Epidemiology and Management of Patients With Kidney Disease and Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) comprises approximately one-half of all diagnoses of heart failure. There is significant overlap of this clinical syndrome with chronic kidney disease (CKD), with many shared comorbid conditions. The presence of CKD in patients with HFpEF is one of the most powerful risk factors for adverse clinical outcomes, including death and heart failure hospitalization. The pathophysiology linking HFpEF and CKD remains unclear, but it is postulated to consist of numerous bidirectional pathways, including endothelial dysfunction, inflammation, obesity, insulin resistance, and impa...
Source: Seminars in Nephrology - May 3, 2024 Category: Urology & Nephrology Authors: Marcelle L. Tuttle, James C. Fang, Mark J. Sarnak, Wendy McCallum Source Type: research
Sodium oligomannate activates the enteroendocrine-vagal afferent pathways in APP/PS1 mice
Acta Pharmacologica Sinica, Published online: 03 May 2024; doi:10.1038/s41401-024-01293-wSodium oligomannate activates the enteroendocrine-vagal afferent pathways in APP/PS1 mice (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - May 3, 2024 Category: Drugs & Pharmacology Authors: Hua-shan Gong Jing-pei Pan Fei Guo Mei-mei Wu Li Dong Yang Li Wei-fang Rong Source Type: research
Semaglutide combined with empagliflozin vs. monotherapy for non-alcoholic fatty liver disease in type 2 diabetes: Study protocol for a randomized clinical trial
This study has been registered with Chinese Clinical Trial Registry (ChiCTR2300070674). (Source: PLoS One)
Source: PLoS One - May 3, 2024 Category: Biomedical Science Authors: Yu-Hao Lin Source Type: research
A new method of alkalinity remediation for Cd-contaminated groundwater by PAAS-modified MgCO < sub > 3 < /sub > /Mg(OH) < sub > 2 < /sub > colloid
Chemosphere. 2024 Apr 30:142200. doi: 10.1016/j.chemosphere.2024.142200. Online ahead of print.ABSTRACTMg(OH)2 dissolves slowly and can provide a long-term source of alkalinity, thus a promising alternative reagent for the in situ remediation of heavy metal polluted groundwater. Unfortunately, it exhibits a relatively poor stabilization effect on heavy metal Cd due to the higher solubility of the resulting stabilized product, Cd(OH)2. To overcome this limitation, we investigated the use of MgCO3/Mg(OH)2 colloid modified by sodium polyacrylate (PAAS) to remove Cd from groundwater. Through ultrasonic dispersion, the molecula...
Source: Chemosphere - May 2, 2024 Category: Chemistry Authors: Bowen Li Meiling Tang Peng Wang Shibin Liu Meng Yao Jun Dong Source Type: research
Synthesis of solid sodium silicate from waste glass and utilization on one-part alkali-activated materials based on spent oil filtering earth
Environ Sci Pollut Res Int. 2024 May 2. doi: 10.1007/s11356-024-33368-w. Online ahead of print.ABSTRACTAlkali activated materials (AAMs) commonly known as geopolymers are considered ecofriendly substitutes for Portland cement. However, these materials still have a significant environmental impact, owing mainly to the use of activators based on commercial chemical products. In this sense, this research focuses on the production and use of waste glass-derived activators AAMs as an alternative to commercial activators. Using a thermochemical synthesis method, activator compositions were systematically designed to achieve pred...
Source: Environmental Science and Pollution Research International - May 2, 2024 Category: Environmental Health Authors: Pedro Delgado-Plana Salvador Bueno-Rodr íguez Luis P érez-Villarejo Dolores Eliche-Quesada Source Type: research
Physicochemical and antioxidant properties of pectin fractions extracted from lemon (Citrus Eureka) peels
In conclusion, this study presents a novel method for extracting various lemon pectin fractions with unique structural and bioactive properties, contributing insights for advanced applications in the food and pharmaceutical sectors.PMID:38697443 | DOI:10.1016/j.ijbiomac.2024.132014 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - May 2, 2024 Category: Biochemistry Authors: Zhipeng Su Yuchen Liu Lingtao Kang Xia Chang Xinjia Tan Dan Shen Xue Wang Hong-Hui Wang Gaoyang Li Source Type: research
Polyacrylamide/sodium alginate/sodium chloride photochromic hydrogel with high conductivity, anti-freezing property and fast response for information storage and electronic skin
In this study, a novel photochromic hydrogel (PAAm/SA/NaCl-Mo7) was prepared by loading ammonium molybdate (Mo7) and sodium chloride (NaCl) into a dual-network hydrogel of polyacrylamide (PAAm) and sodium alginate (SA) using a simple one-pot method. PAAm/SA/NaCl-Mo7 hydrogel has excellent conductivity (175.9 S/cm), water retention capacity and anti-freezing properties, which can work normally at a low temperature of -28.4 °C. In addition, the prepared PAAm/SA/NaCl-Mo7 hydrogel exhibits fast response (<15 s), high transparency (>70 %), good toughness (maximum elongation up to 1500 %), good cyclic compression properti...
