Outcomes of patients treated with a biodegradable-polymer sirolimus-eluting stent versus durable-polymer everolimus-eluting stents after rotational atherectomy
ConclusionIn the whole cohort, Orsiro BP-SES and DP-EES had comparable rates of long-term TLF after RA. In the small stent subgroup, the Orsiro BP-SES with ultra-thin struts showed significant lower rate of TLF at 2  years.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 16, 2021 Category: Cardiology Source Type: research

Early onset of hyperuricemia is associated with increased cardiovascular disease and mortality risk
AbstractBackgroundHyperuricemia is associated with cardiovascular mortality, but the association of the age at hyperuricemia onset with cardiovascular disease (CVD) and mortality is still unclear.ObjectiveThe purpose of this study was to examine the associations of hyperuricemia onset age with CVD and all-cause mortality.MethodsA total of 82,219 participants free of hyperuricemia and CVD from 2006 to 2015 in the Kailuan study were included. The analysis cohort comprised 18,311 new-onset hyperuricemia patients and controls matched for age and sex from the general population. Adjusted associations were estimated using Cox mo...
Source: Clinical Research in Cardiology - April 12, 2021 Category: Cardiology Source Type: research

Incidence, predictors, and outcomes associated with acute kidney injury in patients undergoing transcatheter aortic valve replacement: from the BRAVO-3 randomized trial
ConclusionIn the BRAVO 3 trial, AKI occurred in 17% at 30  days and in 10.7% at 7 days. AKI was associated with a significantly greater adjusted risk for 30-day death. Multivariate predictors of AKI at 30 days included baseline hemoglobin, body weight, and prior coronary artery disease, and predictors at 7 days included pre-existing vascular disease, C KD, transfusion, and valve post-dilation. Bivalirudin was associated with greater AKI within 48 h in the intention to treat but not in the per-protocol analysis.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 11, 2021 Category: Cardiology Source Type: research

Echocardiographic assessment of mitral regurgitation: discussion of practical and methodologic aspects of severity quantification to improve diagnostic conclusiveness
AbstractThe echocardiographic assessment of mitral valve regurgitation (MR) by characterizing specific morphological features and grading its severity is still challenging. Analysis of MR etiology is necessary to clarify the underlying pathological mechanism of the valvular defect. Severity of mitral regurgitation is often quantified based on semi-quantitative parameters. However, incongruent findings and/or interpretations of regurgitation severity are frequently observed. This proposal seeks to offer practical support to overcome these obstacles by offering a standardized workflow, an easy means to identify non-severe mi...
Source: Clinical Research in Cardiology - April 11, 2021 Category: Cardiology Source Type: research

PASCAL mitral valve repair system versus MitraClip: comparison of transcatheter edge-to-edge strategies in complex primary mitral regurgitation
ConclusionIn this highly selected patient group with complex PMR both systems exhibited equal procedural safety. MitraClip and PASCAL reduced qualitative and semi-quantitative parameters of MR to an at least comparable extent.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 10, 2021 Category: Cardiology Source Type: research

Minimally-invasive mitral valve repair of symmetric and asymmetric Barlow ´s disease
AbstractObjectivesBarlow ´s disease represents a wide spectrum of mitral valve pathologies associated with regurgitation (MR), excess leaflet tissue, and prolapse. Repair strategies range from complex repairs with annuloplasty plus neochords through resection to annuloplasty-only. The latter requires symmetric prolapse pat terns and central regurgitant jets. We aimed to assess repair success and durability, survival, and intraoperative outcomes with symmetric and asymmetric Barlow’s disease.MethodsBetween 09/10 and 03/20, 103 patients (of 1939 with mitral valve surgery) presented with Barlow ´s disease. A...
Source: Clinical Research in Cardiology - April 1, 2021 Category: Cardiology Source Type: research

