Hypotensive drugs mitigate the high-sodium diet-induced pro-inflammatory activation of mouse macrophages in vivo
Biomed Pharmacother. 2024 Apr 26;175:116648. doi: 10.1016/j.biopha.2024.116648. Online ahead of print.ABSTRACTNowadays, there is an increasing emphasis on the need to alleviate the chronic inflammatory response to effectively treat hypertension. However, there are still gaps in our understanding on how to achieve this. Therefore, research on interaction of antihypertensive drugs with the immune system is extremely interesting, since their therapeutic effect could partly result from amelioration of hypertension-related inflammation, in which macrophages seem to play a pivotal role. Thus, current comprehensive studies have i...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 27, 2024 Category: Drugs & Pharmacology Authors: Martyna Cie ślik Spencer D Strobel Pawe ł Bryniarski Hanna Twardowska Adam Chmielowski Micha ł Rudek Dominik Felkle Katarzyna Zi ęba Konrad Kaleta Mateusz Jarczy ński Bernadeta Nowak Krzysztof Bryniarski Katarzyna Nazimek Source Type: research
Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in Dextran Sulfate Sodium-Induced Murine Model of Ulcerative Colitis
Medicina (Kaunas). 2024 Mar 26;60(4):539. doi: 10.3390/medicina60040539.ABSTRACTOxidative stress is implicated in the pathogenesis of various acute disorders including ischemia/reperfusion injury, ultraviolet/radiation burn, as well as chronic disorders such as dyslipidemia, atherosclerosis, diabetes mellitus, chronic renal disease, and inflammatory bowel disease (IBD). However, the precise mechanism involved remains to be clarified. We formerly identified a novel apoptosis-inducing humoral protein, in a hypoxia/reoxygenation-conditioned medium of cardiac myocytes, which proved to be 69th tyrosine-sulfated eukaryotic trans...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Akihito Nakajima Tomoyoshi Shibuya Takako Yao Tsutomu Fujimura Kimie Murayama Ko Okumura Akihito Nagahara Yoshinori Seko Source Type: research
Peripheral inflammation triggering central anxiety through the hippocampal glutamate metabolized receptor 1
CONCLUSION: Our work suggests that the hippocampus plays an important role in brain anxiety caused by peripheral inflammation, and over-excitation of hippocampal glutamate synapses by GRM1 activation induces anxiety-like behavior in colitis mice. These findings provide new insights into the central mechanisms underlying anxiety in UC and may contribute to the development of novel therapeutic strategies for UC-associated anxiety.PMID:38676295 | PMC:PMC11053250 | DOI:10.1111/cns.14723 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 27, 2024 Category: Neuroscience Authors: Jun-Meng Wang Yue-Mei Wang Yuan-Bing Zhu Chan Cui Tong Feng Qin Huang Shu-Qing Liu Qiao-Feng Wu Source Type: research
Combined effect of grooves and nanoflower structured Co < sub > 3 < /sub > O < sub > 4 < /sub > coating on bamboo wood for highly efficient solar steam generation at indoor and outdoor conditions
Environ Sci Pollut Res Int. 2024 Apr 27. doi: 10.1007/s11356-024-33420-9. Online ahead of print.ABSTRACTCurrently, interfacial solar steam generation (ISSG) in desalinating water has become very popular for obtaining purified water from polluted water. However, finding an efficient evaporator with low cost is a challenging task for researchers. In this work, we introduce natural bamboo wood (BW) that acts as an interfacial evaporator for obtaining purified water. Four different wood evaporators namely, flat wood (BW-FW), two-cut grooved wood (BW-2G), four-cut grooved wood (BW-4G), and four-cut grooved with Co3O4-coated woo...
Source: Environmental Science and Pollution Research International - April 27, 2024 Category: Environmental Health Authors: Marimuthu Rengasamy Arulmurugan Gnanasekaran Nandhakumar Eswaramoorthy Indhumathy Basker Kamatchi Rajaram Source Type: research
Sediment microbial fuel cell coupled floating treatment wetland for enhancing non-reactive phosphorus removal
This study presents the first investigation on the removal performance and mechanism of three model NRP compounds, sodium tripolyphosphate (STPP), adenosine 5'-monophosphate (AMP) and 2-phosphonobutane-1,2,4-tricarboxylic acid (PBTC), in the sediment microbial fuel cell-floating treatment wetland (SMFC-FTW). Coupling SMFC with plants proved to be effective at removing NRP via electrochemical oxidation and plant uptake, particularly the challenging-to-degrade phosphonates that contain C-P bonds. Compared with the control group, the removal efficiencies of the model NRP in SMFC were observed to increase by 11.9% to 20.8%. SM...
