Mitral annular disjunction in out-of-hospital cardiac arrest patients —a retrospective cardiac MRI study
ConclusionsMAD is rather common in OHCA patients without definitive aetiology undergoing CMR. The presence of MAD was independently associated to OHCA without an identifiable trigger. Further research is needed to understand the exact role of MAD in OHCA patients.Graphical AbstractStudy synopsis - MAD occurs frequently in unknown-cause OHCA and represents an independent marker after adjustment for age, hypertension, and hypercholesterolemia. (Illustration created with biorender.com). MAD mitral annular disjunction, OHCA out-of-hospital cardiac arrest (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 11, 2024 Category: Cardiology Source Type: research
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment
AbstractThe aetiology of heart failure with preserved ejection fraction (HFpEF) is heterogenous and overlaps with that of several comorbidities like atrial fibrillation, diabetes mellitus, chronic kidney disease, valvular heart disease, iron deficiency, or sarcopenia. The diagnosis of HFpEF involves evaluating cardiac dysfunction through imaging techniques and assessing increased left ventricular filling pressure, which can be measured directly or estimated through various proxies including natriuretic peptides. To better narrow down the differential diagnosis of HFpEF, European and American heart failure guidelines advoca...
Source: Clinical Research in Cardiology - April 11, 2024 Category: Cardiology Source Type: research
Mitral annular disjunction in out-of-hospital cardiac arrest patients —a retrospective cardiac MRI study
ConclusionsMAD is rather common in OHCA patients without definitive aetiology undergoing CMR. The presence of MAD was independently associated to OHCA without an identifiable trigger. Further research is needed to understand the exact role of MAD in OHCA patients.Graphical AbstractStudy synopsis - MAD occurs frequently in unknown-cause OHCA and represents an independent marker after adjustment for age, hypertension, and hypercholesterolemia. (Illustration created with biorender.com). MAD mitral annular disjunction, OHCA out-of-hospital cardiac arrest (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 11, 2024 Category: Cardiology Source Type: research
Association of an impaired GH-IGF-I axis with cardiac wasting in patients with advanced cancer
ConclusionIn advanced cancer, reduced LVmass is associated with increased plasma GH and reduced IGF-I/GH ratio, suggesting increasing GH resistance, especially for patients with wasting syndrome with unintentional weight loss. Higher baseline IGF-I was associated with a decrease in relative LVmass during follow-up.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 8, 2024 Category: Cardiology Source Type: research
The role of coronary artery disease in lung transplantation: a propensity-matched analysis
ConclusionIn this cohort, relevant CAD was not associated with worse outcomes and should therefore not be considered a contraindication for LuTx. Nonetheless, cardiovascular events in CAD patients highlight the necessity of control of cardiovascular risk factors and a structured cardiac follow-up. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 8, 2024 Category: Cardiology Source Type: research
Evaluating the predictive value of late gadolinium enhancement assessed by cardiac magnetic resonance on sudden cardiac death in patients selected for implantable cardioverter defibrillator and cardiac resynchronization therapy implantation: a systematic review and meta-analysis
ConclusionLGE-CMR positivity was associated with an increased SCD risk; however, in CRT candidates, the difference in risk reduction between LGE positive vs. negative patients was statistically not significant, suggesting a role of reverse remodeling. LGE-CMR before device implantation could be crucial in identifying high-risk patients even in non-ischemic etiology.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 8, 2024 Category: Cardiology Source Type: research
Association of an impaired GH-IGF-I axis with cardiac wasting in patients with advanced cancer
ConclusionIn advanced cancer, reduced LVmass is associated with increased plasma GH and reduced IGF-I/GH ratio, suggesting increasing GH resistance, especially for patients with wasting syndrome with unintentional weight loss. Higher baseline IGF-I was associated with a decrease in relative LVmass during follow-up.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 8, 2024 Category: Cardiology Source Type: research
The role of coronary artery disease in lung transplantation: a propensity-matched analysis
ConclusionIn this cohort, relevant CAD was not associated with worse outcomes and should therefore not be considered a contraindication for LuTx. Nonetheless, cardiovascular events in CAD patients highlight the necessity of control of cardiovascular risk factors and a structured cardiac follow-up. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 8, 2024 Category: Cardiology Source Type: research
Evaluating the predictive value of late gadolinium enhancement assessed by cardiac magnetic resonance on sudden cardiac death in patients selected for implantable cardioverter defibrillator and cardiac resynchronization therapy implantation: a systematic review and meta-analysis
ConclusionLGE-CMR positivity was associated with an increased SCD risk; however, in CRT candidates, the difference in risk reduction between LGE positive vs. negative patients was statistically not significant, suggesting a role of reverse remodeling. LGE-CMR before device implantation could be crucial in identifying high-risk patients even in non-ischemic etiology.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 8, 2024 Category: Cardiology Source Type: research
Performance of risk models to predict mortality risk for patients with heart failure: evaluation in an integrated health system
ConclusionsThese findings suggest that MARKER-HF, which uses readily available clinical and lab measurements in the EHR and required less imputation and data engineering than SHFM and MAGGIC, is an easier tool to identify high-risk patients in ambulatory clinics who could benefit from referral to a HF specialist.Graphical Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 2, 2024 Category: Cardiology Source Type: research
Impact of pulmonary hypertension on outcomes after TEER in patients suffering from mitral regurgitation
ConclusionPAWP at baseline was significantly and independently associated with HFH and might serve as a valuable parameter for identifying patients at high risk for HFH after M-TEER. ACM and procedural success were not affected by pulmonary arterial pressure before M-TEER. We suggest that the post-capillary component of PH serves as the driving force behind the risk of HFH. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 2, 2024 Category: Cardiology Source Type: research
Drivers and recent trends of hospitalisation costs related to acute pulmonary embolism
ConclusionsWe identified current and emerging cost drivers of hospitalisation for PE, focusing on severe disease and intermediate/high risk of an adverse early outcome. The present study may inform reimbursement decisions by policymakers and help to guide future health economic analysis of advanced treatment options for patients with PE.Graphical Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 2, 2024 Category: Cardiology Source Type: research
Performance of risk models to predict mortality risk for patients with heart failure: evaluation in an integrated health system
ConclusionsThese findings suggest that MARKER-HF, which uses readily available clinical and lab measurements in the EHR and required less imputation and data engineering than SHFM and MAGGIC, is an easier tool to identify high-risk patients in ambulatory clinics who could benefit from referral to a HF specialist.Graphical Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 2, 2024 Category: Cardiology Source Type: research
Impact of pulmonary hypertension on outcomes after TEER in patients suffering from mitral regurgitation
ConclusionPAWP at baseline was significantly and independently associated with HFH and might serve as a valuable parameter for identifying patients at high risk for HFH after M-TEER. ACM and procedural success were not affected by pulmonary arterial pressure before M-TEER. We suggest that the post-capillary component of PH serves as the driving force behind the risk of HFH. (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 2, 2024 Category: Cardiology Source Type: research
Drivers and recent trends of hospitalisation costs related to acute pulmonary embolism
ConclusionsWe identified current and emerging cost drivers of hospitalisation for PE, focusing on severe disease and intermediate/high risk of an adverse early outcome. The present study may inform reimbursement decisions by policymakers and help to guide future health economic analysis of advanced treatment options for patients with PE.Graphical Abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - April 2, 2024 Category: Cardiology Source Type: research
