Sugar-coated survival: N-glycosylation as a unique bearded dragon venom resistance trait within Australian agamid lizards
This study zeroes in on the particular motifs within the orthosteric sites of post-synaptic nicotinic acetylcholine receptors (nAChR) that confer resistance to α-neurotoxins, often through structural alterations of nAChR. This research examined Australian agamid lizards, a primary prey group for Australian elapid snakes, which are subject to predatory selection pressures. We previously showed that Pogona vitticeps (Central bearded dragon) was resistant to α-neurotoxic snake venoms through a steric hindrance form resistance evolving within the nAChR orthosteric, specifically through the 187-189NVT motif resulting in the p...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 26, 2024 Category: Biochemistry Authors: Uthpala Chandrasekara Marco Mancuso Joanna Sumner Dan Edwards Christina N Zdenek Bryan G Fry Source Type: research
Synthesis of C3- < em > epi < /em > -virenose and anomerically activated derivatives
Tetrahedron Lett. 2024 Apr;140:155041. doi: 10.1016/j.tetlet.2024.155041.ABSTRACTA 9-step synthetic route to a protected form of the C3-epimer of virenose from D-fucose is described. C3-epi-virenose is the carbohydrate unit of the bioactive polyketide elsamicin B and part of the carbohydrate unit of elsamicin A. The developed route enabled preparation of anomerically activated forms of this unique C6-deoxy sugar, including derivatives with 1-acetyl, 1-acetylthio, 1-trichloroacetimidate, 1-bromo, and 1-fluoro substituents.PMID:38665383 | PMC:PMC7615872 | DOI:10.1016/j.tetlet.2024.155041 (Source: Tetrahedron Letters)
Source: Tetrahedron Letters - April 26, 2024 Category: Chemistry Authors: Liesa R öder Sofia Torres Venegas Klaus Wurst Thomas Magauer Source Type: research
Sugar-coated survival: N-glycosylation as a unique bearded dragon venom resistance trait within Australian agamid lizards
This study zeroes in on the particular motifs within the orthosteric sites of post-synaptic nicotinic acetylcholine receptors (nAChR) that confer resistance to α-neurotoxins, often through structural alterations of nAChR. This research examined Australian agamid lizards, a primary prey group for Australian elapid snakes, which are subject to predatory selection pressures. We previously showed that Pogona vitticeps (Central bearded dragon) was resistant to α-neurotoxic snake venoms through a steric hindrance form resistance evolving within the nAChR orthosteric, specifically through the 187-189NVT motif resulting in the p...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 26, 2024 Category: Biochemistry Authors: Uthpala Chandrasekara Marco Mancuso Joanna Sumner Dan Edwards Christina N Zdenek Bryan G Fry Source Type: research
Molecules, Vol. 29, Pages 2011: Objective Quantification Technique and Widely Targeted Metabolomics-Based Analysis of the Effects of Different Saccharidation Processes on Preserved French Plums
This study aimed to investigate the distinctive metabolites in samples from various stages of the processing of preserved French plums. The PCF4 exhibited the highest appearance, overall taste, and chroma. Furthermore, utilizing UPLC and ESI-Q TRAP-MS/MS, a comprehensive examination of the metabolome in the processing of preserved French plums was conducted. A total of 1776 metabolites were analyzed. Using WGCNA, we explored metabolites associated with sensory features through 10 modules. Based on this, building the correlation of modules and objective quantification metrics yielded three key modules. After screening for 1...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Yan Dong Yang Wang Tags: Article Source Type: research
A method for estimating the outer exposure of dairy cows to deoxynivalenol (DON) and zearalenone (ZEN) as a precondition for risk assessment based on inner exposure with toxin residue levels in blood and urine as indicators
AbstractDON and ZEN residues in the blood and urine of dairy cows can be used to predict the outer exposure to DON and ZEN expressed per kilogram diet for a risk evaluation based on comparisons to critical dietary concentrations. This method was used to evaluate the exposure of dairy cows from 12 farms located in Brandenburg, Germany, fed rations with unknown DON and ZEN concentrations (N = 244). The corresponding diet concentrations predicted by different methods from analyzed blood and urine samples varied significantly amongst farms from 0 to 1.6 mg/kg for DON and 0 to 3.0 mg/kg for ZEN at a reference dry matter c...
