Recurrent infective endocarditis versus first-time infective endocarditis after heart valve surgery
ConclusionsFollowing heart valve surgery, the risk of recurrent IE was significantly higher than the risk of first-time IE.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 17, 2020 Category: Cardiology Source Type: research

Coronary collaterals in patients with ST-elevation myocardial infarction presenting late after symptom onset
ConclusionSufficient coronary collateralization has a positive impact on microvascular obstruction, infarct size and long-term mortality in STEMI patients presenting between 12 and 48  h after symptom onset. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 13, 2020 Category: Cardiology Source Type: research

Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China
ConclusionPatients with previous cardiovascular metabolic diseases may face a greater risk of developing into the severe condition and the comorbidities can also greatly affect the prognosis of the COVID-19. On the other hand, COVID-19 can, in turn, aggravate the damage to the heart. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 11, 2020 Category: Cardiology Source Type: research

Clinical, procedural and long-term outcome of ischemic VT ablation in patients with previous anterior versus inferior myocardial infarction
AbstractBackgroundOutcome of ischemic VT ablation may differ between patients with previous myocardial infarction (MI) in relation to infarct localization.MethodsWe analyzed procedural data, acute and long-term outcomes of 152 consecutive patients (139 men, mean age 67  ± 9 years) with previous anterior or inferior MI who underwent ischemic VT ablation at our institution between January 2010 and October 2015.ResultsMore patients had a history of inferior MI (58%). Mean ejection fraction was significantly lower in anterior MI patients (28  ± 10% vs. 34 ± 10%,p 
Source: Clinical Research in Cardiology - March 10, 2020 Category: Cardiology Source Type: research

Spot urinary sodium in acute decompensation of advanced heart failure and dilutional hyponatremia: insights from DRAIN trial
AbstractBackgroundDiuretic resistance portends a poor prognosis in acute heart failure, especially in advanced stages. Early  identification of a poor response to diuretics may help to improve treatment and outcomes. Spot natriuresis (UNa+) at 2  h from the start of intravenous furosemide has been proposed as an early indicator of diuretic response. Our paper aimed to determine the role of early natriuresis in patients hospitalized with advanced chronic heart failure (ACHF) and high risk of diuretic resistance.Methods and resultsWe performed a sub-analysis of the DRAIN trial, a randomized clinical trial on 80 p...
Source: Clinical Research in Cardiology - March 6, 2020 Category: Cardiology Source Type: research

Pulmonary vein isolation treats symptomatic AF in a patient with Lamin A/C mutation: case report and review of the literature
Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 6, 2020 Category: Cardiology Source Type: research

Simultaneous two-sided endocarditis: cardiac resynchronization leads and left atrial appendage occluder
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - March 5, 2020 Category: Cardiology Source Type: research

Correction to: One ‑year clinical outcomes in patients with renal insuffciency after contemporary PCI: data from a multicenter registry
The original version of this article unfortunately contained a mistake. The given name and family name of the fourth author Saaraaken Kulenthiran were switched in the original publication. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 25, 2020 Category: Cardiology Source Type: research

Prognostic impact of cancer history in patients undergoing transcatheter aortic valve implantation
AbstractBackgroundThe benefit of TAVI in cancer patients is currently unclear.ObjectivesThe purpose of this study is to investigate prognostic impact of cancer status (active cancer or previous cancer) in severe aortic stenosis (AS) patients undergoing transcatheter aortic valve implantation (TAVI).MethodsConsecutive TAVI patients in the Heart Center Bonn were enrolled and we stratified the patients into three groups: current cancer (active cancer), non-current cancer (previous cancer), or no cancer. The primary outcome was all-cause death within a 5-year follow-up. We evaluated mean aortic pressure gradient (mPG) values f...
Source: Clinical Research in Cardiology - February 18, 2020 Category: Cardiology Source Type: research

Prognosis of persistent mitral regurgitation in patients undergoing transcatheter aortic valve replacement
The objective of this study was to assess imaging predictors of mitral regurgitation (MR) improvement and to evaluate the impact of MR regression on long-term outcome in patients undergoing transcatheter aortic valve replacement (TAVR).BackgroundConcomitant MR is a frequent finding in patients with severe aortic stenosis but usually left untreated at the time of TAVR.MethodsMitral regurgitation was graded by transthoracic echocardiography before and after TAVR in 677 consecutive patients with severe aortic stenosis. 2-year mortality was related to the degree of baseline and discharge MR. Morphological echo analysis was per...
Source: Clinical Research in Cardiology - February 18, 2020 Category: Cardiology Source Type: research