Source: Chemosphere - April 27, 2024 Category: Chemistry Authors: Shuting Shen Longxiao Xie Rui Wan Xiang Li Xiwu Lu Hongliang Dai Source Type: research
Decellularized periosteum and sodium alginate-based photoresponsive dressing with copper selenide nanoparticles for infected-wound healing in diabetic mice
Int J Biol Macromol. 2024 Apr 25:131895. doi: 10.1016/j.ijbiomac.2024.131895. Online ahead of print.ABSTRACTDiabetes-related skin ulcers are of significant clinical concern. Although conventional dressings have been developed, their outcomes have not been adequate, indicating the need to investigate functional dressings for the treatment of diabetic ulcers. Copper selenide nanoparticles (Cu2Se NPs) demonstrate outstanding photoresponsiveness, which is critical to the healing process. However, their limited solubility in water restricts their application. To synthesize the ODT-PMMA@Cu2Se NP-doped decellularized periosteum...
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Zhiwen Su Yan Chen Haifeng Liang Zhongxun Liu Deguang Wu Jian Li Hao Su Yiran Yan Zhi Huang Bo Yu Source Type: research
Chronic Exposure to Arsenic and Fluoride Starting at Gestation Alters Liver Mitochondrial Protein Expression and Induces Early Onset of Liver Fibrosis in Male Mouse Offspring
Biol Trace Elem Res. 2024 Apr 27. doi: 10.1007/s12011-024-04198-1. Online ahead of print.ABSTRACTThe presence of arsenic (As) and fluoride (F-) in drinking water is of concern due to the enormous number of individuals exposed to this condition worldwide. Studies in cultured cells and animal models have shown that As- or F-induced hepatotoxicity is primarily associated with redox disturbance and altered mitochondrial homeostasis. To explore the hepatotoxic effects of chronic combined exposure to As and F- in drinking water, pregnant CD-1 mice were exposed to 2 mg/L As (sodium arsenite) and/or 25 mg/L F- (sodium fluoride). T...
Source: Biological Trace Element Research - April 27, 2024 Category: Biology Authors: Wendy L Gonz ález-Alfonso Pavel Petrosyan Luz M Del Razo Luz C S ánchez-Peña Miguel Tapia-Rodr íguez Rolando Hern ández-Muñoz Mar ía E Gonsebatt Source Type: research
Sediment microbial fuel cell coupled floating treatment wetland for enhancing non-reactive phosphorus removal
This study presents the first investigation on the removal performance and mechanism of three model NRP compounds, sodium tripolyphosphate (STPP), adenosine 5'-monophosphate (AMP) and 2-phosphonobutane-1,2,4-tricarboxylic acid (PBTC), in the sediment microbial fuel cell-floating treatment wetland (SMFC-FTW). Coupling SMFC with plants proved to be effective at removing NRP via electrochemical oxidation and plant uptake, particularly the challenging-to-degrade phosphonates that contain C-P bonds. Compared with the control group, the removal efficiencies of the model NRP in SMFC were observed to increase by 11.9% to 20.8%. SM...
Source: Chemosphere - April 27, 2024 Category: Chemistry Authors: Shuting Shen Longxiao Xie Rui Wan Xiang Li Xiwu Lu Hongliang Dai Source Type: research
Synthesis, Molecular Docking Studies and Biological Evaluation of Thiazolyl Hydrazone Derivatives of Chromone-3-carbaldehyde as Potent Anti-Oxidant and Anti-Inflammatory Agents
CONCLUSION: Thus, these compounds represent an attractive template for the evaluation of new antiinflammatory and antioxidant agents and might be useful for exploring new therapeutic tools.PMID:38676527 | DOI:10.2174/0115734064293848240408085039 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Rakhi Gawali Raghunath Bhosale Rohit Bavi Shravan Jadhav Nargisbano Peerzade Source Type: research
Tracking the therapeutic efficacy of a ketone mono ester and β-hydroxybutyrate for ulcerative colitis in rats: New perspectives
This study found that while both exogenous β-hydroxybutyrate and BD-AcAc 2 produced the same levels of plasma β-hydroxybutyrate, BD-AcAc 2 demonstrated superior effectiveness in mitigating dextran sodium sulfate-induced UC in rats. The mechanism of action involves modulating the NF-κB signaling, inhibiting the NLRP3 inflammasome, regulating antioxidant capacity, controlling tight junction protein expression and a potential to inhibit apoptosis and pyroptosis. Certainly, BD-AcAc 2's anti-inflammatory effects require more than just increasing plasma β-hydroxybutyrate levels and other factors contribute to its efficacy. L...
