A human pluripotent stem cell-derived in vitro model of the blood–brain barrier in cerebral malaria
ConclusionThese findings demonstrate the validity of our hiPSC-BMECs based model of the BBB, that displays enhanced barrier integrity and appropriate TJ protein localization. In the hiPSC-BMEC co-culture withPf-iRBCs, reduced TEER, increased paracellular permeability, changes in TJ protein localization, increase in expression of adhesion molecules, and markers of angiogenesis and cellular stress all point towards a novel model with enhanced barrier properties, suitable for investigating pathogenic mechanisms underlying BBB disruption in CM. (Source: Fluids and Barriers of the CNS)
Source: Fluids and Barriers of the CNS - May 1, 2024 Category: Neuroscience Source Type: research
Activation and inhibition of the sweet taste receptor TAS1R2-TAS1R3 differentially affect glucose tolerance in humans
by Matthew C. Kochem, Emily C. Hanselman, Paul A. S. Breslin
The sweet taste receptor, TAS1R2-TAS1R3, is expressed in taste bud cells, where it conveys sweetness, and also in intestinal enteroendocrine cells, where it may facilitate glucose absorption and assimilation. In the present study, our objective was to determine whether TAS1R2-TAS1R3 influences glu cose metabolism bidirectionally via hyperactivation with 5 mM sucralose (n = 12) and inhibition with 2 mM sodium lactisole (n = 10) in mixture with 75 g glucose loads during oral glucose tolerance tests (OGTTs) in healthy humans. Plasma glucose, insulin, and glucagon w...
Source: PLoS One - May 1, 2024 Category: Biomedical Science Authors: Matthew C. Kochem Source Type: research
Anti-TNF (adalimumab) injection for the treatment of pain-predominant early-stage frozen shoulder: the Anti-Freaze-Feasibility randomised controlled trial
Conclusion
This study demonstrated that current NHS musculoskeletal physiotherapy settings yielded only small numbers of participants, too few to make a trial viable. This was because many patients had passed the early stage of frozen shoulder or had already formulated a preference for treatment.
Trial registration number
ISRCTN 27075727, EudraCT 2021-03509-23, ClinicalTrials.gov NCT05299242 (REC 21/NE/0214). (Source: BMJ Open)
Source: BMJ Open - May 1, 2024 Category: General Medicine Authors: Hopewell, S., Srikesavan, C., Evans, A., Er, F., Rangan, A., Preece, J., Francis, A., Massa, M. S., Feldmann, M., Lamb, S., Nanchahal, J. Tags: Open access, Rehabilitation medicine Source Type: research
Observational study of Safinamide as an add-on to levodopa monotherapy for Parkinson's disease patients with wearing-off in Japan
This study was an exploratory investigation of the efficacy and safety of safinamide in patients with PD and wearing-off treated with oral levodopa alone. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: N. Nishikawa, T. Hatano, K. Nishioka, S.-I. Ueno, S. Saiki, R. Nakamura, A. Yoritaka, T. Ogawa, Y. Shimo, W. Sako, H. Shimura, Y. Furukawa, T. Kamei, T. Ozawa, T. Ishida, N. Hattori Source Type: research
Insights into the capacity fading and failure mechanism of an O3-NaNi1/3Fe1/3Mn1/3O2 layered oxide cathode material for sodium-ion batteries
J. Mater. Chem. A, 2024, Advance Article DOI: 10.1039/D4TA00060A, PaperXiaohan Zhao, Lijuan Hou, Qi Liu, Yanshuo Zhao, Daobin Mu, Zhikun Zhao, Li Li, Renjie Chen, Feng Wu Low-cost sodium-ion batteries hold great potential for large-scale energy storage owing to the abundance of sodium reserves. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - April 30, 2024 Category: Chemistry Authors: Xiaohan Zhao Source Type: research
A high entropy O3-Na1.0Li0.1Ni0.3Fe0.1Mn0.25Ti0.25O2 cathode with reversible phase transitions and superior electrochemical performances for sodium-ion batteries
J. Mater. Chem. A, 2024, Accepted Manuscript DOI: 10.1039/D4TA01137F, PaperArindam Ghosh, Rashmi Hegde, Premkumar Senguttuvan O3-type Ni/Mn/Fe-based layered oxides are very promising cathode materials for Na-ion batteries (SIBs) due to their high redox potential of Ni2+/ Ni4+ and Jahn-Teller inactive centers (Ni2+, Fe3+, and Mn4+).... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - April 30, 2024 Category: Chemistry Authors: Arindam Ghosh Source Type: research
Pharmacokinetic, Pharmacodynamic, and Safety Profiles of Proline Henagliflozin in Chinese Subjects with Varying Degrees of Liver Dysfunction
J Clin Pharmacol. 2024 Apr 30. doi: 10.1002/jcph.2437. Online ahead of print.ABSTRACTProline henagliflozin, a novel selective inhibitor of sodium glucose cotransporter 2, is a treatment for type 2 diabetes mellitus. We designed a parallel-group, open-label, and multicenter study to evaluate the pharmacokinetic (PK), pharmacodynamic (PD), and safety profiles of henagliflozin in Chinese subjects with varying degrees of liver dysfunction. Thirty-two subjects were enrolled and divided into four groups based on liver function (normal liver function, mild, moderate, or severe liver dysfunction). The area under the plasma concent...
