Study describes enzyme's key role in immune response to Chagas disease parasite
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) A study shows that the expression of PI3Kγ protein increases during infection by T. cruzi, an essential response in avoiding excessive inflammation and controlling parasitemia. Heart tissue analyses involving human patients who developed cardiopathy in the disease's chronic stage also provided results. The next challenge is to devise treatment for Chagas using molecules capable of modulating the cellular signaling pathway mediated by PI3Kγ. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 13, 2018 Category: International Medicine & Public Health Source Type: news

Chagas Disease Surveillance Activities - Seven States, 2017
In 2017, Chagas disease was reportable in six states. Most cases identified, including among blood donors, are chronic cases and are not the result of local vectorborne transmission. (Source: PHPartners.org)
Source: PHPartners.org - July 9, 2018 Category: International Medicine & Public Health Source Type: news

Kissing bugs kiss their hiding spots goodbye, thanks to tiny radio transmitters
(Entomological Society of America) In a new pilot study, researchers in Texas successfully attached miniature radio transmitters to kissing bugs and tracked their movements. Also known as triatomine bugs, kissing bugs transmit the pathogen that causes Chagas disease in humans and animals. They typically move at night and hide during day, and uncovering their secretive movements could play a key role in reducing their impact as a disease vector. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 9, 2018 Category: Infectious Diseases Source Type: news

International Chagas Day: MSF Launches Campaign to Raise Awareness
Press releaseInternational Chagas Day: MSF Launches Campaign to Raise AwarenessApril 14, 2018The international medical humanitarian organization Doctors Without Borders/M édecins Sans Frontières (MSF) launched the awareness campaign "A big heart is not always a good thing" for International Chagas Disease Day today. The initiative aims to raise public awareness of a neglected disease that affects the health of more than 6 million people around the world, especially in Latin America where it is endemic. (Source: MSF News)
Source: MSF News - April 14, 2018 Category: International Medicine & Public Health Authors: Brienne Prusak Source Type: news

GHIT Fund launches next phase focusing on access & delivery, bringing total investment to US $123 million
(Burness) The Global Health Innovative Technology (GHIT) Fund today announced a total of 1.6 billion yen (US$15.5 million) and 10 partnerships to support product development of new lifesaving drugs, vaccines and diagnostics for malaria, tuberculosis and neglected tropical diseases such as Chagas disease, schistosomiasis and leishmaniasis. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 28, 2018 Category: Infectious Diseases Source Type: news

Chagas Disease in Our Own Backyards
April 3, 2018 2:00-3:00pm ET. (Source: PHPartners.org)
Source: PHPartners.org - March 22, 2018 Category: International Medicine & Public Health Source Type: news

ASE releases updated guidelines for cardiac US agents
The American Society of Echocardiography (ASE) has published updated guidelines...Read more on AuntMinnie.comRelated Reading: ASE releases guide for imaging Chagas disease Medical societies celebrate ultrasound awareness Medical societies expand collaboration on cardiac registry ASE debuts new educational offerings ASE offers guide for childhood heart disease (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 2, 2018 Category: Radiology Source Type: news

New safety data for the most commonly used drug to treat Chagas disease
(Barcelona Institute for Global Health (ISGlobal)) The frequency of adverse reactions to benznidazole is high when treating chronic Chagas patients, although they were mostly mild effects, according to a study led by ISGlobal, in collaboration with the Hospital Clinic of Barcelona. The results point to the need of finding drug combinations or dosages in order to maintain efficacy but decrease its toxicity. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 20, 2018 Category: Infectious Diseases Source Type: news

Patients with chagas disease are often infected with an intestinal parasite
(Barcelona Institute for Global Health (ISGlobal)) In patients with Chagas Disease, the odds of being infected by the intestinal worm Strongyloides stercoralis increases by two-fold, according to a study led by the Barcelona Institute for Global Health (ISGlobal). The study, published in Plos Neglected Tropical Diseases, underlines the potential benefits of performing a combined screening for both infections among Latin American adults living in Europe. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 14, 2018 Category: International Medicine & Public Health Source Type: news

