Management and outcomes of patients with unstable angina with undetectable, normal, or intermediate hsTnT levels
AbstractBackgroundPatients with unstable angina (UA) are regarded to be at low risk for future coronary events. Guidelines discourage routine coronary angiography and recommend early discharge after individualized risk stratification. The relative value of clinical risk indicators as compared to cardiac troponin (cTn) alone is unsettled in the era of high-sensitivity cardiac troponin (hsTn) assays. We aimed to investigate the clinical characteristics, therapies, and outcomes of UA patients with different hsTnT concentrations.MethodsDuring 12  months, 2525 patients were enrolled. UA was defined as unstable symptoms and...
Source: Clinical Research in Cardiology - July 19, 2019 Category: Cardiology Source Type: research

Residual inflammatory risk in coronary heart disease: incidence of elevated high-sensitive CRP in a real-world cohort
This study aims to identify the share of patients with coronary heart disease (CHD) and residual inflammation who may benefit from anti-inflammatory therapy.MethodshsCRP and low-density lipoprotein (LDL) levels were determined in 2741 all-comers admitted to the cardiological ward of our tertiary referral hospital between June 2016 and June 2018. Patients without CHD, with acute coronary syndrome, chronic or recurrent systemic infection, use of immunosuppressant or anti-inflammatory agents, chronic inflammatory diseases, chemotherapy, terminal organ failure, traumatic injury and pregnancy were excluded.Results856 patients w...
Source: Clinical Research in Cardiology - July 19, 2019 Category: Cardiology Source Type: research

“Myocardial transit-time” (MyoTT): a novel and easy-to-perform CMR parameter to assess microvascular disease
AbstractBackgroundMyocardial microvascular disease may occur during the disease course of different cardiac as well as systemic disorders. With the present study, we introduce a novel and easy-to-perform cardiovascular magnetic resonance (CMR) parameter named “myocardial transit-time” (MyoTT).MethodsN = 20 patients with known hypertrophic cardiomyopathy (HCM) andN = 20 control patients without relevant cardiac disease underwent dedicated CMR studies on a 1.5-T MR scanner. The CMR protocol comprised cine and late-gadolinium-enhancement (LGE) imaging as well as first-pass perfusion acq...
Source: Clinical Research in Cardiology - July 18, 2019 Category: Cardiology Source Type: research

Validation of simple measures of aortic distensibility based on standard 4-chamber cine CMR: a new approach for clinical studies
ConclusionAD measurements are highly reproducible and allow an accurate and rapid assessment of arterial compliance from standard 4-chamber cine CMR.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - July 13, 2019 Category: Cardiology Source Type: research

Treatment of acute pericardial tamponade with a high-vacuum drainage system
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - July 12, 2019 Category: Cardiology Source Type: research

Influence of glycoprotein IIb/IIIa inhibitors on bleeding events after successful resuscitation and percutaneous coronary intervention
We report retrospective data of a single center registry of patients after successful intra- and out-of-hospital cardiac arrest between 2002 and 2013. Inclusion criteria were survival for at least 6 h and successful percutaneous coronary intervention (PCI) within the first 24  h. Patients treated with other fibrinolytic agents or being supported by an extracorporeal life support system were excluded from the analysis.Results310 patients were included in our study. 204 received GPI (GPI+), 106 did not (GPI −). Patients in the GPI+ group were significantly younger (62.8 vs. 68.0 years,p 
Source: Clinical Research in Cardiology - July 12, 2019 Category: Cardiology Source Type: research

Drug interactions with oral anticoagulants in German nursing home residents: comparison between vitamin K antagonists and non-vitamin K antagonist oral anticoagulants based on two nested case –control studies
ConclusionsConcomitant medication needs to be prescribed cautiously and monitored closely in nursing home residents treated with oral anticoagulants.Graphic Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - July 8, 2019 Category: Cardiology Source Type: research

Association of NT-proBNP and GDF-15 with markers of a prothrombotic state in patients with atrial fibrillation off anticoagulation
AbstractWe investigated whether growth differentiation factor-15 (GDF-15), also known as macrophage inhibitory cytokine-1 (MIC-1), levels are associated with a prothrombotic state in atrial fibrillation (AF) as compared to N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin I (cTnI-hs). In 103 patients with AF assessed off anticoagulation (age: 71.0 [65.0 –76.0] years; CHA2DS2-VASc score: 4.6  ± 1.7), we measured endogenous thrombin potential (ETP), plasma fibrin clot permeability (Ks, a measure of clot density) and clot lysis time (CLT) and other hemostati...
Source: Clinical Research in Cardiology - July 6, 2019 Category: Cardiology Source Type: research

