Pharmacokinetic, Pharmacodynamic, and Safety Profiles of Proline Henagliflozin in Chinese Subjects with Varying Degrees of Liver Dysfunction
J Clin Pharmacol. 2024 Apr 30. doi: 10.1002/jcph.2437. Online ahead of print.ABSTRACTProline henagliflozin, a novel selective inhibitor of sodium glucose cotransporter 2, is a treatment for type 2 diabetes mellitus. We designed a parallel-group, open-label, and multicenter study to evaluate the pharmacokinetic (PK), pharmacodynamic (PD), and safety profiles of henagliflozin in Chinese subjects with varying degrees of liver dysfunction. Thirty-two subjects were enrolled and divided into four groups based on liver function (normal liver function, mild, moderate, or severe liver dysfunction). The area under the plasma concent...
Source: The Journal of Clinical Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Likun Ding Lin Yang Danjun Ren Xiaohua Gao Juanli Zhang Meiyou Liu Li Sun Qingbo Diao Sheng Feng Aidong Wen Jingwen Wang Source Type: research
Study on PTFE superhydrophobic coating modified by IC@dMSNs and its enhanced antibacterial effect
CONCLUSION: Compared with PTFE, PTFE-SiO2 and PTFE-IC@dMSNs catheters have good characterization performance, cell compatibility, and anticoagulant properties. PTFE SiO2 and PTFE-IC@dMSNs catheters have good antibacterial performance and tissue safety against E. coli and S. aureus. Relatively, PTFE-SiO2 and PTFE-IC@dMSNs catheter has better antibacterial properties and histocompatibility and has potential application prospects in anti-bacterial catheter development and anticoagulation.PMID:38688357 | DOI:10.1016/j.jare.2024.04.026 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Weixing Zhang Juan Du Fariha Kanwal Khalid Mujasam Batoo Mehwish Aslam Cihui Liu Tonghe Zhu Sajjad Hussain Muhammad Fayyaz Ur Rehman Ruilan Wang Source Type: research
Sodium salt promoted the generation of nano zero valent iron by carbothermal reduction: For activating peroxydisulfate to degrade antibiotic
Bioresour Technol. 2024 Apr 28:130755. doi: 10.1016/j.biortech.2024.130755. Online ahead of print.ABSTRACTCarbothermal reduction is a promising method for the industrial preparation of nano-zero-valent iron. Preparing it also involves very high pyrolysis temperatures, which leads to a significant amount of energy consumption. The temperature required for the preparation of nano-zero-valent iron by carbothermal reduction was reduced by 200 °C by the addition of sodium salt. Carbon-loaded nano zero-valent iron (Fe0/CB-Na) was prepared by carbothermal reduction through the addition of sodium salt. The results showed that Fe0...
Source: Bioresource Technology - April 30, 2024 Category: Biotechnology Authors: Chengjie Xue Yifu Peng Bin Zheng Zhanqiang Fang Yanan Wang Yuchen Yi Source Type: research
Novel guanidine derivatives targeting leukemia as selective Src/Abl dual inhibitors: Design, synthesis and anti-proliferative activity
Bioorg Chem. 2024 Apr 27;147:107410. doi: 10.1016/j.bioorg.2024.107410. Online ahead of print.ABSTRACTA new series of benzene-sulfonamide derivatives 3a-i was designed and synthesized via the reaction of N-(pyrimidin-2-yl)cyanamides 1a-i with sulfamethazine sodium salt 2 as dual Src/Abl inhibitors. Spectral data IR, 1H-, 13C- NMR and elemental analyses were used to confirm the structures of all the newly synthesized compounds 3a-i and 4a-i. Crucially, we screened all the synthesized compounds 3a-i against NCI 60 cancer cell lines. Among all, compound 3b was the most potent, with IC50 of 0.018 μM for normoxia, and 0.001 μ...
Source: Bioorganic Chemistry - April 30, 2024 Category: Chemistry Authors: Amr H Moustafa Asmaa M AboulMagd Ali M Ali Ahmed Khodairy Adel A Marzouk Ayman Nafady Mohamed T M Nemr Source Type: research
Simultaneous Rosiglitazone Release and Low-Density Lipoprotein Removal by Chondroitin Sodium Sulfate/Cyclodextrin/Poly(acrylic acid) Composite Adsorbents for Atherosclerosis Therapy
Biomacromolecules. 2024 Apr 30. doi: 10.1021/acs.biomac.4c00241. Online ahead of print.ABSTRACTAtherosclerosis (AS) is characterized by the accumulation of substantial low-density lipoprotein (LDL) and inflammatory response. Hemoperfusion is commonly employed for the selective removal of LDL from the body. However, conventional hemoperfusion merely focuses on LDL removal and does not address the symptom of plaque associated with AS. Based on the LDL binding properties of acrylated chondroitin sodium sulfate (CSA), acrylated beta-cyclodextrin (CD) and acrylic acid (AA), along with the anti-inflammatory property of rosiglita...