Atrial inflammation in different atrial fibrillation subtypes and its relation with clinical risk factors
ConclusionThe extent of left atrial inflammation in AF patients was not related to the AF risk factors, diabetes and gender, but was associated with increasing age in patients with long-standing persistent/permanent AF. This may be indicative for a role of inflammation in the progression to long-standing persistent/permanent AF with increasing age.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 18, 2020 Category: Cardiology Source Type: research

Regression of cardiac amyloid load documented by cardiovascular magnetic resonance in a patient with hereditary amyloidosis
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 11, 2020 Category: Cardiology Source Type: research

Long-term outcome upon treatment of calcified lesions of the lower limb using scoring angioplasty balloon (AngioSculpt ™)
ConclusionLesion preparation with AngioSculpt ™ scoring balloon represents a safe and effective tool in the treatment of complex femoropopliteal lesions. In this retrospective analysis, AngioSculpt™ scoring balloon angioplasty did not significantly improve vessel patency- both when used as an adjunctive in preparation for stenting and as st and-alone treatment. A prospective study is needed to further investigate the scoring balloon treatment options.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 8, 2020 Category: Cardiology Source Type: research

Compared with matched controls, patients with postoperative atrial fibrillation (POAF) have increased long-term AF after CABG, and POAF is further associated with increased ischemic stroke, heart failure and mortality even after adjustment for AF
ConclusionsPatients with POAF after CABG had three times the incidence of long-term AF compared with both non-POAF patients and matched controls. POAF was associated with long-term ischemic stroke, heart failure, and corresponding mortality even after adjustment for AF during follow-up. The increased overall mortality was partly explained by morbidities associated with POAF.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 8, 2020 Category: Cardiology Source Type: research

Temporal trends in incidence and outcome of acute coronary syndrome
ConclusionIn a large dataset including more than 3.7 million cases, we report an increase in coronary procedures and a reduction of ACS incidence and related mortality in the past decade in Germany. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 7, 2020 Category: Cardiology Source Type: research

Rationale and design of two randomized sham-controlled trials of catheter-based renal denervation in subjects with uncontrolled hypertension in the absence (SPYRAL HTN-OFF MED Pivotal) and presence (SPYRAL HTN-ON MED Expansion) of antihypertensive medications: a novel approach using Bayesian design
ConclusionsThe Bayesian paradigm represents a novel and promising approach in device-based hypertension trials.Clinical trial registrationURL:https://www.clinicaltrials.gov. Unique identifier: NCT02439749 (SPYRAL HTN-OFF MED Pivotal) and NCT02439775 (SPYRAL HTN-ON MED Expansion). (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 7, 2020 Category: Cardiology Source Type: research

Long-term outcome after thrombus aspiration in non-ST-elevation myocardial infarction: results from the TATORT-NSTEMI trial
ConclusionsIn NSTEMI, thrombus aspiration is associated with favorable clinical outcome during long-term follow-up.Clinical trial registrationNCT01612312. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 6, 2020 Category: Cardiology Source Type: research

Medical treatment of octogenarians with chronic heart failure: data from CHECK-HF
AbstractBackgroundElderly heart failure (HF) patients are underrepresented in clinical trials, though are a large proportion of patients in real-world practice. We investigated practice-based, secondary care HF management in a large group of chronic HF patients aged  ≥ 80 years (octogenarians).MethodsWe analyzed electronic health records of 3490 octogenarians with chronic HF at 34 Dutch outpatient clinics in the period between 2013 and 2016 , 49% women. Study patients were divided into HFpEF [LVEF  ≥ 50%;n = 911 (26.1%)], HFrEF [LVEF 
Source: Clinical Research in Cardiology - February 6, 2020 Category: Cardiology Source Type: research

Validation of a fast prognostic score for risk stratification of normotensive patients with acute pulmonary embolism
ConclusionsThe 2019 ESC algorithm provided the best prognostic performance, but also the modified FAST score accurately stratified normotensive PE patients in different risk classes while the Bova score failed to identify patients at highest risk.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 6, 2020 Category: Cardiology Source Type: research

Obesity paradox and perioperative myocardial infarction/injury in non-cardiac surgery
ConclusionObesity class I was associated with a lower incidence of PMI, and obesity in general was associated with a lower all-cause mortality at 365  days. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 5, 2020 Category: Cardiology Source Type: research

