Reply to G. Betts ’s letter referring to “Serum potassium dynamics during acute heart failure hospitalization”
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 21, 2021 Category: Cardiology Source Type: research

Diagnosis and treatment of cardiac amyloidosis: position statement of the German Cardiac Society (DGK)
AbstractSystemic forms of amyloidosis affecting the heart are mostly light-chain (AL) and transthyretin (ATTR) amyloidoses. The latter is caused by deposition of misfolded transthyretin, either in wild-type (ATTRwt) or mutant (ATTRv) conformation. For diagnostics, specific serum biomarkers and modern non-invasive imaging techniques, such as cardiovascular magnetic resonance imaging (CMR) and scintigraphic methods, are available today. These imaging techniques do not only complement conventional echocardiography, but also allow for accurate assessment of the extent of cardiac involvement, in addition to diagnosing cardiac a...
Source: Clinical Research in Cardiology - January 18, 2021 Category: Cardiology Source Type: research

Concomitant tricuspid regurgitation severity and its secondary reduction determine long-term prognosis after transcatheter mitral valve edge-to-edge repair
ConclusionIn this large study, both, severe TR at baseline as well as missing secondary reduction were predictive for impaired long-term prognosis, especially in patients with FMR etiology. TR reduction was associated with increased symptomatic benefit.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 12, 2021 Category: Cardiology Source Type: research

Impact of oral anticoagulation on clinical outcomes of COVID-19: a nationwide cohort study of hospitalized patients in Germany
ConclusionsIn a multivariable analysis, a therapy with both direct oral anticoagulants or vitamin-K antagonists —but not with antiplatelet therapy—was associated with improved clinical outcomes. ACE inhibitors did not impact outcomes. Prospective randomized trials are needed to verify this hypothesis.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 8, 2021 Category: Cardiology Source Type: research

Estimated plasma volume status in heart failure: clinical implications and future directions
AbstractCongestion is one of the main predictors of poor outcome in patients with heart failure (HF). Assessing and monitoring congestion is essential for optimizing HF therapy. Among the various available methods, serial measurements of estimated plasma volume (ePVS) using routine blood count and/or body weight (e.g., the Strauss, Duarte, Hakim formulas) may be useful in HF management. Further prospective study is warranted to determine whether ePVS can help optimize decongestion therapy (loop diuretics, mineralocorticoid receptor antagonists, SGLT2i) in various HF settings. This narrative review summarizes the recent evi...
Source: Clinical Research in Cardiology - January 6, 2021 Category: Cardiology Source Type: research

Effect of frailty on treatment, hospitalisation and death in patients with chronic heart failure
ConclusionFrailty in patients with HeFREF is associated with sub-optimal medical treatment. Frail patients are more likely to die or be admitted to hospital, but whether frail or not, many events are non-CV.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 5, 2021 Category: Cardiology Source Type: research

Energy intake during hospital stay predicts all-cause mortality after discharge independently of nutritional status in elderly heart failure patients
ConclusionsEnergy intake during hospital stay is an independent predictor of the mortality in elderly HF patients, and its assessment together with established predictors improves the mortality risk stratification.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 5, 2021 Category: Cardiology Source Type: research

Guideline-directed medical therapy in real-world heart failure patients with low blood pressure and renal dysfunction
This study initially included 51, 060 HF patients from the Swedish Heart Failure Registry, and finally 1464 HFrEF patients with low BP (systolic BP  ≦ 100 mmHg) and renal dysfunction (estimated glomerular filtration rate (eGFR) ≦ 60 ml/min/1.73m2) were ultimately enrolled. Patients were receiving oral medication for HF at study enrollment, and divided into four groups (group 1 –4: ACEI/ARB + BB + MRA, ACEI/ARB + BB, ACEI/ARB + MRA or ACEI/ARB only, and other). The outcome is time to all-cause mortality.ResultsAmong the s...
Source: Clinical Research in Cardiology - January 4, 2021 Category: Cardiology Source Type: research

