Evidence of Different IL-1 β Activation Pathways in Innate Immune Cells From Indeterminate and Cardiac Patients With Chronic Chagas Disease
Conclusions: We suggest some distinct molecular mechanisms for production of IL-1β in innate immune cells from patients with different clinical forms of Chagas disease. MMP-2 and MMP-9 gelatinases are associated with distinct disease outcomes and IL-1β production. Introduction Chagas disease, also known as American trypanosomiasis, is a neglected parasitic disease caused by the protozoan Trypanosoma cruzi (1), that affects millions of people in the world (2). During the acute phase, a diffuse and intense inflammation in the cardiomyocytes is observed, which is composed mainly of neutrophils, monocytes, and T lymphocytes. Patients in the chronic phase of Chagas disease are classified in different clinical forms according to the symptoms presented: (1) Indeterminate (IND) with no alterations due the infection (3), (2) cardiac (CARD) with chronic alterations in heart function and structure (4, 5), and (3) digestive with gastrointestinal alterations (6). Dilated cardiomyopathy is the most severe alteration, affecting about 30% of patients in the chronic phase of the disease (7–9). Chronic chagasic cardiomyopathy is the main fibrosing myocarditis among the known heart diseases (10), with chronic low intensity inflammation, progressive tissue destruction, cardiac remodeling, and extensive fibrosis in the heart (11). The collagen in cardiac matrix is replaced by weak fibers trough matrix metalloproteinases (MMPs), that cleaves extracellular matrix (ECM) protei...
CONCLUSIONS: Web-based methods need to be complemented by context-tailored, street-outreach activities to recruit rural PWUD. PMID: 32933438 [PubMed - as supplied by publisher]
CONCLUSIONS: Animal-encounter fatalities, analyzed by UCD alone, may be underreported. An initiating animal injury, complicated by comorbidities and fatality, may obscure the causal chain, resulting in misreporting UCD. Ongoing training for medical certifiers is recommended, highlighting accurate identification of UCD and contributing causes in the causal chain of death. PMID: 32933400 [PubMed - as supplied by publisher]
Publication date: 1 January 2021Source: Personality and Individual Differences, Volume 168Author(s): Anthony A. Volk, Kristopher J. Brazil, Prarthana Franklin-Luther, Andrew V. Dane, Tracy Vaillancourt
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New data reinforce strong clinical profile of Vitrakvi™ for patients of all ages with TRK Fusion Cancer including lung and thyroid tumors78% overall response rate (ORR) and median progression-free survival (PFS) of more than 3 years (36.8 months) demonstrate extended benefit in updated data set of 175 adults and children / Majority of adverse events were grade 1 or 2; no new safety signals identified / Consistently high ORRs shown in lung and thyroid data subsets (71 and 75%, respectively) as well as long durability (estimated duration of response at 12 months of 88% and 95%, respectively) / Among patients from integ...
Growth in new pediatric COVID-19 cases has evened out in recent weeks, but children now represent 10% of all COVID-19 cases in the United States.Medscape Medical News
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New sports cardiology guidelines green-light participation in vigorous competitive sports by selected patients with stable coronary artery disease, heart failure, or mild arrhythmiasMedscape Medical News
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