Anti-inflammatory activity of the phenol rich fraction of Garcinia pedunculata Roxb (ex. Buch Ham): an in vitro and in vivo study
This study provides evidence thatG. pedunculata fruit extract plays a critical role in anti-inflammatory activity, indicating that it can be a potential candidate for further investigation in the treatment of inflammation-related diseases. (Source: Inflammopharmacology)
Source: Inflammopharmacology - May 2, 2024 Category: Drugs & Pharmacology Source Type: research
Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine
ConclusionsARG2 produces spermidine endogenously in the intestinal epithelium and has a palliative effect on ulcerative colitis. ARG2 and spermidine are potential novel therapeutic targets for UC. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - May 2, 2024 Category: Gastroenterology Source Type: research
The effect of sodium hyaluronate on dry eye and corneal epithelial thickness following cataract surgery
ConclusionIn the patient group using sodium hyaluronate, significant differences were determined in all dry eye parameters and CCET. The use of hyaluronate sodium drops after cataract surgery was seen to improve dry eye parameters and contribute to a healthy ocular surface by ensuring continuity of the corneal epithelium. (Source: International Ophthalmology)
Source: International Ophthalmology - May 2, 2024 Category: Opthalmology Source Type: research
Contemporary Decongestive Strategies in Acute Heart Failure
Congestion is the primary driver of hospital admissions in patients with heart failure and the key determinant of their outcome. Although intravenous loop diuretics remain the predominant agents used in the setting of acute heart failure, the therapeutic response is known to be variable, with a significant subset of patients discharged from the hospital with residual hypervolemia. In this context, urinary sodium excretion has gained attention both as a marker of response to loop diuretics and as a marker of prognosis that may be a useful clinical tool to guide therapy. (Source: Seminars in Nephrology)
Source: Seminars in Nephrology - May 2, 2024 Category: Urology & Nephrology Authors: Amir Kazory Source Type: research
Myeloid-derived growth factor ameliorates dextran sodium sulfate-induced colitis by regulating macrophage polarization
AbstractInflammatory bowel disease (IBD) is characterized by inflammatory conditions in the gastrointestinal tract. According to reports, IBD prevalence is increasing globally, with heavy economic and physical burdens. Current IBD clinical treatment is limited to pharmacological methods; therefore, new strategies are needed. Myeloid-derived growth factor (MYDGF) secreted by bone marrow-derived mononuclear macrophages has beneficial effects in multiple inflammatory diseases. To this end, the present study aimed to establish an experimental IBD mouse model using dextran sulfate sodium in drinking water. MYDGF significantly a...
Source: Journal of Molecular Medicine - May 2, 2024 Category: Molecular Biology Source Type: research
Influence of compositions of sodium nitrite waste liquids containing Cs+ on geopolymer waste-form ’s mineral-phases under hydrothermally-sintered process
AbstractSodium salt waste (SSW) liquid containing Cs-137 is characterized by complex chemical compositions. Based on the content variation of Cs+, NaNO2 and NaOH in a simulated SSW liquid, the influence of SSW compositions on the structures of geopolymer waste-forms (GWF) was investigated. Especially, the immobilization of SSW liquid easily led to residual sodium salts and deteriorate the properties of GWF. Therefore, a hydrothermally-sintered hybrid process was exploited to remove residual salts to improve GWF ’s mechanical properties and the ability to immobilize Cs+. The process also reduced the volatilization of Cs+ ...
Source: Journal of Radioanalytical and Nuclear Chemistry - May 2, 2024 Category: Nuclear Medicine Source Type: research
Design of novel Cu-doped SnS2 on carbon cloth as a binder-free anode to improve high-rate performance of sodium ion battery
New J. Chem., 2024, Advance Article DOI: 10.1039/D4NJ00677A, PaperTsai-Mu Cheng, Kuan-Hsien Lin, Chutima Kongvarhodom, Hung-Ming Chen, Sadang Husain, Sibidou Yougbar é, Lu-Yin Lin Binder-free Cu-doped SnS2@CC electrodes with vertical grown nanosheet arrays are proposed. The highest capacity of 1092.8 mA h g−1 was got at 0.1 A g−1, indicating that doping Cu can improve rate performance of SnS2, but excess Cu doping leads to reduced rate performance with overloaded defects. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Che...
Source: RSC - New J. Chem. latest articles - May 1, 2024 Category: Chemistry Authors: Tsai-Mu Cheng Source Type: research
SGLT-2 inhibitors May Decrease Recurrent Gout Flares in Patients with Type 2 diabetes
Dr. Bernal
Clinical question: Do SGLT-2 inhibitors decrease gout flares in patients with type 2 diabetes and a known history of gout?
Background: Sodium–glucose cotransporter-2 inhibitors (SGLT-2 inhibitors) are known to decrease serum urate levels and the risk of incident gout. However, their role in secondary prevention of gout flares is unknown.
Study design: Propensity score–matched, new-user cohort study
Setting: British Columbia, Canada
Synopsis: Using a group of population-based, linked, administrative databases, the population of British Columbia was studied. 15,067 patients with gout and type 2 diabetes had f...
