. doi: 10.18502/ijaai.v20i5.7405.ABSTRACTInflammation-induced by the interaction of the Vibrio cholerae with the epithelial cells is considered as a main cause of bacteria spreading through the gastrointestinal tract and its consequences. Because of the immunomodulatory and antibacterial properties of adipose-derived mesenchymal stem cells (AD-MSCs), this study aimed to investigate the effect of AD-MSCs on the interaction of the bacterial-epithelial cell. Caco-2 differentiated to intestinal epithelial cells co-cultured with AD-MSCs in a 1:1 ratio of the surface area o...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Alireza Moulazadeh Sara Soudi Bita Bakhshi Source Type: research

Evaluation of the Ankylosing Spondylitis Transcriptome for Oxidative Phosphorylation Pathway: The Shared Pathway with Neurodegenerative Diseases
In this study, enriched pathways and differentially expressed genes (DEGs) were identified in whole blood transcription data of AS patients obtained from the gene expression omnibus (GEO) database; using gene set enrichment analysis (GSEA) and differential expression analysis. Four pathways, including oxidative phosphorylation, Alzheimer's, Parkinson's, and Huntington's diseases were significantly enriched in AS patients compared to the controls. We identified 22 common genes among the pathways that showed an increasing trend in AS compared to the controls. Five of them including COX7B, NDUFB3, ATP5PF, UQCRB, and NDUFS4 we...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Arezou Lari Hamid Gholami Pourbadie Ali Sharifi-Zarchi Saeed Aslani Leila Nejatbakhsh Samimi Ahmadreza Jamshidi Mahdi Mahmoudi Source Type: research

Study of the Effects of N-acetylcysteine on Inflammatory Biomarkers and Disease Activity Score in Patients with Rheumatoid Arthritis
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):574-583. doi: 10.18502/ijaai.v20i5.7407.ABSTRACTRheumatoid arthritis (RA) is considered as an autoimmune-related condition in which the overproduction of pro-inflammatory cytokines leads to an inflammatory cascade. N-acetylcysteine (NAC) is a potent anti-inflammatory and anti-oxidant agent. We aimed to explore the impact of oral NAC on cytokines activities and clinical indicators in RA patients. In this placebo-controlled randomized double-blind clinical trial, 41 active RA patients were allocated in either NAC (600 mg, twice a day) or placebo group, as add-on therapy to the...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Faezeh Jamali Arman Ahmadzadeh Zahra Sahraei Jamshid Salamzadeh Source Type: research

Induction of Systemic Lupus Erythematosus-like Syndrome in BALB/c Mice Leads to Disturbance in Splenic T Cell Subpopulations
In this study, we evaluated the balance of T cell subsets in BALB/c mice model of SLE induced; using Con A and polyamines as DNA immunogenicity modifiers. BALB/c mice were immunized subcutaneously with 50 µg extracted DNA from cells cultured in different conditions: splenocytes+ polyamines (group P), splenocytes+ Con A (group A), splenocytes+ polyamines+ Con A (group PA) and splenocytes only (control). Anti-double-stranded DNA -(ds-DNA) antibodies, proteinuria, and antinuclear autoantibodies were assessed by enzyme-linked immunosorbent assay, Bradford method, and immunofluorescence respectively. Transcription factors...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Parisa Rahimzadeh Sahar Mortezagholi Mojgan Ghayedi Haideh Namdari Mitra Rahimzadeh Roobina Boghozian Maryam Azimi Eisa Salehi Source Type: research