Superior Effects of High-Intensity Interval vs. Moderate-Intensity Continuous Training on Endothelial Function and Cardiorespiratory Fitness in Patients With Type 1 Diabetes: A Randomized Controlled Trial

This study aimed to compare the effect of high-intensity interval training (HIIT) with moderate-intensity continuous training (MCT) on endothelial function, oxidative stress and clinical fitness in patients with type 1 diabetes. Thirty-six type 1 diabetic patients (mean age 23.5 ± 6 years) were randomized into 3 groups: HIIT, MCT, and a non-exercising group (CON). Exercise was performed in a stationary cycle ergometers during 40 min, 3 times/week, for 8 weeks at 50–85% maximal heart rate (HRmax) in HIIT and 50% HRmax in MCT. Endothelial function was measured by flow-mediated dilation (FMD) [endothelium-dependent vasodilation (EDVD)], and smooth-muscle function by nitroglycerin-mediated dilation [endothelium-independent vasodilation (EIVD)]. Peak oxygen consumption (VO2peak) and oxidative stress markers were determined before and after training. Endothelial dysfunction was defined as an increase
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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Publication date: Available online 30 May 2020Source: Life SciencesAuthor(s): Lakshmikripa Jagannathan, Emily Socks, Priya Balasubramanian, Robert McGowan, Thomas M. Herdt, Reza Kianian, Sheba M.J. MohanKumar, P.S. MohanKumar
Source: Life Sciences - Category: Biology Source Type: research
This study revealed the association between PAH exposure and markers of inflammation and oxidative stress, and the enhanced responses of pre-T2D patients suggested that individuals with metabolic disorders were more susceptible to the adverse health effects of PAH exposure. PMID: 32464779 [PubMed - in process]
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
In this study, five machine learning algorithms and twelve types of molecular fingerprints were employed to generate QSAR discriminant models for mitochondrial toxicity. A threshold moving method was adopted to resolve the imbalance issue in the training data. Consensus of the models by an averaging probability strategy improved prediction performance. The best model has correct classification rates of 81.8% and 88.3% in ten-fold cross validation and external validation, respectively. Substructures such as phenol, carboxylic acid, nitro and arylchloride were found informative through analysis of information gain and freque...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
In this study, mushroom residue was adding in lead-zinc slag to enhance the phytoremediation potential of P. fortunei, the effects of three treatments (lead-zinc slag, red soil, lead-zinc slag + 10% (m/m) mushroom residue) on the growth, physiology and microstructure of P. fortunei were determined. The results showed that the addition of mushroom residue increased the biomass, plant height and chlorophyll concentration of P. fortunei, indicating that the addition of mushroom residue can facilitate the growth of P. fortunei. Moreover, the proportions of oxalate-Pb forms and phosphate-Zn were do...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Abstract Zeranol is an approved but controversial growth-promoting agent for livestock in North America. It is a mycotoxin metabolite secreted by the Fusarium family fungi. The regulatory bodies in this region have established the acceptable daily intake and exposure below the level would not significantly increase the health risk for humans. However, their European counterparts have yet to establish an acceptable level and do not permit the use of this agent in farm animals. Given the growth-promoting ability of zeranol, its effect on energy metabolism was investigated in the current study. Our results indicated ...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Donald Trump and Mike Pence witness launch in FloridaFirst attempt was cancelled minutes from blast-offA rocketship named Dragon breathed new fire into America ’s human spaceflight programme on Saturday, carrying two astronauts on a much-anticipated adventure.Related:Trump wants America looking at the stars as he drags it through the gutterContinue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: SpaceX Nasa Science Trump administration US news Florida Elon Musk Technology World news Source Type: news
BACKGROUND: Dental features have been considered a potential target of verbal bullying (VB) among school-aged children. The authors conducted a study to investigate the association between the presence of oral disorders and the occurrence of VB among 8- th...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
An error was made in the original paper. Prevalence of MMI and SMI for the complete sample should be as follows:20.9% of respondents reported indications of moderate mental illness in wave 1 (2011; n=969) declining to 14.2 14.2% at wave 6 (2016; n=2263); 1...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news
This study aimed to describe the epidemiology of pediatric upper extremity injury secondary to nonballistic firearms in the United States. METHODS: The National Electronic Injury Surveillance Survey (NEISS) database was queried between ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
OBJECTIVES: Heavy consumption of energy drinks appears to pose a public health problem among young adults. This paper examines (i) the prevalence of chronic heavy energy drink use (consuming energy drinks more than once a day) and (ii) its associations wit...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
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