Treatment-Resistant to Antipsychotics: A Resistance to Everything? Psychotherapy in Treatment-Resistant Schizophrenia and Nonaffective Psychosis: A 25-Year Systematic Review and Exploratory Meta-Analysis

Conclusions: CBT, psychosocial intervention, supportive counseling, psychodynamic psychotherapy, and other psychological interventions can be recommended for clinical practice. More studies are needed, especially for non-CBT interventions and for all psychotherapies on negative symptoms.IntroductionSchizophrenia affects approximately 1% of the population, usually starting in adolescence or young adulthood, frequently leading to persistent disability, with a high risk of suicide (8%). Despite the advance in antipsychotics treatment, approximately 30% of patients with schizophrenia show a poor response or no response to antipsychotics (1–7), demonstrating persistent positive symptoms (i.e., hallucinations, delusions). The experience of persistent delusions and hallucinations may result in further disability, poor prognosis, and risk of suicide (8, 9). Finally, treatment-resistant psychosis (TRP) is responsible for increasing health assistance expenditure. For instance, in the United States, treatment-resistant schizophrenia (TRS) adds more than 34 billion dollars in the annual direct medical costs (10).In the presence of pharmacological treatment resistance, can nonpharmacological, psychotherapy-based interventions significantly overcome the therapeutic response deadlock? Which psychotherapy in combination with antipsychotics does work better? Finally, what are the limitations and the pitfalls of the research on psychotherapy in TRS and TRP?This review aims to provid...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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Abstract The role of killer yeasts of the species Debaryomyces hansenii and Wickerhamomyces anomalus in biocontrol of Monilinia fructicola, and their involvement in plant defence mechanisms against brown rot in apple fruits, were investigated. D. hansenii KI2a and W. anomalus BS91 strains showed the highest in vitro biocontrol activity, inhibiting mycelium growth by 69.53% and 66.08% respectively, as compared to control fungal cultures. Brown rot on apple fruits was significantly reduced by BS91 and two strains of D. hansenii KI2a and AII4b by 92.46%, 85.10% and 70.02%, respectively, in comparison to infected frui...
Source: Food Microbiology - Category: Food Science Authors: Tags: Food Microbiol Source Type: research
The co-location of services will help doctors address a wide range of issues for Medicaid patients with chronic conditions and behavioral health needs.
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Most health system executives understand that significant changes are necessary in healthcare to adapt to the preferences of today's consumers while cutting costs and delivering quality care. A recent article quoted an executive of the Cleveland Clinic about three major trends that are shaping the health systems for the future (see:Why Today ’s Hospitals and Health Systems Need to Be More Patient-Centric to Fight Rising Costs). Below is an excerpt from it:“A central challenge for the United States is that between 18 to 20 percent of GDP is going to healthcare, and it’s on track to go higher,&rdqu...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Cost of Healthcare Healthcare Delivery Healthcare Information Technology Medical Research Quality of Care Telemedicine Source Type: blogs
The co-location of services will help doctors address a wide range of issues for Medicaid patients with chronic conditions and behavioral health needs.
Source: Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
This report demonstrates how much sleep-in staff are relied upon. “They’re effectively keeping the care system on its feet. Yet workers are hugely undervalued by employers and paid poverty wages. “It’s totally unacceptable to leave staff to sleep in offices, and not protect them from abuse. “More staff could quit their jobs if employers don’t act, leaving care even more in crisis.” UNISON is now calling on employers to improve sleep-in working conditions such as providing somewhere safe and clean to sleep, carrying out proper risk assessments, and for the government to fund the bac...
Source: UNISON Health and safety news - Category: Occupational Health Authors: Tags: News Press release care homes dave prentis Source Type: news
AbstractEach year, many young professionals forego advanced education in the traditional doctoral programs of medicine, law, and philosophy in favor of pursuing a PhD or professional doctorate in bioethics or healthcare ethics that is offered by several major institutes of higher education across the United States. These graduates often leverage their degrees into careers within the broader field of bioethics. As such, they represent a growing percentage of professional bioethicists in both academia and healthcare nationwide. Given the significant role that doctoral bioethics programs play in the training of future profess...
Source: Journal of Medical Humanities - Category: Medical Ethics Source Type: research
British Journal of Cancer, Published online: 18 June 2019; doi:10.1038/s41416-019-0502-xThe combination of complex karyotype subtypes and IGHV mutational status identifies new prognostic and predictive groups in chronic lymphocytic leukaemia
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
British Journal of Cancer, Published online: 18 June 2019; doi:10.1038/s41416-019-0496-4Dacomitinib, but not lapatinib, suppressed progression in castration-resistant prostate cancer models by preventing HER2 increase
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
AbstractPurpose of ReviewWhilst gait impairment is a main cause for disability in Parkinson ’s disease (PD), its neural control remains poorly understood. We performed a systematic review and meta-analysis of neuroimaging studies of surrogate features of gait in PD.FindingsAssessing the results from PET or SPECT scans after a period of actual walking as well as fMRI during mental imagery or virtual reality (VR) gait paradigms, we found a varying pattern of gait-related brain activity. Overall, a decrease in activation of the SMA during gait was found in PD compared to elderly controls. In addition, the meta-analysis ...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
This study sought to address limited understanding of the inpatient experience of transgender adolescents. This study uses qualitative methods to gain insight into the experience of transgender adolescents and psychiatric care providers on an adolescent inpatient psychiatric unit in the northeast United States. Semi-structured interviews were conducted with patients (9 total, ages 13 –17) and unit care providers (18 total). These interviews were recorded, transcribed, and analyzed using inductive thematic analysis. Patients and providers generally reported a supportive inpatient environment. Factors that contributed ...
Source: Psychiatric Quarterly - Category: Psychiatry Source Type: research
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