Treatment-Resistant to Antipsychotics: A Resistance to Everything? Psychotherapy in Treatment-Resistant Schizophrenia and Nonaffective Psychosis: A 25-Year Systematic Review and Exploratory Meta-Analysis

Conclusions: CBT, psychosocial intervention, supportive counseling, psychodynamic psychotherapy, and other psychological interventions can be recommended for clinical practice. More studies are needed, especially for non-CBT interventions and for all psychotherapies on negative symptoms.IntroductionSchizophrenia affects approximately 1% of the population, usually starting in adolescence or young adulthood, frequently leading to persistent disability, with a high risk of suicide (8%). Despite the advance in antipsychotics treatment, approximately 30% of patients with schizophrenia show a poor response or no response to antipsychotics (1–7), demonstrating persistent positive symptoms (i.e., hallucinations, delusions). The experience of persistent delusions and hallucinations may result in further disability, poor prognosis, and risk of suicide (8, 9). Finally, treatment-resistant psychosis (TRP) is responsible for increasing health assistance expenditure. For instance, in the United States, treatment-resistant schizophrenia (TRS) adds more than 34 billion dollars in the annual direct medical costs (10).In the presence of pharmacological treatment resistance, can nonpharmacological, psychotherapy-based interventions significantly overcome the therapeutic response deadlock? Which psychotherapy in combination with antipsychotics does work better? Finally, what are the limitations and the pitfalls of the research on psychotherapy in TRS and TRP?This review aims to provid...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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The turmoil and devastating destruction of World War II had also ruined dermatology across Europe. In contrast, the Society of Investigative Dermatology (SID; founded in 1937) in the United States functioned successfully and soon became a role model for the leaders of dermatology departments in  various European countries. Our former teachers in dermatology succeeded in overcoming the prejudice and animosity in the western world. This outcome was the conception of the founding fathers (there was no founding lady in the initial group) of the European Society for Dermatological Research (ES DR).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Personal Views & Reflections Source Type: research
Having been involved in the European Society for Dermatological Research (ESDR) from the 1980s, we have had the opportunity to observe the spectacular development of our society from early small meetings in the Netherlands to major international meetings held in many European centers. Our first ESDR meetings were notable because of the stimulating and friendly atmosphere with full sharing of ideas and new discoveries, even prepublication. Such an atmosphere has been preserved over time and has generated many research partnerships, including our own collaboration in keratinocyte (KC) biology and genetic skin diseases.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Personal Views & Reflections Source Type: research
Prof Sam Shuster (born on 24 August 1927, London) was a founding board member and then the President of the European Society for Dermatological Research (ESDR). He is a Fellow of the Royal College of Physicians, member of various dermatological and science associations, and an honorary member of many foreign academy societies. He is an emeritus professor of dermatology from the University of Newcastle Upon Tyne, United Kingdom.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Personal Views & Reflections Source Type: research
Conclusions: There were significant differences with respect to clinical characteristics and comorbidity prevalence according to metformin use among Korean type 2 diabetes patients. Long-term follow-up of these patients is necessary to observe how this difference will affect clinical outcomes for these patients. PMID: 32774367 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
CONCLUSIONS: The study does not seem to exclude that the lethality of COVID-19 may be climate sensitive. Future studies will have to confirm these clues, due to potential confounding factors, such as pollution, population age, and exposure to malaria. PMID: 32767354 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Chen GF, Cheng YR, Ye L, Wang MW, Zhou MY, Zhang F, Chen J, Feng ZH Abstract OBJECTIVE: The World Health Organization reported a cluster of cases of pneumonia of unknown cause detected on December 31, 2019 in China. Unfortunately, a 34-year-old Italian nurse has committed suicide after testing positive for coronavirus. It was the second case of suicide by a nurse in an Italian hospital and occurred only a few days after the first suicide. These consecutive suicides have aroused concern, and it is necessary to investigate the psychological issues of the medical staff in Italy regarding the COVID-19. PMI...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: Serum and exosomal hsa_circ_0000907 and hsa_circ_0057362, especially hsa_circ_0000907, have novel diagnostic capabilities in the early diagnosis of DFU. PMID: 32767340 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: General practitioners, otolaryngology, neurology and audiology specialists should be aware of possible audio-vestibular side effects of drugs, such as hearing loss, tinnitus, dizziness and vertigo. The present guide represents a practical tool to rapidly identify potential audio-vestibular side effects of drugs as reported by the pharmaceutical companies and/or health agencies. PMID: 32767320 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Saito M, Asanuma K, Hatta W, Koike T, Hata T, Fujishima F, Furukawa T, Unno M, Masamune A Abstract A 38-year-old Japanese man who had been diagnosed with appendiceal carcinoid and undergone ileocecal resection 8 years before, presented with duodenal obstruction caused by a submucosal tumor-like appearance. He was diagnosed with long-term recurrence of appendiceal goblet cell carcinoid (GCC) with a multi-morphological pattern based on the histological assessment of a duodenal biopsy and his previously resected appendix. He underwent subtotal stomach-preserving pancreaticoduodenectomy combined with resection...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
This study was carried out to evaluate the potential neuroprotection effect of the aqueous root bark extract of Daniellia oliveri against diazepam-induced amnesia in mice. Thirty-six adult male mice were distributed into six groups: the three test groups received Daniellia oliveri root bark extract (100, 200, and 300 mg/kg), the normal control group received distilled water (10 ml/kg), a positive control group received piracetam (150 mg/kg), and the negative control received diazepam (2.5 mg/kg). Learning and memory were evaluated using the radial arm maze and the T-maze. Biomarkers of oxidative...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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