ASE releases guide for imaging Chagas disease
The American Society of Echocardiography (ASE) has released a new guide for...Read more on AuntMinnie.comRelated Reading: Medical societies celebrate ultrasound awareness Medical societies expand collaboration on cardiac registry ASE: Echo protocol finds kids' heart abnormalities ASE debuts new educational offerings ASE offers guide for childhood heart disease (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - January 3, 2018 Category: Radiology Source Type: news

Chagas Disease (American Trypanosomiasis)
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - December 20, 2017 Category: General Medicine Source Type: news

Does Chagas disease present a health risk to Canadians?
(McGill University Health Centre) Believe it or not, a tropical blood parasite native to Latin America could be harmful to Canadians. Infectious diseases like malaria or Zika may have dominated recent headlines but Chagas -- the 'Kissing Bug' disease -- is in the spotlight following the publication of a new case study in the Canadian Medical Association Journal. Experts from Winnipeg and Montreal warn natives of Latin America and their offspring are at risk of contracting Chagas disease. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 13, 2017 Category: Infectious Diseases Source Type: news

Discovery of a potential therapeutic target to combat trypanosomes
(CNRS) Using cryo-electron microscopy, French researchers at the Institut de Biologie Mol é culaire et Cellulaire (CNRS/Universit é de Strasbourg) have analyzed the structure of trypanosomes parasites in details and revealed one of their potential weak points, which has remained undetected until now. This discovery opens the path to the development of new safer therapies that are less toxic and more specific against trypanosomes, the parasites causing the Chagas disease and the African sleeping sickness. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 26, 2017 Category: Biology Source Type: news

Increasing Acai Sales Demands Vigilance for Chagas Disease Increasing Acai Sales Demands Vigilance for Chagas Disease
Every year, Brazil registers between 110 and 150 new cases of the disease. Confirmation of oral transmission involves a parasitologic examination and epidemiologic evidence.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 13, 2017 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Discovering potential therapeutic protein inhibitors for Chagas disease
(Tokyo Institute of Technology) Scientists at Tokyo Institute of Technology (Tokyo Tech), Nagasaki University have identified four potential protein inhibitors and unlocked drug discovery strategies for the treatment of Chagas disease by using advanced three-dimensional computer simulation by supercomputer TSUBAME in combination with in vitro experiments and X-ray crystallography. Through this " smart drug discovery " in which IT drug discovery and biochemical experiments cooperate, they identified hit compounds for target protein with a hit rate of 20 times or more than conventional High Throughput Screening (HT...
Source: EurekAlert! - Medicine and Health - September 26, 2017 Category: International Medicine & Public Health Source Type: news

Scientists identify new hosts for Chagas Disease vectors
(University of California - Riverside) Solitary weasel-like animals called tayra might look pretty harmless, but some may actually be incubators for a parasite that causes Chagas disease, a chronic, debilitating condition that is spread by insects called kissing bugs and affects more than 8 million people worldwide. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 18, 2017 Category: Infectious Diseases Source Type: news

Abbott Prism Chagas
The ABBOTT PRISM Chagas assay is an in vitro chemiluminescent immunoassay (ChLIA) for the qualitative detection of antibodies to Trypanosoma cruzi (T cruzi), the causative agent of Chagas disease, in human serum and plasma specimens. (Source: What's New at CBER)
Source: What's New at CBER - September 11, 2017 Category: Biomedical Science Source Type: news

Drug For 'Neglected' Chagas Disease Gains FDA Approval Amid Price Worries
U.S. doctors treating Chagas disease have long wanted FDA approval for a treatment that's widely used in Latin America. But when Martin Shkreli took interest, those doctors panicked — then mobilized.(Image credit: Ray Coleman/Science Source) (Source: NPR Health and Science)
Source: NPR Health and Science - September 10, 2017 Category: Consumer Health News Authors: Courtney Columbus Source Type: news

Drug to Treat Chagas Disease to Become Available in the U.S.
Press releaseDrug to Treat Chagas Disease to Become Available in the U.S.August 31, 2017Pharmaceutical company Chemo Group announced today that it will make a drug to treat the neglected tropical disease Chagas available to people in the United States. The U.S. Food and Drug Administration ’s (FDA) approval of the drug, benznidazole, means that Chagas pediatric patients in the U.S. could receive access to a therapy that Doctors Without Borders/Médecins Sans Frontières (MSF) has been using for decades to treat people living with Chagas across Latin America. Though Chagas affects an estimated 300,000 peop...
Source: MSF News - August 31, 2017 Category: International Medicine & Public Health Authors: Brienne Prusak Source Type: news