CMR feature tracking strain patterns and their association with circulating cardiac biomarkers in patients with hypertrophic cardiomyopathy
ConclusionCMR-FT reveals LV and LA dysfunction in HCM despite normal LVEF. The association between impaired LV strain and elevated NT-proBNP and hsTnT indicates a link between unapparent functional abnormalities and disease severity in HCM.Graphic abstract Typical CMR-FT findings in patients with hypertrophic cardiomyopathy (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 29, 2021 Category: Cardiology Source Type: research

Impact of pulse pressure on clinical outcome in extracorporeal cardiopulmonary resuscitation (eCPR) patients
ConclusionIn this analysis, PP occurred to be a valuable parameter to estimate survival and maybe support clinical decision making in the further course of patients after eCPR.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 29, 2021 Category: Cardiology Source Type: research

Physical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study
ConclusionsThese results do not support a causal relationship between PA and sedentary behavior with risk of coronary artery disease, myocardial infarction, and ischemic stroke. Hence, previous observational studies may have been biased.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 27, 2021 Category: Cardiology Source Type: research

Alcohol-induced right bundle branch block is associated with a benign outcome in HOCM after alcohol septum ablation (ASA)
We examined the impact of ASA-induced bundle branch block (BBB) on clinical and hemodynamic features.Methods and resultsWe retrospectively analysed 98 HOCM patients with regard to ASA-induced BBB. Clinical examination was performed at baseline, early after ASA and at chronic follow-up (FU). ASA reduced left ventricular outflow tract gradient (LVOTG) during chronic FU (69.2  ± 41.6 pre vs. 31.8 ± 30.3 mmHg post ASA;p 
Source: Clinical Research in Cardiology - March 26, 2021 Category: Cardiology Source Type: research

Catheter ablation of short-coupled variant of torsade de pointes
Conclusion3D-mapping and intracardiac echocardiography demonstrate that sc-TdP predominantly originates from the MB free wall insertion and its Purkinje network. Catheter ablation of the culprit PVC at the MB free wall junction leads to excellent short- and long-term results and should be considered as first-line therapy in recurrent sc-TdP or electrical storm.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 26, 2021 Category: Cardiology Source Type: research

Incidence and outcomes of perioperative myocardial infarction/injury diagnosed by high-sensitivity cardiac troponin I
ConclusionsUsing hs-cTnI, PMI is less common versus using hs-cTnT. Using hs-cTnI, both PMIInfarct and PMIInjury remain independent predictors of 30-day and 1-year mortality.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 25, 2021 Category: Cardiology Source Type: research

Is there a benefit of ICD treatment in patients with persistent severely reduced systolic left ventricular function after TAVI?
ConclusionIn high-risk TAVI-patients suffering from heart failure with LVEF  ≤ 35%, LVEF improvement to more than 35% did not reduce overall mortality. Patients with postprocedural persistent LVEF reduction did not seem to benefit from ICD treatment. Effects of LVEF improvement and ICD treatment on mortality are masked by the competing risk of death from relevant como rbidities.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 23, 2021 Category: Cardiology Source Type: research

Intravenous iron for heart failure with evidence of iron deficiency: a meta-analysis of randomised trials
ConclusionAdministration of IV iron to patients with heart failure and ID reduces the risk of the composite outcome of first heart failure hospitalisation or cardiovascular mortality, but this outcome may be driven predominantly by an effect on HHF. At least three more substantial trials of intravenous iron are underway.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 23, 2021 Category: Cardiology Source Type: research

Correction to: Predictors of high residual gradient after transcatheter aortic valve replacement in bicuspid aortic valve stenosis
A correction to this paper has been published: https://doi.org/10.1007/s00392-021-01824-z (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 23, 2021 Category: Cardiology Source Type: research

