Evaluation of interleukins (IL-1 α, IL-1Ra, IL-12, IL-17A, IL-31, and IL-33) and chemokines (CXCL10 and CXCL16) in the serum of male patients with ankylosing spondylitis

CONCLUSIONS: Among the eight cytokines examined, IL-17A, CXCL10, and CXCL16 were up-regulated in the serum of AS patients, while IL-31 was down-regulated. The levels of IL-1α, IL-1Ra, IL-12, and IL-33 showed no significant differences between patients and controls. Serum levels of all cytokines were not affected by disease duration, HLA-B27 positivity, or disease activity.PMID:38364743 | DOI:10.1016/j.intimp.2024.111697

Source: International Immunopharmacology - February 16, 2024 Category: Allergy & Immunology Authors: Hanan Y Muhsin Ali Q Khazaal Haneen M Ismaeel Mohammed H Alosami Ali H Ad'hiah Source Type: research