Source: International Journal of Biological Macromolecules - May 2, 2024 Category: Biochemistry Authors: Xiaohu Chen Jiashu Cui Zhisheng Liu Yanen Wang Mingyang Li Juan Zhang Siyu Pan Mengjie Wang Chengwei Bao Qinghua Wei Source Type: research
Construction of a pectin/sodium alginate composite hydrogel delivery system for improving the bioaccessibility of phycocyanin
In conclusion, our findings offer new insights into improving functionality and the effective use of phycocyanin via pectin-based hydrogel spheres.PMID:38697419 | DOI:10.1016/j.ijbiomac.2024.131969 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - May 2, 2024 Category: Biochemistry Authors: Zhixin Li Yuxin Geng Kaixuan Bu Zhengtao Chen Kang Xu Chuanhe Zhu Source Type: research
Salt reduction in myofibrillar protein gel via inhomogeneous distribution of sodium-containing encapsulated fish oil coacervate: Mucopenetration ability of sodium carboxymethyl cellulose
Int J Biol Macromol. 2024 Apr 30;268(Pt 2):131998. doi: 10.1016/j.ijbiomac.2024.131998. Online ahead of print.ABSTRACTThe potential application of fish oil microcapsules as salt reduction strategies in low-salt myofibrillar protein (MP) gel was investigated by employing soy protein isolates/carboxymethyl cellulose sodium (SPI-CMC) coacervates enriched with 25 mM sodium chloride and exploring their rheological characteristics, taste perception, and microstructure. The results revealed that the SPI-CMC coacervate phase exhibited the highest sodium content under 25 mM sodium level, albeit with uneven distribution. Notably, th...
Source: International Journal of Biological Macromolecules - May 2, 2024 Category: Biochemistry Authors: Yongfang Gao Yanjie Guo Jiarui Ye Hafiz Nabeel Ahmad Jie Zhu Source Type: research
A new method of alkalinity remediation for Cd-contaminated groundwater by PAAS-modified MgCO < sub > 3 < /sub > /Mg(OH) < sub > 2 < /sub > colloid
Chemosphere. 2024 Apr 30:142200. doi: 10.1016/j.chemosphere.2024.142200. Online ahead of print.ABSTRACTMg(OH)2 dissolves slowly and can provide a long-term source of alkalinity, thus a promising alternative reagent for the in situ remediation of heavy metal polluted groundwater. Unfortunately, it exhibits a relatively poor stabilization effect on heavy metal Cd due to the higher solubility of the resulting stabilized product, Cd(OH)2. To overcome this limitation, we investigated the use of MgCO3/Mg(OH)2 colloid modified by sodium polyacrylate (PAAS) to remove Cd from groundwater. Through ultrasonic dispersion, the molecula...
Source: Chemosphere - May 2, 2024 Category: Chemistry Authors: Bowen Li Meiling Tang Peng Wang Shibin Liu Meng Yao Jun Dong Source Type: research
Activation of peroxymonosulfate by Fe,N co-doped walnut shell biochar for the degradation of sulfamethoxazole: performance and mechanisms
Environ Pollut. 2024 Apr 30:124018. doi: 10.1016/j.envpol.2024.124018. Online ahead of print.ABSTRACTFe and N co-doped walnut shell biochar (Fe,N-BC) was prepared through a one-pot pyrolysis procedure by using walnut shells as feedstocks, melamine as the N source, and iron(III) chloride as the Fe source. Moreover, pristine biochar (BC), nitrogen-doped biochar (N-BC), and α-Fe2O3-BC were synthesized as controls. All the prepared materials were characterized by different techniques and were used for the activation of peroxymonosulfate (PMS) for the degradation of sulfamethoxazole (SMX). A very high degradation rate for SMX ...
