Development and validation of a photograph-based instrument to assess nutrition literacy: the NUTLY project
Appetite. 2024 Apr 26:107377. doi: 10.1016/j.appet.2024.107377. Online ahead of print.ABSTRACTMost instruments measuring nutrition literacy evaluate theoretical knowledge, not necessarily reflecting skills relevant to food choices. We aimed to develop and validate a photograph-based instrument to assess nutrition literacy (NUTLY) among adults in Portugal. NUTLY assesses the ability to distinguish foods with different nutritional profiles; from each of several combinations of three photographs (two foods with similar contents and one with higher content) participants are asked to identify the food with the highest energy/so...
Source: Appetite - April 28, 2024 Category: Nutrition Authors: Sofia Sousa Gabriela Albuquerque Milton Severo Ana Rute Costa Pedro Moreira Nuno Lunet Patr ícia Padrão Source Type: research
DIREN mitigates DSS-induced colitis in mice and attenuates collagen deposition via inhibiting the Wnt/ β-catenin and focal adhesion pathways
CONCLUSION: DIREN exerts a protective effect against DSS-induced UC by ameliorating colonic fibrosis via regulation of focal adhesion and the WNT/β-catenin signaling pathway, thereby inhibiting fibroblast migration and reducing collagen secretion.PMID:38678963 | DOI:10.1016/j.biopha.2024.116671 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2024 Category: Drugs & Pharmacology Authors: Weizhi Lai Yingying Wang Chen Huang Hao Xu Xunjie Zheng Ke Li Jue Wang Zhaohuan Lou Source Type: research
Cardiovascular outcomes and molecular targets for the cardiac effects of Sodium-Glucose Cotransporter 2 Inhibitors: A systematic review
Biomed Pharmacother. 2024 Apr 27;175:116650. doi: 10.1016/j.biopha.2024.116650. Online ahead of print.ABSTRACTSodium-glucose cotransporter 2 inhibitors (SGLT2i), a new class of glucose-lowering drugs traditionally used to control blood glucose levels in patients with type 2 diabetes mellitus, have been proven to reduce major adverse cardiovascular events, including cardiovascular death, in patients with heart failure irrespective of ejection fraction and independently of the hypoglycemic effect. Because of their favorable effects on the kidney and cardiovascular outcomes, their use has been expanded in all patients with an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 28, 2024 Category: Drugs & Pharmacology Authors: Rosalinda Madonna Filippo Biondi Mattia Alberti Sandra Ghelardoni Letizia Mattii Alberto D'Alleva Source Type: research
APOB and CCL17 as Mediators in the Protective Effect of SGLT2 Inhibition against Myocardial Infarction: Insights from Proteome-wide Mendelian Randomization
CONCLUSION: Based on proteome-wide mendelian randomization, APOB and CCL17 were seen as mediators in the protective effect of SGLT2 inhibition against myocardial infarction.PMID:38679119 | DOI:10.1016/j.ejphar.2024.176619 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Lili Shi Gen Li Ningxin Hou Ling Tu Jun Li Jinlan Luo Shuiqing Hu Source Type: research
Influence of additives and binder on the physical properties of dental silicate glass-ceramic feedstock for additive manufacturing
J Mech Behav Biomed Mater. 2024 Apr 25;155:106563. doi: 10.1016/j.jmbbm.2024.106563. Online ahead of print.ABSTRACTOBJECTIVES: The aim of the study was to investigate the impact of organic additives (binder, plasticizer, and the cross-linking ink) in the formulation of water-based feedstocks on the properties of a dental feldspathic glass-ceramic material developed for the slurry-based additive manufacturing technology "LSD-print."MATERIAL AND METHODS: Three water-based feldspathic feedstocks were produced to study the effects of polyvinyl alcohol (AC1) and poly (sodium 4-styrenesulfonate) (AC2) as binder systems. A feedst...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Moritz Hoffmann Bogna Stawarczyk Jens G ünster Andrea Zocca Source Type: research
Using sequential applications of a novel silver diamine fluoride gel and sodium fluoride varnish to arrest severe early childhood caries lesions: A clinical trial with single group assignment