Predictors of high residual gradient after transcatheter aortic valve replacement in bicuspid aortic valve stenosis
AbstractObjectivesTo define the incidence of high residual gradient (HRG) after transcatheter aortic valve replacement (TAVR) in BAVs and their impact on short term outcome and 1-year mortality.BackgroundTranscatheter heart valves (THVs) offer good performance in tricuspid aortic valves with low rate of HRG. However, data regarding their performance in bicuspid aortic valves (BAV) are still lacking.MethodsThe BEAT (Balloon vs Self-Expandable valve for the treatment of bicuspid Aortic valve sTenosis) registry included 353 consecutive patients who underwent TAVR (Evolut R/PRO or Sapien 3 valves) in BAV between June 2013 and ...
Source: Clinical Research in Cardiology - January 3, 2021 Category: Cardiology Source Type: research

Aortic valve replacement in Germany in 2019
We present the outcome of the complete cohort of all patients undergoing SAVR or TAVI in Germany during the calendar year 2019.Methods and resultsData concerning all isolated aortic valve procedures performed in Germany in 2019 were retrieved from the mandatory nationwide quality control program: 22,973 transvascular (TV)-TAVI procedures, 7905 isolated SAVR (iSAVR), and 1413 transapical (TA)-TAVI. Data was complete in 99.9% (n = 32,156). In-hospital mortality after TV-TAVI (2.3%) was significantly lower when compared with iSAVR (2.8%,p = 0.007) or TA-TAVI (6.3%;p 
Source: Clinical Research in Cardiology - January 2, 2021 Category: Cardiology Source Type: research

Antithrombotic therapy with or without clopidogrel after transcatheter aortic valve replacement. A meta-analysis of randomized controlled trials
ConclusionsIn patients receiving TAVR, a therapeutic strategy of aspirin or OAC with clopidogrel significantly increases the risk of major bleeding without impact on mortality and ischemic outcomes compared to aspirin or OAC without clopidogrel. The performance of different antithrombotic regimens in terms of long-term clinical outcomes and bioprosthesis valve function requires further investigation.Graphic abstractForest plots from pairwise and network meta-analyses associated with an antithrombotic therapy with or without clopidogrel Risk ratio for all outcomes of interest calculated with the pairwise meta-analysis (left...
Source: Clinical Research in Cardiology - December 23, 2020 Category: Cardiology Source Type: research

Correction to: Factors associated with in-hospital mortality and adverse outcomes during the vulnerable post-discharge phase after the first episode of acute heart failure: results of the NOVICA-2 study
The original version of this article unfortunately contained a mistake. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - December 23, 2020 Category: Cardiology Source Type: research

Impact of frailty on periprocedural health care utilization in patients undergoing transcatheter edge-to-edge mitral valve repair
ConclusionFrailty is associated with a mean 32% increase of hospital costs in patients undergoing TMVR, which is primarily the result of a prolonged recovery and increased vulnerability to complications. These findings are valuable for a hospital ’s total cost calculation and resource allocation planning. Since frailty is regarded a potentially reversible health state, preventive interventions may help reduce costs in frail patients.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - December 17, 2020 Category: Cardiology Source Type: research

Predictors of response to cardiac resynchronization therapy in patients with chronic right ventricular pacing
AbstractBackgroundThe benefits of de novo cardiac resynchronization therapy (CRT) in patients with QRS-prolongation and impaired left-ventricular function (LVEF) are well established. Current guidelines also recommend CRT-upgrade in patients requiring permanent or frequent right ventricular pacing (RVP) with symptomatic heart failure and reduced LVEF. Whereas several predictors of response to de novo CRT-implantation such as female gender, QRS-duration, non-ischemic cardiomyopathy (NICM) are known due to large prospective trials, similar factors regarding CRT-upgrade are currently lacking.Methods and resultsWe examine 114 ...
Source: Clinical Research in Cardiology - December 15, 2020 Category: Cardiology Source Type: research