Culprit vessel-related myocardial mechanics and prognostic implications following acute myocardial infarction
ConclusionsCMR allows IRA-specific phenotyping and characterisation of morphologic and functional changes. These alterations carry infarct-specific prognostic implications, and may represent novel diagnostic and therapeutic targets following AMI.Trial registrationClinicalTrials.gov: NCT00712101 and NCT01612312Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - July 5, 2019 Category: Cardiology Source Type: research

Incidence, predictors, and relevance of acute kidney injury in patients undergoing left atrial appendage closure with Amplatzer occluders: a multicentre observational study
ConclusionWhereas mild AKI is common in patients after LAAC, severe AKI is rare. AKI after LAAC is associated with poor baseline renal function, increased doses of contrast (CV/GFR ratio) and impaired outcome. Future studies will be needed to elaborate the benefit of reducing or avoiding contrast volume regarding this endpoint.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - July 5, 2019 Category: Cardiology Source Type: research

Correction to: Antithrombotic therapy in atrial fibrillation: stop triple therapy and start optimizing dual therapy?
The given names and family names of all authors were transposed in the original publication. The correct names are as shown above. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - July 5, 2019 Category: Cardiology Source Type: research

Clinical, angiographic and echocardiographic correlates of epicardial and microvascular spasm in patients with myocardial ischaemia and non-obstructive coronary arteries
ConclusionsOur study showed that specific clinical features are associated with different responses to intracoronary provocative test. Epicardial spasm is more frequent in males and in MINOCA patients, whereas microvascular spasm is more frequent in patients with stable angina and is associated with diastolic dysfunction. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - July 3, 2019 Category: Cardiology Source Type: research

Characteristics and outcomes of HFpEF with declining ejection fraction
AbstractObjectiveSome patients with heart failure with preserved ejection fraction (HFpEF) experience declining of left-ventricular ejection fraction (LVEF) during follow-up. We aim to investigate the characteristics and outcomes of patients with HF with declining ejection fraction (HFdEF).MethodsWe analyzed a prospective, nationwide multicenter cohort with consecutive patients with acute HF enrolled from March 2011 to December 2014. HFpEF was defined as LVEF  ≥ 50% at index admission. After 1 year, HFpEF patients were further classified as HFdEF (LVEF ≥ 50% at admission and  m...
Source: Clinical Research in Cardiology - July 2, 2019 Category: Cardiology Source Type: research

Two birds with one stone: transcatheter valve-in-valve treatment of a failed surgical bioprosthesis with concomitant severe stenosis and paravalvular leak
We present a case of a patient with a degenerated previous implanted biological valve and paravalvular leak. We used the treatment strategy of valve-in-valve with post-dilatation with high-pressure balloon, in a way to treat both, the degenerated valve and the paravalvular leak. The use of a single percutaneous procedure was enough and safe to treat both problems without further complications.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - July 2, 2019 Category: Cardiology Source Type: research

The influence of atrial fibrillation on the levels of NT-proBNP versus GDF-15 in patients with heart failure
In this study we compared the plasma levels of NT-proBNP versus GDF-15 in patients with HF in AF versus sinus rhythm (SR).MethodsIn a post hoc analysis of the index cohort of BIOSTAT-CHF (n = 2516), we studied patients with HF categorized into three groups: (1) AF at baseline (n = 733), (2) SR at baseline with a history of AF (n = 183), and (3) SR at baseline and no history of AF (n = 1025). The findings were validated in the validation cohort of BIOSTAT-CHF (n = 1738).ResultsPlasma NT-proBNP levels of patients who had AF at baseline were higher than tho...
Source: Clinical Research in Cardiology - July 1, 2019 Category: Cardiology Source Type: research

Long- and short-term association of low-grade systemic inflammation with cardiovascular mortality in the LURIC study
ConclusionsThe present findings from the large, prospective LURIC cohort underline the importance of inflammation in CAD and the prognostic relevance of inflammatory biomarkers that independently predict cardiovascular mortality.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - July 1, 2019 Category: Cardiology Source Type: research