Source: Environmental Pollution - May 2, 2024 Category: Environmental Health Authors: Yongtao Xue Mohammadreza Kamali Maria Elisabete V Costa Ian P Thompson Wei Huang Barbara Rossi Lise Appels Raf Dewil Source Type: research
Enhanced ac4C detection in RNA via chemical reduction and cDNA synthesis with modified dNTPs
RNA. 2024 May 2:rna.079863.123. doi: 10.1261/rna.079863.123. Online ahead of print.ABSTRACTThe functional analysis of epitranscriptomic modifications in RNA is constrained by a lack of methods that accurately capture their locations and levels. We previously demonstrated that the RNA modification N4-acetylcytidine (ac4C) can be mapped at base-resolution through sodium borohydride reduction to tetrahydroacetylcytidine (tetrahydro-ac4C), followed by cDNA synthesis to misincorporate adenosine opposite reduced ac4C sites, culminating in C:T mismatches at acetylated cytidines (RedaC:T). However, this process is relatively ineff...
Source: RNA - May 2, 2024 Category: Genetics & Stem Cells Authors: Sebastien Relier Sarah Schiffers Hamid Beiki Shalini Oberdoerffer Source Type: research
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization
J Mol Med (Berl). 2024 May 2. doi: 10.1007/s00109-024-02447-3. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is characterized by inflammatory conditions in the gastrointestinal tract. According to reports, IBD prevalence is increasing globally, with heavy economic and physical burdens. Current IBD clinical treatment is limited to pharmacological methods; therefore, new strategies are needed. Myeloid-derived growth factor (MYDGF) secreted by bone marrow-derived mononuclear macrophages has beneficial effects in multiple inflammatory diseases. To this end, the present study aimed to establish an experimental ...
Source: Molecular Medicine - May 2, 2024 Category: Molecular Biology Authors: Yang Yang Conghui Zhao Zi Yang Conglin Du Zhichao Chang Xin Wen Xiujuan Zhang Yi Liu Liang Hu Zhenhua Gao Source Type: research
Enhanced ac4C detection in RNA via chemical reduction and cDNA synthesis with modified dNTPs
RNA. 2024 May 2:rna.079863.123. doi: 10.1261/rna.079863.123. Online ahead of print.ABSTRACTThe functional analysis of epitranscriptomic modifications in RNA is constrained by a lack of methods that accurately capture their locations and levels. We previously demonstrated that the RNA modification N4-acetylcytidine (ac4C) can be mapped at base-resolution through sodium borohydride reduction to tetrahydroacetylcytidine (tetrahydro-ac4C), followed by cDNA synthesis to misincorporate adenosine opposite reduced ac4C sites, culminating in C:T mismatches at acetylated cytidines (RedaC:T). However, this process is relatively ineff...
Source: RNA - May 2, 2024 Category: Genetics & Stem Cells Authors: Sebastien Relier Sarah Schiffers Hamid Beiki Shalini Oberdoerffer Source Type: research
Activation of peroxymonosulfate by Fe,N co-doped walnut shell biochar for the degradation of sulfamethoxazole: performance and mechanisms
Environ Pollut. 2024 Apr 30:124018. doi: 10.1016/j.envpol.2024.124018. Online ahead of print.ABSTRACTFe and N co-doped walnut shell biochar (Fe,N-BC) was prepared through a one-pot pyrolysis procedure by using walnut shells as feedstocks, melamine as the N source, and iron(III) chloride as the Fe source. Moreover, pristine biochar (BC), nitrogen-doped biochar (N-BC), and α-Fe2O3-BC were synthesized as controls. All the prepared materials were characterized by different techniques and were used for the activation of peroxymonosulfate (PMS) for the degradation of sulfamethoxazole (SMX). A very high degradation rate for SMX ...
Source: Environmental Pollution - May 2, 2024 Category: Environmental Health Authors: Yongtao Xue Mohammadreza Kamali Maria Elisabete V Costa Ian P Thompson Wei Huang Barbara Rossi Lise Appels Raf Dewil Source Type: research
