Lower revascularization rates after high-speed rotational atherectomy compared to modified balloons in calcified coronary lesions: 5-year outcomes of the randomized PREPARE-CALC trial
ConclusionIn patients with severely calcified coronary lesions, using MB or RA for lesion preparation followed by biodegradable polymer SES implantation was associated with comparable rates of TVF at 5  years. However, a significant reduction of TLR was observed after RA. PREPARE-CALC is the first randomized trial showing potential clinical advantages of RA over MB during long-term follow-up.Clinical Trial RegistrationURL:https://www.clinicaltrials.gov. Unique identifier: NCT02502851.Graphical Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 14, 2024 Category: Cardiology Source Type: research

Aortic regurgitation is associated with African American and Asian race, smoking, renal disease, and numerous autoimmune diseases in addition to traditional cardiovascular risk factors  but has lower risk with alcohol intake
ConclusionUsing a very large database, we found new associations between AR and many comorbid conditions, including many inflammatory and chronic degenerative diseases in addition to the known risk factors.Graphical AbstractAortic regurgitation is associated with cardiovascular risk factors, race, and numerous autoimmune diseases. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 13, 2024 Category: Cardiology Source Type: research

Balloon technologies for pulmonary vein isolation —12-month outcome and comparison of the novel radiofrequency balloon with the cryoballoon in patients with paroxysmal atrial fibrillation
ConclusionThe RF-balloon was safe and effective. Compared with the CB, TTI was shorter, but procedure durations and fluoroscopy times were longer. This can be attributed to a learning curve and the initial necessity for separate 3D map preparation. Considering the results with the second-generation RF-balloon, more experience is needed to determine the potential benefits.Graphical Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 13, 2024 Category: Cardiology Source Type: research

Aortic regurgitation is associated with African American and Asian race, smoking, renal disease, and numerous autoimmune diseases in addition to traditional cardiovascular risk factors  but has lower risk with alcohol intake
ConclusionUsing a very large database, we found new associations between AR and many comorbid conditions, including many inflammatory and chronic degenerative diseases in addition to the known risk factors.Graphical AbstractAortic regurgitation is associated with cardiovascular risk factors, race, and numerous autoimmune diseases. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 13, 2024 Category: Cardiology Source Type: research

Balloon technologies for pulmonary vein isolation —12-month outcome and comparison of the novel radiofrequency balloon with the cryoballoon in patients with paroxysmal atrial fibrillation
ConclusionThe RF-balloon was safe and effective. Compared with the CB, TTI was shorter, but procedure durations and fluoroscopy times were longer. This can be attributed to a learning curve and the initial necessity for separate 3D map preparation. Considering the results with the second-generation RF-balloon, more experience is needed to determine the potential benefits.Graphical Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 13, 2024 Category: Cardiology Source Type: research

Sex-specific structural and functional cardiac remodeling during healthy aging assessed by cardiovascular magnetic resonance
ConclusionsIn both sexes, healthy aging was associated with an increase in concentricity and a decline in ventricular dimensions. Furthermore, relevant age-related sex differences in systolic LV performance were observed.Graphical Abstract↓, decrease; ↑, increase; ±, maintaining. Abbreviations: CMR, cardiovascular magnetic resonance; EDV, end-diastolic volume; EF, ejection fraction; LV, left ventricle; MVR, mass-to-volume ratio; RV, right ventricle; SVI, stroke volume index; T, Tesla; VR, volume ratio. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 11, 2024 Category: Cardiology Source Type: research

Transcatheter aortic valve implantation in patients with significant septal hypertrophy
ConclusionAlthough transvalvular mean pressure gradients were significantly higher in patients with increased IVSD after TAVI, acute outcomes were comparable between groups suggesting no early impact of adverse hemodynamics due to elevated IVSD. However, how these differences in hemodynamic findings may affect mid- and long-term outcomes, especially in terms of valve durability, needs to be evaluated in further investigations.Graphical Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 11, 2024 Category: Cardiology Source Type: research

Systematic underestimation of myocardial perfusion reserve by regadenoson stress perfusion CMR —when haste makes waste
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 11, 2024 Category: Cardiology Source Type: research

Sex-specific structural and functional cardiac remodeling during healthy aging assessed by cardiovascular magnetic resonance
ConclusionsIn both sexes, healthy aging was associated with an increase in concentricity and a decline in ventricular dimensions. Furthermore, relevant age-related sex differences in systolic LV performance were observed.Graphical Abstract↓, decrease; ↑, increase; ±, maintaining. Abbreviations: CMR, cardiovascular magnetic resonance; EDV, end-diastolic volume; EF, ejection fraction; LV, left ventricle; MVR, mass-to-volume ratio; RV, right ventricle; SVI, stroke volume index; T, Tesla; VR, volume ratio. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 11, 2024 Category: Cardiology Source Type: research

Transcatheter aortic valve implantation in patients with significant septal hypertrophy
ConclusionAlthough transvalvular mean pressure gradients were significantly higher in patients with increased IVSD after TAVI, acute outcomes were comparable between groups suggesting no early impact of adverse hemodynamics due to elevated IVSD. However, how these differences in hemodynamic findings may affect mid- and long-term outcomes, especially in terms of valve durability, needs to be evaluated in further investigations.Graphical Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 11, 2024 Category: Cardiology Source Type: research

Systematic underestimation of myocardial perfusion reserve by regadenoson stress perfusion CMR —when haste makes waste
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 11, 2024 Category: Cardiology Source Type: research

Ultra-long-term efficacy and safety of catheter-based renal denervation in resistant hypertension: 10-year follow-up outcomes
ConclusionRenal denervation was safe and sustainedly reduced ambulatory and office blood pressure out to 10  years in patients with resistant hypertension.Graphical abstractLeft panel, Change in 24-h and office SBP. Right panel, eGFR over time. SBP, systolic blood pressure; eGFR, estimated glomerular filtration rate. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 7, 2024 Category: Cardiology Source Type: research

Effect of supervised exercise training on cardiovascular function in patients with intermittent claudication: a systematic review and meta-analysis of randomized controlled trials
In conclusion, SET is effective in improving cardiovascular function in patients with IC, which was confirmed on outcomes of cardiovascular function associated with exercise ability. The findings hold out that the standard therapy of SET can improve not only walking distance but also c ardiovascular function in patients with IC. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 7, 2024 Category: Cardiology Source Type: research

Ultra-long-term efficacy and safety of catheter-based renal denervation in resistant hypertension: 10-year follow-up outcomes
ConclusionRenal denervation was safe and sustainedly reduced ambulatory and office blood pressure out to 10  years in patients with resistant hypertension.Graphical abstractLeft panel, Change in 24-h and office SBP. Right panel, eGFR over time. SBP, systolic blood pressure; eGFR, estimated glomerular filtration rate. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 7, 2024 Category: Cardiology Source Type: research

Effect of supervised exercise training on cardiovascular function in patients with intermittent claudication: a systematic review and meta-analysis of randomized controlled trials
In conclusion, SET is effective in improving cardiovascular function in patients with IC, which was confirmed on outcomes of cardiovascular function associated with exercise ability. The findings hold out that the standard therapy of SET can improve not only walking distance but also c ardiovascular function in patients with IC. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 7, 2024 Category: Cardiology Source Type: research