Source: Biomacromolecules - April 30, 2024 Category: Biochemistry Authors: Yujie Xiao Yinghui Xu Xianda Liu Shengjun Cheng Ran Wei Weifeng Zhao Changsheng Zhao Source Type: research
Activation of sawdust biochar with water and wastewater treatment residuals for sorption of perfluorooctanesulfonic acid in water
Chemosphere. 2024 Apr 27:142160. doi: 10.1016/j.chemosphere.2024.142160. Online ahead of print.ABSTRACTRecent research has found biochar to be a cost-effective adsorbent for removal of perfluoroalkyl substances in water. To promote cleaner production and sustainable waste management, this study explored the potential to produce activated biochars by co-pyrolyzing sawdust with iron-rich biosolids and polyaluminum sludge. The maximum capacity to adsorb perfluorooctanesulfonic acid (PFOS) reached 27.2 mg g-1 with biosolids-activated biochar and 19.2 mg g-1 with aluminum sludge-activated biochar, compared to 6.2 mg g-1 with sa...
Source: Chemosphere - April 30, 2024 Category: Chemistry Authors: Kalyani Mer Pubudu Arachchilage Wendong Tao Nosa O Egiebor Source Type: research
Fermentation-inspired macroporous and tough gelatin/sodium alginate hydrogel for accelerated infected wound healing
Int J Biol Macromol. 2024 Apr 28:131905. doi: 10.1016/j.ijbiomac.2024.131905. Online ahead of print.ABSTRACTGelatin and sodium alginate (SA) are two important biological macromolecules, exhibiting excellent biocompatibility and gel-forming ability. However, traditional SA and gelatin hydrogel displays limited mass transport, low porosity, instability, and poor mechanical properties extremely restricted their therapeutic effect and application scenarios. Herein, microbial fermentation and synergistic toughening strategies were used for preparing macroporous and tough hydrogel. The study investigated the fermentation and tou...
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Jing Cheng Rixuan Wang Yanyu Hu Mengxuan Li Lijun You Shaoyun Wang Source Type: research
Partitioning recombinant chitinase from Nicotiana benthamiana by an aqueous two-phase system based on polyethylene glycol and phosphate salts
The objectives of this study were to purify 42 kDa chitinase derived from Trichoderma asperellum SH16 produced in Nicotiana benthamiana by a polyethylene glycol (PEG)/salt aqueous two-phase system (ATPS). The specific activities of the crude chitinase and the partially purified chitinase from N. benthamiana were about 251 unit/mg and 386 unit/mg, respectively. The study found the 300 g/L PEG 6000 + 200 g/L potassium phosphate (PP) and 300 g/L PEG 6000 + 150 g/L sodium phosphate (SP) systems had the highest partitioning efficiency for each salt in primary extraction. However, among the two types of salt, PP displayed higher...
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Nguyen Hoang Tue Nguyen Hoang Phuc Phung Thi Bich Hoa Nguyen Quang Duc Tien Nguyen Hoang Loc Source Type: research
Sustainable, super-stable thermochromic material by coupling hydroxypropyl cellulose and sodium carboxymethyl cellulose
Int J Biol Macromol. 2024 Apr 27:131945. doi: 10.1016/j.ijbiomac.2024.131945. Online ahead of print.ABSTRACTHydroxypropyl cellulose (HPC) is a green thermochromic material in energy-saving buildings, anti-counterfeiting, and data security fields. However, the high lower critical solution temperature (LCST) of HPC, around 42 °C (higher than the human thermal comfort temperature), limits its thermochromic sensitivity, poor stability, and short lifespan. Herein, we developed a durable, high-performance cellulose-based thermochromic composite with a lower LCST and easy preparation capability by combining HPC with sodium carbo...
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Pengyu Pan Yuanyuan Liu Zhishuang Zhu Yang Liu Renzhong Wei Qiang Wang Qingxian Miao Yilian Lei Chengshui Guo Hongjie Zhong Liulian Huang Lihui Chen Jianguo Li Source Type: research
Activation of sawdust biochar with water and wastewater treatment residuals for sorption of perfluorooctanesulfonic acid in water
Chemosphere. 2024 Apr 27:142160. doi: 10.1016/j.chemosphere.2024.142160. Online ahead of print.ABSTRACTRecent research has found biochar to be a cost-effective adsorbent for removal of perfluoroalkyl substances in water. To promote cleaner production and sustainable waste management, this study explored the potential to produce activated biochars by co-pyrolyzing sawdust with iron-rich biosolids and polyaluminum sludge. The maximum capacity to adsorb perfluorooctanesulfonic acid (PFOS) reached 27.2 mg g-1 with biosolids-activated biochar and 19.2 mg g-1 with aluminum sludge-activated biochar, compared to 6.2 mg g-1 with sa...
