Molecules, Vol. 29, Pages 2062: Shoots and Turions of Aquatic Plants as a Source of Fatty Acids
Conclusions: The turions of Utricularia species can be used to obtain oil with unsaturated fatty acids. In addition, the high fatty acid content of turions may explain their ability to survive at low temperatures. (Source: Molecules)
Source: Molecules - April 29, 2024 Category: Chemistry Authors: Maciej Strzemski Lubomir Adamec S ławomir Dresler Barbara Mazurek Katarzyna Dubaj Piotr Stolarczyk Marcin Feldo Bartosz J. P łachno Tags: Communication Source Type: research
Antineoplastic therapy is an independent risk factor for dental caries in childhood cancer patients: a retrospective cohort study
ConclusionChildhood cancer (CC) patients undergoing antineoplastic therapy (AT) exhibit a higher prevalence of dental caries, regardless of income/education, frequency of sugar intake, stimulated salivary flow rate, and microbiota. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 29, 2024 Category: Cancer & Oncology Source Type: research
Sustainable media feedstocks for cellular agriculture
Biotechnol Adv. 2024 Apr 26:108367. doi: 10.1016/j.biotechadv.2024.108367. Online ahead of print.ABSTRACTThe global food system is shifting towards cellular agriculture, a second domestication marked by cultivating microorganisms and tissues for sustainable food production. This involves tissue engineering, precision fermentation, and microbial biomass fermentation to establish food value chains independent of traditional agriculture. However, these techniques rely on growth media sourced from agricultural, chemical (fossil fuels), and mining supply chains, raising concerns about land use competition, emissions, and resour...
Source: Biotechnology Advances - April 28, 2024 Category: Biotechnology Authors: Lutz Grossmann Source Type: research
Trehalose enhanced cold atmospheric plasma-mediated cancer treatment
Biomaterials. 2024 Apr 18;309:122582. doi: 10.1016/j.biomaterials.2024.122582. Online ahead of print.ABSTRACTCold atmospheric plasma (CAP) is a unique form of physical plasma that has shown great potential for cancer therapy. CAP uses ionized gas to induce lethal oxidative stress on cancer cells; however, the efficacy of CAP therapy continues to be improved. Here, we report an injectable hydrogel-mediated approach to enhance the anti-tumor efficacy of CAP by regulating the phosphorylation of eIF2α. We discovered that reactive oxygen and nitrogen species (ROS/RNS), two main anti-tumor components in CAP, can lead to lethal ...
Source: Biomaterials - April 28, 2024 Category: Materials Science Authors: Xiaona Cao Tianxu Fang Mo Chen Tianqin Ning Jianyu Li Peter M Siegel Morag Park Zhitong Chen Guojun Chen Source Type: research
A shift to a standard diet after exposure to a high-fat, high-sucrose diet from gestation to weaning restores brain metabolism and behavioral flexibility in adult rats
In conclusion, switching from an HFS diet to a balanced diet after weaning would have beneficial effects on behavioral flexibility and brain metabolism, without significant sex differences.PMID:38679144 | DOI:10.1016/j.bbr.2024.115020 (Source: Brain Research)
Source: Brain Research - April 28, 2024 Category: Neurology Authors: Sa úl Sal-Sarria Isabel L ópez-Taboada H éctor González-Pardo N élida M Conejo Source Type: research
A shift to a standard diet after exposure to a high-fat, high-sucrose diet from gestation to weaning restores brain metabolism and behavioral flexibility in adult rats
In conclusion, switching from an HFS diet to a balanced diet after weaning would have beneficial effects on behavioral flexibility and brain metabolism, without significant sex differences.PMID:38679144 | DOI:10.1016/j.bbr.2024.115020 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 28, 2024 Category: Neurology Authors: Sa úl Sal-Sarria Isabel L ópez-Taboada H éctor González-Pardo N élida M Conejo Source Type: research
A systematic review on garbage enzymes and their applications in environmental processes
Ecotoxicol Environ Saf. 2024 Apr 27;277:116369. doi: 10.1016/j.ecoenv.2024.116369. Online ahead of print.ABSTRACTUnderstanding the new insight on conversion of organic waste into value-added products can improve the environmental activities driven by microorganisms and return the nutrients to environment and earth. Here, we comprehensively review the available knowledge on application of garbage enzyme (GE) for different environmental activities including waste activated sludge, composting process, landfill leachate treatment, soil remediation and wastewater treatment with special focus on their efficiency. To identify pee...
Source: Ecotoxicology and Environmental Safety - April 28, 2024 Category: Environmental Health Authors: Hasan Pasalari Arash Moosavi Majid Kermani Roya Sharifi Mahdi Farzadkia Source Type: research
Sustainable media feedstocks for cellular agriculture
Biotechnol Adv. 2024 Apr 26:108367. doi: 10.1016/j.biotechadv.2024.108367. Online ahead of print.ABSTRACTThe global food system is shifting towards cellular agriculture, a second domestication marked by cultivating microorganisms and tissues for sustainable food production. This involves tissue engineering, precision fermentation, and microbial biomass fermentation to establish food value chains independent of traditional agriculture. However, these techniques rely on growth media sourced from agricultural, chemical (fossil fuels), and mining supply chains, raising concerns about land use competition, emissions, and resour...