Diuretic treatment in high-risk acute decompensation of advanced chronic heart failure —bolus intermittent vs. continuous infusion of furosemide: a randomized controlled trial
AbstractBackgroundDiuretic resistance is a common issue in patients with acute decompensation of advanced chronic heart failure (ACHF). The aim of this trial was to compare boluses and continuous infusion of furosemide in a selected population of patients with ACHF and high risk for diuretic resistance.MethodsIn this single-centre, double-blind, double-dummy, randomized trial, we enrolled 80 patients admitted for acute decompensation of ACHF (NYHA IV, EF  ≤ 30%) with criteria of high risk for diuretic resistance (SBP ≤ 110 mmHg, wet score ≥ 12/18, and sodium &l...
Source: Clinical Research in Cardiology - June 29, 2019 Category: Cardiology Source Type: research

Predictors of transportation delay in patients with suspected ST-elevation-myocardial infarction in the VIENNA-STEMI network
AbstractObjectiveThe emergency medical service (EMS) provides rapid pre-hospital diagnosis and transportation in ST-elevation myocardial infarction (STEMI) systems of care. Aim of the study was to assess temporal and regional characteristics of EMS-related delays in a metropolitan STEMI network.MethodsPatient call-to-arrival of EMS at site (call-to-site), transportation time from site to hospital (site-to-door), call-to-door, patient ’s location, month, weekday, and hour of EMS activation were recorded in 4751 patients referred to a tertiary center with suspicion of STEMI.ResultsMedian call-to-site, site-to-door, and...
Source: Clinical Research in Cardiology - June 29, 2019 Category: Cardiology Source Type: research

Comparison between treatment of “established” versus complex “off-label” coronary lesions with Absorb ® bioresorbable scaffold implantation: results from the GABI-R ® registry
ConclusionsIn a real-world setting, the majority patients were treated with BRS for off-label indications. The off-label use of BRS compared to confirmed indications appears to be associated with a higher rate of clinical endpoints considering more complex lesions and higher morbidity in this patients ’ group.Graphic abstractComparison between treatment of “established” versus complex “off-label” coronary lesions with Absorb® bioresorbable scaffold implantation: results from the GABI-R® registry. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - June 29, 2019 Category: Cardiology Source Type: research

Association of heart failure duration with clinical prognosis in advanced heart failure
AbstractBackgroundLittle is known about the prognostic impact of heart failure (HF) duration in patients with advanced HF.MethodsA total of 109 consecutive patients with advanced HF referred to the institutional heart transplant program between July 2014 and December 2017 were prospectively enrolled. The patients were divided into two groups according to the HF duration using a pre-specified cutoff (>  18 months,n  =  38; ≤ 18 months,n = 71). The Cox proportional hazards model was generated to investigate the association between the HF duration and a 1-year composit...
Source: Clinical Research in Cardiology - June 27, 2019 Category: Cardiology Source Type: research

Determinants of anti-fibrotic response to mineralocorticoid receptor antagonist therapy: insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) and Early Eplerenone Treatment in Patients with Acute ST-elevation Myocardial Infarction without Heart Failure (REMINDER) trials
AbstractIntroductionAfter myocardial infarction complicated by heart failure or diabetes, eplerenone (compared to placebo) significantly decreases amino-terminal propeptide of type III procollagen (PIIINP). Determining the subset of patients who are more prone to have a decrease in PIIINP and those who may respond better to the anti-fibrotic effects of mineralocorticoid receptor antagonists (MRA) therapy may be relevant for a personalized treatment approach. The aim of this study is to identify predictors of a PIIINP decrease and assess potential subgroups of “responders” to eplerenone.MethodsClinical factors a...
Source: Clinical Research in Cardiology - June 27, 2019 Category: Cardiology Source Type: research

Microvascular spasm in non-ST-segment elevation myocardial infarction without culprit lesion (MINOCA)
AbstractBackgroundUp to 30% of patients with acute coronary syndrome have no culprit lesion. Coronary microvascular spasm is an alternative cause for such a clinical presentation. However, this has rarely been investigated systematically. The aim of our study was to assess the frequency of coronary microvascular spasm in patients with NSTEMI without culprit lesion (MINOCA) by intracoronary acetylcholine testing (ACH-test).MethodsBetween 2014 and 2017, 940 patients with NSTEMI underwent coronary angiography and 125 (13%) had no culprit lesion (
Source: Clinical Research in Cardiology - June 24, 2019 Category: Cardiology Source Type: research