PASCAL versus MitraClip-XTR edge-to-edge device for the treatment of tricuspid regurgitation: a propensity-matched analysis
ConclusionsBoth TTVR devices, PASCAL and MitraClip-XTR, appeared feasible and comparable for an effective TR reduction. Randomized head-to-head comparisons will help to further define the appropriate scope of application of each system. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - December 12, 2020 Category: Cardiology Source Type: research

Developing and validating models to predict sudden death and pump failure death in patients with heart failure and preserved ejection fraction
ConclusionsThe clinical models can predict risks for SD and PFD separately with good discrimination and calibration in HFpEF and are robust in external validation. Adding NT-proBNP further improved model performance. These models may help to identify high-risk individuals for device intervention in future trials.Clinical trial registrationI-Preserve: ClinicalTrials.gov NCT00095238; TOPCAT: ClinicalTrials.gov NCT00094302; CHARM-Preserved: ClinicalTrials.gov NCT00634712.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - December 10, 2020 Category: Cardiology Source Type: research

Determinants of soluble angiotensin-converting enzyme 2 concentrations in adult patients with complex congenital heart disease
AbstractBackgroundAngiotensin-converting enzyme (ACE) 2 is known to be a functional receptor for SARS-CoV-2 in the current pandemic. Soluble ACE2 (sACE2) concentrations are elevated in patients with various cardiovascular disorders including heart failure.MethodsIn a total of 182 consecutive adult patients with complex congenital heart disease (CHD) and 63 healthy controls, sACE2 concentrations were measured in serum using the Human ACE2® assay by Cloud-Clone Corporation and associated with clinical, laboratory and echocardiographic parameters.ResultsMedian sACE2 levels were increased in patients with complex CHD as co...
Source: Clinical Research in Cardiology - December 5, 2020 Category: Cardiology Source Type: research

Scientific publication activity during COVID-19 shutdown
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - November 25, 2020 Category: Cardiology Source Type: research

Longitudinal diastolic strain slope as an early sign for systolic dysfunction among patients with active cancer
This study evaluated the correlation of diastolic strain slope (Dss) with routine echocardiography diastolic parameters and its role in early detection of systolic dysfunction and cardiovascular (CV) mortality within this population.MethodsData were collected from the Israel Cardio-Oncology Registry (ICOR), a prospective registry enrolling adult patient receiving cancer therapy. All patients performed at least three echocardiography exams (T1, T2, T3), including left ventricle Global Longitudinal Strain (LV GLS) and Dss. Systolic dysfunction was determined by either LV GLS relative reduction of  ≥ 15% or L...
Source: Clinical Research in Cardiology - November 21, 2020 Category: Cardiology Source Type: research

Impact of the COVID-19 pandemic on cardiovascular mortality and catherization activity during the lockdown in central Germany: an observational study
AbstractAimsDuring the COVID-19 pandemic, hospital admissions for cardiac care have declined. However, effects on mortality are unclear. Thus, we sought to evaluate the impact of the lockdown period in central Germany on overall and cardiovascular deaths. Simultaneously we looked at catheterization activities in the same region.Methods and resultsData from 22 of 24 public health-authorities in central Germany were aggregated during the pandemic related lockdown period and compared to the same time period in 2019. Information on the total number of deaths and causes of death, including cardiovascular mortality, were collect...
Source: Clinical Research in Cardiology - November 21, 2020 Category: Cardiology Source Type: research

Intensification of pharmacological decongestion but not the actual daily loop diuretic dose predicts worse chronic heart failure outcome: insights from TIME-CHF
AbstractBackgroundBoth loop diuretics (LDs) and congestion have been related to worse heart failure (HF) outcome. The relationship between the cause and effect is unknown. The aim of this study was to investigate the interaction between congestion, diuretic use and HF outcome.MethodsSix hundred and twenty-two chronic HF patients from TIME-CHF were studied. Congestion was measured by means of a clinical congestion index (CCI). Loop diuretic dose was considered at baseline and month 6. Treatment intensification was defined as the increase in LD dose over 6  months or loop diuretic and thiazide or thiazide-like diuretic ...
Source: Clinical Research in Cardiology - November 20, 2020 Category: Cardiology Source Type: research

