A Mainstream View of the Longevity Industry

This popular science article from the AARP is representative of the sort of outsider's view of the longevity industry that is presently dominant. On the one hand, it is good that the media and advocacy organizations such as AARP are finally talking seriously about treating aging as a medical condition. On the other hand, the author looks at two of the most popular areas of development, mTOR inhibitors and senolytics, in a way that makes them seem more or less equivalent, and then further adds diet and exercise as another equivalent strategy. This will be continuing issue, I fear. People, as a rule, don't think about size of effect and quality of therapy when discussing present initiatives. These strategies are in fact very different, and the differences are important. Clearance of senescent cells via senolytic treatments is a radically different and better class of therapy than mTOR inhibition. Senolytics remove a cause of aging in one treatment, improving all aspects of health in later life in consequence, while mTOR inhibitors must be taken continually and only encourage the aging metabolism into a state that is somewhat more resistant to the underlying damage that causes aging. Tackling underlying causes will always be more effective than trying to cope with those causes without repairing them. "We've reached the perfect storm in aging science," says physician Nir Barzilai. "Everything is happening. We have the foundation from decades of anim...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs

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Authors: Ma F, Lv X, Du Y, Chen H, Liu S, Zhao J, Gao Y, An P, Zhou X, Song A, Sun C, Wang G, Ji Y, Wang X, Xu W, Huang G Abstract BACKGROUND: Leukocyte telomere length (LTL) is associated with the aging process and age-related degenerative diseases. The relation of peripheral blood LTL to mild cognitive impairment (MCI) and Alzheimer's disease (AD) and the role of folate and homocysteine (Hcy) in this relation remain unclear. OBJECTIVES: We aimed to investigate the association between LTL and the risks of MCI/AD, and to explore whether folate and Hcy may play a role in this association. METHODS: This case-...
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Authors: Li B, He Y, Ma J, Huang P, Du J, Cao L, Wang Y, Xiao Q, Tang H, Chen S Abstract OBJECTIVE: Gut microbiota changes before the onset of Alzheimer's disease (AD) and the alterations could be detected in the stage of mild cognitive impairment (MCI). The findings might offer diagnostic biomarkers before the onset of dementia. BACKGROUND: AD is the most common cause of dementia, and MCI is the predementia state. Recent studies suggest the alterations in the gut microbial communities associated with AD, whereas the microbiota in MCI before the onset of dementia has not been discovered and characterized in hum...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Authors: Michalek J, Brychtova S, Pink R, Dvorak Z Abstract Oral squamous cell carcinoma (OSCC) is a growing problem worldwide. Several biological and molecular criteria have been established for making a prognosis of OSCC. One of the most important factors affecting the risk of tumor recurrence and overall prognosis is perineural invasion and bone invasion. Perineural invasion is defined as a tumor spreading and the ability of tumor cells to penetrate around or through the nerve tissue. Perineural invasion can cause the tumor to spread to distant areas from the primary tumor location. One possible explanation for ...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research
CONCLUSION: Our experience shows that patients with diagnoses of acute retinal necrosis or progressive outer retinal necrosis have a poor visual prognosis. The occurrence of cytomegalovirus retinitis signifies a very unfavorable survival prognosis in patients who underwent hematopoietic stem cell transplantation; the patients in our study died within 1 year from cytomegalovirus retinitis diagnosis. PMID: 31435074 [PubMed - as supplied by publisher]
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research
For men with localized prostate cancer (CaP), radical prostatectomy (RP) as well as radiotherapy (RT) was associated with lower incidences of progression and metastases than was active monitoring.1 Meanwhile, prospective trial showed these patients with a long life expectancy would benefit from surgical intervention with a mean gain of almost 3-year of life.2 Unfortunately, when localized CaP progressed to incurable metastatic disease ancestral subclones and stromal micro-environment evolved dynamically in space and time following principles of selective evolution, underpinning important emergent features such as therapeut...
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Retrospective evaluations of the treatment of the primary tumor in the setting of metastatic hormone sensitive prostate cancer (mHSPC) are prevalent in the recent literature. The majority of these reports have favored the addition of local therapy1 and form the hypothesis generating support for recently completed and ongoing prospective randomized studies.2,3 Interestingly, in the present retrospective study, cancer-specific survival was not improved with local therapy. This is intriguing since the patients were subject to similar selection biases present in other retrospective reviews favoring local therapy.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
The accuracy of magnetic resonance imaging (MRI) for prostate cancer detection has been demonstrated in multiple studies, but the interpretation of prostate MRI can be quite challenging. In particular, changes caused by aging (ie, hyperplasia) or by pathologic conditions such as inflammation or cancer can lead to a nearly singular appearance on MRI for each prostate. Additionally, the lack of robust standardization across MRI scanners hampers the adoption of quantitative parameters for imaging analysis.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Cystoscopic surveillance, as recommended by the American Urology Association and the European Association of Urology guidelines, is the current gold standard for monitoring non –muscle-invasive bladder cancer (NMIBC).1,2 For low-risk NMIBC, at low risk of recurrence or progression, these guidelines recommend surveillance cystoscopies at 3 and 12 months, and annually thereafter. Moreover, there is recommendation by some national expert bodies to curtail continual cystosco pic surveillance beyond 12 months in those at lowest risk for recurrence.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
The treatment options for metastatic prostate cancer have increased dramatically over the past decade, including novel hormonal therapies, chemotherapies, and radiopharmaceuticals. The administration of myelosuppressive chemotherapies has generally been supervised by medical oncologists in the United States. The oversight of oral agents such as abiraterone  + prednisone (abi) and enzalutamide (enza) has been less well defined. This issue of the Gold Journal describes the increasing role of urologists in prescribing these agents.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
The management of patients with prostate cancer, in contrast to that of most other neoplasms is somewhat unique in that care of patients is typically overseen to a variable degree by a variety of different clinicians including urologists, radiation, and medical oncologists over a disease course that may extend over many years.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
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