Prognostic value of the chest X-ray in patients hospitalised for heart failure
AbstractBackgroundPatients admitted to hospital with heart failure will have had a chest X-ray (CXR), but little is known about their prognostic significance. We aimed to report the prevalence and prognostic value of the initial chest radiograph findings in patients admitted to hospital with heart failure (acute heart failure, AHF).MethodsThe erect CXRs of all patients admitted with AHF between October 2012 and November 2016 were reviewed for pulmonary venous congestion, Kerley B lines, pleural effusions and alveolar oedema. Film projection (whether anterior –posterior [AP] or posterior–anterior [PA]) and cardi...
Source: Clinical Research in Cardiology - March 22, 2021 Category: Cardiology Source Type: research

Outcome of aortic stenosis according to invasive cardiac damage staging after transcatheter aortic valve replacement
The objective of this study was to investigate the prognostic impact of a cardiac damage classification based on invasive hemodynamics in patients with AS undergoing transcatheter aortic valve replacement (TAVR).MethodsA total of 1400 patients with symptomatic AS and full invasive hemodynamic assessment before TAVR were included. Patients were categorized according to their cardiac damage stage into five groups that are defined as: stage 0, no cardiac damage; stage 1, left ventricular damage; stage 2, left atrial and/or mitral valve damage; stage 3, pulmonary vasculature and/or tricuspid valve damage; stage 4, right ventri...
Source: Clinical Research in Cardiology - March 20, 2021 Category: Cardiology Source Type: research

Effects of acute alcohol consumption on cardiac excitation, conduction, and repolarization: results from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW)
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 18, 2021 Category: Cardiology Source Type: research

Iron deficiency and short-term adverse events in patients with decompensated heart failure
AbstractBackgroundFor patients with heart failure (HF), iron deficiency (ID) is a common therapeutic target. However, little is known about the utility of transferrin saturation (TSAT) or serum ferritin for risk stratification in decompensated HF (DHF) or the European Society of Cardiology's (ESC) current definition of ID (ferritin  
Source: Clinical Research in Cardiology - March 15, 2021 Category: Cardiology Source Type: research

Colchicine in ischemic heart disease: the good, the bad and the ugly
AbstractInflammation is the main pathophysiological process involved in atherosclerotic plaque formation, progression, instability, and healing during the evolution of coronary artery disease (CAD). The use of colchicine, a drug used for decades in non-ischemic cardiovascular (CV) diseases and/or systemic inflammatory conditions, stimulated new perspectives on its potential application in patients with CAD. Previous mechanistic and preclinical studies revealed anti-inflammatory and immunomodulatory effects of colchicine exerted through its principal mechanism of microtubule polymerization inhibition, however, other pleiotr...
Source: Clinical Research in Cardiology - March 13, 2021 Category: Cardiology Source Type: research

Impact of chronic obstructive pulmonary disease on 10-year mortality after percutaneous coronary intervention and bypass surgery for complex coronary artery disease: insights from the SYNTAX Extended Survival study
AbstractAimsTo evaluate the impact of chronic obstructive pulmonary disease (COPD) on 10-year all-cause death and the treatment effect of CABG versus PCI on 10-year all-cause death in patients with three-vessel disease (3VD) and/or left main coronary artery disease (LMCAD) and COPD.MethodsPatients were stratified according to COPD status and compared with regard to clinical outcomes. Ten-year all-cause death was examined according to the presence of COPD and the revascularization strategy.ResultsCOPD status was available for all randomized 1800 patients, of whom, 154 had COPD (8.6%) at the time of randomization. Regardless...
Source: Clinical Research in Cardiology - March 12, 2021 Category: Cardiology Source Type: research

Continuation or discontinuation of oral anticoagulants after HAS-BLED scores increase in patients with atrial fibrillation
ConclusionsFor patients whose HAS-BLED scores increased to  ≥ 3, the continuation of OACs was associated with better clinical outcomes. An increased HAS-BLED score in anticoagulated AF patients may not be the only reason to withhold OACs, but reminds physicians to correct modifiable bleeding risk factors and follow up patients more closely.Graphical abstractAssociations between Continuation or Discontinuation of Oral Anticoagulants and Risks of Clinical Outcomes after HAS-BLED Scores IncreasedAF atrial fibrillation;aHR adjusted hazard ratio;ICH intra-cranial hemorrhage;OACs oral anticoagulants (Source: Cli...
Source: Clinical Research in Cardiology - March 11, 2021 Category: Cardiology Source Type: research

