Kids SIPsmartER reduces sugar-sweetened beverages among Appalachian middle-school students and their caregivers: a cluster randomized controlled trial
High consumption of sugar-sweetened beverages (SSB) is a global health concern. Additionally, sugar-sweetened beverage (SSB) consumption is disproportionately high among adolescents and adults in rural Appalac... (Source: International Journal of Behavioral Nutrition and Physical Activity)
Source: International Journal of Behavioral Nutrition and Physical Activity - April 25, 2024 Category: Nutrition Authors: Jamie M. Zoellner, Wen You, Kathleen Porter, Brittany Kirkpatrick, Annie Reid, Donna Brock, Phillip Chow and Lee Ritterband Tags: Research Source Type: research
Enhancing bioelectrochemical hydrogen production from industrial wastewater using Ni-foam cathodes in a microbial electrolysis cell pilot plant
In this study, nickel-foam and stainless-steel wool cathodes were employed as catalysts to critically assess hydrogen production in a 150 L MEC pilot plant treating sugar-based industrial wastewater. Continuous hydrogen production was achieved in the reactor for more than 80 days, with a maximum COD removal efficiency of 40 %. Nickel-foam cathodes significantly enhanced hydrogen production and energy efficiency at non-limiting substrate concentration, yielding the maximum hydrogen production ever reported at pilot-scale (19.07 ± 0.46 L H2 m-2 d-1 and 0.21 ± 0.01 m3 m-3 d-1). This is a 3.0-fold improve in hydrogen product...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Oscar Guerrero-Sodric Juan Antonio Baeza Albert Guisasola Source Type: research
Recalcification stabilizes cadmium but magnifies phosphorus limitation in wastewater-irrigated calcareous soil
In this study, we selected calcareous agricultural soil irrigated with wastewater for over 50 years to examine the recalcification effects of sugar beet factory lime (SBFL) at doses of 0%, 2.5%, 5%, and 10%. We found that SBFL promoted Cd transformation in the soil from active exchangeable species to more stable carbonate-bonded and residual species, which the X-ray diffraction patterns also confirmed results that CdSO4 reduced while CdS and CaCdCO3 increased. Correspondingly, the soil bioavailable Cd concentration was significantly reduced by 65.6-84.7%. The Cd concentrations in maize roots and shoots were significantly r...
Source: Environmental Research - April 24, 2024 Category: Environmental Health Authors: Shuangjin Ma Yahu Hu Zhongren Nan Cuicui Zhao Fei Zang Chuanyan Zhao Source Type: research
The conjugates of 5'-deoxy-5-fluorocytidine and hydroxycinnamic acids - synthesis, anti-pancreatic cancer activity and molecular docking studies
RSC Adv. 2024 Apr 23;14(19):13129-13141. doi: 10.1039/d4ra01683a. eCollection 2024 Apr 22.ABSTRACTNew amide conjugates 1-6 of hydroxycinnamic acids (HCA) and 5'-deoxy-5-fluorocytidine (5-dFCR), the prodrug of 5-fluorouracil (5-FU), were synthesized and tested in vitro against pancreatic cancer lines (PDAC). The compounds showed slightly higher efficacy against primary BxPC-3 cells (IC50 values of 14-45 μM) than against metastatic AsPC-1 (IC50 values of 37-133 μM), and similar to that of 5-FU for both PDAC lines. Compound 1, which has a para-(acetyloxy)coumaroyl substituent, was found to be the most potent (IC50 = 14 μM)...
Source: Adv Data - April 24, 2024 Category: Epidemiology Authors: Marcin Cybulski Magdalena Zaremba-Czogalla Bartosz Trzaskowski Marek Kubiszewski Joanna Tobiasz Anna Jaromin Piotr Krzeczy ński Jerzy Gubernator Olga Michalak Source Type: research
Process Development for the Enzymatic Gram-Scale Production of the Unnatural Nucleotide Sugar UDP-6-azido-GalNAc
ChemSusChem. 2024 Apr 24:e202400311. doi: 10.1002/cssc.202400311. Online ahead of print.ABSTRACTAzido sugars hold great promise as substrates in numerous click-chemistry applications. However, the synthesis of activated azido sugars is limited by cost and complexity. Conventional chemical activation methods are intricate and time-consuming. In response, we have developed a process for the large-scale production of UDP-6-azido-GalNAc through enzymatic nucleotide sugar synthesis on a gram scale. Our optimization strategies encompassed refining the process parameters of an enzyme cascade featuring NahK from Bifidobacterium lo...