Transvascular transcatheter aortic valve implantation in 2017
AbstractBackgroundTranscatheter aortic valve implantation (TAVI) is emerging as the standard of care for patients with severe aortic stenosis. Recent results have been favourable even for patients with low periprocedural risk.MethodsWe analysed the number of procedures, complications, and in-hospital mortality rates of all patients undergoing isolated aortic valve replacement in 2017 in Germany, focussing especially on transvascular (TV) TAVI. Patients were stratified according the German Aortic Valve Score (AKL) into the risk classes low, intermediate, high and very high ( ≥ 10%).ResultsA total of 17,956 TV-TAVI...
Source: Clinical Research in Cardiology - June 24, 2019 Category: Cardiology Source Type: research

Quality of life after catheter and minimally invasive surgical ablation of paroxysmal and early persistent atrial fibrillation: results from the SCALAF trial
In this study, 52 patients with symptomatic paroxysmal or early persistent AF were randomized to either MIPI or CA. QOL was assessed at baseline, 3, 6, and 12  months follow-up using the SF-36 Health Survey Questionnaire. AF-related symptoms were quantified at each follow-up visit using the European Heart Rhythm Association (EHRA) score.ResultsMedian age was 57  years and 78% was male. Paroxysmal AF was present in 74%. At 3 months follow-up, physical role limitations (88.2 ± 29.5; versus 40.9 ± 44.0;P = 0.001, respectively) and bodily pain scores (95.5&...
Source: Clinical Research in Cardiology - June 24, 2019 Category: Cardiology Source Type: research

Validation of National Cardiovascular Data Registry risk models for mortality, bleeding and acute kidney injury in interventional cardiology at a German Heart Center
AbstractBackground and purposeThe National Cardiovascular Data Registry (NCDR) risk scores for mortality, bleeding and acute kidney injury (AKI) are accurate outcome predictors of coronary catheterization procedures in North American populations. However, their application in German clinical practice remained elusive and we thus aimed to verify their use.MethodsNCDR scores for mortality, bleeding and AKI and corresponding clinical outcomes were retrospectively assessed in patients undergoing catheterization for ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI) or fo...
Source: Clinical Research in Cardiology - June 24, 2019 Category: Cardiology Source Type: research

Septal total atrial conduction time for prediction of atrial fibrillation in embolic stroke of unknown source: a pilot study
AbstractBackgroundSubclinical atrial fibrillation (AF) is the underlying cause in a relevant part of patients with embolic stroke of unknown source (ESUS). This pilot study aims to identify novel echocardiographic parameters predicting AF subsequently detected in patients originally hospitalized with ESUS.Methods and resultsPatients with acute ischemic stroke [baseline diagnosis of ESUS (n = 69), stroke of macro- or microvascular cause (n = 16/25), stroke caused by AF (n = 5)] and controls with paroxysmal AF without acute ischemic stroke (n = 22) as well as healthy co...
Source: Clinical Research in Cardiology - June 24, 2019 Category: Cardiology Source Type: research

Cardioverter –defibrillator does not improve short-term survival among patients with non-ischemic cardiomyopathy and reduced left ventricular ejection fraction
ConclusionIn a real-world setting, no benefit was evident for patients with non-ischemic cardiomyopathy and reduced left ventricular ejection fraction by adding ICD therapy in a short-term follow-up of 12  months in contrast to patients with ischemic cardiomyopathy.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - June 24, 2019 Category: Cardiology Source Type: research

Myeloperoxidase in atrial fibrillation: association with progression, origin and influence of renin –angiotensin system antagonists
AbstractBackgroundMyeloperoxidase (MPO), secreted by neutrophils under inflammatory conditions, is elevated in atrial fibrillation (AF). MPO may be involved in atrial remodeling that underpins AF progression characterized by a switch from paroxysmal to persistent AF and the formation of low-voltage areas (LVA). MPO levels are modulated by renin –angiotensin system antagonists (RAS-A), commonly used to treat AF comorbidities, and are associated with reduced AF incidence, implicating a potential link.ObjectiveWe investigated MPO levels in progressing AF in peripheral and left atrial (LA) blood and analyzed a potential ...
Source: Clinical Research in Cardiology - June 24, 2019 Category: Cardiology Source Type: research

The association of reduced global longitudinal strain with cancer therapy-related cardiac dysfunction among patients receiving cancer therapy
ConclusionsReduced GLS is common among patients receiving cancer therapy and may identify patients at increased risk for CTRCD development.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - June 18, 2019 Category: Cardiology Source Type: research