Estimated plasma volume and mortality: analysis from NHANES 1999 –2014
ConclusionAn increase in ePV was associated with increased all-cause and cause-specific mortality. Further studies are needed to explore the mechanism of this relationship and translation into a better outcome.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 5, 2020 Category: Cardiology Source Type: research

Predictive factors and long-term prognosis of transcatheter aortic valve implantation-associated endocarditis
The objective of the present study was to investigate the predictor and long-term outcome of TAVI endocarditis.MethodsConsecutive patients undergoing TAVI at the University of Bonn were prospectively enrolled in this study. Transcatheter heart valve (THV) endocarditis was defined according to Duke criteria. The primary outcome was all-cause death within a 5-year follow-up.Results1448 successful TAVI patients were eligible for the study and 17 patients (1.2%) developed THV endocarditis during the follow-up period (median 294  days). A multivariable logistic regression analysis identified age (odds ratio [OR] 0.90;P&thi...
Source: Clinical Research in Cardiology - February 4, 2020 Category: Cardiology Source Type: research

The association of body mass index with long-term clinical outcomes after ticagrelor monotherapy following abbreviated dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a prespecified sub-analysis of the GLOBAL LEADERS Trial
AbstractBackgroundThe efficacy of antiplatelet therapies following percutaneous coronary intervention (PCI) may be affected by body mass index (BMI).Methods and resultsThis is a prespecified subgroup analysis of the GLOBAL LEADERS trial, a prospective, multicenter, open-label, randomized controlled trial in an all-comer population undergoing PCI, comparing the experimental strategy (23-month ticagrelor monotherapy following 1-month dual antiplatelet therapy [DAPT]) with a reference regimen (12-month aspirin monotherapy following 12-month DAPT). A total of 15,968 patients were stratified by baseline BMI with prespecified th...
Source: Clinical Research in Cardiology - January 31, 2020 Category: Cardiology Source Type: research

Association of estimated plasma volume status with hemodynamic and echocardiographic parameters
AbstractBackgroundEstimated plasma volume status (ePVS) has diagnostic and prognostic value in patients with heart failure (HF). However, it remains unclear which congestion markers (i.e., biological, imaging, and hemodynamic markers) are preferentially associated with ePVS. In addition, there is evidence of sex differences in both the hematopoietic process and myocardial structure/function.Method and resultsPatients with significant dyspnea (NYHA  ≥ 2) underwent echocardiography and lung ultrasound within 4 h prior to cardiac catheterization. Patients were divided according to tertiles based on sex-specif...
Source: Clinical Research in Cardiology - January 31, 2020 Category: Cardiology Source Type: research

Soluble neprilysin, NT-proBNP, and growth differentiation factor-15 as biomarkers for heart failure in dialysis patients (SONGBIRD)
AbstractBackground Dialysis patients are at increased risk of HF. However, diagnostic utility of NT-proBNP as a biomarker is decreased in patients on dialysis. GDF-15 and cNEP are biomarkers of distinct mechanisms that may contribute to HF pathophysiology in such cohorts. The aim of this study was to determine whether growth differentiation factor-15 (GDF-15) and circulating neprilysin (cNEP) improve the diagnosis of congestive heart failure (HF) in patients on dialysis.Methods and resultsWe compared circulating concentrations of NT-proBNP, GDF-15, and cNEP along with cNEP activity in patients on chronic dialysis without...
Source: Clinical Research in Cardiology - January 30, 2020 Category: Cardiology Source Type: research

Natriuretic peptides: biomarkers for atrial fibrillation management
AbstractIn clinical practice, atrial fibrillation (AF) is known as the most common sustained arrhythmia. Therefore, identification of individuals at risk of AF development/recurrence or its associated complications has emerged as a hot topic in the field of cardiology. Recently, several biomarkers have been introduced to predict AF and its consequences; however, use of biomarkers in AF management has not been highly recommended by guidelines yet. While utilization of natriuretic peptides (NPs) including brain (B-type) NPs (BNPs) in heart failure management has been well established, their use in relation to AF has not been...
Source: Clinical Research in Cardiology - January 30, 2020 Category: Cardiology Source Type: research