CONCLUSIONS: Two applications of 38% SDF gel and 2.5% sodium fluoride varnish arrested greater than 90% of carious surfaces at 1 year and with high levels of parental satisfaction.PRACTICAL IMPLICATIONS: Combined treatment was highly efficacious in a population with many caries lesions. This clinical trial was registered at ClinicalTrials.gov. The registration number is NCT05395065.PMID:38678451 | DOI:10.1016/j.adaj.2024.02.013 (Source: Journal of the American Dental Association)
Source: Journal of the American Dental Association - April 28, 2024 Category: Dentistry Authors: Tania Carola Padilla C áceres Sheyla Cervantes-Alag ón Jorge Luis Castillo Claudia Mariela Vera Reyes Marilynn Rothen Lloyd A Mancl Peter Milgrom Source Type: research
In-silico screening and identification of glycomimetic as potential human sodium-glucose co-transporter 2 inhibitor
Comput Biol Chem. 2024 Apr 13;110:108074. doi: 10.1016/j.compbiolchem.2024.108074. Online ahead of print.ABSTRACTSodium-glucose co-transporter 2 (SGLT2) is one of the important targets against type II diabetes mellitus. A typical SGLT2 inhibitor acts by inhibiting glucose reabsorption, thus lowering the blood glucose level. Unlike SGLT1, SGLT2 is responsible for almost 90% glucose reabsorption from glomerular filtrate. The current SGLT2 inhibitors include gliflozins, often prescribed as second or third-line agents in diabetes mellitus. The SGLT2 inhibitors also benefit patients with heart and kidney disease. Due to instabi...
Source: Computational Biology and Chemistry - April 28, 2024 Category: Bioinformatics Authors: Prerna Ganwir Rajendra Bhadane Ganesh U Chaturbhuj Source Type: research
High serum sodium predicts immunotherapy response in metastatic renal cell and urothelial carcinoma
The development of reliable biomarkers for the prediction of immune checkpoint inhibition (ICI) response in patients with metastatic renal cell carcinoma (mRCC) and urothelial carcinoma (mUC) remains an unresolved challenge. Conventional ICI biomarkers typically focus on tumor-related factors such as PD-L1 expression. However, a comprehensive evaluation of the predictive value of serum electrolyte levels, a so far widely unexplored area, is still pending. (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 28, 2024 Category: Cancer & Oncology Authors: KlumperNiklas Kl ümper, Alexander Cox, Markus Eckstein, Christoph Kuppe, Manuel Ritter, Peter Brossart, Julian Luetkens, HolzelMichael Hölzel, Johannes Stein, Jonas Saal Tags: Original Research Source Type: research
Peripheral inflammation triggering central anxiety through the hippocampal glutamate metabolized receptor 1
CONCLUSION: Our work suggests that the hippocampus plays an important role in brain anxiety caused by peripheral inflammation, and over-excitation of hippocampal glutamate synapses by GRM1 activation induces anxiety-like behavior in colitis mice. These findings provide new insights into the central mechanisms underlying anxiety in UC and may contribute to the development of novel therapeutic strategies for UC-associated anxiety.PMID:38676295 | PMC:PMC11053250 | DOI:10.1111/cns.14723 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 27, 2024 Category: Neuroscience Authors: Jun-Meng Wang Yue-Mei Wang Yuan-Bing Zhu Chan Cui Tong Feng Qin Huang Shu-Qing Liu Qiao-Feng Wu Source Type: research
Peripheral inflammation triggering central anxiety through the hippocampal glutamate metabolized receptor 1
CONCLUSION: Our work suggests that the hippocampus plays an important role in brain anxiety caused by peripheral inflammation, and over-excitation of hippocampal glutamate synapses by GRM1 activation induces anxiety-like behavior in colitis mice. These findings provide new insights into the central mechanisms underlying anxiety in UC and may contribute to the development of novel therapeutic strategies for UC-associated anxiety.PMID:38676295 | PMC:PMC11053250 | DOI:10.1111/cns.14723 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 27, 2024 Category: Neuroscience Authors: Jun-Meng Wang Yue-Mei Wang Yuan-Bing Zhu Chan Cui Tong Feng Qin Huang Shu-Qing Liu Qiao-Feng Wu Source Type: research