Simultaneous inferior and anterior infarction or severe right ventricular involvement?
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - June 11, 2019 Category: Cardiology Source Type: research

Choroidal thickness is associated with cardiovascular risk factors and cardiac health: the Gutenberg Health Study
AbstractBackgroundChoroidal thickness is associated with several cardiovascular parameters in case –control studies including patients with manifest disease. So far, it was unclear whether underlying cardiovascular risk factors or the continuum of heart failure may lead to alterations of the choroid. Therefore, our hypothesis was to test in a population-based study, whether choroidal thickness is associated with cardiovascular risk factors and heart disease.MethodsA population-based cross-sectional study was carried out in Germany. A comprehensive medical examination including assessment of cardiovascular risk factor...
Source: Clinical Research in Cardiology - June 5, 2019 Category: Cardiology Source Type: research

Multipoint left ventricular pacing with large anatomical separation improves reverse remodeling and response to cardiac resynchronization therapy in responders and non-responders to conventional biventricular pacing
AbstractBackgroundMultipoint pacing [Multipoint ™ Pacing (MPP), Abbott] via a single left ventricular lead (Quartet™ LV lead, Abbott) improves acute left ventricular (LV) function and response to cardiac resynchronization therapy (CRT). Aim of this study was to examine additional benefits in terms of LV reverse remodeling and CRT response by activating MPP in responders and non-responders to conventional biventricular pacing (CONV).Methods43 consecutive patients receiving CRT (Quadra Assura MP ™, Abbott) received LV dP/dtmax optimized CONV programming for 6  months. MPP programming with large anatomi...
Source: Clinical Research in Cardiology - May 31, 2019 Category: Cardiology Source Type: research

Nucleotide ecto-enzyme metabolic pattern and spatial distribution in calcific aortic valve disease; its relation to pathological changes and clinical presentation
This study investigated location-specific changes of extracellular nucleotide metabolism in aortic valves of patients with calcific aortic valve disease (CAVD). Individual ecto-enzymes and adenosine receptors involved were analyzed together with correlation with CAVD severity and risk factors.ResultsNucleotide and adenosine degradation rates were adversely modified on the aortic surface of stenotic valve as compared to ventricular side, including decreased ATP removal (1.25  ± 0.35 vs. 2.24 ± 0.61 nmol/min/cm2) and adenosine production (1.32  ± 0.12 vs. 2....
Source: Clinical Research in Cardiology - May 29, 2019 Category: Cardiology Source Type: research

Area-based socioeconomic status and mortality: the Ludwigshafen Risk and Cardiovascular Health study
ConclusionLiving in an area with a low abSES was associated with a higher burden of diabetes mellitus, a higher percentage of severe vitamin D deficiency, higher systemic inflammation and a significant increase in mortality.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - May 29, 2019 Category: Cardiology Source Type: research

Atrial high-rate episodes and risk of major adverse cardiovascular events in patients with cardiac implantable electronic devices
AbstractBackgroundPatients with atrial high-rate episodes (AHREs) are at higher risk of thromboembolic events  and mortality. The risk of major adverse cardiovascular events (MACE) in these patients is unknown.ObjectiveTo investigate the risk of MACE in patients implanted with cardiac implantable electronic devices (CIEDs) developing AHREsMethods and resultsWe included 852 consecutive patients undergoing CIEDs implantation. Primary outcome was a composite endpoint of MACEs occurring after AHREs  ≥ 5 min. AHRE was defined as >  175 bpm and lasting ≥ 5 mi...
Source: Clinical Research in Cardiology - May 29, 2019 Category: Cardiology Source Type: research

Antithrombotic therapy in atrial fibrillation: stop triple therapy and start optimizing dual therapy?
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - May 29, 2019 Category: Cardiology Source Type: research

The role of heart rate in the assessment of cardiac autonomic modulation with heart rate variability
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - May 28, 2019 Category: Cardiology Source Type: research

Reply to the letter “The role of heart rate in the assessment of cardiac autonomic modulation with heart rate variability”
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - May 28, 2019 Category: Cardiology Source Type: research

When and how do patients with cardiac amyloidosis die?
ConclusionOur data indicate no differences in MOD between patients with AL and ATTRwt cardiac amyloidosis despite significant differences in clinical presentation and disease progression. Cardiovascular events account for more than two-thirds of fatal casualties in both groups.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - May 27, 2019 Category: Cardiology Source Type: research