Source: Chemosphere - April 30, 2024 Category: Chemistry Authors: Kalyani Mer Pubudu Arachchilage Wendong Tao Nosa O Egiebor Source Type: research
Experimental and simulation studies on the improvement of coal dust pollution by an aqueous solution of sodium α-alkenylsulfonate and amino acid-based surfactants
Environ Pollut. 2024 Apr 27:124041. doi: 10.1016/j.envpol.2024.124041. Online ahead of print.ABSTRACTThe use of surfactants is crucial for the prevention and control of coal dust pollution in coal mining operation areas, yet there still exist many challenges in the control of coal dust pollution. In this paper, the green biomass-based amino acid surfactant sodium myristoyl glutamate (SMG) and the anionic surfactant sodium α-alkenyl sulfonate (AOS) were selected to investigate the improvement of coal dust wettability by single and binary solutions from the macroscopic and microscopic perspectives. Molecular simulations wer...
Source: Environmental Pollution - April 30, 2024 Category: Environmental Health Authors: Huajun Liu Wen Nie Qifan Tian Qiu Bao Wenjin Niu Ruoxi Li Xiaohan Zhang Stephen Nyabire Akanyange Source Type: research
Zibotentan Can Be Co-administered with Contraceptives Containing Ethinyl Estradiol and Levonorgestrel: A Pharmacokinetic Drug-Drug Interaction Study
In conclusion, contraception containing ethinyl estradiol/levonorgestrel is regarded possible under zibotentan-containing treatments. This expands choices for women of childbearing potential, supporting diversity in the ZENITH High Proteinuria trial.PMID:38686600 | DOI:10.1002/cpt.3280 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Anne-Kristina Mercier Abigail K Kois Deeyen Karsanji Richard Baldry Filip Birve Maria Hedwall Oleksandr Molodetskyi Michael Gillen Source Type: research
Simultaneous Rosiglitazone Release and Low-Density Lipoprotein Removal by Chondroitin Sodium Sulfate/Cyclodextrin/Poly(acrylic acid) Composite Adsorbents for Atherosclerosis Therapy
Biomacromolecules. 2024 Apr 30. doi: 10.1021/acs.biomac.4c00241. Online ahead of print.ABSTRACTAtherosclerosis (AS) is characterized by the accumulation of substantial low-density lipoprotein (LDL) and inflammatory response. Hemoperfusion is commonly employed for the selective removal of LDL from the body. However, conventional hemoperfusion merely focuses on LDL removal and does not address the symptom of plaque associated with AS. Based on the LDL binding properties of acrylated chondroitin sodium sulfate (CSA), acrylated beta-cyclodextrin (CD) and acrylic acid (AA), along with the anti-inflammatory property of rosiglita...
Source: Atherosclerosis - April 30, 2024 Category: Cardiology Authors: Yujie Xiao Yinghui Xu Xianda Liu Shengjun Cheng Ran Wei Weifeng Zhao Changsheng Zhao Source Type: research
Pharmacokinetic, Pharmacodynamic, and Safety Profiles of Proline Henagliflozin in Chinese Subjects with Varying Degrees of Liver Dysfunction
J Clin Pharmacol. 2024 Apr 30. doi: 10.1002/jcph.2437. Online ahead of print.ABSTRACTProline henagliflozin, a novel selective inhibitor of sodium glucose cotransporter 2, is a treatment for type 2 diabetes mellitus. We designed a parallel-group, open-label, and multicenter study to evaluate the pharmacokinetic (PK), pharmacodynamic (PD), and safety profiles of henagliflozin in Chinese subjects with varying degrees of liver dysfunction. Thirty-two subjects were enrolled and divided into four groups based on liver function (normal liver function, mild, moderate, or severe liver dysfunction). The area under the plasma concent...
Source: The Journal of Clinical Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Likun Ding Lin Yang Danjun Ren Xiaohua Gao Juanli Zhang Meiyou Liu Li Sun Qingbo Diao Sheng Feng Aidong Wen Jingwen Wang Source Type: research
Simultaneous Rosiglitazone Release and Low-Density Lipoprotein Removal by Chondroitin Sodium Sulfate/Cyclodextrin/Poly(acrylic acid) Composite Adsorbents for Atherosclerosis Therapy
Biomacromolecules. 2024 Apr 30. doi: 10.1021/acs.biomac.4c00241. Online ahead of print.ABSTRACTAtherosclerosis (AS) is characterized by the accumulation of substantial low-density lipoprotein (LDL) and inflammatory response. Hemoperfusion is commonly employed for the selective removal of LDL from the body. However, conventional hemoperfusion merely focuses on LDL removal and does not address the symptom of plaque associated with AS. Based on the LDL binding properties of acrylated chondroitin sodium sulfate (CSA), acrylated beta-cyclodextrin (CD) and acrylic acid (AA), along with the anti-inflammatory property of rosiglita...
Source: Biomacromolecules - April 30, 2024 Category: Biochemistry Authors: Yujie Xiao Yinghui Xu Xianda Liu Shengjun Cheng Ran Wei Weifeng Zhao Changsheng Zhao Source Type: research
