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Diet modulates the gut microbiome, metabolism, and mammary gland inflammation to influence breast cancer risk
This study suggests that dietary-microbiome interactions are key mediators of breast cancer risk.PMID:38701438 | DOI:10.1158/1940-6207.CAPR-24-0055 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Alana A Arnone Adam S Wilson David R Soto-Pantoja Katherine L Cook Source Type: research

Study of Association of Chromosomal Region 1Q21-23 with Rheumatoid Arthritis and Their Correlation with Severity of Disease
CONCLUSION: Bigger cohort studies will allow better genomic elucidation of clinically defined intermediate phenotypes evaluated in RA patients by virtue of the autoimmune origin of the disease and its diverse symptoms in patients. Genetic-molecular studies can be a milestone for adopting effective personalized treatment for such progressively debilitating diseases. How to cite this article: Gauri LA, Meena MK, Singh U, et al. Study of Association of Chromosomal Region 1Q21-23 with Rheumatoid Arthritis and Their Correlation with Severity of Disease. J Assoc Physicians India 2023;71(9):28-32.PMID:38700298 | DOI:10.59556/japi...
Source: Journal of the Association of Physicians of India - May 3, 2024 Category: General Medicine Authors: Liyakat Ali Gauri Manoj Kumar Meena Ummed Singh Nikita Manoj Nadeem Liyakat Ramratan Yadav Ambreen Liyakat None Nisha Source Type: research

Glycemic Control and Mucormycosis during COVID-19 Pandemic in India a Study of Stage and Outcome
CONCLUSION: The study showed a positive correlation between the stage of mucormycosis and serum glycemic control markers at presentation. Clinicians must order blood sugar and HbA1c levels at presentation as cues for a better understanding of disease severity. A thorough clinical examination and history taking for patient risk factors predisposing to mucormycosis are also crucial since the presence of proptosis and coronary artery disease are significantly correlated with the mortality outcomes. The extent of poor glycemic control at presentation was not associated with mortality outcomes. How to cite this article: Sharma ...
Source: Journal of the Association of Physicians of India - May 3, 2024 Category: General Medicine Authors: Vagisha Sharma Kushal Kriplani Isha P Tuli Shilpam Sharma Anurag Narula Source Type: research

Burn Wound Healing Abilities of a Uronic Acid Containing Exopolysaccharide Produced by the Marine Bacterium Halomonas malpeensis YU-PRIM-29( T)
In this study, a bacterial EPS (EPS-H29) from the marine bacterium Halomonas malpeensis YU-PRIM-29 T was used to treat the burn wound in vivo. The biochemical and structural characterizations of EPS-H29 were carried out using standard methods. In addition, FE-SEM, conformational, rheological, and HP-GPC analyses were carried out. In vitro biocompatibility of EPS-H29 was studied in human dermal fibroblasts (HDFs) and keratinocytes (HaCaT). Scratch assay was used to study the wound healing in vitro. For in vivo evaluation, burn wound (second-degree) was created on Wistar albino rats and treated with EPS-H29 along with approp...
Source: Primary Care - May 3, 2024 Category: Primary Care Authors: Athmika Nagaraj Yuvarajan Subramaniyan Suprith Surya Punchappady Devasya Rekha Source Type: research

Did a workplace sugar-sweetened beverage sales ban reduce anxiety-related SSB consumption during the COVID-19 pandemic?
CONCLUSIONS: SSB sales bans likely reduce SSB consumption through multiple pathways; buffering stress-related consumption may be one mechanism.PMID:38698591 | DOI:10.1017/S1368980024000995 (Source: Public Health Nutrition)
Source: Public Health Nutrition - May 3, 2024 Category: International Medicine & Public Health Authors: Laurie M Jacobs Laura A Schmidt Dean Schillinger Jamey M Schmidt Katie E Alegria Bethany Parrett Amanda Pickett Elissa S Epel Source Type: research