Re-appraisal of the obesity paradox in heart failure: a meta-analysis of individual data
ConclusionsThe present study suggests that obesity is a marker of less advanced disease, but does not have an independent protective effect in patients with chronic HF.Graphic abstractCategories of BMI are only predictive of poor outcome in patients aged  >  75 years or with at least one co-morbidity (bottom), but not in those aged 
Source: Clinical Research in Cardiology - March 11, 2021 Category: Cardiology Source Type: research

Analysis of causes of death in patients with implanted defibrillators
ConclusionLife expectancy of ICD patients is lower than for the general population. Mortality is predominantly due to CHF, but there is still a considerable rate of SD. The occurrence of cancers, most importantly bronchial carcinomas, and infections, warrants protective measures. Some deaths during procedures are possibly preventable. Patients with ICDs comprise a vulnerable cohort, and treatment has to be optimized in many directions to improve prognosis.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 9, 2021 Category: Cardiology Source Type: research

Prognostic benefit from an early invasive strategy in patients with non-ST elevation acute coronary syndrome (NSTEACS): evaluation of the new risk stratification in the NSTEACS European guidelines
The objective of our work is to evaluate the prognostic benefit of an early invasive strategy in patients with high-risk NSTACS according to the recommendations of the 2020 clinical practice guidelines during long-term follow-up.MethodsThis retrospective observational study included 6454 consecutive NSTEACS patients. We analyze the effects of early coronary angiography (  140 and (b) patients with “established NSTEMI” (non ST-segment elevation myocardial infarction defined by an increase in troponins) or dynamic ST-T-segment changes with a GRACE risk score   140 [HR 0.62 (IC 95% 0.57–...
Source: Clinical Research in Cardiology - March 9, 2021 Category: Cardiology Source Type: research

Heart failure re-hospitalizations and subsequent fatal events in coronary artery disease: insights from COMMANDER-HF, EPHESUS, and EXAMINE
ConclusionsA first or recurrent HFH is common in patients with CAD and AMI or HFrEF and indicates a poor prognosis. Preventing the development of heart failure after AMI and control of congestion in patients with CAD and HFrEF are key unmet needs and therapeutic targets.RegistrationClinicalTrials.gov Identifier: NCT01877915. URL:https://clinicaltrials.gov/ct2/show/NCT01877915. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 8, 2021 Category: Cardiology Source Type: research

Soluble triggering receptor expressed on myeloid cells-1 is a marker of organ injuries in cardiogenic shock: results from the CardShock Study
ConclusionIn CS patients TREM-1 pathway is highly activated and gives an early prediction of vital organ injuries and outcome.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 7, 2021 Category: Cardiology Source Type: research

Who is who in cardiovascular research? What a review of Nobel Prize nominations reveals about scientific trends
ConclusionWe argue that an analysis of  Nobel Prize nominations can reconstruct important scientific trends within cardiovascular research during the first half of the twentieth century. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 6, 2021 Category: Cardiology Source Type: research

Impact of effective regurgitant orifice area on outcome of secondary mitral regurgitation transcatheter repair
AbstractObjectivesTo assess the value of effective regurgitant orifice (ERO) in predicting outcome after edge-to-edge transcatheter mitral valve repair (TMVR) for secondary mitral regurgitation (SMR) and identify the optimal cut-off for patients ’ selection.MethodsUsing the EuroSMR (European Registry of Transcatheter Repair for Secondary Mitral Regurgitation) registry, that included patients undergoing edge-to-edge TMVR for SMR between November 2008 and January 2019 in 8 experienced European centres, we assessed the optimal ERO threshold associated with mortality in SMR patients undergoing TMVR, and compared characte...
Source: Clinical Research in Cardiology - March 4, 2021 Category: Cardiology Source Type: research

