Zinc Suppresses Colorectal Cancer Development through Cell-mediated Immunity
Yakugaku Zasshi. 2024;144(5):475-481. doi: 10.1248/yakushi.23-00154-1.ABSTRACTZinc is one of the essential trace elements, and is involved in various functions in the body. Zinc deficiency is known to cause immune abnormalities, but the mechanism is not fully understood. Therefore, we focused our research on tumor immunity to elucidate the effect of zinc on colorectal cancer and its mechanisms. Mice were treated with azoxymethane (AOM) and dextran sodium sulfate (DSS) to develop colorectal cancer, then the relationship between zinc content in the diet and the number and area of tumors in the colon was observed. The number ...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Keigo Nishida Naoya Nakagawa Source Type: research
Cardioprotective Potential of Sodium-Glucose Co-Transporter-2 Inhibitors in Cancer Patients Treated With Anthracyclines: An Observational Study
In conclusion, amidst cancer patients receiving anthracycline therapy without preexisting HF, SGLT2i use demonstrates both safety and effectiveness in reducing anthracycline-induced cardiotoxicity, with a decreased incidence of new-onset HF, HF exacerbation, and arrhythmias.PMID:38692401 | DOI:10.1016/j.amjcard.2024.04.032 (Source: Cancer Control)
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Ayman R Fath Mostafa Aglan Amro Aglan Robert J Chilton Anatole Trakhtenbroit Odaye A Al-Shammary Oduro Oppong-Nkrumah Daniel J Lenihan Susan F Dent Prince Otchere Source Type: research
Ertugliflozin for Functional Mitral Regurgitation Associated With Heart Failure: EFFORT Trial
CONCLUSIONS: Among patients with functional MR associated with HF, ertugliflozin significantly improved LV global longitudinal strain and left atrial remodeling, and reduced functional MR. Sodium-glucose cotransporter 2 inhibitors may be considered for patients with functional MR.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04231331.PMID:38690659 | DOI:10.1161/CIRCULATIONAHA.124.069144 (Source: Circulation)
Source: Circulation - May 1, 2024 Category: Cardiology Authors: Duk-Hyun Kang Sung-Ji Park Sung-Hee Shin In-Chang Hwang Yeonyee Elizabeth Yoon Hyung-Kwan Kim Mijin Kim Min-Seok Kim Sung-Cheol Yun Jong-Min Song Seok-Min Kang Source Type: research
Effects of Empagliflozin on vascular and skeletal mineralization in Hyperlipidemic mice
Vascul Pharmacol. 2024 Apr 29:107376. doi: 10.1016/j.vph.2024.107376. Online ahead of print.ABSTRACTCardiovascular disease and osteoporosis, major causes of morbidity and mortality, are associated with hyperlipidemia. Recent studies show that empagliflozin (EMPA), an inhibitor of sodium-glucose cotransporter-2 (SGLT2), improves cardiovascular health. In preclinical animal studies, EMPA mitigates vascular calcification in the males but its effects in the females are not known. Thus, we used female mice to test the effects of EMPA on calcification in the artery wall, cardiac function, and skeletal bone. By serial in vivo mic...