Source: Toxicology and Applied Pharmacology - April 27, 2024 Category: Toxicology Authors: Osama A Mohammed Sameh Saber Mustafa Ahmed Abdel-Reheim Mohannad Mohammad S Alamri Jaber Alfaifi Masoud I E Adam Muffarah Hamid Alharthi Ali M S Eleragi Hanan B Eltahir Mohamed Osama Abdalla Emad Bahashwan Elwathiq Khalid Ibrahim Assad Ali Rezigalla Sameh Source Type: research
Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in Dextran Sulfate Sodium-Induced Murine Model of Ulcerative Colitis
Medicina (Kaunas). 2024 Mar 26;60(4):539. doi: 10.3390/medicina60040539.ABSTRACTOxidative stress is implicated in the pathogenesis of various acute disorders including ischemia/reperfusion injury, ultraviolet/radiation burn, as well as chronic disorders such as dyslipidemia, atherosclerosis, diabetes mellitus, chronic renal disease, and inflammatory bowel disease (IBD). However, the precise mechanism involved remains to be clarified. We formerly identified a novel apoptosis-inducing humoral protein, in a hypoxia/reoxygenation-conditioned medium of cardiac myocytes, which proved to be 69th tyrosine-sulfated eukaryotic trans...
Source: Atherosclerosis - April 27, 2024 Category: Cardiology Authors: Akihito Nakajima Tomoyoshi Shibuya Takako Yao Tsutomu Fujimura Kimie Murayama Ko Okumura Akihito Nagahara Yoshinori Seko Source Type: research
Antitumor Effect and Gut Microbiota Modulation by Quercetin, Luteolin, and Xanthohumol in a Rat Model for Colorectal Cancer Prevention
In this study, we have tested the flavonoids quercetin, luteolin, and xanthohumol as potential antitumor agents in an animal model of colorectal cancer induced by azoxymethane and dodecyl sodium sulphate. Forty rats were divided into four cohorts: Cohort 1 (control cohort), Cohort 2 (quercetin cohort), Cohort 3 (luteolin cohort), and Cohort 4 (xanthohumol cohort). These flavonoids were administered intraperitoneally to evaluate their antitumor potential as pharmaceutical agents. At the end of the experiment, after euthanasia, different physical parameters and the intestinal microbiota populations were analyzed. Luteolin wa...
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Álvaro Pérez-Valero Patricia Magad án-Corpas Suhui Ye Juan Serna-Diestro Sandra Sordon Ewa Huszcza Jaros ław Popłoński Claudio J Villar Felipe Lomb ó Source Type: research
Peripheral inflammation triggering central anxiety through the hippocampal glutamate metabolized receptor 1
CONCLUSION: Our work suggests that the hippocampus plays an important role in brain anxiety caused by peripheral inflammation, and over-excitation of hippocampal glutamate synapses by GRM1 activation induces anxiety-like behavior in colitis mice. These findings provide new insights into the central mechanisms underlying anxiety in UC and may contribute to the development of novel therapeutic strategies for UC-associated anxiety.PMID:38676295 | DOI:10.1111/cns.14723 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 27, 2024 Category: Neuroscience Authors: Jun-Meng Wang Yue-Mei Wang Yuan-Bing Zhu Chan Cui Tong Feng Qin Huang Shu-Qing Liu Qiao-Feng Wu Source Type: research
Ketone body levels and its associations with cardiac markers following an acute myocardial infarction: a post hoc analysis of the EMMY trial
Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have been suggested to exert cardioprotective effects in patients with heart failure, possibly by improving the metabolism of ketone bodies in the myocardium. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 27, 2024 Category: Cardiology Authors: Faisal Aziz, Norbert J. Tripolt, Peter N. Pferschy, Hubert Scharnagl, Mahmoud Abdellatif, Abderrahim Oulhaj, Martin Benedikt, Ewald Kolesnik, Dirk von Lewinski and Harald Sourij Tags: Research Source Type: research
Echocardiographic assessment of cardiovascular involvements in children with cystic fibrosis
Cystic fibrosis (CF) is a fatal disease in which the cystic fibrosis transmembrane conductance regulator (CTFR) gene is mutated, resulting in defect in CFTR protein dependent sodium and chloride transport activity. It has been proved that Dysfunction of CFTR leads to imbalance in regulating the conduction of sodium and chloride ions in epithelial cell membranes and increased mucosal viscosity, which eventually leads to a variety of abnormalities such as pulmonary infection and gastrointestinal involvement [1,2]. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 27, 2024 Category: Respiratory Medicine Authors: Hosseinali Ghaffaripour, Ali Reza Norouzi, Maryam Hassanzad, Fariba Alaei, Mohammad Reza Khalilian, Hojjat Derakhshanfar, Nasrin Elahi Mehr Tags: Original Article Source Type: research