Source: ChemSusChem - April 24, 2024 Category: Chemistry Authors: Hannes Frohnmeyer Jorge M M Verkade Markus Spiertz Andreas Rentsch Niels Hoffmann Milan Sobota Frank Schwede Peter Tjeerdsma Lothar Elling Source Type: research
Metabolomics analysis of larval secretions reveals a caste-driven nutritional shift in a social wasp colony
Insect Biochem Mol Biol. 2024 Apr 22:104128. doi: 10.1016/j.ibmb.2024.104128. Online ahead of print.ABSTRACTSocial wasps exhibit a unique nutritional cycle in which adults feed larvae with prey, and larvae provide adults with larval secretions (LS). LS serves as a vital nutritional source for adults, contributing to the colony's health and reproductive success. The LS nutrient composition has been previously reported in various wasp species, yet these analyses focused solely on worker-destined larvae, overlooking the potential caste designation effects on LS composition. Using metabolomics techniques, we analysed and compa...
Source: Insect Biochemistry and Molecular Biology - April 24, 2024 Category: Biochemistry Authors: Levona Bodner Weronika Jasinska Sofia Bouchebti Inon Scharf Yariv Brotman Eran Levin Source Type: research
Recalcification stabilizes cadmium but magnifies phosphorus limitation in wastewater-irrigated calcareous soil
In this study, we selected calcareous agricultural soil irrigated with wastewater for over 50 years to examine the recalcification effects of sugar beet factory lime (SBFL) at doses of 0%, 2.5%, 5%, and 10%. We found that SBFL promoted Cd transformation in the soil from active exchangeable species to more stable carbonate-bonded and residual species, which the X-ray diffraction patterns also confirmed results that CdSO4 reduced while CdS and CaCdCO3 increased. Correspondingly, the soil bioavailable Cd concentration was significantly reduced by 65.6-84.7%. The Cd concentrations in maize roots and shoots were significantly r...
Source: Environmental Research - April 24, 2024 Category: Environmental Health Authors: Shuangjin Ma Yahu Hu Zhongren Nan Cuicui Zhao Fei Zang Chuanyan Zhao Source Type: research
Effect of Food Composition on the PK of Isoniazid Quantitatively Explained Using Physiologically Based Biopharmaceutics Modeling
AbstractThis work shows the utilization of a physiologically based biopharmaceutics model (PBBM) to mechanistically explain the impact of diverse food types on the pharmacokinetics (PK) of isoniazid (INH) and acetyl-isoniazid (Ac-INH). The model was established and validated using published PK profiles for INH along with a combination of measured and predicted values for the physico-chemical and biopharmaceutical propertied of INH and Ac-INH. A dedicated ontogeny model was developed for N-acetyltransferase 2 (NAT2) in human integrating Michaelis Menten parameters for this enzyme in the physiologically based pharmacokinetic...
Source: The AAPS Journal - April 24, 2024 Category: Drugs & Pharmacology Source Type: research
Glucose monitors may misclassify people as being at risk of diabetes
Our blood sugar levels vary a lot from day to day, so results from continuous glucose monitors need to be interpreted with caution (Source: New Scientist - Health)
Source: New Scientist - Health - April 23, 2024 Category: Consumer Health News Source Type: research
Enhancing sweet potato (Ipomoea batatas) resilience grown in cadmium-contaminated saline soil: a synergistic approach using Moringa leaf extract and effective microorganisms application
Environ Sci Pollut Res Int. 2024 Apr 23. doi: 10.1007/s11356-024-33295-w. Online ahead of print.ABSTRACTRaising soil contamination with cadmium (Cd2+) and salinization necessitates the development of green approaches using bio-elicitors to ensure sustainable crop production and mitigate the detrimental health impacts. Two field trials were carried out to study the individual and combined effects of foliage spraying of Moringa leaf extract (MLE) and soil application of effective microorganisms (EMs) on the physio-biochemical, osmolytes, antioxidants, and performance of sweet potato grown in Cd2+-contaminated salty soil (Cd2...
