The P2X7 Receptor Is Shed Into Circulation: Correlation With C-Reactive Protein Levels

In conclusion, we have shown that the P2X7R is released into the blood in association to MVs/MPs, and that its levels are significantly higher in diseased subjects. Ethics Statement The protocols were approved by the Ethical Committee of Ferrara district (Studies n. 170891 and 040408). All subjects gave written informed consent in accordance with the Declaration of Helsinki. Author Contributions FDV projected this work, planned experiments and wrote the manuscript. ALG was responsible for most of the experiments and for drafting and editing the manuscript. MB collected samples, stratified patients' samples according to diagnosis and performed some of the experiments. JMS was responsible for statistical analysis. AP helped in projecting this work and in the statistical analysis. SP collected samples and stratified patients' samples according to diagnosis. VV-P and ACS performed some of the experiments. Conflict of Interest Statement FDV is a member of the Scientific Advisory Board of Biosceptre Ltd., a UK-based biotech Company involved in the development of P2X7R-targeted therapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments FDV is supported by grants from the Italian Association for Cancer Research (n. IG 13025 and IG 18581), the Ministry of Education of Italy (PRIN 20178YTNWC), and the Ministry...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research