The Role of Innate and Adaptive Immune System in the Pathogenesis of Schizophrenia
Iran J Allergy Asthma Immunol. 2024 Feb 11;23(1):1-28. doi: 10.18502/ijaai.v23i1.14951.ABSTRACTSchizophrenia is one of the most severely debilitating mental disorders that affects 1.1% of the world's population. The exact cause of the disease is not known, but genetics, environmental factors (such as infectious agents, season and region of birth, exposure to viruses, low birth weight, advanced paternal age, and tobacco), and immune system dysfunction can all contribute to the development of schizophrenia. Recently, the role of the immune system in schizophrenia has received much attention. Both acquired and innate immune s...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Marziyeh Soltani Yousef Mirzaei Ali Hussein Mer Mina Mohammad-Rezaei Zahra Shafaghat Soheila Fattahi Fatemeh Azadegan-Dehkordi Meghdad Abdollahpour-Alitappeh Nader Bagheri Source Type: research

Unraveling the Impact of Blood Transfusion on Transcription Factors Regulating T Helper 1, 2, 17 and Regulatory T cells
This study aimed`` to evaluate the effect of blood transfusion on gene expression of transcription factors related to the development of TH1, TH2, TH17 and regulatory T cells (Tregs). In this cross-sectional study, 20 patients diagnosed with abdominal aortic aneurysms requiring surgical repair were studied from January 2018 to August 2020. We utilized real-time PCR to evaluate the expression of transcription factor genes associated with TH1, TH2, TH17, and Treg, namely T-box-expressed-in-T-cells (T-bet), GATA-binding protein 3 (GATA-3), retinoid-related orphan receptor (RORγt), and fork head box protein 3 (Foxp3), respect...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Samad Valizadeh Azita Chegini Faranak Behnaz Ali Akbar Pourfatollah Shahram Samiee Ronak Karbalaeifar Source Type: research

Measurement of the Neutrophils Count and Oxidative Burst in Neutrophils of Patients with Sanjad Sakati Syndrome
In this study, the neutrophil count value and the oxidative burst were evaluated in six patients diagnosed with SSS and six healthy individuals. There was a significant reduction in the neutrophil count observed in SSS patients compared to healthy controls (37.41±7.93 percent vs. 66.5±6.8 percent). However, there was no significant difference in neutrophil oxidative index between patients with SSS and control subjects (172.33±55.08 vs. 217.00±77.38). We concluded that in patients with SSS, the phagocytic activity of neutrophils was not affected by hormonal changes, while the number of neutrophils and neutrophil-to-lymp...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Farhad Abolnezhadian Majid Aminzadeh Sara Iranparast Sajad Dehnavi Fatemeh Dousti Moosa Sharifat Hamid Moradzadegan Source Type: research

Description of a Novel Pathogenic Variant in the ARPC1B and a Severe Allergy in Two Infants
Iran J Allergy Asthma Immunol. 2024 Feb 11;23(1):122-126. doi: 10.18502/ijaai.v23i1.14960.ABSTRACTActinrelated protein 2/3 complex subunit 1B (ARPC1B) deficiency is an inborn error of immunity (IEI) characterized by a combination of immunodeficiency and immune dysregulation and classified as an IEI with allergic manifestations. Here, we describe two patients with pathogenic variants in the ARPC1B gene. The first patient presented with eczema and bronchospasm at six months of age. The second patient presented with eczema and milk protein allergy at five months of age. The c.899_944 (p.Glu300Glyfs*7) pathogenic variant was p...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Oscar Zaveleta Mart ínez Ana Eunice Fregoso-Zu ñiga Cielo Razo Requena Sara Espinosa Padilla Lzbeth Blancas Galicia Source Type: research

Iranian Journal of Allergy, Asthma, and Immunology: A Bibliometric and Altmetric Analysis from 2005 to 2022
This study aimed to present a bibliometric and altmetric Analyses of the Iranian Journal of Allergy, Asthma, and Immunology (IJAAI). The citation performance and altmetric data were extracted from Scopus and Altmetric Explorer, respectively. Analyses were done using SPSS 26, Microsoft Excel, VOSviewer, and CiteSpace. The results of the bibliometric analysis revealed that IJAAI had experienced respectable growth. Among the total citations, 4746 citations belong to the first decade (2005-2014) and 3,035 citations belong to the second (2015-2022). The findings demonstrated the significance of IJAAI among Iranian researchers. ...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Mojgan Zareivenovel Leila Nemati-Anaraki Ali Ouchi Maryam Nourizadeh Motahareh Aghashahi Source Type: research