Source: Vascular Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Sophia Kalanski Stuti Pradhan Andy Hon Yuxuan Xia Nora Safvati Juan Carlos Rivera Mimi Lu Linda L Demer Yin Tintut Source Type: research
Comparison of Effects of Sugammadex and Neostigmine on Postoperative Neuromuscular Blockade Recovery in Patients with Interstitial Lung Diseases Undergoing Transbronchial Cryobiopsy: A Randomized Trial
CONCLUSIONS Sugammadex is more effective than neostigmine in reversing the muscle-relaxant effect of rocuronium bromide in patients with ILDs.PMID:38689479 | DOI:10.12659/MSM.942773 (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 1, 2024 Category: Research Authors: Liya Lu Xiaobo Chen Shiyue Li Yanyi Cen Source Type: research
Chitin-glucan improves important pathophysiological features of irritable bowel syndrome
CONCLUSION: CG decreased visceral perception and intestinal inflammation through master gene regulation and direct binding of microbial products, suggesting that CG may constitute a new therapeutic strategy for patients with IBS or IBS-like symptoms.PMID:38690023 | PMC:PMC11056916 | DOI:10.3748/wjg.v30.i16.2258 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - May 1, 2024 Category: Gastroenterology Authors: Caroline Valibouze Caroline Dubuquoy Philippe Chavatte Micha ël Genin Veronique Maquet Salvatore Modica Pierre Desreumaux Christel Rousseaux Source Type: research
Purification and characterization of glutamate dehydrogenase from rainbow trout (Oncorhynchus mykiss) liver and molecular docking studies
In this study, GDH enzyme was purified from the liver of rainbow trout (Oncorhynchus mykiss) by 2',5'-ADP Sepharose 4B affinity chromatography in one step. As a result of this purification process, GDH enzyme was purified 171-fold with 5.83 U/mg protein-specific activity. The characterization experiments presented that the storage stability of the purified GDH enzyme was determined as −80°C; optimum temperature 40°C; it was determined that the optimum ionic strength was 100 mM phosphate buffer and the optimum pH was 8.00. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and PAGE studies showed th...
Source: Biotechnology and Applied Biochemistry - May 1, 2024 Category: Biochemistry Authors: Onur Ertik,
Refiye Yanardag Tags: ORIGINAL ARTICLE Source Type: research
Effects of supplementation of different selenium sources on lipid profile, selenium, and vitamin E concentration of yolk
AbstractEgg preference as a source of protein also provides beneficial fatty acids, vital for human consumption. However, rich in lipid products are prone to oxidative damage. The study aims to determine the effect of supplementing biogenic selenium (Se) fromStenotrophomonas maltophilia, ADS18 (ADS18) in laying hens ’ diet on yolk lipid oxidation status (MDA), beta-carotene (β-carotene) content, cholesterol, fatty acids, Se, and vitamin E (VE) level. A total of one hundred and twenty (120) laying hens of Lohmann Brown strains aged 50 weeks, weighing 1500 to 2000 g were reared individually in A-shape two-tie r stainless...
Source: Tropical Animal Health and Production - May 1, 2024 Category: Veterinary Research Source Type: research
A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria
ConclusionThese findings demonstrate the validity of our hiPSC-BMECs based model of the BBB, that displays enhanced barrier integrity and appropriate TJ protein localization. In the hiPSC-BMEC co-culture withPf-iRBCs, reduced TEER, increased paracellular permeability, changes in TJ protein localization, increase in expression of adhesion molecules, and markers of angiogenesis and cellular stress all point towards a novel model with enhanced barrier properties, suitable for investigating pathogenic mechanisms underlying BBB disruption in CM. (Source: Fluids and Barriers of the CNS)
Source: Fluids and Barriers of the CNS - May 1, 2024 Category: Neuroscience Source Type: research
Activation and inhibition of the sweet taste receptor TAS1R2-TAS1R3 differentially affect glucose tolerance in humans
by Matthew C. Kochem, Emily C. Hanselman, Paul A. S. Breslin
The sweet taste receptor, TAS1R2-TAS1R3, is expressed in taste bud cells, where it conveys sweetness, and also in intestinal enteroendocrine cells, where it may facilitate glucose absorption and assimilation. In the present study, our objective was to determine whether TAS1R2-TAS1R3 influences glu cose metabolism bidirectionally via hyperactivation with 5 mM sucralose (n = 12) and inhibition with 2 mM sodium lactisole (n = 10) in mixture with 75 g glucose loads during oral glucose tolerance tests (OGTTs) in healthy humans. Plasma glucose, insulin, and glucagon w...