Source: The Journal of Clinical Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Likun Ding Lin Yang Danjun Ren Xiaohua Gao Juanli Zhang Meiyou Liu Li Sun Qingbo Diao Sheng Feng Aidong Wen Jingwen Wang Source Type: research
Novel guanidine derivatives targeting leukemia as selective Src/Abl dual inhibitors: Design, synthesis and anti-proliferative activity
Bioorg Chem. 2024 Apr 27;147:107410. doi: 10.1016/j.bioorg.2024.107410. Online ahead of print.ABSTRACTA new series of benzene-sulfonamide derivatives 3a-i was designed and synthesized via the reaction of N-(pyrimidin-2-yl)cyanamides 1a-i with sulfamethazine sodium salt 2 as dual Src/Abl inhibitors. Spectral data IR, 1H-, 13C- NMR and elemental analyses were used to confirm the structures of all the newly synthesized compounds 3a-i and 4a-i. Crucially, we screened all the synthesized compounds 3a-i against NCI 60 cancer cell lines. Among all, compound 3b was the most potent, with IC50 of 0.018 μM for normoxia, and 0.001 μ...
Source: Bioorganic Chemistry - April 30, 2024 Category: Chemistry Authors: Amr H Moustafa Asmaa M AboulMagd Ali M Ali Ahmed Khodairy Adel A Marzouk Ayman Nafady Mohamed T M Nemr Source Type: research
Experimental and simulation studies on the improvement of coal dust pollution by an aqueous solution of sodium α-alkenylsulfonate and amino acid-based surfactants
Environ Pollut. 2024 Apr 27:124041. doi: 10.1016/j.envpol.2024.124041. Online ahead of print.ABSTRACTThe use of surfactants is crucial for the prevention and control of coal dust pollution in coal mining operation areas, yet there still exist many challenges in the control of coal dust pollution. In this paper, the green biomass-based amino acid surfactant sodium myristoyl glutamate (SMG) and the anionic surfactant sodium α-alkenyl sulfonate (AOS) were selected to investigate the improvement of coal dust wettability by single and binary solutions from the macroscopic and microscopic perspectives. Molecular simulations wer...
Source: Environmental Pollution - April 30, 2024 Category: Environmental Health Authors: Huajun Liu Wen Nie Qifan Tian Qiu Bao Wenjin Niu Ruoxi Li Xiaohan Zhang Stephen Nyabire Akanyange Source Type: research
Sodium salt promoted the generation of nano zero valent iron by carbothermal reduction: For activating peroxydisulfate to degrade antibiotic
Bioresour Technol. 2024 Apr 28:130755. doi: 10.1016/j.biortech.2024.130755. Online ahead of print.ABSTRACTCarbothermal reduction is a promising method for the industrial preparation of nano-zero-valent iron. Preparing it also involves very high pyrolysis temperatures, which leads to a significant amount of energy consumption. The temperature required for the preparation of nano-zero-valent iron by carbothermal reduction was reduced by 200 °C by the addition of sodium salt. Carbon-loaded nano zero-valent iron (Fe0/CB-Na) was prepared by carbothermal reduction through the addition of sodium salt. The results showed that Fe0...