Baseline Severity and Disease Duration Can Predict the Response to Allergen-specific Immunotherapy in Allergic Rhinitis
Iran J Allergy Asthma Immunol. 2024 Feb 11;23(1):52-58. doi: 10.18502/ijaai.v23i1.14953.ABSTRACTAllergen-specific immunotherapy (AIT) has confirmed its efficacy in improving the symptoms of allergic rhinitis. However, no reliable biomarkers have been identified to predict the efficacy of AIT were found. We aimed to find clinical and immunological markers to predict efficacy in children after 2 years of sublingual immunotherapy (SLIT). A total of 285 children diagnosed with allergic rhinitis were recruited. The clinical efficacy was evaluated by comparing endpoint and baseline symptom and medication scores (SMS). Baseline c...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Yan Li Haiqing Xiao Yinhui Zeng Yiquan Tang Lifeng Zhou Wenlong Liu Source Type: research

A Quality-of-life Study in Patients with Anaphylaxis to Hymenoptera Venom in Iran
This study aimed to evaluate the validity and reliability of the Persian version of VQLQ. In this cross-sectional study, VQLQ was translated into Persian according to expert recommendations. The final translated version of VQLQ was then administered to 115 patients with Hymenoptera venom allergy at an asthma and allergy clinic in Iran. More than half of the participants were between 20 and 40 years of age, and 60% were male. Fear, anxiety, and outdoor activities had the most significant impact on the quality of life of patients with Hymenoptera venom allergy. Additionally, quality of life was more affected in women than in...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Mohammad Hasan Bemaniyan Maryam Heidari Marzieh Tavakol Mohammad Nabavi Fatemeh Ramezani Kashal Maryam Gholami Bita Bemaniyan Source Type: research

Different Gene Expression Patterns of IL-1 Family Members in Parkinson's Disease: Results from Bayesian Regression Model
This study aimed to investigate the expression levels of Interleukin(IL)1 receptor accessory protein (IL-1RAcP), IL1β, IL1α, IL33, and IL36 genes in blood cells and serum IL-1β levels in Parkinson's disease patients compared to healthy controls (HCs).I n this case-control study, 44 Parkinson's disease patients and 44 age- and sex-matched HCs were included. Gene expression levels were assessed using Quantitative Real-time PCR, and serum IL-1β levels were measured via enzyme-linked immunosorbent assay. Advanced statistical analyses using the Bayesian regression model in R software were employed. Parkinson's disease patie...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Negin Jafariaghdam Majid Khoshmirsafa Alireza Zamani Elahe Talebi-Ghane Shadi Moradi Faezeh Shahba Mehrdokht Mazdeh Mohammad Mahdi Eftekharian Source Type: research

Tocilizumab Failed to Reduce Mortality in Severe COVID-19 Patients: Results from a Randomized Controlled Clinical Trial
Iran J Allergy Asthma Immunol. 2024 Feb 11;23(1):82-96. doi: 10.18502/ijaai.v23i1.14956.ABSTRACTThe severe coronavirus disease 2019 (COVID-19) is associated with increased levels of blood interleukin (IL)-6. Therefore, it is hypothesized that modulating the levels or effects of IL-6 could diminish airway inflammation and alter the course of COVID-19. We conducted a controlled, randomized, double-blind clinical trial on hospitalized patients with severe COVID-19 in Iran. The patients were randomly distributed by block randomization to take either standard-of-care (SOC) plus 1 or 2 doses of tocilizumab 8 mg/kg or SOC alone. ...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Mona Talaschian Maryam Akhtari Mahdi Mahmoudi Shayan Mostafaei Mohamadreza Jafary Seyyed Mostafa Jalali Kourosh Sadeghi Keivan Gohari Moghadam Hengameh Ansari Tadi Ahmadreza Jamshidi Source Type: research

Exosomes Derived from Heat-shocked Tumor Cells Promote In vitro Maturation of Bone Marrow-derived Dendritic Cells
This study aimed to investigate whether HS-TEXs can promote DC maturation. To generate DC, bone marrow-derived cells were treated with Interleukin-4 and GM-CSF. Exosomes were isolated from heat-treated CT-26 cells. The expression level of HSP in exosomes was checked by western blot and the increase in the expression of this protein was observed. Then, HS-TEXs were co-cultured with iDCs to determine DC maturity, and then DCs were co-cultured with lymphocytes to determine DC activity. Our results showed that DCs treated with HS-TEXs express high levels of molecules involved in DC maturation and function including MHCII, CD40...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Neda Heidari Hajar Abbasi-Kenarsari Bahare Niknam Ali Asadirad Davar Amani Zahra Mirsanei Seyed Mahmood Hashemi Source Type: research

