Spatial Atlas for Mapping Vascular Microcalcification Using 18F-NaF PET/CT: Application in Hyperphosphatemic Familial Tumoral Calcinosis
CONCLUSIONS: This technique affords the ability to visualize spatial patterns of the active microcalcification process in the peripheral vasculature. Further, this technique affords the ability to track microcalcifications at precise locations not only across time but also across subjects. This technique is readily adaptable to other diseases of vascular calcification and may represent a significant advance in the field of vascular biology.PMID:38660800 | DOI:10.1161/ATVBAHA.123.320455 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Aaron J Sheppard Elizabeth H Theng Sriram S Paravastu Natalia M Wojnowski Faraz Farhadi Michael A Morris Iris R Hartley Rachel I Gafni Kelly L Roszko Michael T Collins Babak Saboury Source Type: research
Rational design of a low-cost, simple technology and high-performance CoNi/Co3O4 as a catalyst in sodium borohydride electro-oxidation reaction
We present a simple self-supporting catalyst containing CoNi nanosheets grown on Co3O4 electrodes. In the DBHPFC test, it has a maximum power density of 108.5 mW cm−2, an open circuit potential of 1.8 V, and good operating stability. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - April 24, 2024 Category: Chemistry Authors: Kaixuan Liu Source Type: research
The potential role of SNHG16/ miRNA-146a/ TRAF6 signaling pathway in the protective effect of zoledronate against colorectal cancer and associated osteoporosis in mouse model
Int Immunopharmacol. 2024 Apr 23;133:112125. doi: 10.1016/j.intimp.2024.112125. Online ahead of print.ABSTRACTBone fracture as a consequence of colorectal cancer (CRC) and associated osteoporosis (OP) is considered a risk factor for increasing the mortality rate among CRC patients. SNHG16/ miRNA-146a/ TRAF6 signaling pathway is a substantial contributor to neoplastic evolution, progression, and metastasis. Here, we investigated the effect of zoledronate (ZOL) on the growth of CRC and associated OP in a mouse model. Thirty Balb/c mice were divided into Naïve, azoxymethane (AOM)/dextran sodium sulfate (DSS), and ZOL groups....
Source: International Immunopharmacology - April 24, 2024 Category: Allergy & Immunology Authors: Amany Helmy Mohamed Ahmed Noureldin Hassan Nesma Hussein Abdel Hay Manar Fouad Ahmed Marwa M El Sawy Mohamed M Sonbol Reham Hussein Mohamed Source Type: research
Discovery of baloxavir sodium as a novel anti-CCHFV inhibitor: biological evaluation of in vitro and in vivo
This study identified baloxavir sodium as a novel scaffold structure and mechanism of anti-CCHF compound, providing a promising new strategy for clinical treatment of CCHF after further optimization.PMID:38657838 | DOI:10.1016/j.antiviral.2024.105890 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Kai Liu Liushuai Li Yajie Liu Xi Wang Jia Liu Jiang Li Fei Deng Runze Zhang Yiwu Zhou Zhihong Hu Wu Zhong Manli Wang Chun Guo Source Type: research
Diazoxide and moderate ‐intensity exercise improve skeletal muscle function by decreasing oxidants and enhancing antioxidant defenses in hypertensive male rats
AbstractHigh sodium intake is decisive in the incidence increase and prevalence of hypertension, which has an impact on skeletal muscle functionality. Diazoxide is an antihypertensive agent that inhibits insulin secretion and is an opener of KATP channels (adosine triphosphate sensitive potasium channels). For this reason, it is hypothesized that moderate-intensity exercise and diazoxide improve skeletal muscle function by reducing the oxidants in hypertensive rats. Male Wistar rats were assigned into eight groups: control (CTRL), diazoxide (DZX), exercise (EX), exercise + diazoxide (EX + DZX), hypertension (HTN),...
Source: Physiological Reports - April 24, 2024 Category: Physiology Authors: Estefan ía Bravo Sánchez,
César J. Nolasco Ruíz,
Mariana Gómez‐Barroso,
Christian Cortés Rojo,
Alain R. Rodríguez Orozco,
Alfredo Saavedra Molina,
Salvador Manzo Ávalos,
Rocío Montoya Pérez Tags: ORIGINAL ARTICLE Source Type: research
Insight on capacity fading and failure mechanism of O3-NaNi1/3Fe1/3Mn1/3O2 layered oxide cathode material for sodium ion battery
J. Mater. Chem. A, 2024, Accepted Manuscript DOI: 10.1039/D4TA00060A, PaperXiaohan Zhao, Lijuan Hou, Qi Liu, Yanshuo Zhao, Daobin Mu, Zhikun Zhao, Li Li, Renjie Chen, Feng Wu Low-cost sodium-ion batteries hold great potential for large-scale energy storage owing to abundance in sodium resources reserves. Despite the higher energy density and initial coulombic efficiency of O3-type transition metal... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - April 24, 2024 Category: Chemistry Authors: Xiaohan Zhao Source Type: research
GSE247433 MiR-146a alleviates inflammatory bowel disease in mice through systematical regulation of multiple genetic networks
Contributors : Fengting Zhu ; Taotan Yang ; Changgeng PengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammatory bowel disease (IBD) is a multiple-genes-involved chronic disease and current available targeted drugs for IBD only deliver moderate efficacy. Whether there is a single gene that systematically regulates IBD is not yet known. Here we showed that the expression of miR-146a in colon was elevated in Dextran Sulfate Sodium Salt (DSS)-induced IBD mice and patients with IBD. DSS induced dramatic body weight loss and much more rectal bleeding, shorter colon length and coli...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Development and validation of a nomogram for predicting 28-day mortality in patients with ischemic stroke