Source: Bioresource Technology - April 30, 2024 Category: Biotechnology Authors: Chengjie Xue Yifu Peng Bin Zheng Zhanqiang Fang Yanan Wang Yuchen Yi Source Type: research
Zibotentan Can Be Co-administered with Contraceptives Containing Ethinyl Estradiol and Levonorgestrel: A Pharmacokinetic Drug-Drug Interaction Study
In conclusion, contraception containing ethinyl estradiol/levonorgestrel is regarded possible under zibotentan-containing treatments. This expands choices for women of childbearing potential, supporting diversity in the ZENITH High Proteinuria trial.PMID:38686600 | DOI:10.1002/cpt.3280 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Anne-Kristina Mercier Abigail K Kois Deeyen Karsanji Richard Baldry Filip Birve Maria Hedwall Oleksandr Molodetskyi Michael Gillen Source Type: research
Simultaneous Rosiglitazone Release and Low-Density Lipoprotein Removal by Chondroitin Sodium Sulfate/Cyclodextrin/Poly(acrylic acid) Composite Adsorbents for Atherosclerosis Therapy
Biomacromolecules. 2024 Apr 30. doi: 10.1021/acs.biomac.4c00241. Online ahead of print.ABSTRACTAtherosclerosis (AS) is characterized by the accumulation of substantial low-density lipoprotein (LDL) and inflammatory response. Hemoperfusion is commonly employed for the selective removal of LDL from the body. However, conventional hemoperfusion merely focuses on LDL removal and does not address the symptom of plaque associated with AS. Based on the LDL binding properties of acrylated chondroitin sodium sulfate (CSA), acrylated beta-cyclodextrin (CD) and acrylic acid (AA), along with the anti-inflammatory property of rosiglita...
Source: Atherosclerosis - April 30, 2024 Category: Cardiology Authors: Yujie Xiao Yinghui Xu Xianda Liu Shengjun Cheng Ran Wei Weifeng Zhao Changsheng Zhao Source Type: research
Pharmacokinetic, Pharmacodynamic, and Safety Profiles of Proline Henagliflozin in Chinese Subjects with Varying Degrees of Liver Dysfunction
J Clin Pharmacol. 2024 Apr 30. doi: 10.1002/jcph.2437. Online ahead of print.ABSTRACTProline henagliflozin, a novel selective inhibitor of sodium glucose cotransporter 2, is a treatment for type 2 diabetes mellitus. We designed a parallel-group, open-label, and multicenter study to evaluate the pharmacokinetic (PK), pharmacodynamic (PD), and safety profiles of henagliflozin in Chinese subjects with varying degrees of liver dysfunction. Thirty-two subjects were enrolled and divided into four groups based on liver function (normal liver function, mild, moderate, or severe liver dysfunction). The area under the plasma concent...
Source: The Journal of Clinical Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Likun Ding Lin Yang Danjun Ren Xiaohua Gao Juanli Zhang Meiyou Liu Li Sun Qingbo Diao Sheng Feng Aidong Wen Jingwen Wang Source Type: research
Study on PTFE superhydrophobic coating modified by IC@dMSNs and its enhanced antibacterial effect
CONCLUSION: Compared with PTFE, PTFE-SiO2 and PTFE-IC@dMSNs catheters have good characterization performance, cell compatibility, and anticoagulant properties. PTFE SiO2 and PTFE-IC@dMSNs catheters have good antibacterial performance and tissue safety against E. coli and S. aureus. Relatively, PTFE-SiO2 and PTFE-IC@dMSNs catheter has better antibacterial properties and histocompatibility and has potential application prospects in anti-bacterial catheter development and anticoagulation.PMID:38688357 | DOI:10.1016/j.jare.2024.04.026 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Weixing Zhang Juan Du Fariha Kanwal Khalid Mujasam Batoo Mehwish Aslam Cihui Liu Tonghe Zhu Sajjad Hussain Muhammad Fayyaz Ur Rehman Ruilan Wang Source Type: research
Sodium salt promoted the generation of nano zero valent iron by carbothermal reduction: For activating peroxydisulfate to degrade antibiotic
Bioresour Technol. 2024 Apr 28:130755. doi: 10.1016/j.biortech.2024.130755. Online ahead of print.ABSTRACTCarbothermal reduction is a promising method for the industrial preparation of nano-zero-valent iron. Preparing it also involves very high pyrolysis temperatures, which leads to a significant amount of energy consumption. The temperature required for the preparation of nano-zero-valent iron by carbothermal reduction was reduced by 200 °C by the addition of sodium salt. Carbon-loaded nano zero-valent iron (Fe0/CB-Na) was prepared by carbothermal reduction through the addition of sodium salt. The results showed that Fe0...
Source: Bioresource Technology - April 30, 2024 Category: Biotechnology Authors: Chengjie Xue Yifu Peng Bin Zheng Zhanqiang Fang Yanan Wang Yuchen Yi Source Type: research