The Role of Innate and Adaptive Immune System in the Pathogenesis of Schizophrenia
Iran J Allergy Asthma Immunol. 2024 Feb 11;23(1):1-28. doi: 10.18502/ijaai.v23i1.14951.ABSTRACTSchizophrenia is one of the most severely debilitating mental disorders that affects 1.1% of the world's population. The exact cause of the disease is not known, but genetics, environmental factors (such as infectious agents, season and region of birth, exposure to viruses, low birth weight, advanced paternal age, and tobacco), and immune system dysfunction can all contribute to the development of schizophrenia. Recently, the role of the immune system in schizophrenia has received much attention. Both acquired and innate immune s...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Marziyeh Soltani Yousef Mirzaei Ali Hussein Mer Mina Mohammad-Rezaei Zahra Shafaghat Soheila Fattahi Fatemeh Azadegan-Dehkordi Meghdad Abdollahpour-Alitappeh Nader Bagheri Source Type: research

Unraveling the Impact of Blood Transfusion on Transcription Factors Regulating T Helper 1, 2, 17 and Regulatory T cells
This study aimed`` to evaluate the effect of blood transfusion on gene expression of transcription factors related to the development of TH1, TH2, TH17 and regulatory T cells (Tregs). In this cross-sectional study, 20 patients diagnosed with abdominal aortic aneurysms requiring surgical repair were studied from January 2018 to August 2020. We utilized real-time PCR to evaluate the expression of transcription factor genes associated with TH1, TH2, TH17, and Treg, namely T-box-expressed-in-T-cells (T-bet), GATA-binding protein 3 (GATA-3), retinoid-related orphan receptor (RORγt), and fork head box protein 3 (Foxp3), respect...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Samad Valizadeh Azita Chegini Faranak Behnaz Ali Akbar Pourfatollah Shahram Samiee Ronak Karbalaeifar Source Type: research

Measurement of the Neutrophils Count and Oxidative Burst in Neutrophils of Patients with Sanjad Sakati Syndrome
In this study, the neutrophil count value and the oxidative burst were evaluated in six patients diagnosed with SSS and six healthy individuals. There was a significant reduction in the neutrophil count observed in SSS patients compared to healthy controls (37.41±7.93 percent vs. 66.5±6.8 percent). However, there was no significant difference in neutrophil oxidative index between patients with SSS and control subjects (172.33±55.08 vs. 217.00±77.38). We concluded that in patients with SSS, the phagocytic activity of neutrophils was not affected by hormonal changes, while the number of neutrophils and neutrophil-to-lymp...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Farhad Abolnezhadian Majid Aminzadeh Sara Iranparast Sajad Dehnavi Fatemeh Dousti Moosa Sharifat Hamid Moradzadegan Source Type: research

Description of a Novel Pathogenic Variant in the ARPC1B and a Severe Allergy in Two Infants
Iran J Allergy Asthma Immunol. 2024 Feb 11;23(1):122-126. doi: 10.18502/ijaai.v23i1.14960.ABSTRACTActinrelated protein 2/3 complex subunit 1B (ARPC1B) deficiency is an inborn error of immunity (IEI) characterized by a combination of immunodeficiency and immune dysregulation and classified as an IEI with allergic manifestations. Here, we describe two patients with pathogenic variants in the ARPC1B gene. The first patient presented with eczema and bronchospasm at six months of age. The second patient presented with eczema and milk protein allergy at five months of age. The c.899_944 (p.Glu300Glyfs*7) pathogenic variant was p...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Oscar Zaveleta Mart ínez Ana Eunice Fregoso-Zu ñiga Cielo Razo Requena Sara Espinosa Padilla Lzbeth Blancas Galicia Source Type: research

Iranian Journal of Allergy, Asthma, and Immunology: A Bibliometric and Altmetric Analysis from 2005 to 2022
This study aimed to present a bibliometric and altmetric Analyses of the Iranian Journal of Allergy, Asthma, and Immunology (IJAAI). The citation performance and altmetric data were extracted from Scopus and Altmetric Explorer, respectively. Analyses were done using SPSS 26, Microsoft Excel, VOSviewer, and CiteSpace. The results of the bibliometric analysis revealed that IJAAI had experienced respectable growth. Among the total citations, 4746 citations belong to the first decade (2005-2014) and 3,035 citations belong to the second (2015-2022). The findings demonstrated the significance of IJAAI among Iranian researchers. ...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 15, 2024 Category: Allergy & Immunology Authors: Mojgan Zareivenovel Leila Nemati-Anaraki Ali Ouchi Maryam Nourizadeh Motahareh Aghashahi Source Type: research