Prospective multicentric validation of a novel prediction model for paroxysmal atrial fibrillation
ConclusionsThe prediction scores adequately detected pAF using variables readily available during routine cardiac assessment and echocardiography. The model scores, denoted as ECHO-AF scores, represent simple, highly sensitive and non-invasive tools for detecting pAF that can be easily implemented in the clinical practice and might serve as screening test to initiate further diagnostic investigations for validating the presence of pAF.Graphic abstractProspective validation of a novel prediction model for paroxysmal atrial fibrillation based on echocardiography and medical history parameters by long-term Holter ECG (Source:...
Source: Clinical Research in Cardiology - November 19, 2020 Category: Cardiology Source Type: research

Elevated markers of thrombo-inflammatory activation predict outcome in patients with cardiovascular comorbidities and COVID-19 disease: insights from the LEOSS registry
AbstractAimsSARS-CoV-2 infection is associated with adverse outcomes in patients with cardiovascular disease. Here, we analyzed whether specific biomarkers predict the clinical course of COVID-19 in patients with cardiovascular comorbidities.Methods and resultsWe enrolled 2147 patients with SARS-CoV-2 infection which were included in the Lean European Open Survey on SARS-CoV ‑2 (LEOSS)-registry from March to June 2020. Clinical data and laboratory values were collected and compared between patients with and without cardiovascular comorbidities in different clinical stages of the disease. Predictors for mortality were cal...
Source: Clinical Research in Cardiology - November 19, 2020 Category: Cardiology Source Type: research

Comparison of mechanical circulatory support with venoarterial extracorporeal membrane oxygenation or Impella for patients with cardiogenic shock: a propensity-matched analysis
ConclusionsIn this retrospective analysis of patients with CS, treatment with Impella 2.5/CP or vaECMO was associated with similar hospital and 6-month survival rates. Device-related access-site vascular complications occurred more frequently in the vaECMO group. A randomized trial is warranted to examine the effects of these devices on outcomes and to determine the optimal device choice in patients with CS. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - November 13, 2020 Category: Cardiology Source Type: research

Outcome of patients treated with extracorporeal life support in cardiogenic shock complicating acute myocardial infarction: 1-year result from the ECLS-Shock study
ConclusionThis pilot study showed that randomized studies with ECLS in CS patients are feasible and safe. Small numbers of included patients impede meaningful conclusions about mortality and neurological outcome. Our findings of numerical differences in mortality and survival with severe neurological impairment give an urgent call for larger multi-centric randomized trials assessing the endpoint of all-cause mortality but also considering the effects on neurological outcome measures.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - November 12, 2020 Category: Cardiology Source Type: research

Sinus heart rate post pulmonary vein ablation and long-term risk of recurrences
This study sought to investigate the association of sinus heart rate pre-/post-ablation and recurrences in patients with atrial fibrillation undergoing pulmonary vein isolation (PVI).MethodsBetween January 2012 and December 2017, data of 482 patients undergoing their first PVI were included. Sinus heart rate was recorded before (PRE), directly post-ablation (POST) and 3  months post-ablation (3 M). All patients were screened for atrial tachyarrhythmia recurrences during the one-year follow-up.ResultsIn the total study cohort, the mean resting sinus heart rate at PRE [mean 57.9  bpm (95% CI 57.1–58.7&nb...
Source: Clinical Research in Cardiology - November 12, 2020 Category: Cardiology Source Type: research

Diagnostic value of cardiovascular magnetic resonance in comparison to endomyocardial biopsy in cardiac amyloidosis: a multi-centre study
ConclusionNon-invasive CMR shows an excellent diagnostic accuracy and yield regarding CA. When combined with monoclonal protein studies, CMR can differentiate ATTR from AL with high accuracy and predictive value. However, invasive EMB remains a safe invasive gold-standard and allows to differentiate CA from other cardiomyopathies that can also cause LV hypertrophy. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - November 10, 2020 Category: Cardiology Source Type: research