Source: Environmental Science and Pollution Research International - April 23, 2024 Category: Environmental Health Authors: Abdelsattar Abdelkhalik Nasr M Abdou Mohammad A H Gyushi Ahmed Shaaban Shimaa A Abd El-Mageed Khaulood A Hemida Taia A Abd El-Mageed Source Type: research
Temperature influence on the sensitivity of Artemia franciscana to globally used pesticides - Oxyfluorfen and Copper
Chemosphere. 2024 Apr 21:142092. doi: 10.1016/j.chemosphere.2024.142092. Online ahead of print.ABSTRACTClimate change further the world's human population increase is a mainstream political issue, and it's critical to search for solutions to produce enough food to feed everyone. Pesticides and fertilizers have been used as an easy solution to prevent pests and increase food production. Nevertheless, their overuse has dangerous effects on the ecosystems and communities. Oxyfluorfen (Oxy) and copper (Cu) based formulations are used as pesticides and widely applied on agricultural fields for crop protection. However, they hav...
Source: Chemosphere - April 23, 2024 Category: Chemistry Authors: A F Mesquita F J M Gon çalves A M M Gon çalves Source Type: research
Mechano-sensor Piezo1 inhibits glucagon production in pancreatic α-cells
CONCLUSION: Our study uncovers the regulatory role of the Piezo1 ion channel in α cells. Piezo1 influences glucagon production by affecting mTOR signaling pathway.PMID:38653360 | DOI:10.1016/j.bbadis.2024.167185 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Wenying Guo Luyang Gao Haocong Mo Handan Deng Yawen Zhao Geyang Xu Source Type: research
Temperature influence on the sensitivity of Artemia franciscana to globally used pesticides - Oxyfluorfen and Copper
Chemosphere. 2024 Apr 21:142092. doi: 10.1016/j.chemosphere.2024.142092. Online ahead of print.ABSTRACTClimate change further the world's human population increase is a mainstream political issue, and it's critical to search for solutions to produce enough food to feed everyone. Pesticides and fertilizers have been used as an easy solution to prevent pests and increase food production. Nevertheless, their overuse has dangerous effects on the ecosystems and communities. Oxyfluorfen (Oxy) and copper (Cu) based formulations are used as pesticides and widely applied on agricultural fields for crop protection. However, they hav...
Source: Chemosphere - April 23, 2024 Category: Chemistry Authors: A F Mesquita F J M Gon çalves A M M Gon çalves Source Type: research
Impact of Bacillus cereus SPB-10 on Growth Promotion of Wheat (Triticum aestivum L.) Under Arsenic-Contaminated Soil
This study investigates the impact of bacteria on arsenic reduction in wheat plants, highlighting the potential of microbe-based eco-friendly strategies for plant growth. In the present study, bacterial isolate SPB-10 was survived at high concentration against both form of arsenic (As3+ and As5+). SPB-10 produced 5.2 g/L and 11.3 g/L of exo-polysaccharide at 20 ppm of As3+ and As5+, respectively, whereas qualitative examination revealed the highest siderophores ability. Other PGP attributes such as IAA production were recorded 52.12 mg/L and 95.82 mg/L, phosphate solubilization was 90.23 mg/L and 129 mg/L at 20 ppm of As3+...
Source: Current Microbiology - April 23, 2024 Category: Microbiology Authors: Prabhat K Chauhan Himanshu K Pathak Gopal Dubey Hritik Sharma Sudhir K Upadhyay Source Type: research
Temperature influence on the sensitivity of Artemia franciscana to globally used pesticides - Oxyfluorfen and copper
Chemosphere. 2024 Apr 21;357:142092. doi: 10.1016/j.chemosphere.2024.142092. Online ahead of print.ABSTRACTClimate change further the world's human population increase is a mainstream political issue, and it's critical to search for solutions to produce enough food to feed everyone. Pesticides and fertilizers have been used as an easy solution to prevent pests and increase food production. Nevertheless, their overuse has dangerous effects on the ecosystems and communities. Oxyfluorfen (Oxy) and copper (Cu) based formulations are used as pesticides and widely applied on agricultural fields for crop protection. However, they...
Source: Chemosphere - April 23, 2024 Category: Chemistry Authors: A F Mesquita F J M Gon çalves A M M Gon çalves Source Type: research
