Baby Boomers Changing The Healthcare Landscape

Kendra and Jay Jeffcoat are the quintessential baby boomer couple. Kendra, 69, recently retired after a long and successful career as a college professor and administrator. Jay, 70, who spent his college years as student body president at the University of California, Santa Barbara, protesting the Vietnam War, continues to work full time as a corporate attorney in San Diego. In January 2013, Kendra was diagnosed with stage 4 lung cancer, which had metastasized in her brain. She never smoked, nor was she around secondhand smoke. But as Healthline noted in November 2014, lung cancer among women who don't smoke is on the rise. Kendra endured brain surgery, several courses of chemotherapy, and a clinical trial for a cancer vaccine. She is now being treated with Opdivo, a new immunotherapy medication from Bristol-Myers Squibb that helps a person's immune system fight cancer. It was approved last year by the Food and Drug Administration (FDA). The emergence of immunotherapies is considered a game changer in the treatment of cancer. Kendra and her husband are pleased that this new treatment is available. Kendra said she was shocked when she was first diagnosed, but age has given her the wisdom to deal with it. "The joy of being over 60 is that a person has the experience and wisdom to deal with the realities of a crisis with joy, hope, and laughter," she told Healthline. "Each round of chemo, radiation, vaccine therapy, and now immunotherapy, provides an oppo...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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SMAD4 is the only common SMAD in TGF-β signaling that usually impedes immune cell activation in the tumor microenvironment. However, we demonstrated here that selective deletion of Smad4 in NK cells actually led to dramatically reduced tumor cell rejection and augmented tumor cell metastases, reduced murine CMV clearance, as well as impeded NK cell homeostasis and maturation. This was associated with a downregulation of granzyme B (Gzmb), Kit, and Prdm1 in Smad4-deficient NK cells. We further unveiled the mechanism by which SMAD4 promotes Gzmb expression. Gzmb was identified as a direct target of a transcriptional com...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
The stroma of solid tumors can exclude or limit immune infiltration, or lead to the recruitment of tumor-promoting rather than tumor-attacking immune cells. This finding was reported by Jayaprakash et al. in this issue of the JCI, and it was particularly prominent in the hypoxic zones of tumors in the transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer models. A current clinical goal of immune checkpoint blockade (ICB) is to extend its utility to more patients by converting immunologically “cold” tumors that do not provoke a strong immunological response to “hot” tumors that are invaded b...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Despite the success of immune checkpoint blockade against melanoma, many “cold” tumors like prostate cancer remain unresponsive. We found that hypoxic zones were prevalent across preclinical prostate cancer and resisted T cell infiltration even in the context of CTLA-4 and PD-1 blockade. We demonstrated that the hypoxia-activated prodrug TH-302 reduces or eliminates hypoxia in these tumors. Combination therapy with this hypoxia-prodrug and checkpoint blockade cooperated to cure more than 80% of tumors in the transgenic adenocarcinoma of the mouse prostate–derived (TRAMP-derived) TRAMP-C2 model. Immunofluo...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
A child from Florida is the first person to die of the flu this season. The child was unvaccinated with no known underlying medical conditions. But a new survey shows more parents don't see the benefits of the flu vaccine. CBS News medical contributor Dr. Tara Narula has more.
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
One in four Americans goes to a therapist, and CBT is the most popular and safest treatment for depression. But 43 percent experience anxiety, break ups or other side effects, a German study reveals.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
The paper, titled 'Debt or Death?', used data on 9.5 million nationally-representative patients between 1998 and 2014, who spend an average of $92,098 a year trying to stay alive.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Source: Peerview CME/CE Video Podcast - Internal Medicine International - Category: Internal Medicine Authors: Tags: Science, Medicine Source Type: video
Conclusion: GSTP1 and CYPs expressions are increased in intracranial tumors. These results should be confirmed with larger series and different enzyme subtypes.
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research
Commonwealth Fund–supported researchers at the Long-Term Quality Alliance examined what we know and don’t know about working-age disabled Americans’ needs for long-term support. They share their findings in a new report.        
Source: The Commonwealth Fund: Publications - Category: International Medicine & Public Health Source Type: research
The start-up ’s optofluidic system could help get personalized cancer cell therapies to more people
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
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