Nutritional status and risk of all-cause mortality in patients undergoing transcatheter aortic valve replacement assessment using the geriatric nutritional risk index and the controlling nutritional status score
ConclusionsIn patients undergoing TAVR, low GNRI (but not high CONUT score) was independently associated with a higher risk of 1-year mortality. Further research is required to determine whether nutritional screening and management can improve clinical outcomes in patients undergoing TAVR.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - May 25, 2019 Category: Cardiology Source Type: research

Sex differences in optimal atrioventricular delay in patients receiving cardiac resynchronization therapy
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - May 21, 2019 Category: Cardiology Source Type: research

Progression of left ventricular thrombus in Loeffler ’s endocarditis without eosinophilia—case report and review of the literature
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - May 14, 2019 Category: Cardiology Source Type: research

Prognostic relevance of new onset arrhythmia and ICD shocks in primary prophylactic ICD patients
ConclusionMore than half of primary prophylactic ICD patients with SR at baseline develop new AF or VT/VF after 6  years. New onset arrhythmias of AF and VT/VF are independent prognostic factors for increased mortality in primary prophylactic ICD patients. ICD shocks itself, inappropriate or appropriate, are not additionally associated with a worse outcome. These results support the hypothesis that in clinical practice rather the arrhythmia than the ICD shock itself is responsible for a deteriorated prognosis. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - May 13, 2019 Category: Cardiology Source Type: research

Significance of psychosocial factors in cardiology: update 2018
ConclusionsFor coronary heart disease, chronic heart failure, arterial hypertension, and some arrhythmias, there is robust evidence supporting the relevance of psychosocial factors, pointing to a need for considering them in cardiological care. However, there are still shortcomings in implementing psychosocial treatment, and prognostic effects of psychotherapy and psychotropic drugs remain uncertain. There is a need for enhanced provider education and more treatment trials. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - May 10, 2019 Category: Cardiology Source Type: research

Recurrent cardiac sarcoidosis after heart transplantation
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - May 9, 2019 Category: Cardiology Source Type: research

Temporal trends in management and outcome of pulmonary embolism: a single-centre experience
ConclusionIn-hospital adverse outcomes and 1-year mortality remained stable despite more patients with OHCA, shorter in-hospital stays, more patients discharged early and a more frequent NOAC use. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - May 7, 2019 Category: Cardiology Source Type: research

Plasma protein biomarkers and their association with mutually exclusive cardiovascular phenotypes: the FIBRO-TARGETS case –control analyses
ConclusionPatients with “mutually exclusive” phenotypes display distinct bioprofiles that might underpin different biological pathways, potentially leading to fibrosis.Graphic abstractPlasma protein biomarkers and their association with mutually exclusive cardiovascular phenotypes: the FIBRO-TARGETS case –control analyses. Patients with “mutually exclusive” phenotypes (blue: obesity, hypertension and diabetes) display distinct protein bioprofiles (green: decreased expression; red: increased expression) that might underpin different biological pathways (orange arrow), potentially leading to fib...
Source: Clinical Research in Cardiology - May 6, 2019 Category: Cardiology Source Type: research

Right atrial –right ventricular coupling in heart failure with preserved ejection fraction
AbstractBackgroundRight ventricular (RV) function is prognostically relevant in heart failure with preserved ejection fraction (HFpEF) but data on profound assessment of RV and right atrial (RA) interaction in HFpEF are lacking. The current study characterizes RV and RA interaction using invasive pressure –volume-loop analysis and cardiac magnetic resonance imaging (CMR) data.Methods and resultsWe performed CMR and myocardial feature-tracking in 24 HFpEF patients and 12 patients without HFpEF. Invasive pressure –volume-loops were obtained to evaluate systolic and diastolic RV properties. RV early filling was de...
Source: Clinical Research in Cardiology - May 3, 2019 Category: Cardiology Source Type: research

One year VARC-2-defined clinical outcomes after transcatheter aortic valve implantation with the SAPIEN 3
ConclusionsFor the first time, VARC-2-defined composite endpoints at 1  year are reported and reveal a considerable proportion of patients experiencing the endpoint of time-related valve safety (29%) and clinical efficacy after 30 days (37%). (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - May 2, 2019 Category: Cardiology Source Type: research

An unsolved issue: utility of implantable loop recorder monitoring in cryptogenic stroke patients
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - May 2, 2019 Category: Cardiology Source Type: research