Molecular simulation on the interaction between trehalose and asymmetric lipid bilayer mimicking the membrane of human red blood cells
In this study, we conducted atomistic molecular dynamic simulations on asymmetric model bilayers that mimic the membrane of human red blood cells at various trehalose and water contents. We considered three different hydration levels mimicking the full hydration to desiccation scenarios. Results indicate that the asymmetric distribution of lipids did not significantly influence the computed structural characteristics at full and low hydration. At dehydration, however, the order parameter obtained from the symmetric bilayer is significantly higher compared to those obtained from asymmetric ones. Analysis of hydrogen bonds r...
Source: Cryobiology - April 25, 2024 Category: Biology Authors: Yu Cao Cai Gao Lei Yang Pei Zhou Dongfang Sun Source Type: research
Higher Sugar Intake Associated with Higher Risk of Depression
According to this study.PMID:38661707 | DOI:10.1097/01.NAJ.0001016400.61479.0c (Source: The American Journal of Nursing)
Source: The American Journal of Nursing - April 25, 2024 Category: Nursing Authors: Karen Rosenberg Source Type: research
Molecular simulation on the interaction between trehalose and asymmetric lipid bilayer mimicking the membrane of human red blood cells
In this study, we conducted atomistic molecular dynamic simulations on asymmetric model bilayers that mimic the membrane of human red blood cells at various trehalose and water contents. We considered three different hydration levels mimicking the full hydration to desiccation scenarios. Results indicate that the asymmetric distribution of lipids did not significantly influence the computed structural characteristics at full and low hydration. At dehydration, however, the order parameter obtained from the symmetric bilayer is significantly higher compared to those obtained from asymmetric ones. Analysis of hydrogen bonds r...
Source: Cryobiology - April 25, 2024 Category: Biology Authors: Yu Cao Cai Gao Lei Yang Pei Zhou Dongfang Sun Source Type: research
Higher Sugar Intake Associated with Higher Risk of Depression
According to this study.PMID:38661707 | DOI:10.1097/01.NAJ.0001016400.61479.0c (Source: The American Journal of Nursing)
Source: The American Journal of Nursing - April 25, 2024 Category: Nursing Authors: Karen Rosenberg Source Type: research
Molecular simulation on the interaction between trehalose and asymmetric lipid bilayer mimicking the membrane of human red blood cells
In this study, we conducted atomistic molecular dynamic simulations on asymmetric model bilayers that mimic the membrane of human red blood cells at various trehalose and water contents. We considered three different hydration levels mimicking the full hydration to desiccation scenarios. Results indicate that the asymmetric distribution of lipids did not significantly influence the computed structural characteristics at full and low hydration. At dehydration, however, the order parameter obtained from the symmetric bilayer is significantly higher compared to those obtained from asymmetric ones. Analysis of hydrogen bonds r...
Source: Cryobiology - April 25, 2024 Category: Biology Authors: Yu Cao Cai Gao Lei Yang Pei Zhou Dongfang Sun Source Type: research
Higher Sugar Intake Associated with Higher Risk of Depression
According to this study.PMID:38661707 | DOI:10.1097/01.NAJ.0001016400.61479.0c (Source: The American Journal of Nursing)
Source: The American Journal of Nursing - April 25, 2024 Category: Nursing Authors: Karen Rosenberg Source Type: research
Molecular simulation on the interaction between trehalose and asymmetric lipid bilayer mimicking the membrane of human red blood cells
In this study, we conducted atomistic molecular dynamic simulations on asymmetric model bilayers that mimic the membrane of human red blood cells at various trehalose and water contents. We considered three different hydration levels mimicking the full hydration to desiccation scenarios. Results indicate that the asymmetric distribution of lipids did not significantly influence the computed structural characteristics at full and low hydration. At dehydration, however, the order parameter obtained from the symmetric bilayer is significantly higher compared to those obtained from asymmetric ones. Analysis of hydrogen bonds r...