Source: The Hospitalist - May 1, 2024 Category: Hospital Management Authors: Ronda Whitaker Tags: Autoimmune Diseases In the Literature Pharmacology Rheumatology Source Type: research
Effects of Empagliflozin on vascular and skeletal mineralization in Hyperlipidemic mice
Vascul Pharmacol. 2024 Apr 29:107376. doi: 10.1016/j.vph.2024.107376. Online ahead of print.ABSTRACTCardiovascular disease and osteoporosis, major causes of morbidity and mortality, are associated with hyperlipidemia. Recent studies show that empagliflozin (EMPA), an inhibitor of sodium-glucose cotransporter-2 (SGLT2), improves cardiovascular health. In preclinical animal studies, EMPA mitigates vascular calcification in the males but its effects in the females are not known. Thus, we used female mice to test the effects of EMPA on calcification in the artery wall, cardiac function, and skeletal bone. By serial in vivo mic...
Source: Vascular Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Sophia Kalanski Stuti Pradhan Andy Hon Yuxuan Xia Nora Safvati Juan Carlos Rivera Mimi Lu Linda L Demer Yin Tintut Source Type: research
Chitin-glucan improves important pathophysiological features of irritable bowel syndrome
CONCLUSION: CG decreased visceral perception and intestinal inflammation through master gene regulation and direct binding of microbial products, suggesting that CG may constitute a new therapeutic strategy for patients with IBS or IBS-like symptoms.PMID:38690023 | PMC:PMC11056916 | DOI:10.3748/wjg.v30.i16.2258 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - May 1, 2024 Category: Gastroenterology Authors: Caroline Valibouze Caroline Dubuquoy Philippe Chavatte Micha ël Genin Veronique Maquet Salvatore Modica Pierre Desreumaux Christel Rousseaux Source Type: research
Zinc Suppresses Colorectal Cancer Development through Cell-mediated Immunity
Yakugaku Zasshi. 2024;144(5):475-481. doi: 10.1248/yakushi.23-00154-1.ABSTRACTZinc is one of the essential trace elements, and is involved in various functions in the body. Zinc deficiency is known to cause immune abnormalities, but the mechanism is not fully understood. Therefore, we focused our research on tumor immunity to elucidate the effect of zinc on colorectal cancer and its mechanisms. Mice were treated with azoxymethane (AOM) and dextran sodium sulfate (DSS) to develop colorectal cancer, then the relationship between zinc content in the diet and the number and area of tumors in the colon was observed. The number ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Keigo Nishida Naoya Nakagawa Source Type: research
Analysis of the Divalent Cation Blocking in Ion Channels by Crystal Structure and Molecular Dynamics Simulations
In this study, we elucidated the molecular mechanism of the divalent cation block by reproducing the divalent cation block in NavAb. The X-ray crystal structure of divalent-cation-block mutants show electron density in the ion transmission pathway of the divalent cation blocked mutants, indicating that the mutations increasing the hydrophilicity of the inner vestibule of the pore domain enable a divalent cation to stack into the ion pathway. In molecular dynamics simulations, the stacked calcium ion repels the sodium ions near the channel lumen's entrance at the selective filter's bottom. These results suggest the primary ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Katsumasa Irie Source Type: research
Chitin-glucan improves important pathophysiological features of irritable bowel syndrome
CONCLUSION: CG decreased visceral perception and intestinal inflammation through master gene regulation and direct binding of microbial products, suggesting that CG may constitute a new therapeutic strategy for patients with IBS or IBS-like symptoms.PMID:38690023 | PMC:PMC11056916 | DOI:10.3748/wjg.v30.i16.2258 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 1, 2024 Category: Gastroenterology Authors: Caroline Valibouze Caroline Dubuquoy Philippe Chavatte Micha ël Genin Veronique Maquet Salvatore Modica Pierre Desreumaux Christel Rousseaux Source Type: research
Effects of Empagliflozin on vascular and skeletal mineralization in Hyperlipidemic mice
Vascul Pharmacol. 2024 Apr 29:107376. doi: 10.1016/j.vph.2024.107376. Online ahead of print.ABSTRACTCardiovascular disease and osteoporosis, major causes of morbidity and mortality, are associated with hyperlipidemia. Recent studies show that empagliflozin (EMPA), an inhibitor of sodium-glucose cotransporter-2 (SGLT2), improves cardiovascular health. In preclinical animal studies, EMPA mitigates vascular calcification in the males but its effects in the females are not known. Thus, we used female mice to test the effects of EMPA on calcification in the artery wall, cardiac function, and skeletal bone. By serial in vivo mic...
Source: Vascular Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Sophia Kalanski Stuti Pradhan Andy Hon Yuxuan Xia Nora Safvati Juan Carlos Rivera Mimi Lu Linda L Demer Yin Tintut Source Type: research
Fine extraction of cellulose from corn straw and the application for eco-friendly packaging films enhanced with polyvinyl alcohol
Int J Biol Macromol. 2024 Apr 30;268(Pt 2):131984. doi: 10.1016/j.ijbiomac.2024.131984. Online ahead of print.ABSTRACTBiomass materials substituting for petroleum-based polymers occupy an important position in achieving sustainable development. Cellulose, a typical biomass material, stands out as the primary choice for producing eco-friendly packaging materials. However, it is still a challenge to efficiently utilize cellulose from waste biomass materials in practice. Herein, cellulose-based films were prepared by pretreating waste corn straw, separating straw husk, straw pith and straw leaf, and extracting cellulose throu...
Source: International Journal of Biological Macromolecules - May 1, 2024 Category: Biochemistry Authors: Xin Zhang Changqing Fang Youliang Cheng Mengyao Li Jie Liu Source Type: research