U.S. FDA Approves Chemo Group's Benznidazole to Treat Children with Chagas Disease
WASHINGTON D.C., BUENOS AIRES, Argentina, MADRID and GENEVA, August 31, 2017 -- (Healthcare Sales & Marketing Network) -- On August 29th, the U.S. Food and Drug Administration (FDA) approved Chemo Research's New Drug Application (NDA) for benznidazole. Th... Biopharmaceuticals, FDA Chemo Group, benznidazole, Chagas disease (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - August 31, 2017 Category: Pharmaceuticals Source Type: news

FDA Approves First U.S. Treatment for Chagas Disease (FREE)
By the Editors The FDA has approved benznidazole to treat Chagas disease, a parasitic infection, in children aged 2 to 12 years.The disease … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - August 30, 2017 Category: Primary Care Source Type: news

FDA Approves 1st Treatment for'Kissing Bug' Illness in Children
Benznidazole becomes the nation's only drug for Chagas disease Source: HealthDay Related MedlinePlus Pages: Chagas Disease, Children's Health (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - August 30, 2017 Category: Consumer Health News Source Type: news

FDA approves first U.S. treatment for Chagas disease
The U.S. Food and Drug Administration has granted accelerated approval to benznidazole for use in children ages 2 to 12 years old with Chagas disease. It is the first treatment approved in the United States for the treatment of Chagas disease. Chagas disease, or American trypanosomiasis, is a parasitic infection caused by Trypanosoma cruzi and can be transmitted through different routes, (Source: World Pharma News)
Source: World Pharma News - August 30, 2017 Category: Pharmaceuticals Tags: Featured FDA Regulatory Affairs Source Type: news

That drug meant to transform Martin Shkreli's former Bay Area company? Someone else got to it first
A Peninsula company once led by "pharma bad boy" Martin Shkreli had hoped to bring this drug to the United States to treat Chagas disease. A group of for-profit and non-profit interests beat it to the punch. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - August 30, 2017 Category: Biotechnology Authors: Ron Leuty Source Type: news

That drug meant to transform Martin Shkreli's former Bay Area company? Someone else got to it first
A Peninsula company once led by "pharma bad boy" Martin Shkreli had hoped to bring this drug to the United States to treat Chagas disease. A group of for-profit and non-profit interests beat it to the punch. (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - August 30, 2017 Category: Health Management Authors: Ron Leuty Source Type: news

FDA Approves Benznidazole, First US Drug for Chagas Disease FDA Approves Benznidazole, First US Drug for Chagas Disease
Benznidazole is indicated for treatment of children aged 2 to 12 years with Chagas disease.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 29, 2017 Category: Consumer Health News Tags: Infectious Diseases News Alert Source Type: news

FDA approves first U.S. treatment for Chagas disease
The U.S. Food and Drug Administration today granted accelerated approval to benznidazole for use in children ages 2 to 12 years old with Chagas disease. It is the first treatment approved in the United States for the treatment of Chagas disease. (Source: Food and Drug Administration)
Source: Food and Drug Administration - August 29, 2017 Category: American Health Source Type: news

FDA Approves Benznidazole as First U.S. Treatment for Chagas Disease
August 29, 2017 -- The U.S. Food and Drug Administration today granted accelerated approval to benznidazole for use in children ages 2 to 12 years old with Chagas disease. It is the first treatment approved in the United States for the treatment of... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - August 29, 2017 Category: Drugs & Pharmacology Source Type: news

Pharma bad boy Martin Shkreli is gone, but 2 companies spar over drug he snagged
"Pharma bro" Shkreli brought the Chagas disease drug to KaloBios Pharmaceuticals, but a lawsuit claims it has cost more to develop the drug than was represented. (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - August 4, 2017 Category: Health Management Authors: Ron Leuty Source Type: news