Source: Biotechnology Advances - April 28, 2024 Category: Biotechnology Authors: Lutz Grossmann Source Type: research
Trehalose enhanced cold atmospheric plasma-mediated cancer treatment
Biomaterials. 2024 Apr 18;309:122582. doi: 10.1016/j.biomaterials.2024.122582. Online ahead of print.ABSTRACTCold atmospheric plasma (CAP) is a unique form of physical plasma that has shown great potential for cancer therapy. CAP uses ionized gas to induce lethal oxidative stress on cancer cells; however, the efficacy of CAP therapy continues to be improved. Here, we report an injectable hydrogel-mediated approach to enhance the anti-tumor efficacy of CAP by regulating the phosphorylation of eIF2α. We discovered that reactive oxygen and nitrogen species (ROS/RNS), two main anti-tumor components in CAP, can lead to lethal ...
Source: Biomaterials - April 28, 2024 Category: Materials Science Authors: Xiaona Cao Tianxu Fang Mo Chen Tianqin Ning Jianyu Li Peter M Siegel Morag Park Zhitong Chen Guojun Chen Source Type: research
A shift to a standard diet after exposure to a high-fat, high-sucrose diet from gestation to weaning restores brain metabolism and behavioral flexibility in adult rats
In conclusion, switching from an HFS diet to a balanced diet after weaning would have beneficial effects on behavioral flexibility and brain metabolism, without significant sex differences.PMID:38679144 | DOI:10.1016/j.bbr.2024.115020 (Source: Brain Research)
Source: Brain Research - April 28, 2024 Category: Neurology Authors: Sa úl Sal-Sarria Isabel L ópez-Taboada H éctor González-Pardo N élida M Conejo Source Type: research
A shift to a standard diet after exposure to a high-fat, high-sucrose diet from gestation to weaning restores brain metabolism and behavioral flexibility in adult rats
In conclusion, switching from an HFS diet to a balanced diet after weaning would have beneficial effects on behavioral flexibility and brain metabolism, without significant sex differences.PMID:38679144 | DOI:10.1016/j.bbr.2024.115020 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 28, 2024 Category: Neurology Authors: Sa úl Sal-Sarria Isabel L ópez-Taboada H éctor González-Pardo N élida M Conejo Source Type: research
A systematic review on garbage enzymes and their applications in environmental processes
Ecotoxicol Environ Saf. 2024 Apr 27;277:116369. doi: 10.1016/j.ecoenv.2024.116369. Online ahead of print.ABSTRACTUnderstanding the new insight on conversion of organic waste into value-added products can improve the environmental activities driven by microorganisms and return the nutrients to environment and earth. Here, we comprehensively review the available knowledge on application of garbage enzyme (GE) for different environmental activities including waste activated sludge, composting process, landfill leachate treatment, soil remediation and wastewater treatment with special focus on their efficiency. To identify pee...
Source: Ecotoxicology and Environmental Safety - April 28, 2024 Category: Environmental Health Authors: Hasan Pasalari Arash Moosavi Majid Kermani Roya Sharifi Mahdi Farzadkia Source Type: research
Trehalose enhanced cold atmospheric plasma-mediated cancer treatment
Biomaterials. 2024 Apr 18;309:122582. doi: 10.1016/j.biomaterials.2024.122582. Online ahead of print.ABSTRACTCold atmospheric plasma (CAP) is a unique form of physical plasma that has shown great potential for cancer therapy. CAP uses ionized gas to induce lethal oxidative stress on cancer cells; however, the efficacy of CAP therapy continues to be improved. Here, we report an injectable hydrogel-mediated approach to enhance the anti-tumor efficacy of CAP by regulating the phosphorylation of eIF2α. We discovered that reactive oxygen and nitrogen species (ROS/RNS), two main anti-tumor components in CAP, can lead to lethal ...
Source: Biomaterials - April 28, 2024 Category: Materials Science Authors: Xiaona Cao Tianxu Fang Mo Chen Tianqin Ning Jianyu Li Peter M Siegel Morag Park Zhitong Chen Guojun Chen Source Type: research
A systematic review on garbage enzymes and their applications in environmental processes
Ecotoxicol Environ Saf. 2024 Apr 27;277:116369. doi: 10.1016/j.ecoenv.2024.116369. Online ahead of print.ABSTRACTUnderstanding the new insight on conversion of organic waste into value-added products can improve the environmental activities driven by microorganisms and return the nutrients to environment and earth. Here, we comprehensively review the available knowledge on application of garbage enzyme (GE) for different environmental activities including waste activated sludge, composting process, landfill leachate treatment, soil remediation and wastewater treatment with special focus on their efficiency. To identify pee...
Source: Ecotoxicology and Environmental Safety - April 28, 2024 Category: Environmental Health Authors: Hasan Pasalari Arash Moosavi Majid Kermani Roya Sharifi Mahdi Farzadkia Source Type: research
Molecules, Vol. 29, Pages 2029: Exploring the Key Amino Acid Residues Surrounding the Active Center of Lactate Dehydrogenase A for the Development of Ideal Inhibitors
jun Zhang
Lactate dehydrogenase A (LDHA) primarily catalyzes the conversion between lactic acid and pyruvate, serving as a key enzyme in the aerobic glycolysis pathway of sugar in tumor cells. LDHA plays a crucial role in the occurrence, development, progression, invasion, metastasis, angiogenesis, and immune escape of tumors. Consequently, LDHA not only serves as a biomarker for tumor diagnosis and prognosis but also represents an ideal target for tumor therapy. Although LDHA inhibitors show great therapeutic potential, their development has proven to be challenging. In the development of LDHA inhibitors, the key acti...
Source: Molecules - April 28, 2024 Category: Chemistry Authors: Jie Chen Chen Chen Zhengfu Zhang Fancai Zeng Shujun Zhang Tags: Article Source Type: research
