Knockdown of TOP2A suppresses IL ‐17 signaling pathway and alleviates the progression of ulcerative colitis
ConclusionKnockdown of TOP2A alleviated the progression of UC by suppressing inflammation and inhibited IL-17 signaling pathway. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 25, 2024 Category: Allergy & Immunology Authors: Ou Li,
Xuexiao Li,
Jianping He Tags: ORIGINAL ARTICLE Source Type: research
Continuous Flow Electrochemical Synthesis of Olivine ‐Structured NaFePO4 Cathode Material for Sodium‐Ion Batteries from Recycle LiFePO4
Schematic of the working principle of a continuous flow electrochemical solid-liquid coupled reactor for the synthesis of NFP, by which NFP is successfully synthesized at 50% of the theoretical reductant dosage. The binding energy of NaxFePO4 (0< x< 0.95) is calculated to investigate the incomplete insertion of sodium ions during NFP synthesis. AbstractTo mitigate the environmental impact of the improper disposal of spent LiFePO4 batteries and reduce resource waste, the development of LiFePO4 recycling technologies is of paramount importance. Meanwhile, olivine-structured NaFePO4 in sodium-ion batteries has received ...
Source: Small - April 25, 2024 Category: Nanotechnology Authors: Tongtong Gan,
Jiashu Yuan,
Fang Chen,
Guodong Zhang,
Laihao Liu,
Li Zhou,
Yunfang Gao,
Yonggao Xia Tags: Research Article Source Type: research
Spatial Atlas for Mapping Vascular Microcalcification Using 18F-NaF PET/CT: Application in Hyperphosphatemic Familial Tumoral Calcinosis
CONCLUSIONS: This technique affords the ability to visualize spatial patterns of the active microcalcification process in the peripheral vasculature. Further, this technique affords the ability to track microcalcifications at precise locations not only across time but also across subjects. This technique is readily adaptable to other diseases of vascular calcification and may represent a significant advance in the field of vascular biology.PMID:38660800 | DOI:10.1161/ATVBAHA.123.320455 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Aaron J Sheppard Elizabeth H Theng Sriram S Paravastu Natalia M Wojnowski Faraz Farhadi Michael A Morris Iris R Hartley Rachel I Gafni Kelly L Roszko Michael T Collins Babak Saboury Source Type: research
Spatial Atlas for Mapping Vascular Microcalcification Using 18F-NaF PET/CT: Application in Hyperphosphatemic Familial Tumoral Calcinosis
CONCLUSIONS: This technique affords the ability to visualize spatial patterns of the active microcalcification process in the peripheral vasculature. Further, this technique affords the ability to track microcalcifications at precise locations not only across time but also across subjects. This technique is readily adaptable to other diseases of vascular calcification and may represent a significant advance in the field of vascular biology.PMID:38660800 | DOI:10.1161/ATVBAHA.123.320455 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Aaron J Sheppard Elizabeth H Theng Sriram S Paravastu Natalia M Wojnowski Faraz Farhadi Michael A Morris Iris R Hartley Rachel I Gafni Kelly L Roszko Michael T Collins Babak Saboury Source Type: research
Spatial Atlas for Mapping Vascular Microcalcification Using 18F-NaF PET/CT: Application in Hyperphosphatemic Familial Tumoral Calcinosis
CONCLUSIONS: This technique affords the ability to visualize spatial patterns of the active microcalcification process in the peripheral vasculature. Further, this technique affords the ability to track microcalcifications at precise locations not only across time but also across subjects. This technique is readily adaptable to other diseases of vascular calcification and may represent a significant advance in the field of vascular biology.PMID:38660800 | DOI:10.1161/ATVBAHA.123.320455 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Aaron J Sheppard Elizabeth H Theng Sriram S Paravastu Natalia M Wojnowski Faraz Farhadi Michael A Morris Iris R Hartley Rachel I Gafni Kelly L Roszko Michael T Collins Babak Saboury Source Type: research
Bazedoxifene attenuates dextran sodium sulfate-induced colitis in mice through gut microbiota modulation and inhibition of STAT3 and NF- κB pathways
