Structural effects of oxidation on sugars: glucose as a precursor of gluconolactone and glucuronolactone
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Maider Parra-Santamaria, Aran Insausti, Elena R. Alonso, Francisco J. Basterretxea, Emilio J. Cocinero This atomic-resolution study reveals glucose changes due to oxidation, exploring key carbohydrate aspects like hydrogen bonding, ring-puckering, anomeric effect, and tautomeric selection. Results confirm mutarotation suppression in the gas phase. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - April 25, 2024 Category: Chemistry Authors: Maider Parra-Santamaria Source Type: research
Higher Sugar Intake Associated with Higher Risk of Depression
According to this study.PMID:38661707 | DOI:10.1097/01.NAJ.0001016400.61479.0c (Source: The American Journal of Nursing)
Source: The American Journal of Nursing - April 25, 2024 Category: Nursing Authors: Karen Rosenberg Source Type: research
Structural effects of oxidation on sugars: glucose as a precursor of gluconolactone and glucuronolactone
We present an experimental work on the changes in the structure and interactions of two products of glucose oxidation (D-glucono-1,5-lactone (GlcL) and D-glucurono-6,3-lactone (GlcurL)) with respect to their precursor. Features such as intramolecular interactions, ring puckering and tautomerism were observed.PMID:38661549 | DOI:10.1039/d4cc00735b (Source: Chemical Communications)
Source: Chemical Communications - April 25, 2024 Category: Chemistry Authors: Maider Parra-Santamaria Aran Insausti Elena R Alonso Francisco J Basterretxea Emilio J Cocinero Source Type: research
Kids SIPsmartER reduces sugar-sweetened beverages among Appalachian middle-school students and their caregivers: a cluster randomized controlled trial
CONCLUSIONS: Kids SIPsmartER was effective at reducing SSB consumption among students and their caregivers in the rural, medically underserved Appalachian region. Importantly, SSB effects were even stronger among students and caregivers who were high consumers at baseline.TRIAL REGISTRATION: Clincialtrials.gov: NCT03740113. Registered 14 November 2018- Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03740113 .PMID:38664715 | DOI:10.1186/s12966-024-01594-7 (Source: Health Physics)
Source: Health Physics - April 25, 2024 Category: Physics Authors: Jamie M Zoellner Wen You Kathleen Porter Brittany Kirkpatrick Annie Reid Donna Brock Phillip Chow Lee Ritterband Source Type: research
Molecular simulation on the interaction between trehalose and asymmetric lipid bilayer mimicking the membrane of human red blood cells
In this study, we conducted atomistic molecular dynamic simulations on asymmetric model bilayers that mimic the membrane of human red blood cells at various trehalose and water contents. We considered three different hydration levels mimicking the full hydration to desiccation scenarios. Results indicate that the asymmetric distribution of lipids did not significantly influence the computed structural characteristics at full and low hydration. At dehydration, however, the order parameter obtained from the symmetric bilayer is significantly higher compared to those obtained from asymmetric ones. Analysis of hydrogen bonds r...