ConclusionsUtilizing a comprehensive array of fourteen readily accessible variables, a prognostic nomogram was meticulously formulated and rigorously validated to provide precise prognostication of short-term mortality within the ischemic stroke cohort. (Source: PLoS One)
Source: PLoS One - April 24, 2024 Category: Biomedical Science Authors: Lingyan Fang Source Type: research
Sodium-Glucose Co-transporter 2 Inhibitors and Mycotic Genital or Urinary Tract Infections in Heart Failure
Sodium-glucose co-transporter 2 (SGLT2) inhibitors have proven benefits on clinical outcomes in patients with heart failure (HF).1-6 However, this class of medications increases the risk of mycotic genital infections (MGIs) and urinary tract infections (UTIs), particularly within the first 3-6 months after their initiation.7,8,9 In the EMPEROR-Preserved and EMPEROR-Reduced trials, MGIs and UTIs were among the 3 most common adverse events in the empagliflozin group,1,2 highlighting the clinical relevance of these infections. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - April 24, 2024 Category: Cardiology Authors: Angela Duvalyan, Ricardo M. La Hoz, Darren K McGuire, Mark H. Drazner Tags: Review Article Source Type: research
Effect of Luseogliflozin, a Sodium-Glucose Cotransporter 2 Inhibitor, and Dipeptidyl-Peptidase 4 Inhibitors on the Quality-of-Life and Treatment Satisfaction of Patients With Type 2 Diabetes Mellitus: A Subanalysis of a Multicenter, Open-Label, Randomized-Controlled Trial (J-SELECT Study)
ConclusionsPhysicians should pay attention to side effects of SGLT2is to maintain the patients ’ QOL when SGLT2is are initiated or added-on. Add-on of luseogliflozin increased patients’ QOL more than DPP-4is. Considering patients’ QOL and treatment satisfaction is important for selecting SGLT2is or DPP-4is.Trial RegistrationUMIN000030128 and jRCTs031180241. (Source: Diabetes Therapy)
Source: Diabetes Therapy - April 24, 2024 Category: Endocrinology Source Type: research
Effects of sodium-glucose cotransporter 2 inhibitors on bone metabolism in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
Sodium glucose cotransporter 2 (SGLT2) inhibitors are widely used in type 2 diabetes mellitus (T2DM) therapy. The impact of SGLT2 inhibitors on bone metabolism has been widely taken into consideration. But the... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - April 24, 2024 Category: Endocrinology Authors: Jing Wang, Xin Li, Yang Li and Chen Lei Tags: Research Source Type: research
The IDEAL (Insulin therapy DE-intensificAtion with iglarLixi) Randomised Controlled Trial —Study Design and Protocol
AbstractIntroductionMultiple daily injection insulin regimen (MDI) represents the most intensive insulin regimen used in the management of people with type 2 diabetes (PwT2D). Its efficacy regarding glycaemic control is counterbalanced by the increased risk of hypoglycaemia, frequently observed tendency to weight gain and necessity for frequent glucose monitoring. Recent introduction of novel antidiabetic medications with pleiotropic effects reaching far beyond the reduction of glycaemia (HbA1c), such as the glucagon-like peptide 1 receptor agonist (GLP-1 RA), has significantly widened the therapeutic options available for...
Source: Diabetes Therapy - April 24, 2024 Category: Endocrinology Source Type: research
Tear film stability in patients with symptoms of dry eye after instillation of dual polymer hydroxypropyl guar/sodium hyaluronate vs single polymer sodium hyaluronate
ConclusionBoth DPHG/SH and single polymer SH solutions provide lubrication of the eye surface, however, with no difference in NIKBUT and TMH evaluations for up to two hours following administration. (Source: International Ophthalmology)
Source: International Ophthalmology - April 24, 2024 Category: Opthalmology Source Type: research
Molecules, Vol. 29, Pages 1937: Structure Effects on Swelling Properties of Hydrogels Based on Sodium Alginate and Acrylic Polymers
ński
Hydrogels based on sodium alginate (SA) and partially neutralised poly(acrylic acid) were obtained by radical polymerisation. The hydrogels were cross-linked with N,N′-methylenebisacrylamide (MBA), simultaneously grafting the resulting polymer onto SA. The findings of the FTIR spectroscopy showed that all of the hydrogels were effectively synthesized and sodium alginate was chemically bonded with the poly(sodium acrylate) matrix. DSC analysis of the melting heat and glass transition parameters indicated that the hydrogel structure had changed as a result of the cross-linking process. Sodium alginate...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Grzegorz Kowalski Mariusz Witczak Łukasz Kuterasiński Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1940: Protective Effect of Perilla Seed Meal and Perilla Seed Extract against Dextran Sulfate Sodium-Induced Ulcerative Colitis through Suppressing Inflammatory Cytokines in Mice
n Kangwan
An excessive inflammatory response of the gastrointestinal tract is recognized as one of the major contributors to ulcerative colitis (UC). Despite this, effective preventive approaches for UC remain limited. Rosmarinic acid (RA), an enriched fraction from Perilla frutescens, has been shown to exert beneficial effects on disease-related inflammatory disorders. However, RA-enriched perilla seed meal (RAPSM) and perilla seed (RAPS) extracts have not been investigated in dextran sulfate sodium (DSS)-induced UC in mice. RAPSM and RAPS were extracted using the solvent-partitioning method and analyzed with high-pre...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Natticha Sumneang Komsak Pintha Sarawut Kongkarnka Maitree Suttajit Napapan Kangwan Tags: Article Source Type: research