This study highlights gut microbiota's role in IBD drug development, offering insights for BZA's future development and its clinical applications.PMID:38663540 | DOI:10.1016/j.ejphar.2024.176611 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 25, 2024 Category: Drugs & Pharmacology Authors: Liumei Liang Jingdan Zhang Junxiong Chen Yu Tian Weiqian Li Mengchen Shi Sijing Cheng Yinhai Zheng Chen Wang Huanliang Liu Xiangling Yang Weibiao Ye Source Type: research
Spatial Atlas for Mapping Vascular Microcalcification Using 18F-NaF PET/CT: Application in Hyperphosphatemic Familial Tumoral Calcinosis
CONCLUSIONS: This technique affords the ability to visualize spatial patterns of the active microcalcification process in the peripheral vasculature. Further, this technique affords the ability to track microcalcifications at precise locations not only across time but also across subjects. This technique is readily adaptable to other diseases of vascular calcification and may represent a significant advance in the field of vascular biology.PMID:38660800 | DOI:10.1161/ATVBAHA.123.320455 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Aaron J Sheppard Elizabeth H Theng Sriram S Paravastu Natalia M Wojnowski Faraz Farhadi Michael A Morris Iris R Hartley Rachel I Gafni Kelly L Roszko Michael T Collins Babak Saboury Source Type: research
Acetyl-CoA-dependent ac < sup > 4 < /sup > C acetylation promotes the osteogenic differentiation of LPS-stimulated BMSCs
Int Immunopharmacol. 2024 Apr 24;133:112124. doi: 10.1016/j.intimp.2024.112124. Online ahead of print.ABSTRACTThe impaired osteogenic capability of bone marrow mesenchymal stem cells (BMSCs) caused by persistent inflammation is the main pathogenesis of inflammatory bone diseases. Recent studies show that metabolism is disturbed in osteogenically differentiated BMSCs in response to Lipopolysaccharide (LPS) treatment, while the mechanism involved remains incompletely revealed. Herein, we demonstrated that BMSCs adapted their metabolism to regulate acetyl-coenzyme A (acetyl-CoA) availability and RNA acetylation level, ultimat...
Source: International Immunopharmacology - April 25, 2024 Category: Allergy & Immunology Authors: Yujia Bai Wenjie Zhang Lili Hao Yiqing Zhao I-Chen Tsai Yipin Qi Qiong Xu Source Type: research
Nitazoxanide protects against experimental ulcerative colitis through improving intestinal barrier and inhibiting inflammation
In conclusion, nitazoxanide protects against DSS-induced ulcerative colitis in mice through improving intestinal barrier and inhibiting inflammation and the underlying mechanism involves AMPK activation and JAK2/STAT3 inhibition.PMID:38663798 | DOI:10.1016/j.cbi.2024.111013 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - April 25, 2024 Category: Molecular Biology Authors: Hu-Tai-Long Zhu Jing Luo Yi Peng Xiao-Fan Cheng Shang-Ze Wu Yin-Di Zhao Le Chang Zhi-Jie Sun De-Li Dong Source Type: research
The cardiovascular safety of sodium nitroprusside in acute heart failure
Expert Opin Drug Saf. 2024 Apr 25. doi: 10.1080/14740338.2024.2348570. Online ahead of print.NO ABSTRACTPMID:38661629 | DOI:10.1080/14740338.2024.2348570 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 25, 2024 Category: Drugs & Pharmacology Authors: Pier Paolo Bocchino Filippo Angelini Guglielmo Gallone Simone Frea Gaetano Maria De Ferrari Source Type: research
Synthesis and evaluation of pentacyclic triterpenoids conjugates as novel HBV entry inhibitors targeting NTCP receptor
In this study, pentacyclic triterpenoids (PTs) including glycyrrhetinic acid (GA), oleanolic acid (OA), ursolic acid (UA) and betulinic acid (BA) were modified via molecular hybridization with podophyllotoxin respectively, and resulted in thirty-two novel conjugates. The anti-HBV activities of conjugates were evaluated in HepG2.2.15 cells. The results showed that 66% of the conjugates exhibited lower toxicity to the host cells and had significant inhibitory effects on the two HBV antigens, especially HBsAg. Notably, the compounds BA-PPT1, BA-PPT3, BA-PPT4, and UA-PPT3 not only inhibited the secretion of HBsAg but also supp...