Outcomes in patients with dual antegrade conduction in the atrioventricular node: insights from a multicentre observational study
ConclusionThis first multicentre study investigating patients with supraventricular tachycardia and dual antegrade conduction in the AV node demonstrates that catheter ablation is safe and effective while long-term patient outcome is good. Autonomic tone dependent changes in ante- vs. retrograde conduction via slow and/or fast pathway can challenge the diagnosis and therapy in some patients.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 30, 2020 Category: Cardiology Source Type: research

Higher doses of loop diuretics limit uptitration of angiotensin-converting enzyme inhibitors in patients with heart failure and reduced ejection fraction
AbstractBackgroundLoop diuretics are frequently prescribed to patients with heart failure and reduced ejection fraction (HFrEF) for the treatment of congestion; however, they might hamper uptitration of inhibitors of the renin –angiotensin system.MethodsLoop diuretic dose at baseline was recorded in 2338 patients with HFrEF enrolled in BIOSTAT-CHF, an international study of HF patients on loop diuretic therapy who were eligible for uptitration of angiotensin-converting enzyme inhibitors (ACEi)/mineralocorticoid receptor antagonists (MRA). The association between loop diuretic dose and uptitration of ACEi/MRA to perce...
Source: Clinical Research in Cardiology - January 30, 2020 Category: Cardiology Source Type: research

Functional neuroimaging in the acute phase of Takotsubo syndrome: volumetric and functional changes of the right insular cortex
AbstractBackgroundA brain –heart interaction has been proposed in Takotsubo syndrome (TTS). Structural changes in the limbic system and hypoconnectivity between certain brain areas in the chronic phase of the disease have been reported, but little is known concerning functional neuroimaging in the acute phase. We hypothesi zedh anatomical and functional changes in the central nervous system and investigated whole-brain volumetric and functional connectivity alterations in the acute phase TTS patients compared to controls.MethodsAnatomical and resting-state functional magnetic resonance imaging were performed in postm...
Source: Clinical Research in Cardiology - January 30, 2020 Category: Cardiology Source Type: research

Geographical differences in heart failure characteristics and treatment across Europe: results from the BIOSTAT-CHF study
ConclusionThe BIOSTAT-CHF study showed significant differences in the clinical features, treatment and prognosis in European patients with HF. Patients from the Mediterranean centers less often had the HF treatments up-titrated; however, the treatment up-titration benefited patients irrespective of their geographical region and should be part of the “default” clinical practice. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 29, 2020 Category: Cardiology Source Type: research

Drug-coated balloon versus drug-eluting stent in small coronary artery lesions: angiographic analysis from the BASKET-SMALL 2 trial
AbstractBackgroundThe randomized BASKET-SMALL 2 trial showed non-inferiority for treatment with drug-coated balloon (DCB) compared with drug-eluting stents (DES) in patients undergoing percutaneous coronary intervention (PCI) for de novo lesions in small coronary arteries regarding clinical endpoints at 1  year. In this predefined substudy, we investigated the angiographic findings in patients undergoing a clinically indicated follow-up angiography during the study phase.MethodsEight-hundred and eighty-three patients underwent PCI with either DES or DCB in a culprit vessel  
Source: Clinical Research in Cardiology - January 29, 2020 Category: Cardiology Source Type: research

Transcatheter aortic valve implantation in nonagenarians: insights from the German Aortic Valve Registry (GARY)
AbstractObjectiveThe aim of this study was to compare the outcome of nonagenarians ( ≥ 90 years) with that of younger (
Source: Clinical Research in Cardiology - January 28, 2020 Category: Cardiology Source Type: research

Correction to: Electromagnetic interference in implantable cardioverter defibrillators: present but rare
The original version of this article unfortunately contained a mistake. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 17, 2020 Category: Cardiology Source Type: research

The association of conventionally medicated systolic and diastolic blood pressure level and mortality from cardiovascular disease: is the lower the better in high stroke population?
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 16, 2020 Category: Cardiology Source Type: research

Publisher Correction to: Efficacy of an implantable cardioverter-defibrillator in patients with diabetes and heart failure and reduced ejection fraction
The article was initially published with incorrect copyright information or changed later to incorrect copyright information. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 16, 2020 Category: Cardiology Source Type: research