Imaging strategies for safety surveillance after renal artery denervation
AbstractRenal denervation has emerged as a safe and effective therapy to lower blood pressure in hypertensive patients. In addition to the main renal arteries, branch vessels are also denervated in more contemporary studies. Accurate and reliable imaging in renal denervation patients is critical for long-term safety surveillance due to the small risk of renal artery stenosis that may occur after the procedure. This review summarizes three common non-invasive imaging modalities: Doppler ultrasound (DUS), computed tomography angiography (CTA), and magnetic resonance angiography (MRA). DUS is the most widely used owing to cos...
Source: Clinical Research in Cardiology - March 1, 2021 Category: Cardiology Source Type: research

Heart failure and atrial fibrillation in patients with an interatrial shunt
AbstractObjectiveCongenital interatrial shunt can unload the left atrium (LA) and may lower the risk of new-onset heart failure (HF) or atrial fibrillation (AF). We evaluated the risk of new-onset HF or AF in patients with and without interatrial shunt.MethodsWe enrolled 2660 consecutive patients with acute stroke or transient ischemic attack (TIA) who underwent transesophageal echocardiography at Seoul National University Bundang Hospital from January 1, 2006 to December 31, 2018. The primary outcomes were 10-year new-onset HF, new-onset AF, and new-onset HF or AF composite.ResultsOverall, 466 (17.5%) patients with an int...
Source: Clinical Research in Cardiology - March 1, 2021 Category: Cardiology Source Type: research

Combined renal and common hepatic artery denervation as a novel approach to reduce cardiometabolic risk: technical approach, feasibility and safety in a pre-clinical model
AbstractBackgroundCardiovascular and metabolic regulation is governed by neurohumoral signalling in relevant organs such as kidney, liver, pancreas, duodenum, adipose tissue, and skeletal muscle. Combined targeting of relevant neural outflows may provide a unique therapeutic opportunity for cardiometabolic disease.ObjectivesWe aimed to investigate the feasibility, safety, and performance of a novel device-based approach for multi-organ denervation in a swine model over 30 and 90  days of follow-up.MethodsFive Yorkshire cross pigs underwent combined percutaneous denervation in the renal arteries and the common hepatic ...
Source: Clinical Research in Cardiology - February 26, 2021 Category: Cardiology Source Type: research

Preload dependence of pulmonary haemodynamics and right ventricular performance
ConclusionRapid volemic changes may affect FTR grading, RV size and contractility, with RV longitudinal strain being less variable than conventional parameters. SPAP decreases after HD, and this reduction is related to age and greater diminution of theE/eʹ ratio.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 24, 2021 Category: Cardiology Source Type: research

Echocardiographic evidence of an intrapulmonary shunt in a patient with severe liver cirrhosis
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 23, 2021 Category: Cardiology Source Type: research

The risk of valve thrombosis is higher with intra-annular versus supra-annular transcatheter aortic valve prosthesis. A meta-analysis from randomized controlled trials
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 19, 2021 Category: Cardiology Source Type: research

The importance of including uric acid in the definition of metabolic syndrome when assessing the mortality risk
AbstractIntroductionSerum uric acid (SUA) has been depicted as a contributory causal factor in metabolic syndrome (MS), which in turn, portends unfavourable prognosis.AimWe assessed the prognostic role of SUA in patients with and without MS.MethodsWe used data from the multicentre Uric Acid Right for Heart Health study and considered cardiovascular mortality (CVM) as death due to fatal myocardial infarction, stroke, sudden cardiac death, or heart failure.ResultsA total of 9589 subjects (median age 58.5  years, 45% males) were included in the analysis, and 5100 (53%) patients had a final diagnosis of MS. After a median...
Source: Clinical Research in Cardiology - February 18, 2021 Category: Cardiology Source Type: research

