Impaired Fibroblast Growth Factor 21 (FGF21) Associated with Visceral Adiposity Leads to Insulin Resistance: The Core Defect in Diabetes Mellitus
Curr Diabetes Rev. 2024 Apr 26. doi: 10.2174/0115733998265915231116043813. Online ahead of print.ABSTRACTThe Central nervous system (CNS) is the prime regulator of signaling pathways whose function includes regulation of food intake (consumption), energy expenditure, and other metabolic responses like glycolysis, gluconeogenesis, fatty acid oxidation, and thermogenesis that have been implicated in chronic inflammatory disorders. Type 2 diabetes mellitus (T2DM) and obesity are two metabolic disorders that are linked together and have become an epidemic worldwide, thus raising significant public health concerns. Fibroblast g...
Source: Current Diabetes Reviews - April 27, 2024 Category: Endocrinology Authors: Unnati Jain Priyanka Srivastava Ashwani Sharma Subrata Sinha Surabhi Johari Source Type: research
Oenothera biennis with strong copper toxicity resistance enriches trace copper in seeds under copper pollution soil
Ecotoxicol Environ Saf. 2024 Apr 25;277:116382. doi: 10.1016/j.ecoenv.2024.116382. Online ahead of print.ABSTRACTExcess copper (Cu) imparts negative effects on plant growth and productivity in soil. To develop the ability of O. biennis to govern pollution soil containing excessive Cu, we investigated seed germination, seedling growth, and seed yield. Furthermore, Cu content and the expression levels of Cu transport related genes in different tissues were measured under exogenous high concentration Cu. O. biennis seeds were sensitive to excess Cu, with an observed reduction in the germination rate, primary root length, fres...
Source: Ecotoxicology and Environmental Safety - April 27, 2024 Category: Environmental Health Authors: Jie Dong Shuchang Yang Zhiling Kou Yunting Chen Tao Yang Peng Gao Wuhua Zhang Jinzhu Zhang Daidi Che Aoxue Wang Source Type: research
Elucidation of inhibitory effects of bioactive anthraquinones towards formation of DNA advanced glycation end products (DNA-AGEs)
Int J Biol Macromol. 2024 Apr 25:131810. doi: 10.1016/j.ijbiomac.2024.131810. Online ahead of print.ABSTRACTDNA is essential in biological processes as it directs transcription and translation assisting in RNA and protein synthesis. Extended periods of elevated blood glucose levels cause non-enzymatic DNA glycation, which results in the formation of DNA-AGEs and the production of free radicals, causing structural perturbation of DNA. In this work, we have investigated the glycation of calf thymus DNA and examined its inhibition by two anthraquinone derivatives, purpurin, and aloin. Ribose sugar served as the glycating agen...
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Sana Quraishi Sadia Nudrat Kalpana Kumari Erica W M Marboh Kripamoy Aguan Atanu Singha Roy Source Type: research
Mixed-phase weak anion-exchange/reversed-phase LC-MS/MS for analysis of nucleotide sugars in human fibroblasts
In conclusion, a novel, semi-quantitative method was established for the analysis of nucleotide sugars that can be applied to diagnose several genetic glycosylation disorders in fibroblasts and beyond.PMID:38676823 | DOI:10.1007/s00216-024-05313-w (Source: Analytical and Bioanalytical Chemistry)
Source: Analytical and Bioanalytical Chemistry - April 27, 2024 Category: Chemistry Authors: Moritz Rahm Hanneke Kwast Hans J C T Wessels Marek J Noga Dirk J Lefeber Source Type: research
Phytochemicals, Herbal Extracts, and Dietary Supplements for Metabolic Disease Management
Endocr Metab Immune Disord Drug Targets. 2024 Apr 26. doi: 10.2174/0118715303287911240409055710. Online ahead of print.ABSTRACTComprehensive and effective care techniques have become essential due to the global epidemic dimensions of metabolic disorders, including diabetes, obesity, and cardiovascular ailments. Recent research highlights the potential of dietary supplements, herbal extracts, and phytochemicals in treating metabolic diseases. This abstract conveys the current state of the science in this field by highlighting these findings' underlying mechanisms and potential therapeutic applications. Plant-based diets con...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Praveen Halagali Aparna Inamdar Jagroop Singh Amit Anand Poulami Sadhu Rashmi Pathak Himanshu Sharma Deepak Biswas Source Type: research
Techno-economic analysis of biomass value-added processing informed by pilot scale de-ashing of paper sludge feedstock
Bioresour Technol. 2024 Apr 25:130744. doi: 10.1016/j.biortech.2024.130744. Online ahead of print.ABSTRACTPaper sludge biomass represents an underutilized feedstock rich in pulped and processed cellulose which is currently a waste stream with significant disposal cost to industry for landfilling services. Effective fractionation of the cellulose from paper sludge presents an opportunity to yield cellulose as feedstock for value-added processes. A novel approach to cellulose fractionation is the sidehill screening system, herein studied at the pilot-plant scale. Composition analysis determined ash removal and carbohydrate r...