Source: Cryobiology - April 25, 2024 Category: Biology Authors: Yu Cao Cai Gao Lei Yang Pei Zhou Dongfang Sun Source Type: research
External validation of the colorectal cancer risk score LiFeCRC using food frequency questions in the HUNT study
ConclusionReadily available clinical variables and food frequency questions in a modified LiFeCRC score can identify patients at risk of CRC and may improve primary prevention by motivating to lifestyle change or participation in the CRC screening programme. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 25, 2024 Category: Gastroenterology Source Type: research
Cancers, Vol. 16, Pages 1664: L-Glyceraldehyde Inhibits Neuroblastoma Cell Growth via a Multi-Modal Mechanism on Metabolism and Signaling
We describe a novel multi-modal mechanism by which the L-isomer of GA (L-GA) inhibits neuroblastoma cell growth. L-GA induces significant changes in the metabolic profile, promotes oxidative stress and hinders nucleotide biosynthesis. GC-MS and 13C-labeling was employed to measure the flow of carbon through glycolytic intermediates under L-GA treatment. It was found that L-GA is a potent inhibitor of glycolysis due to its proposed targeting of NAD(H)-dependent reactions. This results in growth inhibition, apoptosis and a redox crisis in neuroblastoma cells. It was confirmed that the redox mechanisms were modulated via L-GA...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Martin Forbes Richard Kempa Guido Mastrobuoni Liam Rayman Matthias Pietzke Safak Bayram Birte Arlt Annika Spruessel Hedwig E. Deubzer Stefan Kempa Tags: Article Source Type: research
The genotype of barley cultivars influences multiple aspects of their associated microbiota via differential root exudate secretion
by Alba Pacheco-Moreno, Anita Bollmann-Giolai, Govind Chandra, Paul Brett, Jack Davies, Owen Thornton, Philip Poole, Vinoy Ramachandran, James K. M. Brown, Paul Nicholson, Chris Ridout, Sarah DeVos, Jacob G. Malone
Plant-associated microbes play vital roles in promoting plant growth and health, with plants secreting root exudates into the rhizosphere to attract beneficial microbes. Exudate composition defines the nature of microbial recruitment, with different plant species attracting distinct microbiota to enable optimal adaptation to the soil environment. To more closely examine the relationship between plant genotype a...
Source: PLoS Biology: Archived Table of Contents - April 25, 2024 Category: Biology Authors: Alba Pacheco-Moreno Source Type: research
Kids SIPsmartER reduces sugar-sweetened beverages among Appalachian middle-school students and their caregivers: a cluster randomized controlled trial
High consumption of sugar-sweetened beverages (SSB) is a global health concern. Additionally, sugar-sweetened beverage (SSB) consumption is disproportionately high among adolescents and adults in rural Appalac... (Source: International Journal of Behavioral Nutrition and Physical Activity)
Source: International Journal of Behavioral Nutrition and Physical Activity - April 25, 2024 Category: Nutrition Authors: Jamie M. Zoellner, Wen You, Kathleen Porter, Brittany Kirkpatrick, Annie Reid, Donna Brock, Phillip Chow and Lee Ritterband Tags: Research Source Type: research
Enhancing bioelectrochemical hydrogen production from industrial wastewater using Ni-foam cathodes in a microbial electrolysis cell pilot plant
In this study, nickel-foam and stainless-steel wool cathodes were employed as catalysts to critically assess hydrogen production in a 150 L MEC pilot plant treating sugar-based industrial wastewater. Continuous hydrogen production was achieved in the reactor for more than 80 days, with a maximum COD removal efficiency of 40 %. Nickel-foam cathodes significantly enhanced hydrogen production and energy efficiency at non-limiting substrate concentration, yielding the maximum hydrogen production ever reported at pilot-scale (19.07 ± 0.46 L H2 m-2 d-1 and 0.21 ± 0.01 m3 m-3 d-1). This is a 3.0-fold improve in hydrogen product...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Oscar Guerrero-Sodric Juan Antonio Baeza Albert Guisasola Source Type: research
Recalcification stabilizes cadmium but magnifies phosphorus limitation in wastewater-irrigated calcareous soil
In this study, we selected calcareous agricultural soil irrigated with wastewater for over 50 years to examine the recalcification effects of sugar beet factory lime (SBFL) at doses of 0%, 2.5%, 5%, and 10%. We found that SBFL promoted Cd transformation in the soil from active exchangeable species to more stable carbonate-bonded and residual species, which the X-ray diffraction patterns also confirmed results that CdSO4 reduced while CdS and CaCdCO3 increased. Correspondingly, the soil bioavailable Cd concentration was significantly reduced by 65.6-84.7%. The Cd concentrations in maize roots and shoots were significantly r...