Pathomechanisms and therapeutic opportunities in radiation-induced heart disease: from bench to bedside
AbstractCancer management has undergone significant improvements, which led to increased long-term survival rates among cancer patients. Radiotherapy (RT) has an important role in the treatment of thoracic tumors, including breast, lung, and esophageal cancer, or Hodgkin's lymphoma. RT aims to kill tumor cells; however, it may have deleterious side effects on the surrounding normal tissues. The syndrome of unwanted cardiovascular adverse effects of thoracic RT is termed radiation-induced heart disease (RIHD), and the risk of developing RIHD is a critical concern in current oncology practice. Premature ischemic heart diseas...
Source: Clinical Research in Cardiology - February 16, 2021 Category: Cardiology Source Type: research

Impact of sinus rhythm versus atrial fibrillation on left ventricular remodeling after transcatheter aortic valve replacement
ConclusionsThe present study identified a significant association of AF with changes in LVMI after TAVR, which was also shown to be associated with clinical outcome. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 10, 2021 Category: Cardiology Source Type: research

Pacemaker lead-associated tricuspid regurgitation in patients with or without pre-existing right ventricular dilatation
This study investigated the progression of tricuspid regurgitation (TR) in patients with or without pre-existing right ventricular dilatation (RVD) undergoing pacemaker implantation.MethodsPatients were included if they had implantation of transtricuspid pacemaker lead and completed echocardiography before and after implantation. The cohort was divided in patients with and without RVD (cut-off basal RV diameter  ≥ 42 mm). TR was graded in none/mild, moderate, and severe. Worsening of one grade was defined as progression. Survival analyses were plotted for 10 years.ResultsIn total, 990 patients we...
Source: Clinical Research in Cardiology - February 10, 2021 Category: Cardiology Source Type: research

Prognostic value of NT-proBNP for myocardial recovery in peripartum cardiomyopathy (PPCM)
ConclusionsWe have demonstrated that NT-proBNP has a prognostic value in predicting LV recovery of patients with PPCM. Patients with NT-proBNP of  ≥ 900 pg/ml were less likely to show any improvement in LVEF or LVEDD. Our findings have implications for clinical practice as patients with higher NT-proBNP might require more aggressive therapy and more intensive follow-up. Point-of-care NT-proBNP for diagnosis and risk stratification warr ants further investigation. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 8, 2021 Category: Cardiology Source Type: research

Prognostic impact of mean heart rate by Holter monitoring on long-term outcome in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention
AbstractBackgroundPrevious studies have shown elevated admission heart rate (HR) was associated with worse outcome in patients with myocardial infarction (MI). However, the prognostic value of mean heart rate (MHR) with Holter monitoring remains unclear.ObjectivesOur present study aims to evaluate the impact of MHR by Holter monitoring on long-term mortality in patients with ST-segment elevation myocardial infarction (STEMI).Methods1013 STEMI patients were divided into four groups according to the quartiles of MHR by Holter monitoring, Q1 (  78 bpm). The endpoint was long-term all-cause mortality. The predictiv...
Source: Clinical Research in Cardiology - February 6, 2021 Category: Cardiology Source Type: research

Acute chest pain with ST-segment elevation in lead V1 –V3: when you hear hoofbeats, also look for zebras
AbstractST-segment elevation (STE) in the anterior precordial leads is the hallmark of anterior myocardial infarction. In rare cases, this ECG pattern may be due to isolated infarction of the right ventricle since leads V1 –V3 directly overlie the right ventricular free wall. Herein, we aimed to provide clues to recognize and understand this diagnostic pitfall through a series of 4 patients presenting with STE in the anterior leads. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 6, 2021 Category: Cardiology Source Type: research

Letter to the editors referring to Caravaca Perez, P., Gonz ález-Juanatey, J.R., Nuche, J. et al. (2020). Serum potassium dynamics during acute heart failure hospitalization. Clinical Research in Cardiology .
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 4, 2021 Category: Cardiology Source Type: research