Pharma bad boy Martin Shkreli is gone, but 2 companies spar over drug he snagged
"Pharma bro" Shkreli brought the Chagas disease drug to KaloBios Pharmaceuticals, but a lawsuit claims it has cost more to develop the drug than was represented. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - August 4, 2017 Category: Biotechnology Authors: Ron Leuty Source Type: news

Pharma bad boy Martin Shkreli is gone, but 2 companies spar over drug he snagged
"Pharma bro" Shkreli brought the Chagas disease drug to KaloBios Pharmaceuticals, but a lawsuit claims it has cost more to develop the drug than was represented. (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - August 4, 2017 Category: Health Management Authors: Ron Leuty Source Type: news

Pharma bad boy Martin Shkreli is gone, but 2 companies spar over drug he snagged
"Pharma bro" Shkreli brought the Chagas disease drug to KaloBios Pharmaceuticals, but a lawsuit claims it has cost more to develop the drug than was represented. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - August 4, 2017 Category: Biotechnology Authors: Ron Leuty Source Type: news

Chagas Disease in the United States: Improving Patient Diagnosis and Treatment
September 14, 2017 Bronx, NY.(Montefiore Albert Einstein College of Medicine) (Source: PHPartners.org)
Source: PHPartners.org - August 2, 2017 Category: International Medicine & Public Health Source Type: news

UTEP Scientists awarded patent for Chagas disease vaccine
(The University of Texas at El Paso) A pair of scientists at The University of Texas at El Paso is one step closer to developing the first ever clinical Chagas disease vaccine.Researchers Rosa Maldonado, Ph.D., and Igor Almeida, Ph.D., both faculty in the Department of Biological Sciences, recently were granted a patent for " Mucin-Associated Surface Protein As Vaccine Against Chagas Disease. " (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 22, 2017 Category: Infectious Diseases Source Type: news

Autochthonous Transmission of Trypanosoma cruzi to Humans Autochthonous Transmission of Trypanosoma cruzi to Humans
What do we currently know about the autochthonous transmission of Chagas disease caused by T cruzi in the United States?Emerging Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 29, 2017 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

Increased Mortality in Blood Donors Positive for Chagas Disease Increased Mortality in Blood Donors Positive for Chagas Disease
Blood donors seropositive for Chagas disease, a result of infection with Trypanosoma cruzi, have a risk of death more than twice as high as that of similar seronegative donors, according to a death certificate linkage study from Brazil.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - May 22, 2017 Category: Pathology Tags: Infectious Diseases News Source Type: news

Deaths from Chagas disease under-reported
Chagas disease, affecting millions of people in Central and South America, is classified as one of the 17 most important neglected diseases by the World Health Organization. Now, researchers have found that even the non-symptomatic stage of Chagas infection, which can last for many years, more than doubles a person's risk of death. The new study also concludes that deaths from Chagas have likely been under-reported in the past. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 18, 2017 Category: Science Source Type: news

Deaths from Chagas disease under-reported
(PLOS) Chagas disease, affecting millions of people in Central and South America, is classified as one of the 17 most important neglected diseases by the World Health Organization. Now, researchers have found that even the non-symptomatic stage of Chagas infection, which can last for many years, more than doubles a person's risk of death. The new study, published in PLOS Neglected Tropical Diseases, also concludes that deaths from Chagas have likely been under-reported in the past. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 18, 2017 Category: Infectious Diseases Source Type: news

Merck partners with University of California, San Diego (UCSD) to fight Neglected Tropical Diseases
Merck, a leading science and technology company, today announced that it has agreed with the University of California, San Diego (UCSD) to share compounds under the WIPO Re:Search open innovation umbrella, thereby deepening its efforts in the fight against Neglected Tropical Diseases (NTDs) to identify potential cures for leishmaniasis, Chagas disease (American trypanosomiasis) and human African trypanosomiasis (HAT, sleeping sickness). (Source: World Pharma News)
Source: World Pharma News - April 20, 2017 Category: Pharmaceuticals Tags: Featured Merck Group Business and Industry Source Type: news

Chagas Disease Presents Public Health Challenge in the U.S.
Without early treatment, Chagas disease can cause heart failure (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - April 20, 2017 Category: Respiratory Medicine Tags: Cardiology, Family Medicine, Infections, Internal Medicine, Nursing, Pathology, Pulmonology, Institutional, Source Type: news