Impact of renal function on clinical outcomes after PCI in ACS and stable CAD patients treated with ticagrelor: a prespecified analysis of the GLOBAL LEADERS randomized clinical trial
AbstractBackgroundImpaired renal function (IRF) is associated with increased risks of both ischemic and bleeding events. Ticagrelor has been shown to provide greater absolute reduction in ischemic risk following acute coronary syndrome (ACS) in those with versus without IRF.MethodsA pre-specified sub-analysis of the randomized GLOBAL LEADERS trial (n = 15,991) comparing the experimental strategy of 23-month ticagrelor monotherapy (after 1-month ticagrelor and aspirin dual anti-platelet therapy [DAPT]) with 12-month DAPT followed by 12-month aspirin after percutaneous coronary intervention (PCI) in ACS and sta...
Source: Clinical Research in Cardiology - January 10, 2020 Category: Cardiology Source Type: research

Prasugrel use and clinical outcomes by age among patients undergoing PCI for acute coronary syndrome: from the PROMETHEUS study
AbstractBackgroundPrasugrel is a potent thienopyridine that may be preferentially used in younger patients with lower bleeding risk.ObjectiveWe compared prasugrel use and outcomes by age from the PROMETHEUS study. We also assessed age-related trends in treatment effects with prasugrel versus clopidogrel.MethodsPROMETHEUS was a multicenter acute coronary syndrome (ACS) percutaneous coronary intervention (PCI) registry. We compared patients in age tertiles (T1    70 years). Major adverse cardiac events (MACE) were a composite of death, myocardial infarction, stroke or unplanned revascularization. Data were...
Source: Clinical Research in Cardiology - January 8, 2020 Category: Cardiology Source Type: research

Edoxaban versus warfarin in vitamin K antagonist experienced and na ïve patients from the edoxaban versus warfarin in subjects undergoing cardioversion of atrial fibrillation (ENSURE-AF) randomised trial
ConclusionsEdoxaban had comparable efficacy and safety to optimized anticoagulation with enox –warf. The primary efficacy and safety endpoint outcomes were broadly similar between VKA experienced or naïve patients. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 8, 2020 Category: Cardiology Source Type: research

High density mapping and catheter ablation of atrial tachycardias in adults with congenital heart disease
ConclusionHigh density mapping of AT using the grid-style catheter showed promising results with respect to procedural and midterm outcome and fluoroscopy time. Using the grid-style catheter might offer advantages compared to other multi-electrode catheters used for high density mapping of AT in patients with CHD. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 2, 2020 Category: Cardiology Source Type: research

Atrial fibrillation ablation in adults with congenital heart disease on uninterrupted oral anticoagulation is safe and efficient
ConclusionsAF ablation in ACHD patients is feasible and safe regardless of CHD complexity. Success rates in patients with paroxysmal AF are high and comparable to patients without CHD. In ACHD patients with persistent AF, success rates of ablation are markedly reduced which might be due to a different and/or more extensive (bi-)atrial substrate. In the cohort of complex ACHD patients with persistent AF as the dominant AF type, long-term success of AF ablation is limited. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 1, 2020 Category: Cardiology Source Type: research

Right ventricular involvement is an important prognostic factor and risk stratification tool in suspected cardiac sarcoidosis: analysis by cardiac magnetic resonance imaging
AbstractBackgroundLate gadolinium enhancement imaging (LGE) of the left ventricle (LV) by cardiac magnetic resonance (CMR) has prognostic value for patients with cardiac sarcoidosis (CS). Right ventricle (RV) dysfunction is also associated with adverse outcomes in patients with heart failure. Therefore, we sought to determine if RV LGE and dysfunction predicted adverse events in patients with suspected CS.MethodsIn 103 consecutive patients with suspected CS who underwent CMR, functional and remodeling indexes of both the LV and RV were measured and the extent and localization of LGE were also analyzed. Major adverse cardia...
Source: Clinical Research in Cardiology - December 23, 2019 Category: Cardiology Source Type: research

Amplified P-wave duration predicts new-onset atrial fibrillation in patients with heart failure with preserved ejection fraction
AbstractBackgroundAtrial fibrillation (AF) increases morbidity and mortality in heart failure with preserved ejection fraction (HFpEF), yet identification of HFpEF-patients at risk for new-onset AF is challenging. Amplified P-wave duration (APWD) non-invasively detects arrhythmogenic atrial substrate with high accuracy. We hypothesized that APWD may help in the prediction of new-onset AF in HFpEF.MethodsPatients with suspected HFpEF (n = 99, left ventricular ejection fraction >  50%, no evidence of valvulopathy, coronary artery disease, or non-cardiac dyspnea) underwent exercise testing with ...
Source: Clinical Research in Cardiology - December 21, 2019 Category: Cardiology Source Type: research

