Superior Effects of High-Intensity Interval vs. Moderate-Intensity Continuous Training on Endothelial Function and Cardiorespiratory Fitness in Patients With Type 1 Diabetes: A Randomized Controlled Trial

Conclusion In young adults with type 1 diabetes without known complications and in moderate glycemic control, HIIT proved to be superior to MCT in improving endothelial dysfunction and physical fitness during a training period of 8-weeks. The effect on endothelial function was closely related to improvement in physical fitness and did not depend on glycemic control changes. Thus, HIIT can be recommended as a useful and safe non-pharmacological alternative to improve vascular function in patients with type 1 diabetes. Long-term studies to examine the efficacy of HIIT in preventing micro- and macrovascular disease are still required. Ethics Statement This clinical trial was registered at ClinicalTrials.gov Identifier: NCT03451201. This study protocol was approved by the Hospital de Clínicas de Porto Alegre (HCPA) ethics board (CAEE 54928116.0.0000.5327) and the reported investigations were carried out in accordance with the principles of the Declaration of Helsinki. All participants provided oral and written consent prior to inclusion in the study. Author Contributions WB was the mentor of the study, designed, and organized the logistics at Hospital de Clínicas de Porto Alegre (HCPA), submitted the manuscript, conceived and executed the study, including the supervised exercise sessions. AdS performed all ultrasound examinations and obtained FMD data. JF and JR-K collected the data and organized the database at the Exercise Research Laboratory. AR-O implemente...
Source: Frontiers in Physiology - Category: Physiology Source Type: research