Burn Wound Healing Abilities of a Uronic Acid Containing Exopolysaccharide Produced by the Marine Bacterium Halomonas malpeensis YU-PRIM-29 T 
In this study, a bacterial EPS (EPS-H29) from the marine bacterium Halomonas malpeensis YU-PRIM-29 T was used to treat the burn wound in vivo. The biochemical and structural characterizations of EPS-H29 were carried out using standard methods. In addition, FE-SEM, conformational, rheological, and HP-GPC analyses were carried out. In vitro biocompatibility of EPS-H29 was studied in human dermal fibroblasts (HDFs) and keratinocytes (HaCaT). Scratch assay was used to study the wound healing in vitro. For in vivo evaluation, burn wound (second-degree) was created on Wistar albino rats and treated with EPS-H29 along with approp...
Source: Applied Biochemistry and Biotechnology - May 3, 2024 Category: Biochemistry Authors: Athmika Nagaraj Yuvarajan Subramaniyan Suprith Surya Punchappady Devasya Rekha Source Type: research

Isolation of four new monoterpenes from Ailanthus altissima (mill.) Swingle and their enzyme inhibitory effects
Fitoterapia. 2024 May 1:105984. doi: 10.1016/j.fitote.2024.105984. Online ahead of print.ABSTRACTA phytochemical study of the ethanol extract from Ailanthus altissima (Mill.) Swingle leaves resulted in the isolation of four new monoterpenoids (1-3, 5). The structures were elucidated using HRESIMS data, NMR spectroscopic data, quantum chemical calculations for NMR and ECD, and custom DP4+ probability analysis. Additionally, the absolute configuration of sugar was determined by acid hydrolysis. Compounds 1-4 are cyclogeraniane monocyclic monoterpenes, while compound 5 contains an acyclic mycrane monoterpenes skeleton. Anti-t...
Source: Fitoterapia - May 3, 2024 Category: Biochemistry Authors: Qi Song Zhi-Kang Duan Ya-Nuo Tan Zhi-Heng Gao Dai Liu Jin-Le Hao Bin Lin Xiao-Xiao Huang Shao-Jiang Song Source Type: research

Transcriptome analysis of apical meristem enriched bud samples for size dependent flowering commitment in Crocus sativus reveal role of sugar and auxin signalling
CONCLUSION: Transcripts belong to key pathways including phenylpropanoid biosynthesis, hormone signaling and carbon metabolism were found significantly modulated. KEGG assessment and protein-protein interaction analysis confirm the expression data. Findings unravel the genetic determinants driving the size dependent flowering in Crocus sativus.PMID:38700570 | DOI:10.1007/s11033-024-09574-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - May 3, 2024 Category: Molecular Biology Authors: Anjali Chaudhary Kunal Singh Source Type: research

Cofactor engineering in thermoanaerobacterium aotearoense SCUT27 for maximizing ethanol yield and revealing an enzyme complex with high ferredoxin-NAD + reductase activity
Bioresour Technol. 2024 May 1:130784. doi: 10.1016/j.biortech.2024.130784. Online ahead of print.ABSTRACTThermoanaerobacterium aotearoense SCUT27 is a prominent producer of biofuels from lignocellulosic materials. To provide sufficient NAD(P)H for ethanol production, redox-related genes, including lactate dehydrogenase (ldh), redox-sensing transcriptional repressor (rex), and hydrogenase (hfsB), were knocked out. However, the growth of strain PRH (Δldh/Δrex/ΔhfsB) was suppressed due to the intracellular redox state imbalance with the increased NADH concentration. Coincidentally, when the Bcd-EtfAB (BCD) complex was over...
Source: Bioresource Technology - May 3, 2024 Category: Biotechnology Authors: Kaiqun Dai Chunyun Qu Xin Li Yang Lan Hongxin Fu Jufang Wang Source Type: research

