Random Mutagenesis Applied to Reveal Factors Involved in Oxidative Tolerance and Biofilm Formation in Foodborne Cronobacter malonaticus

Conclusion In summary, the factors involved in tolerance to oxidative stress in C. malonaticus were identified including Trx2, Grx3, Pank, STPK, PK, PLA, FeoA, and Alr2. A positive relationship between biofilm-forming ability and oxidative tolerance was also observed, which might indicated that biofilm formation was related with environmental stress. The findings here provide valuable information for deeply understanding molecular mechanism about tolerance to oxidative stress. Author Contributions XZ carried out the experiments and analyzed the data. MZ carried out the experiments and analyzed the data. LT analyzed the data and carried out the experiments. DO carried out the partial experiments. YW analyzed the data. JZ modified the manuscript. QW and YY designed and modified the manuscript. Funding The financial support of the National Key Research and Development program (2017YFC1601200 and 2017YFC1601202), National Natural Science Foundation of China (31671951), the Anhui provincial Grand Project special of Science and Technology (15czz03109), the Science and Technology Planning Project of Guangdong Province (2016A050502033), and Project of Science and Technology in Guangzhou (201604020036). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We gratefully acknowledge Prof. Xu, M.Y (Guangdong Instit...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research