Source: Bioresource Technology - April 27, 2024 Category: Biotechnology Authors: Phoenix Tiller Hyeonji Park David Cruz Rios Edgar Carrejo David K Johnson Ashutosh Mittal Richard Venditti Sunkyu Park Source Type: research
Identification of hyperthermophilic D-allulose 3-epimerase from Thermotoga sp. and its application as a high-performance biocatalyst for D-allulose synthesis
This study offers a promising resource for the enzyme engineering of DAEs and a high-performance biocatalyst for industrial D-allulose production.PMID:38676737 | DOI:10.1007/s00449-024-02989-3 (Source: Bioprocess and Biosystems Engineering)
Source: Bioprocess and Biosystems Engineering - April 27, 2024 Category: Biomedical Engineering Authors: Ji-Dong Shen Bao-Ping Xu Te-Li Yu Yong-Xiang Fei Xue Cai Liang-Gang Huang Li-Qun Jin Zhi-Qiang Liu Yu-Guo Zheng Source Type: research
Phloridzin's Diabetic Wound Healing Potential through DPP-4 Enzyme Inhibition: A Review Article
This study offers new research directions for examining phloridzin's capacity to withstand oxidative stress, as well as for redefining its tactical function as a powerful DPP-4 inhibitor to regulate the process involved in the healing of diabetic wounds.PMID:38676506 | DOI:10.2174/0115733998291941240416053855 (Source: Current Diabetes Reviews)
Source: Current Diabetes Reviews - April 27, 2024 Category: Endocrinology Authors: Khushi Sharma Vadivelan Ramachandran Ashutosh Sharma Tharani Mohanasundaram Harshini Mageshkumar Source Type: research
Impaired Fibroblast Growth Factor 21 (FGF21) Associated with Visceral Adiposity Leads to Insulin Resistance: The Core Defect in Diabetes Mellitus
Curr Diabetes Rev. 2024 Apr 26. doi: 10.2174/0115733998265915231116043813. Online ahead of print.ABSTRACTThe Central nervous system (CNS) is the prime regulator of signaling pathways whose function includes regulation of food intake (consumption), energy expenditure, and other metabolic responses like glycolysis, gluconeogenesis, fatty acid oxidation, and thermogenesis that have been implicated in chronic inflammatory disorders. Type 2 diabetes mellitus (T2DM) and obesity are two metabolic disorders that are linked together and have become an epidemic worldwide, thus raising significant public health concerns. Fibroblast g...
