Molecules in the hippo pathway that regulate Th17 differentiation reveal the severity of ankylosing spondylitis
ConclusionOur findings suggest that the Hippo pathway plays a significant role in the regulation of Th17 differentiation and disease activity in patients with AS. The upregulation of TAZ and downregulation of key Hippo pathway proteins, such as MST1/2 and NDR1/2, may contribute to AS pathogenesis. These proteins may serve as biomarkers and may lead to the development of novel therapeutic strategies for AS.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Xiaohan Xu,
Wanlin Liu,
Yue Liu,
Dongmei Wu,
Bo Pang,
Zhe Zhao,
Yanan Zhao,
Hongxiao Liu Tags: ORIGINAL ARTICLE Source Type: research