“Get with the Guidelines Heart Failure Risk Score” for mortality prediction in patients undergoing MitraClip
AbstractBackgroundReliable risk scores in patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) are lacking. Heart failure is common in these patients, and risk scores derived from heart failure populations might help stratify TMVR patients.MethodsConsecutive patients from three Heart Centers undergoing TMVR were enrolled to investigate the association of the “Get with the Guidelines Heart Failure Risk Score” (comprising the variables systolic blood pressure, urea nitrogen, blood sodium, age, heart rate, race, history of chronic obstructive lung disease) with all-cause mortality.ResultsAmong...
Source: Clinical Research in Cardiology - January 31, 2021 Category: Cardiology Source Type: research

Ten-year all-cause death following percutaneous or surgical revascularization in patients with prior cerebrovascular disease: insights from the SYNTAX Extended Survival study
AbstractBackgroundCoronary bypass artery grafting (CABG) has a higher procedural risk of stroke than percutaneous coronary intervention (PCI), but may offer better long-term survival. The optimal revascularization strategy for patients with prior cerebrovascular disease (CEVD) remains unclear.Methods and resultsThe SYNTAXES study assessed the vital status out to 10  year of patients with three-vessel disease and/or left main coronary artery disease enrolled in the SYNTAX trial. The relative efficacy of PCI vs. CABG in terms of 10 year all-cause death was assessed according to prior CEVD. The primary endpoint was ...
Source: Clinical Research in Cardiology - January 30, 2021 Category: Cardiology Source Type: research

Outcomes in patients with acute myocardial infarction and new atrial fibrillation: a nationwide analysis
ConclusionsIn a large and systematic nationwide analysis, AF first recorded in the first 30  days after AMI was independently associated with higher risks of death and ischemic stroke than those in patients with no AF or previously known AF.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 28, 2021 Category: Cardiology Source Type: research

Impaired in vitro growth response of plasma-treated cardiomyocytes predicts poor outcome in patients with transthyretin amyloidosis
AbstractObjectivesDirect toxic effects of transthyretin amyloid in patient plasma upon cardiomyocytes are discussed. However, no data regarding the relevance of this putative effect for clinical outcome are available. In this monocentric prospective study, we analyzed cellular hypertrophy after phenylephrine stimulation in vitro in the presence of patient plasma and correlated the cellular growth response with phenotype and prognosis.Methods and resultsProgress in automated microscopy and image analysis allows high-throughput analysis of cell morphology. Using the InCell microscopy system, changes in cardiomyocyte ’s...
Source: Clinical Research in Cardiology - January 22, 2021 Category: Cardiology Source Type: research

Short-term cardiac outcome in survivors of COVID-19: a systematic study after hospital discharge
ConclusionsIn a short-term follow-up, no abnormalities were identified in the heart of survivors of COVID-19, nor cardiac differences were detected between patients who had different severity of illness. With the limitations of a cross-sectional study, these findings suggest that patients who recover from COVID-19 do not have considerable cardiac sequelae.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 22, 2021 Category: Cardiology Source Type: research

Reply to G. Betts ’s letter referring to “Serum potassium dynamics during acute heart failure hospitalization”
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 21, 2021 Category: Cardiology Source Type: research

Diagnosis and treatment of cardiac amyloidosis: position statement of the German Cardiac Society (DGK)
AbstractSystemic forms of amyloidosis affecting the heart are mostly light-chain (AL) and transthyretin (ATTR) amyloidoses. The latter is caused by deposition of misfolded transthyretin, either in wild-type (ATTRwt) or mutant (ATTRv) conformation. For diagnostics, specific serum biomarkers and modern non-invasive imaging techniques, such as cardiovascular magnetic resonance imaging (CMR) and scintigraphic methods, are available today. These imaging techniques do not only complement conventional echocardiography, but also allow for accurate assessment of the extent of cardiac involvement, in addition to diagnosing cardiac a...
Source: Clinical Research in Cardiology - January 18, 2021 Category: Cardiology Source Type: research