Transcatheter versus surgical aortic valve replacement in low-risk patients: a meta-analysis of randomized trials
ConclusionTAVR in low-risk patients is superior to SAVR for the majority of outcomes.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - December 20, 2019 Category: Cardiology Source Type: research

Impact of recruitment and retention on all-cause mortality in a large all-comers randomised controlled trial: insights from the GLOBAL LEADERS trial
AbstractObjectiveRecruitment and retention in trials may bias the results and subsequently complicate their interpretation and validity. The aim of this study is to evaluate the impact of recruitment and retention on all-cause mortality in a large all-comers trial.MethodsThe recruitment rate in each investigating center of the GLOBAL LEADERS trial was assessed and the 130 centers were subdivided into low and high recruiters according to the median, with all-cause mortality then compared between the two groups. Vital status was obtained from public records in patients with incomplete follow-up.ResultsThe trial randomized 15...
Source: Clinical Research in Cardiology - December 11, 2019 Category: Cardiology Source Type: research

Strain analysis reveals subtle systolic dysfunction in confirmed and suspected myocarditis with normal LVEF. A cardiac magnetic resonance study
AbstractAimsLake Louise Criteria (LLC) are time-dependent and some acute myocarditis (AM) with preserved left ventricular ejection fraction (LVEF) could be missed, due to the limited accessibility of Cardiac Magnetic Resonance (CMR). We aimed to assess the potential value of cardiac strain measured by feature tracking (FT) imaging in this population.Methods and resultsEighty-three patients with clinically suspected AM and normal LVEF were divided into 39 “confirmed AM” (positive LLC) and 44 “suspected AM” (negative LLC). An age and gender-matched sample of 42 normal subjects underwent CMR. In all gr...
Source: Clinical Research in Cardiology - December 11, 2019 Category: Cardiology Source Type: research

Single chamber implantable cardioverter defibrillator compared to dual chamber implantable cardioverter defibrillator: less is more! Data from the German Device Registry
AbstractBackgroundIn patients with high risk for sudden cardiac death the implantation of a defibrillator is an established treatment. However the benefits and risks for patients in accordance to the number of the leads are not clear. Even in the current guidelines a recommendation to this question is missing. We analyzed advantage and disadvantages of single-chamber implantable cardioverter defibrillators (VVI-ICD) versus dual-chamber implantable cardioverter defibrillators (DDD-ICD) in the prospective German Device Registry.MethodsThe data of 2240 patients who underwent ICD implantation in 45 German Centers between Janua...
Source: Clinical Research in Cardiology - December 10, 2019 Category: Cardiology Source Type: research

Correction to: The potential prognostic utility of  salivary galectin-3 concentrations in heart failure
The original version of this article unfortunately contained a mistake. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - December 10, 2019 Category: Cardiology Source Type: research

Comparison of current German and European practice in cardiac resynchronization therapy: lessons from the ESC/EHRA/HFA CRT Survey II
ConclusionThis analysis from the European CRT Survey II overall shows good guideline adherence, high implantation success and a low rate of complications in daily practice. There are some regional differences in baseline characteristics, CRT indication, and procedural aspects. The use of remote monitoring in Germany lags behind other European countries.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - December 6, 2019 Category: Cardiology Source Type: research

One-year clinical outcomes in patients with renal insufficiency after contemporary PCI: data from a multicenter registry
AbstractBackgroundChronic kidney disease (CKD) is highly prevalent in patients with coronary artery disease (CAD).ObjectiveThe outcome following revascularization using contemporary technologies (new-generation abluminal sirolimus-eluting stents with thin struts) in patients with CKD (i.e., glomerular filtration rate of  
Source: Clinical Research in Cardiology - December 2, 2019 Category: Cardiology Source Type: research

Left ventricular remodelling among Turner syndrome patients: insights from non-invasive 3D echocardiography-derived pressure –volume loop analysis
Conclusions3DSTE and non-invasive left ventricular PVL analysis might be useful tools to detect early cardiac changes in TS. Arterial elastance seems to be significantly increased in TS patients, independent of cardiovascular morbidity. Compared with normal weight TS patients, overweight/obese TS patients displayed lower left ventricular efficiency. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - November 30, 2019 Category: Cardiology Source Type: research