Source: Mycotoxin Research - April 26, 2024 Category: Toxicology Source Type: research
Structural effects of oxidation on sugars: glucose as a precursor of gluconolactone and glucuronolactone
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Maider Parra-Santamaria, Aran Insausti, Elena R. Alonso, Francisco J. Basterretxea, Emilio J. Cocinero This atomic-resolution study reveals glucose changes due to oxidation, exploring key carbohydrate aspects like hydrogen bonding, ring-puckering, anomeric effect, and tautomeric selection. Results confirm mutarotation suppression in the gas phase. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - April 25, 2024 Category: Chemistry Authors: Maider Parra-Santamaria Source Type: research
Higher Sugar Intake Associated with Higher Risk of Depression
According to this study.PMID:38661707 | DOI:10.1097/01.NAJ.0001016400.61479.0c (Source: The American Journal of Nursing)
Source: The American Journal of Nursing - April 25, 2024 Category: Nursing Authors: Karen Rosenberg Source Type: research
Structural effects of oxidation on sugars: glucose as a precursor of gluconolactone and glucuronolactone
We present an experimental work on the changes in the structure and interactions of two products of glucose oxidation (D-glucono-1,5-lactone (GlcL) and D-glucurono-6,3-lactone (GlcurL)) with respect to their precursor. Features such as intramolecular interactions, ring puckering and tautomerism were observed.PMID:38661549 | DOI:10.1039/d4cc00735b (Source: Chemical Communications)
Source: Chemical Communications - April 25, 2024 Category: Chemistry Authors: Maider Parra-Santamaria Aran Insausti Elena R Alonso Francisco J Basterretxea Emilio J Cocinero Source Type: research
Kids SIPsmartER reduces sugar-sweetened beverages among Appalachian middle-school students and their caregivers: a cluster randomized controlled trial
CONCLUSIONS: Kids SIPsmartER was effective at reducing SSB consumption among students and their caregivers in the rural, medically underserved Appalachian region. Importantly, SSB effects were even stronger among students and caregivers who were high consumers at baseline.TRIAL REGISTRATION: Clincialtrials.gov: NCT03740113. Registered 14 November 2018- Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03740113 .PMID:38664715 | DOI:10.1186/s12966-024-01594-7 (Source: Health Physics)
Source: Health Physics - April 25, 2024 Category: Physics Authors: Jamie M Zoellner Wen You Kathleen Porter Brittany Kirkpatrick Annie Reid Donna Brock Phillip Chow Lee Ritterband Source Type: research
Molecular simulation on the interaction between trehalose and asymmetric lipid bilayer mimicking the membrane of human red blood cells
In this study, we conducted atomistic molecular dynamic simulations on asymmetric model bilayers that mimic the membrane of human red blood cells at various trehalose and water contents. We considered three different hydration levels mimicking the full hydration to desiccation scenarios. Results indicate that the asymmetric distribution of lipids did not significantly influence the computed structural characteristics at full and low hydration. At dehydration, however, the order parameter obtained from the symmetric bilayer is significantly higher compared to those obtained from asymmetric ones. Analysis of hydrogen bonds r...
Source: Cryobiology - April 25, 2024 Category: Biology Authors: Yu Cao Cai Gao Lei Yang Pei Zhou Dongfang Sun Source Type: research
The antiglycation potential of H1 receptor antagonists - in vitro studies in bovine serum albumin model and in silico molecular docking analyses
Biomed Pharmacother. 2024 Apr 24;175:116632. doi: 10.1016/j.biopha.2024.116632. Online ahead of print.ABSTRACTThe H1 receptor belongs to the family of rhodopsin-like G-protein-coupled receptors activated by the biogenic amine histamine. H1 receptor antagonists are widely used in the treatment of allergies. However, these drugs could have a much broader spectrum of activity, including hypoglycemic effects, which can broaden the spectrum of their use. The aim of the study was to evaluate the antiglycation potential of twelve H1 receptor antagonists (diphenhydramine, antazoline, promethazine, ketotifen, clemastine, pheniramin...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 25, 2024 Category: Drugs & Pharmacology Authors: Grzegorz Biedrzycki Blanka Wolszczak-Biedrzycka Justyna Dorf Daniel Michalak Ma łgorzata Żendzian-Piotrowska Anna Zalewska Mateusz Maciejczyk Source Type: research
The effects of Atractylodes macrocephala extract BZEP self-microemulsion based on gut-liver axis HDL/LPS signaling pathway to ameliorate metabolic dysfunction-associated fatty liver disease in rats
CONCLUSION: BZEPWR and BZEP exert restorative and reversal effects on the pathophysiological damage to the gut-liver axis in MAFLD rats, and the therapeutic mechanism may be related to the regulation of the intestinal flora and the HDL/LPS signaling pathway.PMID:38663104 | DOI:10.1016/j.biopha.2024.116519 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 25, 2024 Category: Drugs & Pharmacology Authors: Bo Li Xiao-Feng Jiang Ying-Jie Dong Yi-Piao Zhang Xing-Li-Shang He Cheng-Liang Zhou Yan-Yan Ding Ning Wang Yi-Bin Wang Wan-Qi Cheng Ning-Hua Jiang Jie Su Gui-Yuan Lv Su-Hong Chen Source Type: research
Kids SIPsmartER reduces sugar-sweetened beverages among Appalachian middle-school students and their caregivers: a cluster randomized controlled trial
CONCLUSIONS: Kids SIPsmartER was effective at reducing SSB consumption among students and their caregivers in the rural, medically underserved Appalachian region. Importantly, SSB effects were even stronger among students and caregivers who were high consumers at baseline.TRIAL REGISTRATION: Clincialtrials.gov: NCT03740113. Registered 14 November 2018- Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03740113 .PMID:38664715 | DOI:10.1186/s12966-024-01594-7 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Jamie M Zoellner Wen You Kathleen Porter Brittany Kirkpatrick Annie Reid Donna Brock Phillip Chow Lee Ritterband Source Type: research
Higher Sugar Intake Associated with Higher Risk of Depression
According to this study.PMID:38661707 | DOI:10.1097/01.NAJ.0001016400.61479.0c (Source: The American Journal of Nursing)
Source: The American Journal of Nursing - April 25, 2024 Category: Nursing Authors: Karen Rosenberg Source Type: research
Structural effects of oxidation on sugars: glucose as a precursor of gluconolactone and glucuronolactone
We present an experimental work on the changes in the structure and interactions of two products of glucose oxidation (D-glucono-1,5-lactone (GlcL) and D-glucurono-6,3-lactone (GlcurL)) with respect to their precursor. Features such as intramolecular interactions, ring puckering and tautomerism were observed.PMID:38661549 | DOI:10.1039/d4cc00735b (Source: Chemical Communications)
Source: Chemical Communications - April 25, 2024 Category: Chemistry Authors: Maider Parra-Santamaria Aran Insausti Elena R Alonso Francisco J Basterretxea Emilio J Cocinero Source Type: research