Source: PLoS One - May 1, 2024 Category: Biomedical Science Authors: Matthew C. Kochem Source Type: research
Anti-TNF (adalimumab) injection for the treatment of pain-predominant early-stage frozen shoulder: the Anti-Freaze-Feasibility randomised controlled trial
Conclusion
This study demonstrated that current NHS musculoskeletal physiotherapy settings yielded only small numbers of participants, too few to make a trial viable. This was because many patients had passed the early stage of frozen shoulder or had already formulated a preference for treatment.
Trial registration number
ISRCTN 27075727, EudraCT 2021-03509-23, ClinicalTrials.gov NCT05299242 (REC 21/NE/0214). (Source: BMJ Open)
Source: BMJ Open - May 1, 2024 Category: General Medicine Authors: Hopewell, S., Srikesavan, C., Evans, A., Er, F., Rangan, A., Preece, J., Francis, A., Massa, M. S., Feldmann, M., Lamb, S., Nanchahal, J. Tags: Open access, Rehabilitation medicine Source Type: research
Observational study of Safinamide as an add-on to levodopa monotherapy for Parkinson's disease patients with wearing-off in Japan
This study was an exploratory investigation of the efficacy and safety of safinamide in patients with PD and wearing-off treated with oral levodopa alone. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: N. Nishikawa, T. Hatano, K. Nishioka, S.-I. Ueno, S. Saiki, R. Nakamura, A. Yoritaka, T. Ogawa, Y. Shimo, W. Sako, H. Shimura, Y. Furukawa, T. Kamei, T. Ozawa, T. Ishida, N. Hattori Source Type: research
Insights into the capacity fading and failure mechanism of an O3-NaNi1/3Fe1/3Mn1/3O2 layered oxide cathode material for sodium-ion batteries
J. Mater. Chem. A, 2024, Advance Article DOI: 10.1039/D4TA00060A, PaperXiaohan Zhao, Lijuan Hou, Qi Liu, Yanshuo Zhao, Daobin Mu, Zhikun Zhao, Li Li, Renjie Chen, Feng Wu Low-cost sodium-ion batteries hold great potential for large-scale energy storage owing to the abundance of sodium reserves. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - April 30, 2024 Category: Chemistry Authors: Xiaohan Zhao Source Type: research
A high entropy O3-Na1.0Li0.1Ni0.3Fe0.1Mn0.25Ti0.25O2 cathode with reversible phase transitions and superior electrochemical performances for sodium-ion batteries
J. Mater. Chem. A, 2024, Accepted Manuscript DOI: 10.1039/D4TA01137F, PaperArindam Ghosh, Rashmi Hegde, Premkumar Senguttuvan O3-type Ni/Mn/Fe-based layered oxides are very promising cathode materials for Na-ion batteries (SIBs) due to their high redox potential of Ni2+/ Ni4+ and Jahn-Teller inactive centers (Ni2+, Fe3+, and Mn4+).... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - April 30, 2024 Category: Chemistry Authors: Arindam Ghosh Source Type: research
Pharmacokinetic, Pharmacodynamic, and Safety Profiles of Proline Henagliflozin in Chinese Subjects with Varying Degrees of Liver Dysfunction
J Clin Pharmacol. 2024 Apr 30. doi: 10.1002/jcph.2437. Online ahead of print.ABSTRACTProline henagliflozin, a novel selective inhibitor of sodium glucose cotransporter 2, is a treatment for type 2 diabetes mellitus. We designed a parallel-group, open-label, and multicenter study to evaluate the pharmacokinetic (PK), pharmacodynamic (PD), and safety profiles of henagliflozin in Chinese subjects with varying degrees of liver dysfunction. Thirty-two subjects were enrolled and divided into four groups based on liver function (normal liver function, mild, moderate, or severe liver dysfunction). The area under the plasma concent...
Source: The Journal of Clinical Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Likun Ding Lin Yang Danjun Ren Xiaohua Gao Juanli Zhang Meiyou Liu Li Sun Qingbo Diao Sheng Feng Aidong Wen Jingwen Wang Source Type: research