Source: Bioorganic Chemistry - April 25, 2024 Category: Chemistry Authors: Yixin Chen Meitao Duan Xiangwan Wang Jianling Xu Shuo Tian Xiaotian Xu Ao Duan Ahmed Mahal Yongyan Zhu Quanhong Zhu Source Type: research
Revealing Na+-coordination Induced Failure Mechanism of Metal Sulfide Anode for Sodium Ion Batteries
Angew Chem Int Ed Engl. 2024 Apr 25:e202403463. doi: 10.1002/anie.202403463. Online ahead of print.ABSTRACTMetal sulfide (MS) is regarded as a promising candidate of the anode materials for sodium-ion battery (SIB) with ideal capacity and low cost, yet still suffers from the inferior cycling stability and voltage degradation. Herein, the coordination relationship between the discharge product Na2S with the Na+ (NaPF6) in the electrolyte, is revealed as the root cause for the cycling failure of MS. Na+-coordination effect assistants the dissolution of Na2S, further delocalizing Na2S from the reaction interface under the fun...
Source: Angewandte Chemie - April 25, 2024 Category: Chemistry Authors: Yuchen Fu Jun Sun Yunsheng Zhang Wei Qu Weichao Wang Meng Yao Yun Zhang Qian Wang Yongfu Tang Source Type: research
Acetyl-CoA-dependent ac < sup > 4 < /sup > C acetylation promotes the osteogenic differentiation of LPS-stimulated BMSCs
Int Immunopharmacol. 2024 Apr 24;133:112124. doi: 10.1016/j.intimp.2024.112124. Online ahead of print.ABSTRACTThe impaired osteogenic capability of bone marrow mesenchymal stem cells (BMSCs) caused by persistent inflammation is the main pathogenesis of inflammatory bone diseases. Recent studies show that metabolism is disturbed in osteogenically differentiated BMSCs in response to Lipopolysaccharide (LPS) treatment, while the mechanism involved remains incompletely revealed. Herein, we demonstrated that BMSCs adapted their metabolism to regulate acetyl-coenzyme A (acetyl-CoA) availability and RNA acetylation level, ultimat...
Source: International Immunopharmacology - April 25, 2024 Category: Allergy & Immunology Authors: Yujia Bai Wenjie Zhang Lili Hao Yiqing Zhao I-Chen Tsai Yipin Qi Qiong Xu Source Type: research
Defining the in vivo role of mTORC1 in thyrocytes by studying the TSC2 conditional knockout mouse model
CONCLUSIONS: Our thyrocyte-specific mouse model reveals that mTORC1 activation inhibits TH biosynthesis, suppresses thyrocyte gene expression, and promotes growth and proliferation.PMID:38661550 | DOI:10.1089/thy.2024.0053 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 25, 2024 Category: Endocrinology Authors: Camila Ludke Rossetti Bruna Lourenconi Alves Flavia Leticia Martins Pecanha Aime Franco Vania Nos é Everardo Magalh ães Carneiro John I Lew Ernesto Bernal-Mizrachi Joao Pedro Werneck de Castro Source Type: research
Spatial Atlas for Mapping Vascular Microcalcification Using 18F-NaF PET/CT: Application in Hyperphosphatemic Familial Tumoral Calcinosis
CONCLUSIONS: This technique affords the ability to visualize spatial patterns of the active microcalcification process in the peripheral vasculature. Further, this technique affords the ability to track microcalcifications at precise locations not only across time but also across subjects. This technique is readily adaptable to other diseases of vascular calcification and may represent a significant advance in the field of vascular biology.PMID:38660800 | DOI:10.1161/ATVBAHA.123.320455 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Aaron J Sheppard Elizabeth H Theng Sriram S Paravastu Natalia M Wojnowski Faraz Farhadi Michael A Morris Iris R Hartley Rachel I Gafni Kelly L Roszko Michael T Collins Babak Saboury Source Type: research