Source: Cryobiology - April 25, 2024 Category: Biology Authors: Yu Cao Cai Gao Lei Yang Pei Zhou Dongfang Sun Source Type: research
Higher Sugar Intake Associated with Higher Risk of Depression
According to this study.PMID:38661707 | DOI:10.1097/01.NAJ.0001016400.61479.0c (Source: The American Journal of Nursing)
Source: The American Journal of Nursing - April 25, 2024 Category: Nursing Authors: Karen Rosenberg Source Type: research
Molecular simulation on the interaction between trehalose and asymmetric lipid bilayer mimicking the membrane of human red blood cells
In this study, we conducted atomistic molecular dynamic simulations on asymmetric model bilayers that mimic the membrane of human red blood cells at various trehalose and water contents. We considered three different hydration levels mimicking the full hydration to desiccation scenarios. Results indicate that the asymmetric distribution of lipids did not significantly influence the computed structural characteristics at full and low hydration. At dehydration, however, the order parameter obtained from the symmetric bilayer is significantly higher compared to those obtained from asymmetric ones. Analysis of hydrogen bonds r...
Source: Cryobiology - April 25, 2024 Category: Biology Authors: Yu Cao Cai Gao Lei Yang Pei Zhou Dongfang Sun Source Type: research
Higher Sugar Intake Associated with Higher Risk of Depression
According to this study.PMID:38661707 | DOI:10.1097/01.NAJ.0001016400.61479.0c (Source: The American Journal of Nursing)
Source: The American Journal of Nursing - April 25, 2024 Category: Nursing Authors: Karen Rosenberg Source Type: research
Molecular simulation on the interaction between trehalose and asymmetric lipid bilayer mimicking the membrane of human red blood cells
In this study, we conducted atomistic molecular dynamic simulations on asymmetric model bilayers that mimic the membrane of human red blood cells at various trehalose and water contents. We considered three different hydration levels mimicking the full hydration to desiccation scenarios. Results indicate that the asymmetric distribution of lipids did not significantly influence the computed structural characteristics at full and low hydration. At dehydration, however, the order parameter obtained from the symmetric bilayer is significantly higher compared to those obtained from asymmetric ones. Analysis of hydrogen bonds r...
Source: Cryobiology - April 25, 2024 Category: Biology Authors: Yu Cao Cai Gao Lei Yang Pei Zhou Dongfang Sun Source Type: research
Higher Sugar Intake Associated with Higher Risk of Depression
According to this study.PMID:38661707 | DOI:10.1097/01.NAJ.0001016400.61479.0c (Source: The American Journal of Nursing)
Source: The American Journal of Nursing - April 25, 2024 Category: Nursing Authors: Karen Rosenberg Source Type: research
External validation of the colorectal cancer risk score LiFeCRC using food frequency questions in the HUNT study
ConclusionReadily available clinical variables and food frequency questions in a modified LiFeCRC score can identify patients at risk of CRC and may improve primary prevention by motivating to lifestyle change or participation in the CRC screening programme. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 25, 2024 Category: Gastroenterology Source Type: research
Cancers, Vol. 16, Pages 1664: L-Glyceraldehyde Inhibits Neuroblastoma Cell Growth via a Multi-Modal Mechanism on Metabolism and Signaling
We describe a novel multi-modal mechanism by which the L-isomer of GA (L-GA) inhibits neuroblastoma cell growth. L-GA induces significant changes in the metabolic profile, promotes oxidative stress and hinders nucleotide biosynthesis. GC-MS and 13C-labeling was employed to measure the flow of carbon through glycolytic intermediates under L-GA treatment. It was found that L-GA is a potent inhibitor of glycolysis due to its proposed targeting of NAD(H)-dependent reactions. This results in growth inhibition, apoptosis and a redox crisis in neuroblastoma cells. It was confirmed that the redox mechanisms were modulated via L-GA...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Martin Forbes Richard Kempa Guido Mastrobuoni Liam Rayman Matthias Pietzke Safak Bayram Birte Arlt Annika Spruessel Hedwig E. Deubzer Stefan Kempa Tags: Article Source Type: research
The genotype of barley cultivars influences multiple aspects of their associated microbiota via differential root exudate secretion
by Alba Pacheco-Moreno, Anita Bollmann-Giolai, Govind Chandra, Paul Brett, Jack Davies, Owen Thornton, Philip Poole, Vinoy Ramachandran, James K. M. Brown, Paul Nicholson, Chris Ridout, Sarah DeVos, Jacob G. Malone
Plant-associated microbes play vital roles in promoting plant growth and health, with plants secreting root exudates into the rhizosphere to attract beneficial microbes. Exudate composition defines the nature of microbial recruitment, with different plant species attracting distinct microbiota to enable optimal adaptation to the soil environment. To more closely examine the relationship between plant genotype a...
Source: PLoS Biology: Archived Table of Contents - April 25, 2024 Category: Biology Authors: Alba Pacheco-Moreno Source Type: research