Impact of cancer history on clinical outcome in patients undergoing transcatheter edge-to-edge mitral repair
AbstractBackgroundLittle is known about the prevalence of a history of cancer and its impact on clinical outcome in mitral regurgitation (MR) patients undergoing transcatheter mitral valve repair (TMVR).ObjectivesThe purpose of this study is to investigate the prevalence of cancer, baseline inflammatory parameters, and clinical outcome in MR patients undergoing TMVR.MethodsConsecutive patients undergoing a MitraClip procedure were enrolled, and the patients were stratified into two groups: cancer and non-cancer. Baseline complete blood counts (CBC) with differential hemograms were collected prior to the procedure to calcul...
Source: Clinical Research in Cardiology - November 9, 2020 Category: Cardiology Source Type: research

Transcatheter tricuspid valve-in-valve replacement in two patients with Ebstein anomaly: technical considerations
Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - November 9, 2020 Category: Cardiology Source Type: research

Prognostic impact of coronary chronic total occlusion on recurrences of ventricular tachyarrhythmias and ICD therapies
ConclusionA coronary CTO even in the presence of less developed collaterals and more complex CTO category is associated with increasing risk of recurrent ventricular tachyarrhythmias at 5  years in consecutive ICD recipients. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - November 4, 2020 Category: Cardiology Source Type: research

Pulmonary embolism in patients with COVID-19: characteristics and outcomes in the Cardio-COVID Italy multicenter study
AbstractBackgroundPulmonary embolism (PE) has been described in coronavirus disease 2019 (COVID-19) critically ill patients, but the evidence from more heterogeneous cohorts is limited.MethodsData were retrospectively obtained from consecutive COVID-19 patients admitted to 13 Cardiology Units in Italy, from March 1st to April 9th, 2020, and followed until in-hospital death, discharge, or April 23rd, 2020. The association of baseline variables with computed tomography-confirmed PE was investigated by Cox hazards regression analysis. The relationship betweend-dimer levels and PE incidence was evaluated using restricted cubic...
Source: Clinical Research in Cardiology - November 3, 2020 Category: Cardiology Source Type: research

Correction to: The influence of atrial fibrillation on the levels of NT-proBNP versus GDF-15 in patients with heart failure
The original article can be found online. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - November 3, 2020 Category: Cardiology Source Type: research

A drug-induced hypotensive challenge to verify catheter-based radiofrequency renal denervation in an obese hypertensive swine model
ConclusionRenin secretion induced by HC was attenuated following RDN and may serve as an indicator for patient selection and guide successful RDN procedures. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - November 2, 2020 Category: Cardiology Source Type: research

Six-minute walk test: prognostic value and effects of nebivolol versus placebo in elderly patients with heart failure from the SENIORS trial
AbstractBackgroundThere is limited information about the 6-min walk test (6MWT) in elderly patients with heart failure. We evaluated 6MWT and the effect of nebivolol on 6MWT from the SENIORS trial.Methods and resultsThe SENIORS trial evaluated nebivolol versus placebo on death and hospitalisation in patients aged  ≥ 70 years with heart failure. A total of 1982 patients undertook a 6MWT at baseline and 1716 patients at 6 months. Patients were divided into tertiles (≤ 200 m, 201 to ≤ 300 m and >  300 m) and to change in distance walked betw...
Source: Clinical Research in Cardiology - November 2, 2020 Category: Cardiology Source Type: research

Pitfalls of the S-ICD therapy: experiences from a large tertiary centre
ConclusionThe S-ICD is a valuable option for many patients for the prevention of sudden cardiac death. Nonetheless, certain problems are immanent to the S-ICD (limited re-programming options, size of the generator) and should be addressed in future generations of the S-ICD.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - November 1, 2020 Category: Cardiology Source Type: research