Synthesis, Molecular Docking Studies and Biological Evaluation of Thiazolyl Hydrazone Derivatives of Chromone-3-carbaldehyde as Potent Anti-Oxidant and Anti-Inflammatory Agents
CONCLUSION: Thus, these compounds represent an attractive template for the evaluation of new antiinflammatory and antioxidant agents and might be useful for exploring new therapeutic tools.PMID:38676527 | DOI:10.2174/0115734064293848240408085039 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Rakhi Gawali Raghunath Bhosale Rohit Bavi Shravan Jadhav Nargisbano Peerzade Source Type: research
Bear Bile Powder Improves Ulcerative Colitis by Protecting the Intestinal Mechanical Barrier and Regulating Intestinal Flora
CONCLUSION: Oral administration of a certain dose of BBP can significantly improve the symptoms of ulcerative colitis in mice. Part of the reason may be that it increases the expression of tight junction proteins, regulates specific flora in the intestine of mice, and maintains intestinal barrier homeostasis. In the future, the clinical application value of BBP will be explored, and BBP will be developed as a drug with the potential to treat UC and alleviate the pain of UC patients.PMID:38676524 | DOI:10.2174/0113816128294893240403074953 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 27, 2024 Category: Drugs & Pharmacology Authors: Zi-Bo Liu Xun Ye Chun-Jie Wu Da-Neng Wei Source Type: research
Peripheral inflammation triggering central anxiety through the hippocampal glutamate metabolized receptor 1
CONCLUSION: Our work suggests that the hippocampus plays an important role in brain anxiety caused by peripheral inflammation, and over-excitation of hippocampal glutamate synapses by GRM1 activation induces anxiety-like behavior in colitis mice. These findings provide new insights into the central mechanisms underlying anxiety in UC and may contribute to the development of novel therapeutic strategies for UC-associated anxiety.PMID:38676295 | PMC:PMC11053250 | DOI:10.1111/cns.14723 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 27, 2024 Category: Neuroscience Authors: Jun-Meng Wang Yue-Mei Wang Yuan-Bing Zhu Chan Cui Tong Feng Qin Huang Shu-Qing Liu Qiao-Feng Wu Source Type: research
Tracking the therapeutic efficacy of a ketone mono ester and β-hydroxybutyrate for ulcerative colitis in rats: New perspectives
This study found that while both exogenous β-hydroxybutyrate and BD-AcAc 2 produced the same levels of plasma β-hydroxybutyrate, BD-AcAc 2 demonstrated superior effectiveness in mitigating dextran sodium sulfate-induced UC in rats. The mechanism of action involves modulating the NF-κB signaling, inhibiting the NLRP3 inflammasome, regulating antioxidant capacity, controlling tight junction protein expression and a potential to inhibit apoptosis and pyroptosis. Certainly, BD-AcAc 2's anti-inflammatory effects require more than just increasing plasma β-hydroxybutyrate levels and other factors contribute to its efficacy. L...
Source: Toxicology and Applied Pharmacology - April 27, 2024 Category: Toxicology Authors: Osama A Mohammed Sameh Saber Mustafa Ahmed Abdel-Reheim Mohannad Mohammad S Alamri Jaber Alfaifi Masoud I E Adam Muffarah Hamid Alharthi Ali M S Eleragi Hanan B Eltahir Mohamed Osama Abdalla Emad Bahashwan Elwathiq Khalid Ibrahim Assad Ali Rezigalla Sameh Source Type: research
Synthesis, Molecular Docking Studies and Biological Evaluation of Thiazolyl Hydrazone Derivatives of Chromone-3-carbaldehyde as Potent Anti-Oxidant and Anti-Inflammatory Agents
CONCLUSION: Thus, these compounds represent an attractive template for the evaluation of new antiinflammatory and antioxidant agents and might be useful for exploring new therapeutic tools.PMID:38676527 | DOI:10.2174/0115734064293848240408085039 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Rakhi Gawali Raghunath Bhosale Rohit Bavi Shravan Jadhav Nargisbano Peerzade Source Type: research