Source: Current Diabetes Reviews - April 27, 2024 Category: Endocrinology Authors: Unnati Jain Priyanka Srivastava Ashwani Sharma Subrata Sinha Surabhi Johari Source Type: research
Phytochemicals, Herbal Extracts, and Dietary Supplements for Metabolic Disease Management
Endocr Metab Immune Disord Drug Targets. 2024 Apr 26. doi: 10.2174/0118715303287911240409055710. Online ahead of print.ABSTRACTComprehensive and effective care techniques have become essential due to the global epidemic dimensions of metabolic disorders, including diabetes, obesity, and cardiovascular ailments. Recent research highlights the potential of dietary supplements, herbal extracts, and phytochemicals in treating metabolic diseases. This abstract conveys the current state of the science in this field by highlighting these findings' underlying mechanisms and potential therapeutic applications. Plant-based diets con...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Praveen Halagali Aparna Inamdar Jagroop Singh Amit Anand Poulami Sadhu Rashmi Pathak Himanshu Sharma Deepak Biswas Source Type: research
Mixed-phase weak anion-exchange/reversed-phase LC-MS/MS for analysis of nucleotide sugars in human fibroblasts
In conclusion, a novel, semi-quantitative method was established for the analysis of nucleotide sugars that can be applied to diagnose several genetic glycosylation disorders in fibroblasts and beyond.PMID:38676823 | DOI:10.1007/s00216-024-05313-w (Source: Analytical and Bioanalytical Chemistry)
Source: Analytical and Bioanalytical Chemistry - April 27, 2024 Category: Chemistry Authors: Moritz Rahm Hanneke Kwast Hans J C T Wessels Marek J Noga Dirk J Lefeber Source Type: research
Oenothera biennis with strong copper toxicity resistance enriches trace copper in seeds under copper pollution soil
Ecotoxicol Environ Saf. 2024 Apr 25;277:116382. doi: 10.1016/j.ecoenv.2024.116382. Online ahead of print.ABSTRACTExcess copper (Cu) imparts negative effects on plant growth and productivity in soil. To develop the ability of O. biennis to govern pollution soil containing excessive Cu, we investigated seed germination, seedling growth, and seed yield. Furthermore, Cu content and the expression levels of Cu transport related genes in different tissues were measured under exogenous high concentration Cu. O. biennis seeds were sensitive to excess Cu, with an observed reduction in the germination rate, primary root length, fres...
Source: Ecotoxicology and Environmental Safety - April 27, 2024 Category: Environmental Health Authors: Jie Dong Shuchang Yang Zhiling Kou Yunting Chen Tao Yang Peng Gao Wuhua Zhang Jinzhu Zhang Daidi Che Aoxue Wang Source Type: research
Phytochemicals, Herbal Extracts, and Dietary Supplements for Metabolic Disease Management
Endocr Metab Immune Disord Drug Targets. 2024 Apr 26. doi: 10.2174/0118715303287911240409055710. Online ahead of print.ABSTRACTComprehensive and effective care techniques have become essential due to the global epidemic dimensions of metabolic disorders, including diabetes, obesity, and cardiovascular ailments. Recent research highlights the potential of dietary supplements, herbal extracts, and phytochemicals in treating metabolic diseases. This abstract conveys the current state of the science in this field by highlighting these findings' underlying mechanisms and potential therapeutic applications. Plant-based diets con...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Praveen Halagali Aparna Inamdar Jagroop Singh Amit Anand Poulami Sadhu Rashmi Pathak Himanshu Sharma Deepak Biswas Source Type: research
Techno-economic analysis of biomass value-added processing informed by pilot scale de-ashing of paper sludge feedstock
Bioresour Technol. 2024 Apr 25:130744. doi: 10.1016/j.biortech.2024.130744. Online ahead of print.ABSTRACTPaper sludge biomass represents an underutilized feedstock rich in pulped and processed cellulose which is currently a waste stream with significant disposal cost to industry for landfilling services. Effective fractionation of the cellulose from paper sludge presents an opportunity to yield cellulose as feedstock for value-added processes. A novel approach to cellulose fractionation is the sidehill screening system, herein studied at the pilot-plant scale. Composition analysis determined ash removal and carbohydrate r...
Source: Bioresource Technology - April 27, 2024 Category: Biotechnology Authors: Phoenix Tiller Hyeonji Park David Cruz Rios Edgar Carrejo David K Johnson Ashutosh Mittal Richard Venditti Sunkyu Park Source Type: research
Identification of hyperthermophilic D-allulose 3-epimerase from Thermotoga sp. and its application as a high-performance biocatalyst for D-allulose synthesis
This study offers a promising resource for the enzyme engineering of DAEs and a high-performance biocatalyst for industrial D-allulose production.PMID:38676737 | DOI:10.1007/s00449-024-02989-3 (Source: Bioprocess and Biosystems Engineering)
Source: Bioprocess and Biosystems Engineering - April 27, 2024 Category: Biomedical Engineering Authors: Ji-Dong Shen Bao-Ping Xu Te-Li Yu Yong-Xiang Fei Xue Cai Liang-Gang Huang Li-Qun Jin Zhi-Qiang Liu Yu-Guo Zheng Source Type: research
