DIREN mitigates DSS-induced colitis in mice and attenuates collagen deposition via inhibiting the Wnt/ β-catenin and focal adhesion pathways

CONCLUSION: DIREN exerts a protective effect against DSS-induced UC by ameliorating colonic fibrosis via regulation of focal adhesion and the WNT/β-catenin signaling pathway, thereby inhibiting fibroblast migration and reducing collagen secretion.PMID:38678963 | DOI:10.1016/j.biopha.2024.116671
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Source Type: research