Long-term outcome of perimembranous VSD closure using the Nit-Occlud ® Lê VSD coil system
ConclusionThe Nit-Occlud ® Lê VSD coil offers the possibility of an effective and safe approach in patients with aneurysmal perimembranous ventricular septal defects. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - October 31, 2020 Category: Cardiology Source Type: research

Safety and patient-reported outcomes in index ablation versus repeat ablation in atrial fibrillation: insights from the German Ablation Registry
In this study, we report safety data and procedural details of patients undergoing index ablation versus repeat ablation in a registry-based real-life setting.MethodsPatients from the German Ablation Registry, a prospective, multicentre registry of patients undergoing ablation between January 2007 and January 2010 were included.ResultsA total of 4155 patients were enrolled in the study. Group I (index ablation) consisted of 3377/4155 (82.1%) and group II (repeat ablation) of 738/4155 (17.9%). Patients in group I had a significantly higher ratio of paroxysmal AF (69.3% vs 61.9%,p 
Source: Clinical Research in Cardiology - October 28, 2020 Category: Cardiology Source Type: research

Transcatheter and surgical aortic valve replacement in patients with bicuspid aortic valve
AbstractObjectivesTo compare the outcomes after surgical (SAVR) and transcatheter aortic valve replacement (TAVR) for severe stenosis of bicuspid aortic valve (BAV).MethodsWe evaluated the early and mid-term outcome of patients with stenotic BAV who underwent SAVR or TAVR for aortic stenosis from the nationwide FinnValve registry.ResultsThe FinnValve registry included 6463 AS patients and 1023 (15.8%) of them had BAV. SAVR was performed in 920 patients and TAVR in 103 patients with BAV. In the overall series, device success after TAVR was comparable to SAVR (94.2% vs. 97.1%,p = 0.115). TAVR was associated wit...
Source: Clinical Research in Cardiology - October 24, 2020 Category: Cardiology Source Type: research

Elevated high-sensitivity troponin T levels at 1-year follow-up are associated with increased long-term mortality after TAVR
AbstractBackgroundElevated pre-procedural high-sensitivity troponin T (hs-TnT) levels predict adverse outcomes in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). It is unknown whether elevated troponin levels still provide prognostic information during follow-up after successful TAVR. We evaluated the long-term implications of elevated hs-TnT levels found at 1-year post-TAVR.Methods and resultsThe study included 349 patients who underwent TAVR for severe AS from 2010 –2019 and for whom 1-year hs-TnT levels were available. Any required percutaneous coronary intervent...
Source: Clinical Research in Cardiology - October 24, 2020 Category: Cardiology Source Type: research

Clinical risk predictors in atrial fibrillation patients following successful coronary stenting: ENTRUST-AF PCI sub-analysis
ConclusionAfter PCI in AF patients, increasing CHA2DS2-VASc score was associated with increased bleeding rates and CHA2DS2-VASc score ( ≥ 5) predicted the occurrence of stent thrombosis. Paroxysmal AF was associated with MI. These findings may have important clinical implications in AF patients. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - October 24, 2020 Category: Cardiology Source Type: research

Atrial fibrillation ablation strategies and technologies: past, present, and future
AbstractCatheter ablation is an established treatment option for atrial fibrillation (AF), and pulmonary vein isolation (PVI) has become the gold standard in AF ablation. AF recurrence after PVI remains an important clinical problem. Recovery of conduction from the pulmonary veins (PVs) is considered the dominant mechanism for AF recurrence in paroxysmal AF. However, the underlying mechanism of AF recurrence after PVI is more complex in patients with persistent and longstanding persistent AF. Different ablation technologies and energy sources have been developed aimed at improving lesion quality and durability with an acce...
Source: Clinical Research in Cardiology - October 22, 2020 Category: Cardiology Source Type: research

