Valve unit instead of intensive or intermediate care unit admission following transcatheter edge-to-edge mitral valve repair is safe and reduces postprocedural complications
ConclusionsFollowing M-TEER postprocedural monitoring on a VU instead of an ICU/IMC is safe, reduces complications, and spares ICU capacities. Patients with advanced heart failure have a higher risk for unplanned ICU/IMC treatment after M-TEER.Graphical abstractValve unit instead of intensive or intermediate care unit admission following transcatheter edge-to-edge mitral valve repair is safe and reduces postprocedural complications. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 14, 2024 Category: Cardiology Source Type: research
Sodium glucose cotransporter 2 inhibitors with cardiac arrhythmias in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized placebo-controlled trials
ConclusionSGLT2 inhibitors were associated with a reduced risk of atrial arrhythmias in patients with T2DM. Our results support the use of SGLT2 inhibitors in T2DM with high cardiovascular risk populations. We also recommend the long-term use of SGLT2 inhibitors to achieve further benefits.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 14, 2024 Category: Cardiology Source Type: research
Relevance of mexiletine in the era of evolving antiarrhythmic therapy of ventricular arrhythmias
AbstractDespite impressive developments in the field of ventricular arrhythmias, there is still a relevant number of patients with ventricular arrhythmias who require antiarrhythmic drug therapy and may, e.g., in otherwise drug and/or ablation refractory situations, benefit from agents known for decades, such as mexiletine. Through its capability of blocking fast sodium channels in cardiomyocytes, it has played a minor to moderate antiarrhythmic role throughout the recent decades. Nevertheless, certain patients with structural heart disease suffering from drug-refractory, i.e., mainly amiodarone refractory ventricular arrh...
Source: Clinical Research in Cardiology - February 14, 2024 Category: Cardiology Source Type: research
Cost-effectiveness of a multidimensional post-discharge disease management program for heart failure patients —economic evaluation along a one-year observation period
ConclusionsThe economic evaluation along the cohort study showed that the HerzMobil Tirol is very cost-effective compared to UC and cost-saving in a sensitivity analysis correcting for “non-HF related costs.” These findings promote a widespread adoption of telemedicine-assisted DMP for HF.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 14, 2024 Category: Cardiology Source Type: research
Sex-related differences in patients presenting with heart failure –related cardiogenic shock
ConclusionsIn this large HF-CS registry, sex disparities in risk factors and clinical presentation were observed. Despite these differences, the use of treatments was comparable, and both sexes exhibited similarly high mortality rates. Further research is necessary to evaluate if sex-tailored treatment, accounting for the differences in cardiovascular risk factors and clinical presentation, might improve outcomes in HF-CS.Graphical abstractSex-related differences in clinical characteristics, shock severity, and mortality in patients with heart failure –related cardiogenic shock. Summary for the main study findings. AMI, ...
Source: Clinical Research in Cardiology - February 14, 2024 Category: Cardiology Source Type: research
Correction to: The Zwolle experience with left bundle branch area pacing using stylet-driven active fixation leads
(Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 12, 2024 Category: Cardiology Source Type: research
A novel score to predict in-hospital mortality for patients with acute coronary syndrome and out-of-hospital cardiac arrest: the FACTOR study
ConclusionThe FACTOR score demonstrated a reliable prognostic tool for health care providers in assessing in-hospital mortality of OHCA patients. Early acknowledgement of a poor prognosis may help in patient management and allocation of resources.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 8, 2024 Category: Cardiology Source Type: research
Epicardial ventricular tachycardia ablation: safety and efficacy of access and ablation using low-iodine content
ConclusionsIn this large single-centre experience, epicardial access and ablation were safe and feasible. Although long-term clinical VT recurrence rates were low, overall VT recurrences as well as mortality were high advocating for a highly experienced, interdisciplinary approach including intense management of underlying cardiac disease/heart failure. Routine usage of D5W was safe and associated with comparable short- or long-term clinical or overall VT freedom.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 7, 2024 Category: Cardiology Source Type: research
Epicardial adipose tissue as an independent predictor of long-term outcome in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement
ConclusionIncreased EAT volume is an independent predictor of all-cause mortality in patients with severe AS undergoing TAVR. It can be easily obtained from pre-TAVR planning CTs and may thus qualify as a novel marker to improve prognostication and management of patient with severe AS.Trial registrationDRKS, DRKS00024479.Graphical abstractAS, aortic stenosis; TAVR, transcatheter aortic valve replacement; EAT, epicardial adipose tissue (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 7, 2024 Category: Cardiology Source Type: research
Epicardial ventricular tachycardia ablation: safety and efficacy of access and ablation using low-iodine content
ConclusionsIn this large single-centre experience, epicardial access and ablation were safe and feasible. Although long-term clinical VT recurrence rates were low, overall VT recurrences as well as mortality were high advocating for a highly experienced, interdisciplinary approach including intense management of underlying cardiac disease/heart failure. Routine usage of D5W was safe and associated with comparable short- or long-term clinical or overall VT freedom.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 7, 2024 Category: Cardiology Source Type: research
Epicardial adipose tissue as an independent predictor of long-term outcome in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement
ConclusionIncreased EAT volume is an independent predictor of all-cause mortality in patients with severe AS undergoing TAVR. It can be easily obtained from pre-TAVR planning CTs and may thus qualify as a novel marker to improve prognostication and management of patient with severe AS.Trial registrationDRKS, DRKS00024479.Graphical abstractAS, aortic stenosis; TAVR, transcatheter aortic valve replacement; EAT, epicardial adipose tissue (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 7, 2024 Category: Cardiology Source Type: research
Circulating osteoprotegerin as a cardiac biomarker for left ventricular diastolic dysfunction in patients with pre-dialysis chronic kidney disease: the KNOW-CKD study
ConclusionsElevated serum OPG levels are associated with the risk of LVDD in patients with pre-dialysis CKD. The measurement of serum OPG levels may help the diagnosis of LVDD, which is an important echocardiographic feature of HFpEF.Graphical Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - February 6, 2024 Category: Cardiology Source Type: research