Source: Environmental Research - April 24, 2024 Category: Environmental Health Authors: Shuangjin Ma Yahu Hu Zhongren Nan Cuicui Zhao Fei Zang Chuanyan Zhao Source Type: research
The conjugates of 5'-deoxy-5-fluorocytidine and hydroxycinnamic acids - synthesis, anti-pancreatic cancer activity and molecular docking studies
RSC Adv. 2024 Apr 23;14(19):13129-13141. doi: 10.1039/d4ra01683a. eCollection 2024 Apr 22.ABSTRACTNew amide conjugates 1-6 of hydroxycinnamic acids (HCA) and 5'-deoxy-5-fluorocytidine (5-dFCR), the prodrug of 5-fluorouracil (5-FU), were synthesized and tested in vitro against pancreatic cancer lines (PDAC). The compounds showed slightly higher efficacy against primary BxPC-3 cells (IC50 values of 14-45 μM) than against metastatic AsPC-1 (IC50 values of 37-133 μM), and similar to that of 5-FU for both PDAC lines. Compound 1, which has a para-(acetyloxy)coumaroyl substituent, was found to be the most potent (IC50 = 14 μM)...
Source: Adv Data - April 24, 2024 Category: Epidemiology Authors: Marcin Cybulski Magdalena Zaremba-Czogalla Bartosz Trzaskowski Marek Kubiszewski Joanna Tobiasz Anna Jaromin Piotr Krzeczy ński Jerzy Gubernator Olga Michalak Source Type: research
Process Development for the Enzymatic Gram-Scale Production of the Unnatural Nucleotide Sugar UDP-6-azido-GalNAc
ChemSusChem. 2024 Apr 24:e202400311. doi: 10.1002/cssc.202400311. Online ahead of print.ABSTRACTAzido sugars hold great promise as substrates in numerous click-chemistry applications. However, the synthesis of activated azido sugars is limited by cost and complexity. Conventional chemical activation methods are intricate and time-consuming. In response, we have developed a process for the large-scale production of UDP-6-azido-GalNAc through enzymatic nucleotide sugar synthesis on a gram scale. Our optimization strategies encompassed refining the process parameters of an enzyme cascade featuring NahK from Bifidobacterium lo...
Source: ChemSusChem - April 24, 2024 Category: Chemistry Authors: Hannes Frohnmeyer Jorge M M Verkade Markus Spiertz Andreas Rentsch Niels Hoffmann Milan Sobota Frank Schwede Peter Tjeerdsma Lothar Elling Source Type: research
Metabolomics analysis of larval secretions reveals a caste-driven nutritional shift in a social wasp colony
Insect Biochem Mol Biol. 2024 Apr 22:104128. doi: 10.1016/j.ibmb.2024.104128. Online ahead of print.ABSTRACTSocial wasps exhibit a unique nutritional cycle in which adults feed larvae with prey, and larvae provide adults with larval secretions (LS). LS serves as a vital nutritional source for adults, contributing to the colony's health and reproductive success. The LS nutrient composition has been previously reported in various wasp species, yet these analyses focused solely on worker-destined larvae, overlooking the potential caste designation effects on LS composition. Using metabolomics techniques, we analysed and compa...
Source: Insect Biochemistry and Molecular Biology - April 24, 2024 Category: Biochemistry Authors: Levona Bodner Weronika Jasinska Sofia Bouchebti Inon Scharf Yariv Brotman Eran Levin Source Type: research
Effect of Food Composition on the PK of Isoniazid Quantitatively Explained Using Physiologically Based Biopharmaceutics Modeling
AbstractThis work shows the utilization of a physiologically based biopharmaceutics model (PBBM) to mechanistically explain the impact of diverse food types on the pharmacokinetics (PK) of isoniazid (INH) and acetyl-isoniazid (Ac-INH). The model was established and validated using published PK profiles for INH along with a combination of measured and predicted values for the physico-chemical and biopharmaceutical propertied of INH and Ac-INH. A dedicated ontogeny model was developed for N-acetyltransferase 2 (NAT2) in human integrating Michaelis Menten parameters for this enzyme in the physiologically based pharmacokinetic...
Source: The AAPS Journal - April 24, 2024 Category: Drugs & Pharmacology Source Type: research