Functional and prognostic implications of cardiac magnetic resonance feature tracking-derived remote myocardial strain analyses in patients following acute myocardial infarction
ConclusionCMR-FT-derived RM CS is a useful parameter to characterize the response of the remote myocardium and allows improved stratification following AMI beyond commonly used parameters, especially of high-risk patients.Trial registrationClinicalTrials.gov, NCT00712101 and NCT01612312Graphic abstractDefining remote segments (R) in the presence of infarct areas (I) for the analysis of remote circumferential strain (CS). Remote CS was significantly lower in patients who suffered major adverse cardiac events (MACE) and a cutoff value for remote CS of − 25.8% best identified high-risk patients. In addition, impaired re...
Source: Clinical Research in Cardiology - October 20, 2020 Category: Cardiology Source Type: research

Early results of a real-world series with two transapical transcatheter mitral valve replacement devices
ConclusionsTMVR was performed successfully in these selected patients with complete elimination of MR in the majority of patients. Short-term mortality was low and most patients experienced persisting functional improvement.Graphic abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - October 19, 2020 Category: Cardiology Source Type: research

Serum potassium dynamics during acute heart failure hospitalization
AbstractBackgroundAvailable information about prognostic implications of potassium levels alteration in the setting of acute heart failure (AHF) is scarce.ObjectivesWe aim to describe the prevalence of dyskalemia (hypo or hyperkalemia), its dynamic changes during AHF-hospitalization, and its long-term clinical impact after hospitalization.MethodsWe analyzed 1779 patients hospitalized with AHF who were included in the REDINSCOR II registry. Patients were classified in three groups, according to potassium levels both on admission and discharge: hypokalemia (potassium    5 mEq/L).ResultsThe prevalence of hy...
Source: Clinical Research in Cardiology - October 17, 2020 Category: Cardiology Source Type: research

Metabolomic profiling of patients with high gradient aortic stenosis undergoing transcatheter aortic valve replacement
ConclusionMetabolic profiling identified significant and reversible changes in circulating metabolites of patients with AS. The correlation of circulating metabolites with clinical parameters supports the use of these data to identify novel diagnostic as well as prognostic markers for disease screening, pathophysiological studies as well as patient surveillance. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - October 14, 2020 Category: Cardiology Source Type: research

Risk of mortality following transcatheter aortic valve replacement for low-flow low-gradient aortic stenosis
AbstractBackgroundLow-flow low-gradient (LF-LG) aortic stenosis (AS) is associated with high mortality, even after transcatheter aortic valve replacement (TAVR). Further knowledge of risk indicators is needed and a clinical risk score would be desirable for optimizing patient selection and therapeutic strategy.MethodsThe study cohort comprised of 219 consecutive LF-LG AS patients undergoing TAVR from 2008 to 2018 in two high-volume German centers. Predictive factors for one-year all-cause mortality were defined according to a Cox proportional hazard model.ResultsAt one-year follow-up after TAVR, 28% of patients had died. A...
Source: Clinical Research in Cardiology - October 14, 2020 Category: Cardiology Source Type: research

Substrate characterization for ventricular tachycardia ablation using a new image processing service
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - October 13, 2020 Category: Cardiology Source Type: research

Thromboembolic complications in adult congenital heart disease: the knowns and the unknowns
AbstractDespite impressive improvement in long-term survival, adults with congenital heart disease (CHD) remain exposed to a significant cardiovascular morbidity over lifetime. Thromboembolic events (TE) are a major issue. Specific anatomic groups have been shown a particular high risk of TE, including cyanotic heart disease and Fontan circulation. Many intercurrent clinical factors add a substantial risk such as intracardiac medical devices, atrial arrhythmia, endocarditis, or pregnancy. Nevertheless, what is unknown exceeds what is known, especially regarding the management of this heterogenous patient population. Antico...
Source: Clinical Research in Cardiology - October 9, 2020 Category: Cardiology Source Type: research

Effects of surgical and FFP2/N95 face masks on cardiopulmonary exercise capacity: the numbers do not add up
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - October 9, 2020 Category: Cardiology Source Type: research

Response to Letter to the editors of Hopkins et al.: Effects of surgical and FFP2/N95 face masks on cardiopulmonary exercise capacity: the numbers do not add up
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - October 9, 2020 Category: Cardiology Source Type: research