Illness from'Kissing Bug' Now Widespread in U.S.
Without early treatment, Chagas disease can cause heart failure Source: HealthDay Related MedlinePlus Page: Chagas Disease (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - April 18, 2017 Category: Consumer Health News Source Type: news

Illness From'Kissing Bug' Now Widespread in U.S.
TUESDAY, April 18, 2017 -- It's spread by an insect that's often called the " kissing bug. " And now, the parasitic infection know as Chagas disease is prevalent in the United States, new research shows. Investigators tested nearly 5,000 Latin... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 18, 2017 Category: Journals (General) Source Type: news

Chagas disease: The Brazilian forest bites back
Bugs that lost their natural habitat through deforestation in the Amazon region are spreading disease in human settlements (Source: FT.com - Drugs and Healthcare)
Source: FT.com - Drugs and Healthcare - April 18, 2017 Category: Pharmaceuticals Source Type: news

Disease Burden Growing as Vector Insects Adapt to Climate Change
Dry drains will reduce the numbers of mosquitoes breeding, but now the Aedes aegypti mosquito is going underground to breed underground in available water and flying to feed. Credit: Zadie Neufville/IPSBy Zadie NeufvilleKINGSTON, Jamaica, Apr 18 2017 (IPS)There were surprised gasps when University of the West Indies (UWI) Professor John Agard told journalists at an Intergovernmental Panel on Climate Change (IPCC) meeting in late November 2016 that mosquitoes were not only living longer, but were “breeding in septic tanks underground”.For many, it explained why months of fogging at the height of Zika and Chikung...
Source: IPS Inter Press Service - Health - April 18, 2017 Category: Global & Universal Authors: Zadie Neufville Tags: Caribbean Climate Wire Climate Change Featured Headlines Health Latin America & the Caribbean Projects Water & Sanitation Chagas Disease Intergovernmental Panel on Climate Change (IPCC) mosquitoes Zika Virus Source Type: news

First large-scale survey of Chagas disease in the United States confirms that the'silent killer' is a major public health challenge for the country
A study of almost 5,000 Latin American-born residents of Los Angeles County found that 1.24 percent tested positive for Chagas disease, a parasitic infection that can cause life-threatening heart damage if not treated early. Chagas disease is one of the leading causes of heart failure in Latin America. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 13, 2017 Category: Science Source Type: news

First large-scale survey of Chagas disease in the United States confirms that the 'silent killer' is a major public health challenge for the country
(Drugs for Neglected Diseases Initiative) A study of almost 5,000 Latin American-born residents of Los Angeles County found that 1.24 percent tested positive for Chagas disease, a parasitic infection that can cause life-threatening heart damage if not treated early. Chagas disease is one of the leading causes of heart failure in Latin America. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 13, 2017 Category: Infectious Diseases Source Type: news

Negative regulator stops extreme immune response to parasite, averting multi-organ damage
(Osaka University) A new study from Osaka University identified a role for the BATF2 protein in negatively regulating the immune response to infection by the protozoan parasite Trypanosoma cruzi, which is responsible for Chagas disease. BATF2 was shown to inhibit production of the IL-23 cytokine, thus limiting immunopathology mediated by another cytokine, IL-17. This furthers understanding of the host response to parasitic infection, and is likely to be applicable to other immune disorders. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 3, 2017 Category: Biology Source Type: news

[Report] Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites
We report a way to selectively kill Trypanosoma by blocking glycosomal/peroxisomal import that depends on the PEX14-PEX5 protein-protein interaction. We developed small molecules that efficiently disrupt the PEX14-PEX5 interaction. This results in mislocalization of glycosomal enzymes, causing metabolic catastrophe, and it kills the parasite. High-resolution x-ray structures and nuclear magnetic resonance data enabled the efficient design of inhibitors with trypanocidal activities comparable to approved medications. These results identify PEX14 as an “Achilles’ heel” of the Trypanosoma suitable for the de...
Source: ScienceNOW - March 31, 2017 Category: Science Authors: M. Dawidowski Source Type: news