Production of levulinic acid from macroalgae by hydrothermal conversion with ionic resin catalyst
This study focuses on the production of levulinic acid from G. verrucosa using hydrothermal conversion with an ionic resin Purolite CT269DR as the catalyst. By optimization of the conversion condition, a 30.3 % (22.58 g/L) yield of levulinic acid (LA) (based on carbohydrate content) was obtained at 200 °C for 90 min with 12.5 % biomass and 50 % catalyst loading of biomass quantity. Simultaneously, formic acid yielded 14.0 % (10.42 g/L). The LA yield increased with increasing combined severity (CS) levels under tested ranges. Furthermore, the relationship between CS and LA synthesis was effectively fitted to the nonlinear ...
Source: Bioresource Technology - May 3, 2024 Category: Biotechnology Authors: Youngshin Park Gwi-Taek Jeong Source Type: research

Agricultural Waste Management by Production of Second-Generation Bioethanol from Sugarcane Bagasse Using Indigenous Yeast Strain
This study optimizes both fermentation process and pretreatment of sugarcane bagasse to maximize bioethanol yield and demonstrates the ability of isolated strain to effectively utilize xylose as a carbon source. The desirable characteristics depicted by strain Clavispora lusitaniae shows its promising utilization in management of industrial waste like sugarcane bagasse by its conversion into renewable biofuels like bioethanol.PMID:38700667 | DOI:10.1007/s00284-024-03668-y (Source: Current Microbiology)
Source: Current Microbiology - May 3, 2024 Category: Microbiology Authors: Sidra Ali Qurrat Ul Ain Rana Fatima Riaz Abdul Haq Wasim Sajjad Rahul Gauttam Mahwish Ali Malik Badshah Source Type: research

Effects of different light conditions on morphological, anatomical, photosynthetic and biochemical parameters of Cypripedium macranthos Sw
In this study, the morphological (plant height, leaf length and width, stem diameter and leaf number), anatomical (epidermal cell density and thickness, Stomatal length and width), photosynthetic (net photosynthetic rate, transpiration rate, stomatal conductance, intercellular CO2 concentration, relative humidity, leaf temperature and chlorophyll fluorescence parameters) and biochemical parameters (the content of soluble sugar, soluble protein, proline, malondialdehyde and electrical conductivity) of Cypripedium macranthos Sw. in Changbai Mountain were determined under different light conditions (L10, L30, L50, L100). The ...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Yuqing Zhang Wei Liu Xi Lu Shuang Li Ying Li Yuze Shan Shizhuo Wang Yunwei Zhou Lifei Chen Source Type: research

Synthesis, conformational analysis and antimicrobial activity of 10-benzyl-1,2,4-triazolo[4,3- b ]1,2,4-triazino[5,6- b ]indole acyclo C -nucleoside analogs
Nucleosides Nucleotides Nucleic Acids. 2024 May 2:1-23. doi: 10.1080/15257770.2024.2348741. Online ahead of print.ABSTRACTCondensation of 5-benzyl-3-hydrazino-1,2,4-triazino[5,6-b]indole with various sugar aldoses or ketoses gave the corresponding sugar hydrazones as single geometrical isomer or exist in E/Z tautomeric isomers. The hydrazones underwent heterocyclization with Fe(Ш)Cl3 to give the N2-adduct acyclo C-nucleosides: 3-(alditol-1yl)-10-benzyl-1,2,4-triazolo[4,3-b]1,2,4-triazino[5,6-b]indoles rather than the N4-adduct: 10-(alditol-1-yl)-3-benzyl-1,2,4-triazolo[3,4-c]1,2,4-triazino[5,6-b] indoles on the basis of c...
Source: Nucleosides, Nucleotides and Nucleic Acids - May 3, 2024 Category: Biochemistry Authors: Adel Z Nasr Reda M Keshk El-Sayed M Abdelrehim Asmaa S Sallam Source Type: research